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To investigate the relationship between serum E-selectin and vitamin A and the severity of neonatal respiratory distress syndrome (ARDS) and their predictive efficacy in death. 82 premature infants were selected from January 2021 to December 2022. All premature infants were examined by chest radiograph at admission. According to the description of chest radiograph at admission, respiratory distress syndrome was divided into 4 grades, and serum e-selectin and vitamin A were detected. The incidence of respiratory distress syndrome (ARDS) in 82 premature infants was analyzed. The serum E-selectin and vitamin A levels were compared between ARDS group and non-DS group. The levels of serum E-selectin and vitamin A in different grades of children with respiratory distress syndrome were compared. The prognosis of premature infants with respiratory distress syndrome was recorded, and the levels of serum E-selectin and vitamin A were compared between survival group and death group. ROC curve was used to analyze the predictive value of serum E-selectin and vitamin A on the severity and death of premature neonatal respiratory distress syndrome. The serum E-selectin and serum vitamin A in the non-respiratory distress syndrome group were lower than those in the respiratory distress syndrome group (P<0.05). The levels of serum E-selectin and vitamin A in children with different grades of respiratory distress syndrome were significant(P<0.05). The level of serum E-selectin in grade IV group was higher than that in grade Ⅰ, Ⅱ and Ⅲ, and vitamin A was lower than that in grade IV group. The level of serum E-selectin in group Ⅲ was higher than that in group Ⅰ and group Ⅱ, and vitamin A was lower. The level of serum E-selectin in group Ⅱ was higher than that in group Ⅰ, and vitamin A was significantly lower, all P<0. 05. The level of serum E-selectin and vitamin A in the death group were lower than those in the survival group (P<0.05). The diagnostic sensitivity of serum e-selectin was 0.962, specificity was 0.914, truncation value was 63.185ng/L, AUC was 0.979, 95% CI was 0.952~1.000, P=0.000. The diagnostic sensitivity of vitamin A was 0.808, specificity was 0.886, truncation value was 0.635 μmol/L, AUC was 0.891, 95%CI was 0.803-0.980, P=0.000. The diagnostic sensitivity of serum E-selectin was 0.907, specificity was 0.895, cut-off value was 72.560 ng/L, AUC was 0.931, 95%CI was 0.869~0.994, P=0.000. The diagnostic sensitivity of vitamin A was 0.721, specificity was 0.842, truncation value was 0.570 μmol/L, AUC was 0.841, 95%CI was 0.747-0.936, P=0.000. Serum E-selectin, vitamin A can be used to evaluate the severity of premature neonatal respiratory distress syndrome and predict the death of infants with respiratory distress syndrome. [ABSTRACT FROM AUTHOR]

Objective: Analyze the promotion and application value of "two-stage three-step method" screening and diagnosis process in screening newborn congenital heart disease in Xi ’an and Xianyang area. Methods: Fetuses and newborns born in the hospital from January 1, 2021 to December 31, 2021 were selected as the study subjects, and the data of precordial screening in fetal period,neonatal period and infancy were collected, and the newborns were divided into murmur group, positive transcutaneous oxygen saturation group and double-positive group to evaluate the "two-phase, three-step method We evaluated the value of the "two-stage,three-step" screening method. Results: A total of 12318 neonates were screened and 497 were positive. 126 cases were confirmed and the actual incidence was 10.23‰. Among the confirmed cases of children with CHD, the top 3 disease types were atrial septal defect in 66cases（52.38%), ventricular septal defect in 41 cases（32.54%) and patent ductus arteriosus in 11 cases（8.73%) . The detection rate of single heart murmur was 1.49%, the sensitivity was 82.5%, and the specificity was 99.3%. In the positive percutaneous oxygen saturation group of 147 cases, the detection rate, sensitivity and specificity of pure percutaneous oxygen saturation were 1.19%, 58.7% and 99.4%.In the double-positive group of 166 cases, the detection rate, sensitivity and specificity were 1.35%, 94.4% and 99.6%, respectively.Conclusion: The "two-stage three-step" screening and diagnostic procedure, especially the combined screening of cardiac auscultation and percutaneous oxygen saturation, is beneficial to the early detection of neonatal CHD, and is worthy of popularization and application [ABSTRACT FROM AUTHOR]

Background and purpose: Perineural invasion is a prognostic factor in colorectal cancer. It is unclear whether perineural invasion is a prognostic factor in in node-negative (ypⅠ-Ⅱ) rectal cancer patients who received neoadjuvant radiotherapy because there may be varying degrees of tumor regression. This study aimed to investigate prognostic value of perineural invasion in node-negative rectal cancer patients who received neoadjuvant radiotherapy. Methods: A total of 5 222 patients who received neoadjuvant radiotherapy and were diagnosed with stage ypⅠ-Ⅱ rectal cancer from the Surveillance, Epidemiology, and End Results (SEER) database between 2000 and 2018 were identified and clinicopathological features and cancer-specific survival outcomes were retrospectively analyzed. Chi-square analysis was used to compare clinicopathological features between two groups. Kaplan- Meier survival analysis and the log-rank test were used to estimate the 5-year cancer-specific survival. Multivariable Cox regression analyses were used to identify the independent prognostic factor. Results: Compared with patients without perineural invasion, patients with perineural invasion were more likely to be black, have elevated carcinoembryonic antigen (CEA), stage Ⅱ disease, tumor＜5 cm and poorer differentiated tumors (P＜0.05). Patients without perineural invasion had superior cancer-specific survival than those with perineural invasion (5-years survival rate: 85.3% vs 68.9%). The survival difference was more evident in patients with stage ypⅡ cancer. Multivariable Cox regression analyses demonstrated that perineural invasion was an independent prognostic factor in node-negative rectal cancer patients who received neoadjuvant radiotherapy. Conclusion: Perineural invasion is associated with oncological outcomes of node-negative rectal cancer patients who received neoadjuvant radiotherapy, thus it could serve as a prognostic factor in these patients. [ABSTRACT FROM AUTHOR]

Objective·To investigate the effect of Leptospira interrogans 56606v on apoptosis of murine neutrophils and related mechanisms. Methods·Murine neutrophils were infected with Leptospira interrogans 56606v at indicated multiplicity of infection (MOI was 100, 300 and 500 respectively) and time points (0.5,6,12 and 24 h), with uninfected neutrophils as control. Cells treated with an equal amount of cell culture medium containing 4 μmol/L astrosporine (STS) were used as positive control for apoptosis. The apoptosis was analyzed by using flow cytometry. The cleavage of caspase-3 and activation of nuclear factor-κB (NF-κB) pathway were detected in murine neutrophils infected with Leptospira interrogans 56606v by Western blotting, and the inhibitory effect of NF-κB inhibitor BAY 11-7082 on NF-κB pathway was also verified by Western blotting. The role of NF-κB pathway in the inhibition of neutrophil apoptosis induced by Leptospira interrogans 56606v was further explored by adding NF-κB inhibitor BAY 11-7082. Macrophages were co-incubated with Leptospira-infected or-uninfected carboxyfluorescein diacetate succinimidyl ester (CFSE) -labeled neutrophils, and flow cytometry was used to detect the phagocytosis of neutrophils by macrophages to reflect the effect of the neutrophil apoptosis inhibition induced by Leptospira interrogans 56606v infection on efferocytosis. Results·The results of flow cytometry showed that the apoptosis rate of neutrophils in Leptospira infection group was decreased compared with the uninfected control group. The inhibition of Leptospira interrogans 56606v on neutrophil apoptosis was enhanced with the increase of MOI. Compared with the uninfected control group, the difference was statistically significant under different MOIS (P= 0.000). The apoptosis rate was lower than that of the corresponding uninfected control group when Leptospira interrogans 56606v with MOI=100 infected neutrophils for 0.5, 6 and 12 h (P<0.05), and the apoptosis of neutrophils was enhanced after treatment with STS. The cleavage of caspase-3 was significantly reduced after infection with Leptospira interrogans 56606v and the phosphorylation of NF-κB was significantly increased after infection demonstrated by Western blotting. The activation of NF-κB pathway in both post-infection and non-infection conditions was significantly inhibited by BAY 11-7082. The apoptosis rate of murine neutrophils infected with or without Leptospira interrogans 56606v was significantly increased by BAY 11-7082 (P=0.000). The neutrophils infected with Leptospira interrogans 56606v were significantly less phagocytosed by macrophages than those uninfected (P=0.027). Conclusion·Leptospira interrogans 56606v inhibits the apoptosis of murine neutrophils by activating the NF-κB pathway, which further reduces efferocytosis of macrophages on neutrophils. [ABSTRACT FROM AUTHOR]

