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Накопились новые данные, свидетельствующие о наличии патогенетически обоснованной взаимосвязи между бронхиальной астмой (БА), пневмонией и гастроэзофагеальной рефлюксной болезнью (ГЭРБ) у детей. Частые срыгивания и рвота сопровождаются развитием воспалительных процессов в пищеводе. Отсутствие разрешения патологического процесса в легких становится поводом для поиска причин затяжного течения болезни. У детей с сочетанным течением воспалительных изменений в легких и ГЭРБ антирефлюксные программы должны проводиться в течение ближайших двух недель после их развития для предотвращения обострения. При высокой частоте встречаемости ГЭРБ и наличия бронхиальной обструкции в алгоритм обследования сочетанной патологии необходимо включать эзофагогастродуоденоскопию, внутрипищеводную рН-метрию с последующей медикаментозной коррекцией. При сочетанном течении заболеваний органов дыхания и пищеварения лечение должно включать препараты, действие которых направлено как на купирование бронхообструктивного синдрома (БОС), так и на уменьшение клинических симптомов ГЭРБ. Приведенный клинический случай демонстрирует процесс постановки диагноза и эффективность комплексной терапии.

Swiss psychiatrist Carl Jung had a lifelong interest in the I Ching after discovering it in 1919. Jung's interest in the I Ching is arguably more practical than purely theoretical or intellectual, and references to I Ching divination appear frequently in his various publications, seminars, letters and clinical practice records. After a few observations on the history of the study of the I Ching in China, the author categorizes Jung's three uses of the I Ching as physical use (to preview future potentials of outer reality), psychological use (to reveal one's psychological state), and psychical approach (to engage with the divine through "神"["shen", spiritual agencies]). Finally, the author discusses the current Jungian engagement by demonstrating clinical cases in contemporary times. Some Jungian analysts practise I Ching divination to obtain insights into the physical and psychological state of therapeutic relationships and for personal development. This paper is a historical and critical engagement of the Jungian practice of I Ching divination. [ABSTRACT FROM AUTHOR]

Objective. Comparative pharmacoeconomic evaluation of upadacitinib, baricitinib and dupilumab for the treatment of moderate to severe atopic dermatitis.Materials and methods. Study design — retrospective. Pharmacoeconomic analysis method — cost-effectiveness analysis, budget impact analysis. Data sources. On the effectiveness of compared alternatives — meta-analysis of randomized clinical trials for the compared drugs, clinical recommendations; on the cost of drugs — the state register of maximum selling prices.Results. Lowest cost-effectiveness (CER) values for both EASI-75 and EASI-90 responses were for upadacitinib. For upadacitinib 15 mg/day, the cost of achieving EASI-75 and EASI-90 responses was reduced by 63.9 and 70.3%, respectively compared to dupilumab and by 44.2 and 46.8% compared to baricitinib. For upadacitinib 30 mg/day, the reduction in the cost of achieving the effect compared to dupilumab will be, respectively, 40.8 and 56.2%, and compared with baricitinib — 8,5 and 21.4%. The budget impact analysis (BIA) showed that the increase in the share of upadacitinib from 15 to 35%, and the proportion of baricitinib — from 5 to 10% due to a decrease in the proportion of patients, receiving dupilumab will reduce the budget impact in the treatment of patients with severe atopic dermatitis on the scale of the Russian Federation by a total of 11.6% (RUB 1.25 billion) with a single-step change from the first year and by 7.9% (RUB 0.86 billion) with a gradual change over 3 years. An analysis of missed opportunities showed that if the share of upadacitinib changes to 35% 741 patients can be additionally provided with therapy in the first year, 629 patients in the second year and 567 patients in the third (with a target population size of 4929 patients).Conclusion. Increasing the share of upadacitinib will not only significantly reduce the burden on the budget of the healthcare system by refusing to use more expensive dupilumab in some patients, but also increase the proportion of patients achieving the goals of therapy in terms of EASI-75 and EASI-90.

To date, there are over 150 approaches, programs, interventions and therapies for Autism Spectrum Disorder (ASD). Wheeler et al. (2015) categorise these into the following, although some therapies include more than one approach: behavioural, developmental, educational, social-relational, pharmacological, psychological, complementary and alternative. But as Bleiweiss (2020) summarises, what they all have in common is an individual approach specifically to each child. But the need for information and training provided by professionals in the field is pressing. He points to educational and behavioural interventions as the most effective, but only when implemented early, and with the parents' ongoing involvement. This survey attempts to provide a "snapshot" of the approaches and programs in place in Bulgaria, and to what extent parents can make informed choices about the best therapy for their child. [ABSTRACT FROM AUTHOR]

Experiments on the implementation of anti-Emeriosis measures were carried out on 1-3- month-old rabbits of the Californian and giant breeds, as well as crossbred rabbits. In order to increase the effectiveness of the activities, proper conditions for the rabbit feeding, care, and housing were created. The experiment duration was 10 days. The research results showed that "MODUS GRANUM" granules, as well as the necessary care and keeping lead to a decrease of the intensity of Eimeria invasion, and the use of 0.01% iodine solution gives a positive therapeutic effect. [ABSTRACT FROM AUTHOR]

The review analyzes 47 publications describing the process occurring in the human body with involvement of pyridoxine (vitamin B6). The special emphasis is put on the role of vitamin B6 in prevention of adverse reactions to medications or their relief due to a comprehensive effect on many organs and systems.

