Search

Objective To investigate the internal exposure levels of selenium, arsenic, chromium, and cadmium in blood and urine of general population in Jiangxi Province from 2017 to 2018, Methods A multi -stage complex sampling method was employed to detect the content of selenium, arsenic, chromium, and cadmium in the fasting venous whole blood and urine samples of 720 selected subjects using Inductively Coupled Plasma Mass Spectrometry (ICP-MS). The exposure situation of residents in different genders, ages, urban and rural areas, and monitoring sites was analyzed. Spearman correlation was used to evaluate the bivariate correlation between blood metal concentrations and urine metal levels. Results The median levels of blood selenium and urine selenium in the general population of Jiangxi Province from 2017 to 2018 were 90.89 [Xg/L and 13.67 |Xg/L, respectively. The median levels of blood arsenic and urine arsenic were 1.26 |Xg/L and 24.03 |Jig/L, respectively. The median levels of blood chromium and urine chromium were 0.51 |Jig/L and 1.84 (Jig/L, respectively. The median levels of blood cadmium and urine cadmium were 0.85 fig/L and 0,61 |Jig/L, respectively. There were statistically significant differences in blood selenium (Z=-5.09, P < 0.01) and urine selenium concentrations (Z=-3.94, P < 0.05) between different urban and rural areas, with concentrations higher in urban areas. Except for blood cadmium and urine cadmium, there were statistically significant differences in the concentration levels of other inorganic substances between different monitoring sites (P < 0.05). Differences in blood selenium (i7=34,56; P < 0.05), blood cadmium (H=54.14, P < 0.05), and urine cadmium (H-63,447, P < 0.05) among different age groups were statistically significant, with concentrations gradually increasing with age. No statistically significant differences in concentrations of other inorganic substances between different genders were found (P > 0,05) except for urine selenium (Z二一3.77, P < 0,05). The strongest correlation coefficient among the four inorganic substances was 0.419 for blood cadmium and urine cadmium. Conclusion Residents in different regions of Jiangxi Province exhibit varying levels of internal exposure to selenium, arsenic, and chromium. Cadmium showed no regional differences in [ABSTRACT FROM AUTHOR]

Copyright of Feed Research is the property of Editorial Board of Feed Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To investigate the changes and significance of Toll-like receptor 7 （TLR7）， TLR9 and type I interferon （IFN- Ⅰ） in children with severe mycoplasma pneumoniae pneumonia （SMPP）. Methods 80 children with mycoplasma pneumoniae pneumonia （MPP） were divided into the non-severe MPP （MPP group） and SMPP groups （SMPP group）. 26 healthy children who underwent outpatient physical examination were chosen as the control group. Serum samples in each group were collected. In the SMPP group， bronchoalveolar lavage fl uid （BALF） on the affected and contralateral sides of 26 children with unilateral lung consolidation， atelectasis， lung abscess or lung tissue necrosis on imaging examination were collected. The levels of TLR7， TLR9， myeloid differentiation factor 88 （MyD88）， interferon-α （IFN-α） and IFN-β in the serum and BALF samples were determined by enzyme-linked immunosorbent assay （ELISA）. Results The serum levels of TLR7， TLR9， MyD88， IFN-α and IFN-β in the SMPP and MPP groups were significantly higher than those in the control group， and the levels of all cytokines in the SMPP group were significantly higher compared with those in the MPP group （all P < 0.05）. The levels of TLR7， TLR9， MyD88， IFN-α and IFN-β in the BALF on the affected side were significantly higher than those on the contralateral side （all P < 0.01）. The area under the receiver operating characteristic curve （AUC） of serum TLR7 and MyD88 levels for predicting SMPP was 0.709 and 0.723. Conclusions Over-induced and generated TLR7， TLR9， IFN-α and IFN-β may be pathogenic factors for the incidence of SMPP and severe local lung tissue injury in children with SMPP. TLR7 and MyD88 can be used as predictors of SMPP to guide clinical treatment. [ABSTRACT FROM AUTHOR]

Precision medicine refers to implement “tailored” health care and clinical decision-making based on the patient’s intrinsic biological information and clinical signs. Major breakthroughs have been made not only in targeted therapy of gastric cancer and in the analysis and identification of biological markers, but also in the development of minimally invasive and precise surgery. Traditional Chinese medicine is a system that is characterized by a high degree of “individualized medicine”, where attention is paid to the influence of various factors such as constitution, environment, and lifestyle on individual differences. “Inflammation cancer transformation” of chronic gastritis is a complex process that encompasses the digestology and oncology, involving a dynamic evolution that spans multiple pathological stages. Guided by the ideology of “preventive treatment”, Chinese medicine pays special attention to the precise prevention and treatment across the whole process and all factors involved in “inflammation cancer transformation” of chronic gastritis. The ultimate aim is to provide (i) targeted and precise management for different pathological stages, different syndrome characteristics, and different population characteristics; and (ii) active intervention based on “principle, methodology, formula, medication” at each pathological stage, so as to block disease progression and reduce the incidence of gastric cancer. This paper discusses the advantages of traditional Chinese medicine in precision medicine, from the perspective of accuracy in theory, prevention, differentiation, and treatment, in order to provide a reference for delaying, blocking, or even reversing the process of “inflammatory cancer transformation” of chronic gastritis. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Beijing University of Traditional Chinese Medicine is the property of Journal of Beijing University of Traditional Chinese Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of New Medicine is the property of Sun Yat Sen University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Practical Pharmacy & Clinical Remedies is the property of Editorial Department of Practical Pharmacy & Clinical Remedies and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Beijing University of Traditional Chinese Medicine is the property of Journal of Beijing University of Traditional Chinese Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Electronic Components & Materials is the property of Electronic Components & Materials and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Beijing University of Traditional Chinese Medicine is the property of Journal of Beijing University of Traditional Chinese Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Since "deterioration of chronic gastritis into gastric cancer" is the main cause of gastric cancer, active prevention and treatment of such deterioration is of great significance for reducing the incidence of gastric cancer. However, many bottlenecks in model establishment have restricted the development of basic research and application in this field, e. g. the selection of model factors, model preparation methods, model evaluation at different pathological stages, the way of combining WM disease and TCM pattern in model establishment, and model pattern determination. Based on the research findings of the present team in the last 5 years as well as global research progress, problems in the establishment of the animal models of gastritis deteriorating into gastric carcinoma with consideration of both WM disease and TCM pattern were analyzed one by one and possible solutions were proposed. We simulated the clinical features of the multifactorial disease and provided two rat models with MNNG as the main factor. Compared with the existing models, they are proved more in line with clinical characteristics of the disease and yield higher success rates for model establishment and better stability by multiple experiments. They may become powerful tools for animal research in this field. [ABSTRACT FROM AUTHOR]

