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BACKGROUND: Mesenchymal stem cells are used in flap ischemia-reperfusion injury due to their antioxidant and inflammatory inhibition, and angiogenesis induction. OBJECTIVE: To review the mechanism and latest treatment progress of mesenchymal stem cells in the treatment of flap ischemia-reperfusion injury, and to provide a basis for further theoretical research and clinical rational application. METHODS: We searched the relevant articles indexed in CNKI, WanFang and PubMed databases. Chinese and English search terms were “mesenchymal stem cells; flap ischemia reperfusion injury; conditioned medium; exosomes; oxidative stress; inflammatory reactions; angiogenesis”. Relevant literature since 2010 was searched, and 74 articles were finally included after excluding the literature that had little to do with the topic of the article, poor quality and outdated content. RESULTS AND CONCLUSION: (1) Mesenchymal stem cells play significant roles in antioxidation, inhibition of inflammation and induction of angiogenesis and have great potential in the treatment of flap ischemia-reperfusion injury. (2) However, the defects of mesenchymal stem cells themselves and the decline of therapeutic effect in recent years have put the development and application of mesenchymal stem cells into a bottleneck period, and the research on the plasticity of mesenchymal stem cells conditioned medium and its exosomes and mesenchymal stem cells came into being, and the therapeutic effect was significantly better than the use of mesenchymal stem cells alone. (3) Therefore, a more comprehensive understanding of the mechanism of action and the latest treatment progress of mesenchymal stem cells in the treatment of flap ischemia-reperfusion injury is of great significance for the research of mesenchymal stem cells and the treatment of flap ischemia-reperfusion injury. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

BACKGROUND: Mesenchymal stem cells have great potential in the treatment of ischemia-reperfusion injury of skin flaps. However, their defects and the decline of their role in the treatment of ischemia-reperfusion injury of skin flaps restrict their wide application. OBJECTIVE: To review the strategies for improving the treatment of ischemia-reperfusion injury of skin flaps with mesenchymal stem cells, and provide a reference for its further theoretical research and clinical application. METHODS: Relevant documents included in CNKI, WanFang and PubMed were searched. The Chinese and English search terms were “mesenchymal stem cell, ischemia-reperfusion adjustment of skin flap, mesenchymal stem cells, stem cells, skin flap, ischemia-reperfusion injury, pretreatment, gene modification, biomaterial packaging, joint application”. The relevant documents since 2007 were retrieved, and the documents with little relationship between the research content and the article theme, poor quality and outdated content were eliminated through reading the article, and finally 75 documents were included for summary. RESULTS AND CONCLUSION: (1) Mesenchymal stem cells can inhibit inflammatory reactions, resist oxidative stress and induce angiogenesis, which has great potential in the treatment of skin flap ischemia-reperfusion injury. (2) Although mesenchymal stem cells have shown great potential in the treatment of skin flap ischemia-reperfusion injury, their shortcomings in treatment have limited their widespread clinical application. Through pre-treatment (cytokines, hypoxia, drugs, and other pre-treatment mesenchymal stem cells), gene-modified mesenchymal stem cells, biomaterial encapsulation of mesenchymal stem cells, as well as the combined use of mesenchymal stem cells and other drugs or therapeutic methods, can not only overcome the shortcomings of mesenchymal stem cells in treatment, but also improve their therapeutic effectiveness in skin flap ischemia-reperfusion injury. (3) Therefore, further improving the effectiveness of mesenchymal stem cells in treating skin flap ischemia-reperfusion injury and exploring its therapeutic potential are of great significance for the research of mesenchymal stem cells and the treatment of skin flap ischemia-reperfusion injury. [ABSTRACT FROM AUTHOR]

Copyright of Lubrication Engineering (0254-0150) is the property of Editorial Office of LUBRICATION ENGINEERING and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of China Fiber Inspection / Zhongguo Xian-Jian is the property of China Fiber Inspection and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of China Fiber Inspection is the property of China Fiber Inspection and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