Recent years, with the widespread use of video surveillance technology, video anomaly detection, which can intelligently analyze massive videos and quickly discover the abnormalities, has received wide attention. This paper aims to give a comprehensive survey on deep learning based video anomaly detection methods. Firstly, a brief introduction of video anomaly detection is given, including the basic concepts, basic tasks, modeling process, learning paradigms as well as the evaluation perspectives. Secondly, the video anomaly detection methods are classified into four categories: reconstruction-based, prediction-based, classification-based, and regression-based. Their basic modeling ideas, typical algorithms, advantages, and disadvantages are discussed in detail. On this basis, the commonly used single-scene video anomaly detection public datasets and evaluation indicators are introduced, and the performance of representative anomaly detection algorithms is compared and analyzed. Finally, summary is conducted, and the future development directions related to datasets, algorithm and evaluation criteria of video anomaly detection are proposed. [ABSTRACT FROM AUTHOR]

Objectives: Synthetic aperture sonar (SAS) is one kind of high resolution underwater imaging sonar. Its principle is to use small array to simulate large aperture array by uniforming linear motion along the direction of flight track, and realize coherent processing of echo signal to obtain high resolution two-dimensional sonar image, which is independent of imaging distance and acoustic wavelength. The back projection algorithm is an accurate point-by-point imaging algorithm, which is characterized by accurate focusing ability, suitable for wide beam and large scene imaging, and easy to realize motion compensation, but it has the disadvantages of low computational efficiency. In recent years, with the development of computer technology, especially the appearance of graphics processor unit, it has powerful computing power and provides a new way to accelerate the back projection algorithm. Methods: We propose a fast accurate back projection algorithm for multi-receiver SAS in heterogeneous environment. On the basis of analyzing the principle of accurate back-projection imaging algorithm, the pulse compression and time-consuming azi-muth accumulation are transformed into a single instruction multi-threaded mode, and the imaging process is accelerated by the powerful multi-core computing ability of graphics processor unit. Results: The validity and efficiency of the proposed fast imaging algorithm are verified by the imaging experiments performed on simulated and real SAS data. Compared with the serial imaging algorithm, its acceleration ratio is as high as 326.3 and 333.6. For large-scale data imaging processing, it shows excellent acceleration performance. Conclusions: The proposed back projection imaging algorithm greatly improves the imaging efficiency and meets the needs of real-time SAS imaging, which lays the foundation for subsequent motion compensation. [ABSTRACT FROM AUTHOR]

Objective To explore whether the cognitive fusion method encouraging patients' participation can improve the appearance satisfaction of circumcision. Methods From November 2019 to August 2020, 105 patients who needed circumcision due to phimosis and excessive length of prepuce were selected. According to whether patients participated in the operation design or not, all patients were divided into cognitive fusion circumcision group (46 cases) and common circumcision group (59 cases). Both groups received circumcision. One month later, patient satisfaction in both groups was scored and compared by self-designed scale. Results The overall scores of satisfaction, scores of postoperative efficacy and very satisfied rate in the cognitive fusion circumcision group were significantly higher than those in the common circumcision group (P<0.05). There was no statistical significance in the overall satisfaction rate between cognitive fusion circumcision group and common circumcision group (P>0.05). Conclusion Application of cognitive fusion method could increase patient satisfaction of appearance after circumcision. This principle could be extended to other similar operations. [ABSTRACT FROM AUTHOR]

[Objective] The purpose of this paper was to clarify the effect of diversity mixed interplanting mode on rice photosynthesis, and provide a favorable basis for the further application of diversity mixed interplanting in the field. [Method] The rice varieties Gangyou 157 (main planted variety) and Huangkenuo (interplanted variety) were selected, and their relative chlorophyll content SPAD values and photosynthesis were measured under the mixed interplanting and mono-planting modes, and the occurrence and damage of rice blast and the agronomic characteristics of rice were investigated. [Result] When Gangyou 157 in the interplanting mode, the SPAD value of the inner row was significantly higher than that of the outer row and mono-planting treatments.There was no significant difference in the SPAD value of Huangkenuo under the two planting modes.The net photosynthetic rate of Gangyou 157 in the interplanting mode was significantly lower than that of the mono-planting treatment (decrease by 14.36%), and there was no significant difference when compared with the outer row. The transpiration rate, stomatal conductance and intercellular CO2 concentration were significant differences in all treatments. The net photosynthetic rate, transpiration rate, stomatal conductance and intercellular CO2 concentration of Huangkenuo were not significantly different under the interplanting and mono-planting modes.Gangyou 157 and Huangkenuo had no significant difference in water use efficiency under interplanting and mono-planting modes. The rice blast disease index of Huangkenuo under the interplanting mode（2.79 ± 0.86） was significantly lower than that of the mono-planting（43.65 ± 6.11）,and its plant height under the interplanting mode（138.93±2.91）cm was significantly lower than that of the mono-planting（152.07 ± 2.27）cm, and the number of tillers of Huangkenuo under the mono-planting mode（9.75 ± 0.59） was significantly higher than that of the interplanting（7.04 ± 0.73）.There was no significant difference in disease index, plant height and tiller number of Gangyou 157 under the two planting modes. The yield per hectare of Huangkenuo under the diversity mixed-interplanting mode(6.23 t/hm² ) was significantly higher than that of the mono-planting model（4.50 t/hm²; the yield per hectare of Gangyou 157 under two planting modes was no significant difference. [Conclusion] Under the diversity mixed interplanting mode, the chlorophyll content of the main cultivars increased significantly, the photosynthetic rate decreased significantly, and other photosynthetic characteristics were no significant changes; the performance of the interplanted cultivars was not significantly different from that in the mono-planting mode. At the same time, the incidence of diseases of interplanted varieties was significantly reduced, without affecting the main varieties. [ABSTRACT FROM AUTHOR]

Objective To study the effect of intragastric administration of slightly alkaline embelin and ammonium hydroxide solution on hepatocyte mitosis of mice. Methods We selected 50 Kunming mice. The mice in the high-, medium-, and low-dose embelin groups were given slightly alkaline embelin and ammonium hydroxide solution (20 ml/kg) by gavage at the concentrations of 0. 02, 0. 01, and 0. 00 125 mg/mL; the mice in the blank group were given 20 ml/kg of distilled water by gavage, and the solvent group with 0. 025 % ammonia solution (pH 8. 2) 20 ml/kg, once per day for 7 days. On the next day after the last dose, we took the liver for histopathological examination and observed the nuclear chromosome of the hepatocytes in the divisive phase. We counted the number of abnormal mitotic hetapocytes and the total number of dividing phase hetapocytes. The percentage of abnormal mitotic hetapocytes in the total number of dividing phase hetapocytes was calculated. Results After 7 -day treatment of slightly alkaline embelin and ammonium hydroxide solution by means of intragastric administration, histopathology examination showed that unclear material staining was specific in abnormal mitotic hetapocytes, the nuclear chromosomes was in a loose state, or was distributed at both ends poles of cell nucleus in spallation and fragments state, or was distributed in non-central position of the two progeny hetapocytes condensed into fine grains state. The total number of dividing phase hetapocytes, abnormal mitotic hetapocytes, and percentages of abnormal mitotic hetapocytes in the total number of dividing phase hetapocytes in the high-dose and medium-dose embelin groups were greater than those in the solvent group and blank group. Conclusion The slightly alkaline embelin and ammonium hydroxide solution (0. 02 and 0. 01 mg/mL) has an effect on mitosis of liver cells, which can destroy the equal distribution of nucleus and cytoplasm in the nucleus of two poles or two progeny nucleus, stop liver cell division or cause liver cell death. [ABSTRACT FROM AUTHOR]

