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目的抑郁症是一种常见的精神疾病，对患者的身体健康有着深远的影响。抑郁症与较高的细菌感染风险相关；然而，这是否是一种因果关系，以及抑郁症如何影响感染仍不清楚。因此，本研究旨在通过构建慢性不可预测轻度应激（CUMS）模型，探究抑郁表型在小鼠细菌感染中的作用。方法小鼠经CUMS诱导4周，通过行为学测试评估抑郁表型。随后，小鼠腹腔注射肺炎克雷伯菌模拟细菌感染，感染后48 h收集血清和腹腔组织。苏木精-伊红染色（ HE）观察组织病理学改变，酶联免疫吸附试验（ELISA）检测炎性因子水平。此外，对感染前收集的小鼠粪便样本进行肠道菌群16S rDNA基因测序分析，并检测未感染小鼠结肠组织中NF-κB/NLRP3信号通路的表达水平。结果行为学测试结果显示，与对照组相比，CUMS小鼠体质量显著降低（Pt=5.426），蔗糖偏好率显著降低（Pt=4.937），游泳静止时间显著增加（Pt=16.37），旷场中央区域停留时间显著减少（Pt=3.575）。生存分析显示，与对照组小鼠相比，感染后CUMS小鼠的生存率显著降低（PPt=4.025）、肾脏（Pt=2.828）、肠系膜（Pt=5.367）组织损伤程度明显加重。ELISA结果显示，炎症因子IL-6（Pt=3.365）、IL-1β（Pt=4.061）、TNF-α（Pt=4.460）和LPS（Pt=27.24）水平升高。16S rDNA测序结果显示，CUMS小鼠肠道菌群结构发生改变，与对照组小鼠明显不同，表现出菌群失调。与对照组相比，CUMS小鼠结肠组织中NF-κB（Pt=6.825）和NLRP3（Pt=9.561）的表达水平升高。结论CUMS小鼠发生更严重的细菌感染。CUMS诱导的抑郁表型可能因为破坏肠道菌群组成和激活NF-κB/NLRP3信号通路，增加了小鼠对细菌感染的易感性。

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Aiming at the problem of identifying the characteristics of ash accumulation and shadow of photovoltaic modules, the difference of photovoltaic characteristic curves of ash accumulation and shadow was analyzed in detail, and the time-varying characteristics of the inflection point of the shadow photovoltaic curve were revealed. The number of inflection points of the characteristic curve and the current and voltage characteristic conditions were proposed to form the input feature quantity of the training model, and the dust accumulation and shadow recognition model was trained based on the CatBoost algorithm. Finally, the performance analysis and comparative test of the recognition model trained by CatBoost algorithm, ID3 and GA-BP algorithm were carried out by using the measured data of photovoltaic modules, and the results show that the recognition model trained based on CatBoost has strong discrimination and high diagnostic accuracy, which is of great engineering application value. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Oncology is the property of Chinese Journal of Oncology / Zhonghua Zhongliu Zazhi and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Oncology is the property of Chinese Journal of Oncology / Zhonghua Zhongliu Zazhi and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

[Abstract] Objective To explore the correlation between cognitive impairment and anemia. Methods A total of 2 089 elderly patients admitted to the First Affiliated Hospital of Chongqing Medical University from January 2012 to December 2021 and a township hospital in 2021 were selected as the study objects, and were divided into the normal cognitive group (1 257 cases) and the cognitive impairment group (832 cases). The differences of anemia and related indicators between the two groups were analyzed, and the correlation be- tween cognitive impairment and anemia was analyzed by univariate and multivariate logistic regression mod- els. Results Among the 2 089 patients, 832 (39.8%) had cognitive impairment and 884(42.3%) had anemia. The incidence of anemia in the cognitive impairment group [56. 4% (469/832)] was significantly higher than that in the cognitive normal group [33.0% (415/1 257)]. Anemia had a significant effect on cognitive impair- ment (OR = 2.621, 95% CI: 2. 188-3. 140, P<0.05). After adjusting for gender, age, marital status, educa- tion, residence, and current place of residence, anemia still significantly affected the occurrence of cognitive im- pairment (OR = 2. 159,95% CI: 1.757-2.653, P<0.05). The severity of cognitive impairment was positively correlated with the severity of anemia (r=0. 253, P<0.05). Conclusion Cognitive impairment is associated with anemia, which is a risk factor for cognitive impairment. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