In promoting the development of China's digital economy, relevant departments have given full play to the underpinning role of the rule of law, actively promoted the formulation of laws and regulations in the field of data, and put in place a foundational legal system for data that combines vertical and horizontal aspects. Firstly, this paper introduces the basic overview of China's data legal system, including both horizontal system and vertical system. Secondly, it analyzes the vertical system, including data legislation at central and local levels, and covering laws, administrative regulations, departmental rules, local regulations and local administrative rules. Thirdly, it analyzes the horizontal system, including legal systems in the fields of data security and development, personal information protection, commercial data circulation and government data management. Finally, this paper summarizes the achievements of China's data legislation and deficiencies of the current data law system, and puts forward suggestions for improvement. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Kunming Medical University / Kunming Yike Daxue Xuebao is the property of Kunming Medical Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

BACKGROUND: Previous studies have confirmed that Xiaozhong Zhitong Mixture can alleviate ischemia-reperfusion injury of skin flaps, but its metabolomic mechanism has not been reported. OBJECTIVE: To explore the mechanism of Xiaozhong Zhitong Mixture against ischemia-reperfusion injury of rat skin flaps. METHODS: A rat skin flap ischemia-reperfusion injury model was established. Related metabolomics techniques were used to analyze the endogenous levels of metabolite samples from normal rats, model rats and rats after intervention with Xiaozhong Zhitong Mixture. Relevant biomarkers were retrieved and identified and metabolic pathways were then constructed. RESULTS AND CONCLUSION: Xiaozhong Zhitong Mixture could significantly reduce the pathological changes of skin flap tissue in rats with skin flap ischemiareperfusion injury. Significantly differential metabolites, including malonic acid and 3-(3-hydroxyphenyl)propionic acid, were identified and imported into MetaboAnalyst 4.0 and KEGG databases for metabolic pathway analysis. After intervention, the metabolic pathways of Xiaozhong Zhitong Mixture included pyrimidine metabolism and phenylalanine metabolism. To conclude, Xiaozhong Zhitong Mixture improves ischemia-reperfusion injury of rat skin flap by regulating the metabolic pathways such as pyrimidine and phenylalanine metabolic pathways, which thereby provides a theoretical basis for clarifying the mechanism of Xiaozhong Zhitong Mixture in the treatment of ischemia-reperfusion injury of rat skin flap. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Oncology is the property of Chinese Journal of Oncology / Zhonghua Zhongliu Zazhi and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The rise and development of the metaverse have brought challenges to legal regulation. The metaverse is not a place outside the law, it also needs to abide by the law and ensure the correct operation in the legal orbit. Firstly, the development characteristics of the metaverse were summarized, such as technological, commercial, social as well as transnational, and the risks and responses were analyzed. Secondly, the main legal conundrums of the metaverse were analyzed including cybersecurity, personal information and privacy protection, data governance, virtual property, ecological governance, platform liability, and cybercrime. Finally, the idea of regulating metaverse development according to law was put forward, it was suggested to adhere to the principle of safe and controllable development, the appropriately advanced layout of legislation of metaverse, promote regulations in main areas through legislative means such as enactment, reform, abolition, and interpretation, and achieved good governance through good laws. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Pesticide Science / Nongyaoxue Xuebao is the property of Chinese Journal of Pesticide Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The Personal Information Protection Law was deliberated in August, 2021 and officially implemented in November, promoting the establishment of China’s legal system for the protection of personal information. Firstly, the background of the Law was systematically introduced, which has gone through three deliberations and adheres to problem orientation, with distinctive features and great significance. Secondly, the rules of the Law were analyzed, focusing on the scope of the concept of personal information, the basic principles of processing personal information, the basis of legality, the rights and obligations of relevant subjects, the cross-border provision rules, as well as the legal liability. Finally, the development of personal information from indirect protection to direct protection and to comprehensive protection was summarized. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Silk is the property of Zhejiang Sci-Tech University Magazines and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Silk is the property of Zhejiang Sci-Tech University Magazines and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Kunming Medical University / Kunming Yike Daxue Xuebao is the property of Kunming Medical Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Kunming Medical University / Kunming Yike Daxue Xuebao is the property of Kunming Medical Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective　To investigate the clinical and CT image characteristics of COVID-19 pneumonia， and the predictive value of CT in the early stage of different clinical types. Methods　Chest CT and clinical data of confirmed 143 patients with COVID-19 pneumonia in January to February 2020 were enrolled. According to the diagnosis and treatment of COVID-19 pneumonia （trial version 7），all the patients were classified into the mild （n = ），common （n = 92），severe （n = 36），and critical （n = 5） type， and their clinical findings and CT findings were analyzed. CT features included lesions' distribution， density， extension， shape， interior/ periphery features， vascular changes. Then the prediction performance of image features were analyzed. Results　The main clinical manifestations were fever （60/143，41.9%） and cough （57/143，39.9%）. High fever was more common seen in severe patients. Severe and critical types were more common in elderly patients. And the total number of lymphocytes reduced （0.6±0.2x10^9/L） in critical patients. Except for mild patients， there were 6 cases without the obvious abnormality in the first CT diagnosis. In the remaining 109 cases， the number of pulmonary segments involved in the first CT examination of severe patients was significantly higher than that of common patients （5.88 ± 6）（P < 0.001）. Severe and critical COVID-19 showed wedge-shape （ 59/109，54.1%） or Ficus crown sign （ 35/109，32.1%） lesions more frequently than in common COVID-19 and the thickening of blood vessels （ 87/109，79.8%） and vascular clustering signs （65/109，59.6%） in / around the lesions were more likely to occur in severe and critical types （P < 0.05）. There was no significant difference in the number of lesions， lesion density， lesion morphology （round， irregular） and internal/peripheral features of the lesion （crazy-paving sign， halo sign， bronchiectasis） （P > 0.05）. Area under the curve （AUC） of the number of involved lung segments， wedge-shape and Ficus crown sign （AUC：0.769，0.759，0.697，respectively） were higher compared with that of thickening of blood vessels and vascular clustering signs （AUC：0.626，0.667，respectively） . Combined model resulted in a further increased diagnostic performance （AUC：0.854）. Conclusion　Chest CT findings not only play an important role in the early diagnosis of COVID-19，but also can evaluate the severity and prognosis of patients. [ABSTRACT FROM AUTHOR]