We propose a combined minimum discontinuity phase unwrapping algorithm based on clusters. The wrapped phase image is tessellated into small regular blocks by the main node according to the com - puting resources and then sent to the idle computing nodes. During the unwrapping process of single block, the wrapped phase quality map is firstly computed and the wrapped phase image is partitioned into high and low quality areas; then the quality-guided and minimum discontinuity combined phase unwrapping algorithm is performed to get the initial unwrapped result. After the local unwrapping process is finished, the initial unwrapped result and the region partition result are sent to the main node. When all the blocked phases are unwrapped, the main node performs the minimum discontinuity optimization process on the bor- der of different blocks and the adjacent low quality areas to get the final unwrapped result. Tests performed on the simulated and the real InSAS (interferometric synthetic aperture sonar) interferograms based on clus- ters confirm the validity and efficiency of the proposed algorithm. [ABSTRACT FROM AUTHOR]

Objective To study the relationship between the levels of serum EB virus capsid antigen immunoglobulin A (VCA-IgA), carcinoembryonic antigen (CEA) and serum cytokeratin 19 fragment 21-1 (CYFRA21-1) and clinical stages of nasopharyngeal carcinoma (NPC). Methods 100 NPC patients in our hospital from January 2014 to January 2018 were selected as the observation group, another 80 subjects were selected as the control group. Serum VCA-IgA, CEA and CYFRA21-1 levels in all subjects were detected, their relevance to clinical stages was analyzed. Results The serum levels of VCA-IgA, CEA and CYFRA21-1 in the observation group were higher than those in the control group (P<0.05). The serum levels of VCA-IgA, CEA and CYFRA21-1 showed an upward trend in clinical stages. The serumlevels of VCA-IgA, CEA and CYFRA21-1 in stage IV were significantly higher than those in stage I, II and III. The serum levels of VCA-IgA, CEA and CYFRA21-1 in stage III were significantly higher than those in stage I and II. Level (P<0.05), there were no significant differences between stage I and II (P>0.05). Spearman correlation analysis found that serum VCA-IgA, CEA and CYFRA21-1 levels were positively correlated with clinical stages of NPC patients (P<0.05). Conclusion The higher the serum levels of VCA-IgA, CEA and CYFRA21-1, the later the stage may be. It has certain reference value for clinical staging of NCP patients. [ABSTRACT FROM AUTHOR]

Complex image registration is one of the most important steps during the process of interferometric signal processing, and its efficiency directly affects the performance of interferometric signal processing system. In order to improve the efficiency of complex image registration algorithm, we propose an opti⁃ mized complex image registration algorithm for interferometric synthetic aperture sonar (InSAS) in shared memory environment. Firstly, after analyzing the characteristic of calculation and parallelism of each pro⁃ cessing step for complex image registration, an optimized computation method for coarse registration and refine registration is proposed for the massive sliding operation based on the coherence of data in adjacent windows. Then, in order to make full use of multi-core computing resource to accelerate the process of complex image registration, OpenMP instructions are used to parallel design and task allocation for coarse and refine registration, complex image interpolation and wrapped phase extraction. Finally, the correctness and efficiency of the proposed method are verified by the parallel complex image registration for InSAS. [ABSTRACT FROM AUTHOR]

凋亡是细胞在内外微环境改变时,以半胱氨酸蛋白酶(caspase)激活为主要特征,多种途径、多个细胞器共同参与的一种调控性细胞死亡。凋亡可分为内源性凋亡和外源性凋亡。肾小管上皮细胞凋亡相关的主要蛋白有Bcl-2蛋白家族、死亡受体、caspase。Bcl-2蛋白家族主要参与肾小管上皮细胞内源性凋亡,死亡受体主要参与肾小管上皮细胞外源性凋亡,caspase激活是肾小管上皮细胞凋亡的核心机制。丝裂原活化蛋白激酶(MAPK)、酪氨酸激酶(JAK)-转导和转录激活因子(STAT)、3-磷酸肌醇激酶(PI3K)-丝氨酸/苏氨酸激酶(Akt)等多种信号通路也参与肾小管上皮细胞凋亡。MAPK信号通路广泛参与肾脏缺血再灌注损伤导致的肾小管上皮细胞凋亡; JAKSTAT信号通路中与肾小管上皮细胞凋亡最相关的是JAK2和STAT3; PI3K-Akt信号通路可发挥抗凋亡作用。 [ABSTRACT FROM AUTHOR]

Objective To evaluate the relationship between vitamin E status and osteoporosis in early stage of postmenopausal women. Methods Anthropometric data, osteoporosis risk factors, vitamin E serum levels, bone mineral density (BMD), and other serum parameters which may influence BMD in postmenopausal women were collected in a cross-sectional study. The association between osteoporosis and age, age of menopause, body mass index, osteocalcin, calcium, vitamin D, vitamin E (measured as 25 hydroxyvitamin D and as α-tocopherol/lipids ratio, respectively), bone alkaline phosphatase, smoking status, leisure physical activity, and alcohol intake were analyzed using a multivariate logistic regression and multi-linear regression analysis in 232 early postmenopausal women. Results A lower vitamin E/lipid ratio was associated with osteoporosis in multivariate logistic regression. In a multivariate linear model with BMD of the lumbar spine as a dependent variable, the vitamin E/lipid ratio was clearly related with BMD of the lumbar spine (F ratio = 6.28, P = 0.001). BMD of the lumbar spine was significantly higher in the highest tertial of the vitamin E/lipid ratio than in the lowest tertial. The mean vitamin E/lipid ratio was significantly lower in osteoporotic postmenopausal women (3.1±0.5 μmol/mmol) than normal (neither osteoporotic nor osteopenic) postmenopausal women (3.6±0.6 μmol/mmol) using multivariable-adjusted BMD. Conclusion These findings highlight that vitamin E may increase BMD in healthy postmenopausal women. [ABSTRACT FROM AUTHOR]

The physicochemical properties and fatty acid composition of gardenia fruit oil were studied by ultrasound-assisted extraction. The acid value, iodine value,saponification value, phospholipid content, water and volatile matter content of gardenia fruit oil were1.84 mgKOH/g, 120.72 g/100 g, 193.3 mgKOH/g, 1.54 mg/g and 1.65%. There were mainly 14 kinds of fatty acids in the oil. The content of unsaturated fatty acid was 82.66%, mainly linoleic acid (59.25%) and oleic acid (21.47%). The content of saturated fatty acids was relatively low, mainly palmitic acid (8.78%). The gardenia fruit has high oil content and rich nutrients, fatty acid composition is infinitely close to the 1∶1∶1 golden ratio proposed by the World Health Organization and the Chinese Nutrition Society. It is a potential oil resource with high development value. [ABSTRACT FROM AUTHOR]

Underwater push-out docking method was adopted in the final joint of Shenzhen-Zhongshan Link immersed tunnel, and the MGB slide-rail was used as the bottom sliding system during the push-out process. A test structure with the same load as the construction site was established in order to analyze the structural stress. The friction coefficient between MGB slide-rail and anticorrosive coating in final joint of Shenzhen - Zhongshan Link under different construction loads and lubrication conditions was studied by using the test structure, and was compared with the friction coefficient provided by the manufacturer. The research results indicate that the friction coefficient of MGB material decreases with the increase of load. The static friction coefficient ranges from 0.181 to 0.266 in the case of dry friction, and the sliding friction coefficient ranges from 0.150 to 0.226. The friction coefficient under water lubrication conditions is smaller than dry friction, and it is related to the contact interface. It is recommended to test the friction coefficient based on the actual load and friction interface conditions in engineering project. [ABSTRACT FROM AUTHOR]

This paper proposed an efficient range Doppler imaging algorithm for multi-array synthetic aperture sonar (SAS) in shared memory environment based on OpenMP, which solved the imaging problem of low efficiency by multi-core CPU resources. Considered the parallel characteristic of range Doppler algorithm for multi-array SAS, it parallelized the signal processing process such as preprocessing, range compression, phase compensation, range cell migration compensation and azimuth compression based on OpenMP, which greatly enhanced the reconstruction process of SAS image by multi-core CPU resources. The imaging test performed on real data shows that the speedup of the parallel imaging algorithm is up to 19. 86 times, which meets the demand for real-time processing of SAS imaging. [ABSTRACT FROM AUTHOR]

