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Copyright of Coal Science & Technology (0253-2336) is the property of Coal Science & Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Coal Geology & Exploration is the property of Xian Research Institute of China Coal Research Institute and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

To explore and study the effects of caffeic acid on the growth of esophageal squamous cell carcinomaKYSE450 transplanted tumors in nude mice and its molecular mechanism. Nude mice with transplanted esophageal squamous cell carcinoma (n=48) were randomly divided into three groups-model group, 5-fluorouracil group and caffeic acid group. The three groups were injected intraperitoneally with 0.2 mL saline, 5-fluorouracil 25 g/kg, 5-fluorouracil 25g/kg and caffeic acid 50 mg/kg, twice a week for 4 weeks. The body weight of the 5-fluorouracil group and the caffeic acid group were higher than that of the model group in the 2nd and 4th weeks of treatment (P<0.05), and the caffeic acid group were higher than that of the 5-fluorouracil group (P<0.05). The tumor volume in the 5-fluorouracil group and the caffeic acid group at the 2nd and 4th weeks of treatment were less than that of the model group (P<0.05), and the caffeic acid group were higher than that in the 5-fluorouracil group (P<0.05). The levels of serum TNF-α and IL-6 in the 5-fluorouracil group and caffeic acid group were lower than those in the model group (P<0.05), and the caffeic acid group were lower than that in the 5-fluorouracil group (P<0.05) at the 4th weeks of treatment. The relative expression levels of Bax and Caspase-3 protein and apoptosis index of xenograft tumors in the 5-fluorouracil group and caffeic acid group were higher than the model group (P<0.05), and the caffeic acid group were higher than that of the 5-fluorouracil group at the 4th weeks of treatment(P<0.05).The application of caffeic acid in nude mice with esophageal squamous cell carcinoma can play a synergistic effect with5-fluorouracil. It can promote the apoptosis of transplanted tumor cells, inhibit the expression of inflammatory factors, and reduce the total number of blood vessels by up-regulating the expression of Bax and Caspase-3 proteins. Thereby inhibiting the growth of transplanted tumors, and promoting the restoration of nude mice body weight. [ABSTRACT FROM AUTHOR]

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)