Objective: To investigate the value of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) combined with platelet-lymphocyte ratio (PLR) and neutrophil-lymphocyte ratio (NLR) in predicting short-term prognosis of acute cerebral infarction. Methods: The clinical data of 80 patients with acute cerebral infarction who were admitted to our hospital from January 2015 to December 2019 were retrospectively analyzed. According to the modified Rankin Scale (MRS) score differences, all the patients were divided into good prognosis group (mRS score ≤ 2 scores) with 50 cases and poor prognosis group (mRS score >2 scores) with 30 cases. DCE-MRI related parameters[relative value of capacity transfer constant(rKtrans), relative value of the rate constant(rKep), relative value of extracellular space volume fraction outside the blood vessel (rVe)], PLR, NLR and baseline data at admission were compared between the two groups, and Multivariate Logistic regression was used to analyze the influencing factors of poor short-term prognosis in patients with acute cerebral infarction. In addition, receiver operating characteristic (ROC) curve was used to analyze the efficacy of DCE-MRI combined with PLR and NLR in predicting short-term prognosis of acute cerebral infarction. Results: All DCE-MRI parameters in the good prognosis group were significantly higher than those in the poor prognosis group(P<0.05). PLR, NLR, age and National Institutes of Health Stroke Scale (NIHSS) score at admission in the good prognosis group were lower than those in the poor prognosis group (P<0.05). Multivariate logistic regression analysis showed that: PLR, NLR, age and NIHSS score at admission were independent risk factors for poor short-term prognosis of patients with acute cerebral infarction (OR>1, P<0.05). The area under the curve, sensitivity, specificity and Youden index of DCE-MRI combined with PLR and NLR in predicting poor short-term prognosis of acute cerebral infarction were higher than those of the above single prediction. Conclusion: DCE-MRI combined with PLR and NLR has a high value in predicting poor short-term prognosis of acute cerebral infarction, and has certain application value. [ABSTRACT FROM AUTHOR]