Aiming to solve the low efficiency imaging of multi-array synthetic aperture sonar, this paper proposed a fast imaging method for multi-array synthetic aperture sonar in heterogeneous environment. It considered the range Doppler algorithm characteristic for multi-array synthetic aperture sonar and different calculation features between CPU and GPU, the intensive calculation such as range compression, phase compensation, range cell migration compensation and azimuth compression was implemented on GPU, which greatly enhanced the imaging efficiency for multi-array synthetic aperture sonar. In the end, it verifies the validity and efficiency of the proposed method through the imaging experiment performed on real data and the speedup is up to 14.45 times compared to the serial algorithm. [ABSTRACT FROM AUTHOR]

In order to solve the unwrapping problem of low efficiency for large interferogram, we propose a new phase unwrapping algorithm in shared memory environment, which is designed based on quality-guided and minimum discontinuity optimization strategies. The three processes, phase quality map computing, high and low quality area’s partition and low quality area’s optimization, are parallelized in shared memory environment. In order to fully use the multi-core computing ability, a dynamic allocation method for computing task is designed for the optimization process of low quality are- as. Unwrapping tests performed on simulated and InSAR interferogram show that the proposed algo rithm improves the high quality of unwrapped result and greatly optimizes the efficiency. [ABSTRACT FROM AUTHOR]

Phase unwrapping is one of the key processing steps during reconstruction the digital elevation model from the signal of interferometric synthetic aperture radar(InSAR) or interferometric synthetic aperture sonar(InSAS). In order to solve the problem of low unwrapping efficiency with large interferogram, we propose a blocked minimum discontinuity phase unwrapping algorithm in shared memory environment. The whole phase quality map is computed firstly through multi-cores of CPU, then wrapped phase image and phase quality map are tessellated into small regular blocks, which are unwrapped by the quality guided and minimum discontinuity optimization method simultaneously. In the end, the minimum discontinuity optimization process is performed again on the border of different blocks and the low quality areas located on the border to get the final merged unwrapped result in the main thread. Tests performed on the simulated and real InSAS interferogram show that the speed up reaches 3.98 and 2.26 respectively. [ABSTRACT FROM AUTHOR]

氧化应激是机体受到各种有害的刺激时所作出的一种应激反应,最终对机体各种细胞及组织器官造成损害。多种肾脏疾病的发生发展都有氧化应激的参与。在一些肾脏疾病中,当机体受到各种有害刺激时发生脂质过氧化,DNA和蛋白质等被损害,不但损伤肾脏细胞,而且产生一些活性氧(ROS),伴随机体本身的抗氧化能力的减弱,从而发生氧化应激,与其他一些因素共同作用,对肾脏造成损害。氧化应激在各种肾脏疾病中所起到的作用不同,探讨氧化应激在肾脏疾病发生发展中的作用有助于为肾脏疾病的治疗提供新的思路。 [ABSTRACT FROM AUTHOR]

BACKGROUND: Skeletal muscle satellite cells have been found to possess the potential of stem cells that have the ability to self-renew with the roles of repair and regeneration. Therefore, it can be used to treat myofibrosis. OBJECTIVE: To explore the function, molecular regulation and related mechanisms of skeletal muscle satellite cells, and to promote the repair and regeneration of skeletal muscle fibers, thereby providing new ideas and intervention strategies for the rehabilitation and treatment of skeletal muscle injury. METHODS: A computer-based online search was conducted in PubMed, Mendeley, Google Scholar, and CNKI databases from 1995 to November 2016 for the relevant literature using the keywords of “skeletal muscle,satellite cells, stem cell, muscle repair”. Data screening, processing, and summarization were performed. RESULTS AND CONCLUSION: According to the inclusion criteria, 51 eligible articles were enrolled. Analysis results show that skeletal muscle satellite cells are closely related to muscle fiber lesions. Based on the mechanism of skeletal muscle lesions, the regeneration and repair mechanisms of skeletal muscle satellite cells are explored. Skeletal muscle tissue is a functional and sound system that can regenerate and repair through skeletal muscle satellite cells. The function of skeletal muscle satellite cells is controlled by intracellular and extracellular information networks, which can enhance endogenous satellite cell viability. When the skeletal muscle is injured or malnourished, the viability of skeletal muscle satellite cells is inhibited, further inducing skeletal muscle fiber degeneration. Therefore, skeletal muscle fiber lesions can be treated through skeletal muscle satellite cell transplantation and stimulating the viability of endogenous skeletal muscle satellite cells, which provides intervention strategies for skeletal muscle repair and regeneration. [ABSTRACT FROM AUTHOR]

We propose a non-recursive minimum discontinuity phase unwrapping algorithm for im­proved efficiency. After analyzing the principles of minimum discontinuity phase unwrapping algo­rithm* a stack is used to store the intermediate results during edge spreading and circle canceling processes and thena non-recursive algorithm for phase unwrapping is implemented. The new algorithm was combined with the quantized quality-guided phase unwrapping algorithm, which enhances the un­wrapping efficiency by restricting the optimization area. Unwrapping tests performed on InSAR and InSAS interferograms show that the proposed method maintains high quality unwrapping results and greatly improves efficiency. [ABSTRACT FROM AUTHOR]

Innovative experiment teaching mode is the guidance to promote the reform of the experimental teaching in universities. It enhances the cultivation of students' practical and comprehensive ability, meets the need of social development. Innovative experimental teaching mode based on marine equipment and technology adapts the direction of the marine equipment and technical personnel in our country. Combined with the intelligent manufacturing and marine economic development, the innovative experimental teaching is emphatically discussed with teaching interaction and intelligent experimental teaching pattern, marine equipment functional experiment teaching mode and the experimental cooperation between school and enterprise. Through developing the innovative experimental teaching mode, experimental teaching level and students' participation and awareness are improved. It realizes the natural transition among learn theoretical knowledge in practice, operation skills and social demand. These experiences can provide a reference for the innovative experimental teaching renewal and development. [ABSTRACT FROM AUTHOR]

We proposed a parallel quality-guided phase unwrapping algorithm in shared memory environment. The intrinsic relationship between the neighboring phase points about quality value computing is analyzed firstly, and then the row and column arrays are used to store the intermediate results in order to eliminate the repeated computation of gradient. The computing task is allocated by row, which can simplify the computing of row and column gradient mean values. Finally, the allocation of computing task is realized using OpenMP instructions, and the quality map is computed in parallel. The inherent parallelism of quality guided process is also analyzed in-depth, but subject to the repetitive thread startup and exit overhead, it is difficult to reflect the advantage of speed. Unwrapping tests performed on InSAR and InSAS interferogram show that the proposed method greatly improves the efficiency of phase unwrapping, and provides a foundation for improving the solution precision under real-time conditions. [ABSTRACT FROM AUTHOR]

We propose a combined phase unwrapping algorithm using region partitioning. The wrapped phase image is partitioned into high and low quality areas according to its quality map- and a quality guided algorithm is performed to gel the initial unwrapped result. A quality guided strategy is adopted to identify low quality areas- and each low quality area is stored separately. The low quality areas are optimized by a minimum discontinuity phase unwrapping algorithm one by one. and then the final unwrapped result is obtained. An unwrapping test performed on an InSAR interferogram shows that the proposed algorithm is more efficient than the minimum discontinuity phase unwrapping algorithm, and the unwrapped result was more accurate than results obatained from a quality guided algorithm. [ABSTRACT FROM AUTHOR]

Based on the function model of TS-InSAR (time series interferometric synthetic aperture radar) technique, this paper establishes stochastic function models (weighted/equal-weight) for single-master and multi-master image TS-InSAR method respectively to enrich the mathematical model of TS-InSAR. A simulation test is used to estimate the precision of model parameters for our equal-weighted function model (stochastic model). Compared to the equal-weight model, the precision of deformation parameters shows little improvement over the weighted model. However, complications in the weighted model means that much disk-space is consumed with low computational efficiency. Most computers therefore cannot undertake TS-InSAR analysis tasks with reasonable hardware configuration. At present, the equal-weight model is feasible for TS-InSAR. [ABSTRACT FROM AUTHOR]