To observe the efficacy of phacoemulsification (PE) combined with intraocular lens implantation (IOL) in the treatment of cataract, and to analyze the influencing factors of postoperative anterior chamber exudation. Methods: 406 cases (482eyes) of cataract patients who were treated with PE combined with IOL in our hospital from January 2018 to February 2021 were retrospectively analyzed. The changes of visual acuity and postoperative complications were observed. The influencing factors of postoperative anterior chamber exudation were analyzed by univariate and multivariate Logistic regression. Results The proportion of postoperative visual acuity of 0.6~0.9 and ≥ 1.0 eyes in cataract patients was higher than that before operation (P<0.05). Postoperative complications occurred in 46 eyes of cataract patients, including lens pigmentation, posterior capsule opacity and corneal edema in 3 eyes, fibrous exudative membrane in 2 eyes and anterior chamber exudation in 35 eyes, respectively, with a complication rate of 9.54% (46/482). Univariate analysis showed that anterior chamber exudation after PE combined with IOL was related to hypertension history, high myopia, glaucoma, preoperative intraocular pressure > 21 mmHg, intraoperative posterior capsular rupture of crystalline body, uveitis, intraoperative pupil diameter < 3 mm and lens nucleus grade ≥ grade IV (P<0.05). Multivariate Logistic regression analysis showed that preoperative intraocular pressure > 21 mmHg, glaucoma, high myopia, intraoperative posterior capsular rupture of crystalline body, uveitis and lens nucleus grade ≥ IV were the influencing factors of postoperative anterior chamber exudation (P<0.05). Conclusion: PE combined with IOL in the treatment of cataract has good curative effect, can effectively improve the visual acuity of patients, and the incidence of complications is low. Postoperative anterior chamber exudation is affected by many factors. In clinical work, intervention and treatment measures should be formulated according to relevant factors to reduce the risk of postoperative anterior chamber exudation. [ABSTRACT FROM AUTHOR]

BACKGROUND: Stem cell transplantation has brought hope for many difficult diseases, but the survival number of transplanted cells is small and the secretion function is poor, so it is difficult to play a therapeutic effect, which hinders the clinical application of stem cell transplantation. Hypoxic preconditioning can effectively improve the biological characteristics of implanted cells, such as proliferation activity, anti-apoptotic ability and secretion function. Therefore, human amniotic mesenchymal stem cells pretreated with hypoxia may play a better therapeutic role in tissue damage repair. OBJECTIVE: To study the effects of hypoxic preconditioning on the biological characteristics of human amniotic mesenchymal stem cells. METHODS: The mechanical method and enzymatic digestion were used to separate human amniotic mesenchymal stem cells, and then cultured it up to the third generation. After having hypoxic pretreatment (3% O2) for 48 hours, the nomoxic (21% O2) control group was set. The proliferation activity and DNA synthesis rate of human amniotic mesenchymal stem cells in the two groups were detected by CCK-8 and Edu proliferation experiments. The two groups of cells were cultured by serum-free medium for 24 hours. Apoptosis was detected using Annexin V-FITC/PI assay. The supernatant was collected. The levels of angiogenic factors secreted in the supernatant were detected by using the Proteome Profiler. RESULTS AND CONCLUSION: Hypoxic preconditioning does not affect the characteristics of human amniotic mesenchymal stem cells, but can improve the proliferation activity of human amniotic mesenchymal stem cells; in serum-free culture conditions, hypoxic preconditioning can enhance the anti-apoptotic effect of human amniotic mesenchymal stem cells, and secrete more angiogenic factors. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Practical Oncology Journal is the property of Journal of Practical Oncology Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To investigate the effect of different retention time of silicone drainage tube for lacrimal passage on the quality of life, vision and recurrence rate of chronic dacryocystitis patients. Methods: 91 cases (128 eyes) of chronic dacryocystitis patients who came to our hospital from January 2018 to December 2019 were selected retrospectively. According to the time of catheter retention after operation, they were divided into two groups: group A and group B, among group A had catheter for 6 weeks and 44 cases (61 eyes). Group B was had catheter for 12 weeks, 47 cases (67 eyes). The curative effect, vision, complication rate, incidence rate of chief complaint of tear spillation, quality of life and recurrence rate were compared between the two groups. Results: The total effective rate of extubation day in group A was higher than that of group B (P<0.05), and there was no statistically significant difference between the two groups in the total effective rate 3 months after extubation (P>0.05). The scores of social function, physical pain, mental health, physiological function, energy, emotional function, physiological function and overall health in the two groups at 6 months after extubation were all higher than those before operation (P<0.05), but there was no statistical difference between the two groups (P>0.05). There was no statistical difference of vision between the two groups before operation, 3 months after extubation and within the group (P>0.05). There was no statistical difference in the incidence rate of chief complaint of tear spillation between the two groups (P>0.05). The incidence rate of complications and recurrence rate in group A were lower than those in group B (P<0.05). Conclusions: The duration of in- dwelling of the silica gel drainage tube in the lacrimal duct has no significant influence on the curative effect, vision, quality of life, and incidence rate of chief complaint of tear spillation in patients with chronic dacryocystitis. However, the complication rate and recurrence rate of patients who have been indwelling for 6 weeks are lower than those who have been indwelling for 12 weeks, suggesting that the duration of indwelling of the silica gel drainage tube in the lacrimal duct should be shortened as much as possible according to the specific conditions of patients. [ABSTRACT FROM AUTHOR]

