Objective To explore the clinical characteristics, diagnosis and treatment and follow-up of children kawasaki disease （KD）, amd to provide reference for clinical diagnosis and treatment. Methods From January 2011 to January 2015, in Department of Pediatrics, Shaanxi Province People's Hospital, the clinical data of 170 children with kawasaki disease, including general data, clinical manifestations, diagnosis, treatment and follow- up were retrospectively analyzed. Results （1） Clinical characteristics：there were 170 cases of typical KD in children with KD, accounted for 77.1% （131/170 cases）, 39 cases of incomplete KD, accounted for22.9%. The male to female ratio of Typical KD was 1.86：1, incomplete KD was 1.19：1. There were 46 cases complicated with coronary artery damage （27.1%,46/170 cases）, including 38 cases of coronary artery expansion （22.4%, 38/170 cases）, 6 cases of coronary artery aneurysm （3.5%, 6/170 cases）, and 2 cases of giant coronary artery aneurysm （1.1%,2/170 cases）. Blood system involved in 161 cases （94.7%,161/170 cases）, Digestive system involved in 98 cases （57.6%,98/170 cases）, Respiratory system involved in 78 cases （45.9%,78/170 cases）, Urinary tract involved in 40 cases （23.5%, 40/170 cases）, joints pain involved in 5 cases （2.9%,5/170 cases）, the central nervous system involved in 3 cases （1.8%,3/170 cases）. Conclusion（1）The preference age of KD is〈 5 years old, the boy is more common in girls; （2） KD can involve multiple systems, KD coronary artery expansion is given priority to transient expansion, in addition to the cardiovascular complications,we should pay attention to other system damage,so that early recognition; （3） The early use of IVIG combined with aspirin has better prognosis, Methylprednisolone has good effect for those KD patients without response to intravenous immunoglobulin （IVIG）; （4） The overall follow- up shows that the younger the age, the stronger the adherence, and the easier to adhere to visit on a regular basis. [ABSTRACT FROM AUTHOR]