We proposed a fast back-projection algorithm for multi-receiver synthetic aperture sonar (SAS) in a shared memory environment. A two-dimensional dynamic data structure was used to keep the delay time and the compensation phase information was designed based on the characteristics of the back-projection algorithm, which helps to eliminate repeated delay time computation for the same range. In the shared memory environment, we combine the focusing operation for the near and far distance of the image scene to achieve a computation load balance. An imaging test performed on real SAS data confirms the proposed algorithm is accurate and efficient. [ABSTRACT FROM AUTHOR]

Objective To satisfy the needs of reservoir stimulation in tight sandstone gas reservoirs and solve the problem of fracturing flow back fluid treatment in the field, a variable viscosity slick water (VSW) system has been developed through self-associating emulsion polymerization. This fluid mainly consists of one multi-functional thickener. Methods The on-line conversion was realized by concentration control of slick water and sand-carrying fluid, the resistance reduction, temperature and shear resistance, suspended proppant capability, gel breaking and core damage of fracturing fluid were evaluated. Finally the fracturing fluid was applied in Sulige gas field. Results The results show that the viscosity of the high-viscosity slick water is 9:3 mPa •sand 64 mPa • s with a formula of 1. 0% VSW in clean water and standard saltwater. The viscosity after shearing at 90 'C and 170 s-1 for 1 h is 78 mPa • s, the sand-c,1rrying performance of this system is good, the sedimentation velocity is 0. 84 mm/s for 0. 425-0. 850 mm ceramsite proppant. With a formula of 0. 1 %-0. :3 % VSW, the resistance reduction rate of low-viscosity slippery water can exceed 75%. The viscosity of the high-viscosity slick water gel breaker is 1. 74 mPa • s, and the destruction rate to the core matrix is less than 10%. The maximum sand concentration of on-site fracturing construction is 700 kg/m³, and the average unblocked flow rate is 104. 69 X 104 m:1 /d. The recovery rate of flowback fluid reaches 97. 5 %. Conclusions The fracturing fluid system has good viscosity increasing and salt resistance, excellent resistance reduction performance, good temperature and shear resistance, high flow back utilization rate and significant yield increase effect. [ABSTRACT FROM AUTHOR]

Permeable type shore connection structure was first applied in the Dalian Bay Subsea Tunnel Project. Numerical simulation method is used to calculate the flow field and water exchange after the construction of the shore connection structure of Dalian Bay subsea tunnel, and the results were compared with the traditional impermeable type. The research results show that the water flow in the permeable type shore connection structure will produce obvious flow across the direction of the tunnel, which can improve the water exchange on both sides of the tunnel and promote the exchange of surrounding water. The permeable type structure has the value of promotion and application. [ABSTRACT FROM AUTHOR]

Epimedium (Berberidaceae) is a hot and difficult topic in taxonomy, and its taxa have been published and revised frequently. In order to more clearly understand the variation of Epimedium, this paper systematically sorted out the important characters of Epimedium on the basis of consulting the research results and specimens, combined with the field investigation and analysis of the research group. The petal pattern is the most important basis for the taxonomy of Epimedium, but it is not absolutely stable, and there may be abundant variations in petal morphology within the species. The colors of petals and anthers, and even the size of flowers should not be used as the main basis for classification at least in some taxa. The rhizome type (compact or long creeping) is a useful taxonomic character in most taxa, but it should be based on extensive investigations. There are abundant variations in most taxa on the number and arrangement of leaves on flowering stem, which is difficult to be applied in practice. The variation of non-glandular hair characteristics is very complex and various, so they should not be used as a key basis for species identification. The plants of genus Epimedium are generally shorter after cultivation, which suggests that it is necessary to conduct survey and morphological observation in natural habitats to understand the morphological characteristics of species. The genus Epimedium in China is still in active evolution, and its morphological variation is complicated. Therefore, cautions should be taken in species identification and resource utilization. [ABSTRACT FROM AUTHOR]

【Objective】Drought is one of the main abiotic factors that affect rice productivity. Rice yield can be ensured by screening drought-resistant rice.【Method】Ninety-three single-segment substitution lines (SSSLs) constructed from Oryza. meridionalis and O. glumaepatula and their recipient parents ‘Huajingxian 74’(HJX74) were used as the test materials. And 20% PEG-6000 was adopted to simulate drought conditions to perform drought tolerance tests at the seedling stage. Besides, four growth and development traits (relative seedling height, relative seedling dry weight, relative root dry weight and relative root length) were used as evaluation indicators. The membership function method was utilized to sort SSSLs and screen SSSLs with relevant traits significantly different from HJX74. Based on the QTL identification and additive effect analysis, QTL related to drought tolerance traits at the seedling stage was preliminarily identified.【Result】The analysis of correlation between the four growth and development traits and the average membership function value revealed that they were all extremely significantly positively correlated, and could be used as indicators for identifying and evaluating the drought tolerance in the seedling stage of SSSLs. According to the analysis result of the membership function method, the average membership function value of the tested SSSLs ranged from 0.20 to 0.71, and the average membership function value of HJX74 was 0.54. The average membership function value of 29 SSSLs was greater than that of HJX74. Among them, M124 had the largest membership function value, indicating strong drought tolerance of M124. Through single factor analysis of variance, 7 relative seedling height QTLs (qRSH1-1, qRSH1-2, qRSH2-1, qRSH3-1, qRSH3-2, qRSH5-1, and qRSH6-1) were identified from 8 SSSLs (M78-1, M78-2, M124, M107, M151, M103, M130, M115), which were distributed on Chromosomes 1, 2, 3, 5, and 6. Their additive effect was 0.05-0.06, and the phenotypic contribution rate was 6.97%-9.01%. Three relative root dry weight QTLs (qRRDW10-1, qRRDW11-1, and qRRDW11-2) were identified from three SSSLs (M79, M145, M148), which were distributed on chromosomes 10 and 11. The additive effect was 0.12-0.20, and the phenotypic contribution rate was 12.51%-19.95%. A relative seedling dry weight QTL (qRSDW5-1) was identified from 2 drought-tolerant SSSLs (M80, X149), and distributed on chromosome 5, with the additive effect of 0.07 and the phenotypic contribution rate of 10.5%.【Conclusion】A total of 13 SSSLs with droughttolerant QTLs at the seedling stage are screened, laying a solid foundation for further study on fine mapping and cloning. [ABSTRACT FROM AUTHOR]

Simulating and calculating the conformation, morphology and dimensions of polymer chains, is a virtual simulation experiment project at the molecular level. It is based on the theoretical work of Nobel laureates de Gennes and P. J. Flory, and is developed through the transformation of the project team’s own teaching and research achievements and collaborative research and development between teachers and students. Compared with small molecular compounds, the research methods for polymer chains are significantly different, especially in the need to use statistical methods to describe the conformation and morphology of polymer chains, and calculate the average dimensions of polymer chains. This cannot be achieved by classical physical chemistry methods. From development to teaching practice and subsequent improvements, the project naturally incorporates ideological and political elements from multiple dimensions such as Nobel Prize achievements, philosophical thoughts, scientific thinking, the history of disciplinary development, and teaching and research achievements were integrated into the update of teaching content. [ABSTRACT FROM AUTHOR]

Objectives: Complex image registration is crucial in interferometric synthetic aperture sonar (InSAS) signal processing. The registration quality directly influences the generation of interferogram and the subsequent reconstruction of digital elevation model. The traditional global polynomial surface fitting method has the disadvantage of low accuracy for large scene InSAS images. Therefore, a registration method based on piecewise surface fitting is proposed to overcome the problem. Methods: Firstly, the whole image is partitioned into several pieces along range direction with partly overlapped. Then, polynomial surface fitting is performed using control points in each piece. Finally, the global offset surface is obtained by merging those local surface fitting results. Results: Through the simulation and real data experiments, the accuracy of complex image registration using the proposed method is higher than the result of global polynomial surface fitting method. Conclusions: The evaluation has been carried out with the root mean squared error, correlation coefficient, residue numbers, which indicates the validity of the proposed approach. [ABSTRACT FROM AUTHOR]