Pyrolysis technology is one of the main ways to treat the biomass wastes. A typical agricultural and forestry waste, corn straw contains alkali metals and other catalytic components, showing the excellent pyrolysis behavior with high volatile matter while low ash content. Another typical municipal solid waste, the sludge contains a large amount of thermally degradable organic matter, pathogenic microorganisms, toxic and harmful organic matter. There is relatively high moisture and ash content in the sludge, compared with the corn straw. The co-pyrolysis of the sludge and the corn straw can be an effective way to improve the energy efficiency, thereby to enhance the performance of the products. As such, it can fully realize the complementary advantages of two wastes. In this study, a ThermoGravimetric Analysis (TGA) test was performed on the mixed samples with the corn stalk and municipal sludge in the mass ratio of 9:1, 3:7, 5:5, 7:3, and 1:9 at different heating rates (10, 20, and 30 ℃/min), in order to explore the pyrolysis characteristics and the Degree of Synergy (DS) in the single and mixed samples. A Coats Redfern method was used to clarify the kinetic of weight loss curves. The results indicated that there were great differences in pyrolysis characteristics between corn stalks and municipal sludge, where the residual rate differed by 18.57 percentage points, the comprehensive pyrolysis index differed by 35.73×10-5, and the activation energy differed by 35.31 -46.88 kJ/mol. Specifically, the activation energy of sludge pyrolysis was lower than that of corn straw. Furthermore, the activation energy increased with the increase of heating rate, with the maximum of 30 ℃/min. The initial temperature of pyrolysis decreased from 360.3 ℃ to 440.3 ℃, with the content of municipal sludge varied from 10% to 90%, while the main pyrolysis interval of mixed samples became longer from 277.7-360.3 ℃, shifting to the high temperature zone. The residual rate increased from 33.69% to 45.83%, whereas, the maximum weight loss rate decreased from 7.88 to 3.11%/min. There was a similar behavior in the comprehensive pyrolysis index, indicating a decrease from 8.5×10-5 to 1.7×10-5. The starting temperature of pyrolysis in the mixed samples was significantly improved by the municipal sludge, but some negative effects also occurred, including the longer interval time of pyrolysis, the higher residual rate, the slower weight loss rate, and the lower comprehensive pyrolysis index. The comprehensive pyrolysis index of mixed samples was lower than that of theoretical value, indicating an inhibitory effect in the co-pyrolysis of mixed samples. The activation energy required for the individual pyrolysis of corn stalks was greater than that of municipal sludge. The increase of activation energy varied at low and high temperature in the mixed samples of corn stalks and municipal sludge, as the heating rate increased. The activation energy of pyrolysis in the mixed samples decreased from 66.01-46.16 kJ/mol to 44.47-17.04 kJ/mol, as the content of municipal sludge increased from 10% to 90%. The findings can provide insightful data support to the co-pyrolysis of corn straw and municipal sludge, and the further application of products in low-carbon agriculture. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Oncology is the property of Chinese Journal of Oncology / Zhonghua Zhongliu Zazhi and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Oncology is the property of Chinese Journal of Oncology / Zhonghua Zhongliu Zazhi and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of Journal of Zhengzhou University (Natural Science Edition) is the property of Journal of Zhengzhou University (Natural Science Edition) Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Oncology is the property of Chinese Journal of Oncology / Zhonghua Zhongliu Zazhi and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of Chinese Journal of Oncology is the property of Chinese Journal of Oncology / Zhonghua Zhongliu Zazhi and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Clinical Hepatology / Linchuang Gandanbing Zazhi is the property of Journal of Clinical Hepatology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Oncology is the property of Chinese Journal of Oncology / Zhonghua Zhongliu Zazhi and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Oncology is the property of Chinese Journal of Oncology / Zhonghua Zhongliu Zazhi and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Modern Medicine & Health is the property of Journal of Modern Medicine & Health and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Modern Medicine & Health is the property of Journal of Modern Medicine & Health and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

运用Copula模型研究随机变量间的相关结构，是近年来金融统计分析中的一个热点.在龚金国和史代敏提出时变Copula非参数模型的基础上，利用时间序列的极限理论研究了时变参数估计量的大样本性质，并给出了时变Copula模型的非参数估计算法.研究结果表明，时变Copula非参数模型的时变参数估计量具有一致性和渐近正态性.

提出了整数值随机游走过程，推导出该随机游走过程的若干和式的极限分布.证明了无截距、无时间趋势的单位根过程的自回归系数的最小二乘估计量的极限分布不再是Weiner过程的泛函，而是依概率收敛到真值1，最后还用Monte Carlo模拟验证了该结论的合理性.

建立了特殊的一阶随机系数整值滑动平均模型.研究发现：固定指标t,该过程服从泊松分布；求得该过程的期望、方差、协方差；证明了该过程是宽平稳过程,均值具有遍历性；得到了模型参数的区间估计与具有一致性与无偏性的矩法估计,并对估计量的效果进行了模拟研究.