Copyright of China Tropical Medicine is the property of China Tropical Medicine Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Acta Scientiarum Naturalium Universitatis Sunyatseni / Zhongshan Daxue Xuebao is the property of Sun-Yat-Sen University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Dalian Polytechnic University is the property of Journal of Dalian Polytechnic University Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Kunming Medical University / Kunming Yike Daxue Xuebao is the property of Kunming Medical Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Kunming Medical University / Kunming Yike Daxue Xuebao is the property of Kunming Medical Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

目的 探讨心肺复苏术(CPR)实时反馈装置在心肺复苏教学中的作用。方法 选取2017级 64名本科生进行 CPR培训,将其分成传统教学组(32名)及反馈装置组(32名)。传统教学组采用传统的教学 方法,即经过教师带教,在模拟人身上进行联系;反馈装置组即经过教师带教讲解,在配有实时反馈装置的模拟 人身上进行练习。最后对两组学生通过 CPR 评分量表进行考核,比较两种方法的教学效果。结果 通过1周 的练习,反馈装置组学生的最后考核得分明显高于传统组,差异有统计学意义(P<0.05)。结论 CPR 实时反 馈装置在规范化技能培训中有重要作用,可以实时反馈操作的有效性,提高学生的积极性,能更有效地提高培 训的效率,使学生快速且标准地掌握 CPR的操作。 [ABSTRACT FROM AUTHOR]

Copyright of Rare Metal Materials & Engineering is the property of Northwest Institute for Nonferrous Metal Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Rare Metal Materials & Engineering is the property of Northwest Institute for Nonferrous Metal Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Rare Metal Materials & Engineering is the property of Northwest Institute for Nonferrous Metal Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Kunming Medical University / Kunming Yike Daxue Xuebao is the property of Kunming Medical Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of China Medical University is the property of Journal of China Medical University Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of China Tropical Medicine is the property of China Tropical Medicine Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

In the final joint construction of the island & immersed tube project for the HZMB, because of an abnormal deposition, and special desilting construction conditions, high quality requirements, construction difficulty and the safety risk are very high. By applying special dredging vessels, the scene simulation operation, to take effective measures such as optimizing the stationing, eventually a complete success. In this paper, we introduced the construction conditions, risk analysis and response, and implementation process of dredging operation in detail. It is hoped that it can be used for reference in the construction of high precision silt construction under similar extreme conditions in the future [ABSTRACT FROM AUTHOR]

Copyright of Journal of Kunming Medical University / Kunming Yike Daxue Xuebao is the property of Kunming Medical Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Kunming Medical University / Kunming Yike Daxue Xuebao is the property of Kunming Medical Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Application Research of Computers / Jisuanji Yingyong Yanjiu is the property of Application Research of Computers Edition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)