The 2015 Nepal Mw 7.9 earthquake occurred in the central segment of the Himalayan collision zone where the rigid Indian plate is underthrusted beneath the Tibetan Plateau. Refining the coseismic slip distribution and afterslip of the earthquake has great significance for better understanding the seismogenic mechanism in Himalaya orogenic belt. We adopted the angular dislocation elements to construct the rampflat- ramp-flat fault geometry of the main Himalayan thrust. In combining with GPS and InSAR data, we inverted the coseismic slip distribution and afterslip of the Nepal earthquake. The result shows that the mainshock is dominated by thrust slip with minor right-lateral strike-slip. The maximum slip of the mainshock is up to 7.8 m at a depth of 15 km, near to the intersection between the upper flat and mid-crust ramp. The total geodetic moment based on our preferred slip model is M0=8.39×1020 N·m, corresponding to an Mw of 7.93 assuming a shear modulus of 30 GPa. The released moment is mainly confined to the depth of 15— 25 km, in which nearly 50% of the released moment locates at the ramp of upper crust. The maximum slip could be underestimated if we ignore the mid-crust ramp. The inferred afterslip primarily concentrates on the downdip of the coseismic rupture. The afterslip is characterized by pure thrust slip with the maximal amplitude of 0.5 m. The total released moment by the afterslip is estimated to be 1.02×1020 N·m, equiva⁃ lent to an Mw 7.3 earthquake, approximately 12% of the coseismic moment. The coseismic static Coulomb stress change suggests that the southern part to the rupture zone of the Nepal earthquake with a width of about 60 km is largely promoted by the 2015 Nepal earthquake. Considering the fact that this area is strongly locked during the interseismic period, the near-term seismic hazard in this area deserves special attention. [ABSTRACT FROM AUTHOR]

Complex image registration is a crucial step in interferometric synthetic aperture sonar (InSAS) signal processing. The registration quality directly influences the generation of interferogram and subsequent reconstruction of digital elevation model (DEM). Utilizing the geometric model of imaging, the rational function relationship between offset and slant range is deduced, thus this paper propose a new InSAS complex image registration method based on second order rational function surface fitting. Compared with the traditional polynomial surface fitting method, the proposed method in this paper has the advantages of higher precision and smaller calculation cost. The evaluation has been carried out using the root mean squared error(RMSE), correlation coefficient,residue numbers and computing time as the criteria. Simulation and real data experiments results indicate the validity of the proposed method. [ABSTRACT FROM AUTHOR]

In this paper, reactive carbamate surfactants (RCS-10) have been synthesized using stearyl alcohol polyoxyethylene ether (AEO) and 2-isocyanatoethyl methacrylate (IEM), and characterized using Fourier transform infrared spectrometry (FTIR) and nuclear magnetic resonance (¹H-NMR). And the critical micelle concentration (CMC) of RCS-10 was 5. 19 X10-4 mol/L, which was measured by surface tension method at room temperature. Additionally a novel hydrophobically associative polymer has been synthesized by copolymerizing RCS-10 with acrylamide, 2-acrylamido-2-methylpropane sulfonic acid, and acrylic acid, and the rheological properties of its aqueous solution have been analyzed. The results showed that the modified and unmodified polyacrylamide solutions exhibit viscosity retentions of 97.73% and 87.07%, respectively, at 120 °C under a shear rate of 170 s-1. Thus, RCS-10 polymerization improves the heat and shear resistance and the storage and loss moduli of the polyacrylamide, indicating a structural-stability enhancement on polymerization. Therefore, RHPAM exhibits high potential to improve the heat and shear resistance of fracturing fluids and enhance oil recovery. [ABSTRACT FROM AUTHOR]

Objective To investigate the safety and efficacy of a traditional Chinese medicine ( TCM) treatment of pediatric Henoch-Schönlein purpura nephritis ( HSPN) ( proteinuria below the nephrotic level). Methods This study was a prospective multicenter stratified randomized controlled trial. In total, 316 children diagnosed with HSPN were divided into the Chinese medicine group (mild: n = 132; severe: n = 83) and the Western medicine group (mild: n = 60; severe: n = 41). Patients in the Chinese medicine group were treated with tripterygium wilfordii multiglucoside + sulfotanshinone sodium injection+ Qingre Zhixue Formula, the starting dose of tripterygium wilfordii multiglucoside for the Chinese medicine mild group was 1. 5 mg / (kg·d), while that for the Chinese medicine severe group was 2 mg / (kg·d). Patients in the Western medicine mild group were treated with low-molecular-weight heparin calcium + benazepril + dipyridamole + a TCM simulator. In addition, patients in the Western medicine severe group received prednisone. The patients were treated for 12 weeks and followed up for 36 weeks. The urinary protein levels and urinary red blood cell (RBC) count were investigated in the 4th week and the 12th week. In addition, the recurrence rate at the end of 48 weeks of follow-up was calculated, and the incidence of adverse events at the end of 12 weeks of treatment was calculated. Results The urinary protein levels in the Chinese medicine group, the Chinese medicine mild group and the Chinese medicine severe group at the 4th week and the 12th week were significantly lower than in the Western medicine group, the Western medicine mild group and the Western medicine severe group (P<0. 01). The urinary RBC counts in the Chinese medicine group, the Chinese medicine mild group and the Chinese medicine severe group at the 4th week and the 12th week were significantly lower than in the Western medicine group, the Western medicine mild group and the Western medicine severe group ( P < 0. 01). No significant difference in recurrence rate was found between the Chinese medicine group and the Western medicine group, between the Chinese medicine mild group and the Western medicine mild group, or between the Chinese medicine severe group and the Western medicine severe group. The incidence of adverse events was lower in the Chinese medicine group than in the Western medicine group, and it was lower in the Chinese medicine severe group than in the Western medicine severe group (P<0. 01), but there was no significant difference between the Chinese and Western medicine mild groups. Conclusion Chinese medicine alone can be used to reduce urinary protein levels and urinary RBC counts in both mild and severe HSPN. The effect of Chinese medicine on proteinuria was quicker than that of Western medicine, and the incidence of adverse events was significantly lower in the Chinese medicine group than in the Western medicine group. The stepwise Chinese medicine scheme, which is mainly based on tripterygium wilfordii multiglucoside combined with Qingre Zhixue Formula, shows an excellent curative effect and fewer adverse events, indicating it is worthy of clinical promotion. [ABSTRACT FROM AUTHOR]

Objective To observe the effect of goal-directed fluid therapy (GDFT) based on stroke volume variation (SVV) and conventional fluid infusion on the circulation and recovery of gastrointestinal function after laparoscopic radical gastrectomy for gastric cancer in elderly patients. Methods We selected 80 cases of laparoscopic radical gastrectomy and randomly divided them into target group and conventional group. Patients in conventional group received conventional fluid infusion scheme for fluid infusion, and the target group with SVV of target management solution for fluid guide. We compared the varieties of the hemodynamic parameters and application of vasoactive drugs in the two groups. We also compared the two groups in infusion volume and type, blood loss, urine volume; preoperative and postoperative data such as hemoglobin (Hb), hematocrit (Hct), blood urea nitrogen (BUN), and creatinine (Ccr). Moreover, we observed the postoperative gastrointestinal function recovery and postoperative complications of the two groups. Results The baseline values of MAP and HR (T1) in the two groups of patients did not differ significantly (P>0.05). Comparison of the two groups with anesthesia at different time segments in MAP and HR revealed that T1-T2, T1-T3, and T1-T4 differences were significantly lower in the target group than in the conventional group (P<0.05), but the two groups had no significant difference in T1-T5, T1-T6 MAP and HR (P>0.05). The two groups differed significantly in hemodynamic adverse events and vasoactive drugs administration (P<0.05). The total amount of intraoperative fluid and crystal input were lower in the target group than in the conventional group (P<0.05). Moreover, colloid input was higher than that in the conventional group (P<0.05). The urine and bleeding volumes were lower in the target group than in the conventional group (P<0.05). There were not significant differences between the two groups in postoperative day 1 Hb, Hct, BUN and Ccr values (P>0.05). The postoperative exhaust recovery time, liquid food intake time and defecation recovery time were significantly shorter in the target group than in the conventional group (P<0.05). The postoperative complications were significantly fewer in the target group (P<0.05). Conclusion GDFT based on SVV can not only maintain the stable hemodynamics of elderly patients undergoing laparoscopic radical gastrectomy for gastric cancer, but also promote the recovery of postoperative gastrointestinal function and decrease the complications. Therefore, it is superior to the traditional fluid replacement program for fluid treatment. [ABSTRACT FROM AUTHOR]