Objective To discover the potential effect targets and signaling pathway of Manpixiao (MPX), an experiential formula of Professor Lu Zhizheng's for chronic atrophic gastritis (CAG) through biological network and modular analysis, and explain its potential effect mechanism at point of bioinformatics. Methods The active principles of MPX and of MPX-corresponded target and CAG-related target were obtained by using Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP), BATMAN-TCM, Online Mendelian Inheritance in Man (OMIM), Human Phenotype Ontology (HPO) and DisgeNet Database. The known protein-protein interaction (PPI) was obtained through Human Protein Reference Database (HPRD) and Biological General Repository for Interaction Datasets (BioGRID) for establishing MPX-CAG PPI network. The core functional modules were excavated by using ClusterONE software. Cluego software was used for functional explanation of gene ontology (GO) of the modules, and Kyoto Encyclopedia of Genes and Genomes (KEGG) was used for enrichment analysis of signaling pathway of the modules. Results There were 1885 MPX-corresponded genes and 209 CAG-related genes obtained after retrieving databases. There were 44 nodes and 292 edges for establishing MPX-CAG PPI network, among them there were 31 nodes for establishing core network modules. The results of GO functional explanation and KEGG signaling pathway enrichment analysis showed that the mechanism of MPX in CAG treatment might be related some signaling pathways related to inflammatory reactions and tumors including to IL-17 signaling pathway, inflammatory bowel disease, HIF-1 signaling pathway and VEGF signaling pathway. MPX might take part in GO-related differentiation, metabolism and apoptosis, especially it had important relative effects on targets of tumor protein 53 (TP53), interleukin family cytokines, PTGS2/COX-2, tumor necrosis factor-α (TNF-α), vascular endothelial growth factor A (VEGF-A) and epidermal growth factor receptor (EGFR). Conclusion MPX can alleviate gastric microenvironment possibly through regulating immune inflammatory reactions, gastric acid secretion and VEGF, and play a role in CAG treatment and control of CAG malignant transformation. The study provides a useful exploration on the pharmacological and pharmacodynamic mechanism of MPX. On the other hand, it also provides research ideas and methodology reference for explaining the effect mechanism of famous physicians' experience formulas. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Beijing University of Traditional Chinese Medicine is the property of Journal of Beijing University of Traditional Chinese Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The inflammation-cancer transformation of chronic gastritis is a classical model of malignant transformation from chronic uncontrollable inflammation cancer, and traditional Chinese medicine (TCM) plays an important role in delaying, blocking and reversing the progress of this disease. From the perspective of TCM, TCM cognition on inflammation-cancer transformation of chronic gastritis, and the function, value, bottleneck problem and countermeasure of TCM in controlling thus progress are expounded. At present stage, there are relatively few TCM literatures on discussion of inflammation-cancer transformation of chronic gastritis, and no systematic research Results achieved. The TCM theory of “dynamic thinking” and “preventive treatment of disease” plays an important role in the prevention and treatment of inflammation-cancer transformation of chronic gastritis. TCM has advantages in removing causes of disease, alleviating patients’ clinical symptoms and improving the pathological morphology of gastric mucosa. In the process of controlling inflammation-cancer transformation of chronic gastritis, TCM has the characteristics of higher safety, lower drug dependence and good compliance. It is of great significance and value to control the progress of the disease and reduce the incidence of gastric cancer. However, there are still some problems including a lack of systematic ideas of differentiation and treatment in clinical practice, unclear time for intervention of inflammation-cancer transformation of chronic gastritis, and indistinct combined effects with Western medicine at the present stage. The bottleneck problems are manifested as program in scientific research cannot reflect TCM characteristics, systematic mechanism exploration is in shortage, and research Results are difficult to be applied in clinical practice. Therefore, further consideration and measures are needed in controlling inflammation-cancer transformation of chronic gastritis by TCM [ABSTRACT FROM AUTHOR]

Copyright of Piezoelectrics & Acoustooptics is the property of Piezoelectric & Acoustooptic and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Beijing University of Traditional Chinese Medicine is the property of Journal of Beijing University of Traditional Chinese Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)