The density peak clustering algorithm cannot adaptively cluster because it cannot adaptively select the clustering center and cutoff distance dc according to data set， so that an adaptive density peak clustering(ADPC) algorithm was proposed. Firstly， a parameter μi that comprehensively considers the local density ρi and cutoff distance δi was proposed， and the cluster center was automatically determined according to the sorting and downtrend of μi. Then， an adaptive selection of dc was made based on the concept of Gini coefficient. Finally， the ADPC algorithm was verified and compared with the DPC and K-means algorithm. The experimental results show that the ADPC algorithm has higher ARI， NMI and AC values， and has a better clustering effect. [ABSTRACT FROM AUTHOR]

Objective To investigate the clinical features, diagnostic and therapeutic methods of primary hepatic neuroendocrine carcinoma. Methods The clinicopathological data of fourteen patients with primary hepatic neuroendocrine carcinoma confirmed by pathology were analyzed retrospectively and related literatures were reviewed. Results The fourteen patients, including eight males and six females, had an age range of 23-58 years (mean 45.9 years). Four tumors were located in the right liver lobe, four in the left liver lobe and six in both. The clinical manifestations were nonspecific and variable. The most common clinical manifestation was abdominal distention or right upper quadrant pain. Radiological findings were not specific and could not distinguish primary hepatic neuroendocrine tumor from hepatocellular carcinoma. Diagnosis of primary hepatic neuroendocrine tumor was confirmed by pathology using immunohistochemical staining and by the absence of extrahepatic primary lesions. Extrahepatic primary neuroendocrine carcinoma was ruled out by ultrasonography, computed tomography (CT), magnetic resonance imaging (MRI), positron emission tomography-computed tomography (PET-CT), preoperative gastrointestinal endoscopy and long-term postoperative follow up. Three patients received surgical treatment, two cases received surgical resection and radiofrequency ablation (RFA), six patients received transarterial chemoembolization, one case received orthotopic liver transplantation, one case only received exploratory laparotomy, and one case received chemotherapy. All 14 patients were followed up and seven of them are still alive, the others died of liver failure or recurrence. Conclusions Primary hepatic neuroendocrine carcinomas are extremely rare. Its diagnosis should be confirmed by pathology. Preoperative fine needle biopsy is strongly recommended. Prognosis is relatively favorable. Surgical resection is treatment of first choice, and TACE, RFA, and chemotherapy can be used for unresectable patients. [ABSTRACT FROM AUTHOR]

Objective To explore the effect and the possible mechanism of albumin on transdifferentiation of renal tubular epithelial cells. Methods The renal tubular epithelial cells (HK-2 cells) in the logarithmic phase were treated with human serum albumin (HSA) 5 mg/mL for 24 h. The expression of kidney injury molecule-1 (KIM-1), E-cadherin, α-smooth muscle actin (α-SMA), p-p38 and p38 proteins before and after HSA treatment was detected by Western blotting. Next, the HK-2 cells were divided into two groups: KIM-1 silencing group and empty vector control group, which were transfected with KIM-1 siRNA plasmid or empty vector, respectively, then the expression of E-cadherin, α-SMA and KIM-1 was detected after treatment with HSA 5 mg/mL for 24 h. At last, the HK-2 cells were divided into three groups:SB203580 + KIM-1 group, KIM-1 group, and HSA group. The cells in the SB203580 + KIM-1 group were transfected with KIM-1 overexpression plasmid for 48 h and then were pretreated with 10 μmol/L SB203580, a specific inhibitor of p38 mitogen-activated protein kinase (MAPK) for 1 h. The cells in the KIM-1 group were only transfected with KIM-1 overexpression plasmid for 48 h. The expression of E-cadherin, α-SMA, KIM-1, p-p38 and p38 proteins in the above three groups was detected by Western blotting after treatment with HSA 5 mg/mL for 24 h. Results The protein expression of E-cadherin decreased, α-SMA, KIM-1, and p-p38 increased in HK-2 cells treated with 5 mg/mL HSA as compared with those before HSA treatment (all P ＜ 0. 05), while the change of p38 protein was statistically significant (P ＞ 0. 05). Compared with the empty vector control group, the protein expression of E-cadherin increased, α-SMA and KIM-1 decreased in the KIM-1 silencing group (all P ＜ 0. 05). In the KIM-1 group, SB203580 + KIM-1 group and HSA group, the protein expression of E-cadherin increased in turn, α-SMA and p-p38 decreased in turn (all P ＜ 0. 05), and no statistically significant difference was found in the p38 protein among three groups (P ＞ 0. 05). The protein expression of KIM-1 in the SB203580+ KIM-1 group and KIM-1 group increased as compared with that of the HSA group, while there was no statistically significant difference between the SB203580 + KIM-1 group and KIM-1 group (P ＞ 0. 05). Conclusion Albumin can promote transdifferentiation of renal tubular epithelial cells probably by promoting the expression of KIM-1 in renal tubular epithelial cells and then activating the p38 MAPK pathway. [ABSTRACT FROM AUTHOR]

An optimal irrigation management needs to clarify the effects of technical parameters on the crop growth, dry matter accumulation, seed yield, and the distribution of water and salt in soil. In this study, a two-year field experiment was conducted from April to October in 2018 and 2019, to investigate the effects of various amount of drip irrigation and emitter discharge rate on cotton growth at the 31st Regiment in Korla of Southern Xinjiang (86°56′58″E, 40°53′03″N). Three levels of drip irrigation were designed, including the full irrigation (W3:100% ETc, ETc is the crop evapotranspiration), moderate irrigation (W2:80% ETc), and low irrigation (W1:60% ETc). Two of emitter discharge rate (1.8 and 2.4 L/h) were applied to explore the optimal combination of drip irrigation amount and emitter discharge rate for cotton production, resulting in a total of six treatments with three replicates. Cotton growth indexes were measured, including the yield and its components, soil water moisture, and soil salinity. The main results were as follows: 1) There were significant effects of irrigation amount and emitter discharge rate on plant height, stem diameter, leaf area index, dry matter accumulation, yield and its components. In the bolling opening stage of 2018 and 2019, the plant height in the W1 treatment decreased by 10.40% and 11.22%, compared with that in the W3, respectively. The leaf area index in the W1 treatment was 22.52% and 44.16% lower than that in the W3. The plant height in the W1 treatment was 11.38% and 4.64% lower than that in the W3, when the emitter discharge rate was D2.4. The leaf area index in the W1 treatment was 24.55% and 53.83% lower than that in the W3. At the same rate of emitter discharge, the growth indexes, yield and its components of cotton increased with the increase of irrigation amount. Specifically, the cotton growth indexes, seed cotton yield and its components of W3 were significantly higher than those of W1 and W2. Under the same irrigation amount, the plant height, stem diameter, leaf area index, dry matter accumulation, effective boll number, 100-boll weight, and seed cotton yield were higher at the emitter discharge rate of D2.4, compared with those of D1.8. In 2018 and 2019, the yields of three irrigations amount under D2.4 increased by 4.81%, 8.39%, 4.69% and 4.98%, 7.23% and 11.06%, compared with those under D1.8. The corresponding water use efficiency under D2.4 was 13.48%, 5.44%, 8.99% and 5.61%, 5.36%,0.84% higher than that under D1.8, respectively. 2) The water use efficiency and irrigation water use efficiency decreased with the increase of irrigation amount. In W1 treatment, there was significantly higher than those of other irrigation treatments, at the same emitter discharge rate. The water use efficiency and irrigation water use efficiency at the emitter discharge rate of D2.4 were significantly higher than those D1.8 under the same irrigation amount. 3) The irrigation amount and emitter discharge rate had significant effects on soil water content and salinity distribution. The soil water content in the W3 was higher than those of W1 and W2 at the same emitter discharge rate. The distribution of soil water content in the D2.4 was more uniform than that in the D1.8 under the same irrigation amount. In the salinity of 0-40 cm soil layer, a gradual accumulation trend occurred during the whole growing season of cotton. The soil salinity decreased with the increase of irrigation amount at the same emitter discharge rate. The soil salinity in the D2.4 was lower than that of D1.8. When the irrigation amount was 100% ETc and the emitter discharge rate was D2.4, the soil water content was higher, the horizontal distribution of soil profile was more uniform, and the soil salinity was lower, indicating an optimal combination of parameters for the cotton growth. These results demonstrate that the irrigation amount of W3 (100%ETc) combined with emitter discharge rate of 2.4 L/h can be the optimal irrigation strategy for the cotton production in Southern Xinjaing, with the highest seed cotton yield of 7361.44 kg/hm2 in 2018, and 7837.91 kg/hm² in 2019, respectively. This finding can provide a theoretical basis to guide the efficient cotton production with water saving and salt control in the Korla region of Southern Xinjiang, China. [ABSTRACT FROM AUTHOR]

To investigate the effect of probiotics combined with triple therapy on ( ) - related gastritis in children and its influence on inflammatory factors. 93 cases of related gastritis in our hospital from January 2017 to June 2018 were selected, and they were divided into study group (n=47) and control group (n=46) according to the method of random number table. The control group was treated with triple therapy. The study group was treated with probiotics on the basis of the control group, the clinical effect, total score of clinical symptoms, inflammatory factors, HP eradication rate, incidence and recurrence of adverse reactions were compared. After 1 month treatment, the total clinical effective rate of the study group was 87.23% (41/47), which was higher than 69.57% (32/46) of the control group (P<0.05). The total score of clinical symptoms after 2 weeks and 1 month treatment and the levels of serum tumor necrosis factor-α (TNF-α), hypersensitive c-reactive protein (hs-CRP), interleukin-6 (IL-6) after 1 month treatment of the two groups decreased (P<0.05), and those of the study group were lower than those of the control group (P<0.05). The eradication rate of HP of the study group was higher than that of the control group (P<0.05). There was no significant difference in the incidence of adverse reactions and recurrence rate between the two groups (P>0.05). The curative effect of probiotics combined with triple therapy in the treatment of HP related gastritis in children is definite, which can improve the clinical symptoms and reduce the level of inflammatory factors with good drug safety in children. [ABSTRACT FROM AUTHOR]

Objective: To investigate the effect of probiotics combined with triple therapy on (HP) - related gastritis in children and its influence on inflammatory factors. 93 cases of related gastritis in our hospital from January 2017 to June 2018 were selected, and they were divided into study group (n=47) and control group (n=46) according to the method of random number table. The control group was treated with triple therapy. The study group was treated with probiotics on the basis of the control group, the clinical effect, total score of clinical symptoms, inflammatory factors, HP eradication rate, incidence and recurrence of adverse reactions were compared. After 1 month treatment, the total clinical effective rate of the study group was 87.23% (41/47), which was higher than 69.57% (32/46) of the control group (P<0.05). The total score of clinical symptoms after 2 weeks and 1 month treatment and the levels of serum tumor necrosis factor-琢(TNF-琢), hypersensitive c-reactive protein (hs-CRP), interleukin-6 (IL-6) after 1 month treatment of the two groups decreased (P<0.05), and those of the study group were lower than those of the control group (P<0.05). The eradication rate of HP of the study group was higher than that of the control group (P<0.05). There was no significant difference in the incidence of adverse reactions and recurrence rate between the two groups (P>0.05). The curative effect of probiotics combined with triple therapy in the treatment of HP related gastritis in children is definite, which can improve the clinical symptoms and reduce the level of inflammatory factors with good drug safety in children. [ABSTRACT FROM AUTHOR]

Objective: To investigate the effect of Jiangqi Zhixue Decoction on the TXB2 and 6-Keto-PGFl α levels in children with peptic ulcer acute bleeding. Methods: Sixty children with peptic ulcer bleeding who were admitted to our hospital from October 2015 to October 2018 were randomly divided into two groups, with 30 cases in each group. The control group was treated with fumotidine, and the study group was treated with Jiangqi Zhixue Decoction on the basis of control group. The total effective rate, changes of TXB2, 6-Keto-PGFlcx levels and coagulation function indicators before and after treatment were compared between two groups. Results: After treatment, the total effective rate of study group was significantly higher than that in the control group (P<0.05). The levels of TT, PT, aPTT and 6-Keto-PGFl α in the two groups were significantly lower than those before treatment, and the PLT, Fbg and TXB2 levels were significantly higher than before treatment, and the improvement of the above indicators in the study group were superior to those of the control group(P<0.05). Conclusion: Jiangqi Zhixue Decoction combined with famotidine was significantly better than motidine alone in the treatment of children with peptic ulcer acute bleeding, which may be related to the improvement ofTXB2 and 6-Keto-PGFl α levels. [ABSTRACT FROM AUTHOR]

Objective To understand the survival rate.factors affecting the survival rate and death causes in the patients with continuous ambulatory peritoneal dialysis (CAPD) by retrospectively analyzing the data of CAPD patients to adopt the effective measures by aiming at various factors. Methods The retrospective analysis was performed on the survival rate and its influencing factors in 308 patients with definitely diagnosed end stage renal disease and conducting CAPD exceeding 3 months in the hospital from January 1.2010 to October 1.2017.Then the influence of related factors such as the age. Alb level, residual renal function, dialysis related peritonitis.dialysis sufficiency, volume, blood pressure. calcium and phosphorus metabolism on the survival rate was analyzed. The various factors were analyzed by using the Kaplan-Meier method. The multivariate analysis was performed by using the Cox regression model. Results The anemia degree, poor nutritional status, low residual renal function value, peritonitis occurrence during dialysis in first time peritoneal dialysis were the risk factors of poor survival rate in CAPD patients;the nutritional status and residual renal function in the first time dialysis were the independent risk factors affecting the survival rate in the CAPD patients. Among 308 cases of CAPD, 86 cases (27.92%) died, including 68 cases (79.07%) of cardiovascular events, 10 cases (11.63%) of peritoneal infection,3 cases(3.49%) of digestive tract bleeding,2 cases(2.33%) of cerebral infarction and 3 cases (3.49%) of others. Conclusion The influencing factors of survival in CAPD patients are mainly the anemia degree in the first time peritoneal dialysis,nutritional status,residual renal function and dialysis related peritonitis occurrence. The nutritional status at the first time peritoneal dialysis and residual renal function are the independent risk factors. The cardiovascular events is the main death cause of CAPD patients,followed by peritoneal infection. [ABSTRACT FROM AUTHOR]

Objective · To compare the response and consequence of momacrophages infectedLeptospira interrogans 56606v and 56606a, and explore the mechanisms of pathogenic Leptospira to cadisease. Methods · Peritoneal macrophages of C57BL/6 mice were infectedpathogenic Leptospira 56606v and non-pathogenic Leptospira 56606a respectively. Immunofluorescence staining was performed to observe phagocytosis and clearance of Leptospira after infection, and realtime-PCR was used to determine cytokine production of macrophages. Results · After 72-hour infection, strain 56606v exhibited a lower phagocytic rate but survived after incubation with peritoneal macrophages compared with strain 56606a, which showed a higher phagocytic rate but was cleared at that time point. Additionally, cytokine production of macrophages incubated with 56606v was lower than that with 56606a. Conclusion · Leptospira interrogans strain 56606v can survive in macrophages, which may contribute to evasion phagocytic clearance and lead to disease, while strain 56606a can be cleared, which implicates a lower pathogenicity. [ABSTRACT FROM AUTHOR]

Aiming at applying big data analysis methods into elevator fault diagnosis and prediction, first, a large number of elevator inspection data was collected, and feature parameters related to car vibration were extracted from the inspection data. Then, the overall scheme was presented. By using supervised and unsupervised learning methods, data mining and analysis were conducted on the extracted feature parameters to find out the intrinsic relationship between the faults of elevator mechanical system and the car vibration signal. Finally, the elevator mechanical system faults could be diagnosed and predicted according to the magnitude of vibration characteristics and their changing trends.The results indicate that big data analysis method can be used to accurately diagnose and predict the failure of elevator mechanical system. [ABSTRACT FROM AUTHOR]