Arteria Lusoria, an aberrant or anomalous right subclavian artery is the most frequent anomaly of aortic arch. It may be associated with other congenital anomalies of the heart and great vessels – rarely including truncus bicaroticus and even more rarely-aneurysmal formation. Here we report the case of 50- year old male with complaints of chest pain, spread out toward chest bone, pain in the left region of neck, who had aneurysms of ascending aorta, aortic arch and a.lusoria and truncus bicaroticus too. A.Lusoria aneurysm was with 6h8 sm size and ostium from the side of thoracic aorta. We made one after another mediastinal aortic debranching with right and left carotid-subclavian artery baypass and endovascular treatment with two stent-grafts implantatipn in ascending aorta and aortic arch. The early postoperative period was uneventful, with stable hemodynamic without catecholamins usage. We didn’t have high level of enzymes for myocardial necrosis, without rhythm and heart conduction disorders and without ischemic disturbances of left upper limb with pulsatile flow to the distal artery and so too without neurological deficit from central nervous system. Aneurysm of arteria Lusoria should be suspected in the presence of a right superior mediastinal mass on X-Ray and should be considered as a cause of new-onset dyspnea, chest pain, or dysphagia. Despite disagreement among investigators regarding the need to restore pulsatile blood flow to the right arm, we recommend reconstructing that flow, when possible. [ABSTRACT FROM AUTHOR]

В психиатрической практике при лечении пациентов с депрессивными расстройствами все большее предпочтение отдают антидепрессантам из группы селективных ингибиторов обратного захвата серотонина (СИОЗС). В литературе все чаще встречаются упоминания о различном влиянии СИОЗС на уровень когнитивных функций при лечении депрессии. Однако на сегодняшний день нет однозначных данных о положительном или отрицательном влиянии антидепрессантов из группы СИОЗС на когнитивные функции у пациентов. Цель исследования – оценить изменение когнитивных функций у пациентов с депрессивными расстройствами в процессе терапии антидепрессантами из группы СИОЗС. Материал и методы исследования: Было обследовано 30 пациентов женского пола с депрессивными расстройствами, которые проходили лечение в клинике Научно-исследовательского института психического здоровья Томского национального исследовательского медицинского центра Российской академии наук в течение 28–30 дней. Всем пациентам были назначены антидепрессанты из группы СИОЗС. Исследование уровня когнитивных функций проводили до и после курса терапии с помощью компьютерных тестов Go/Nogo, Corsi и Stroop. В качестве контрольной группы было обследовано 30 психически здоровых лиц, сопоставимых по полу, возрасту и уровню образования с группой пациентов. Результаты: Анализ данных показал, что пациенты после курса терапии совершали меньшее количество ошибок в тесте Go/Nogo и затрачивали меньшее количество времени на выполнение теста Stroop. При этом статистически значимых различий в тесте Corsi обнаружено не было. Заключение: Представленные нами данные показывают, что у пациентов депрессивными расстройствами наблюдаются улучшение уровня ингибиторного (сдерживающего) контроля и снижение когнитивной ригидности после 28–30-дневного курса терапии СИОЗС.

The aim of study was to examine the prevalence of glaucoma and its treatment schemes among the population over 65 years in Sofia. Materials and Methods: Free prophylactic ophthalmological examinations of elderly people in Sofia, announced througt the national mass media, were conducted in 2016 and 2017. Results: 12% of examined patients have anamnestic data for glaucoma. 43% of them receive conservative monotherapy. Prostaglandin analogues (57%) are most commonly used, followed by β-blockers, carbonic anhydrase inhibitors and α2-agonists. Fixed combinations are used by 86% of the patients requiring treatment with two medications and 100% of the patients who apply four medications to achieve control on disease. Conclusion: Therapeutic approach and therapeutic schemes for control of glaucoma in the elderly Sofia citizens are similar to approaches and schemes used in most countries and correspond to the recommendations of the European and World Glaucoma Societies, American Academy of Ophthalmology and other national ophthalmological societies. Β-blockers are the most commonly used medications in combined antiglaucoma therapy, and prostaglandin analogues are the most used group in monotherapy. Fixed combinations are preferred in cases requiring combined therapy to minimize side effects of the use of multiple vials and to improve patient compliance. The common use of preservative-free preparations is seen. [ABSTRACT FROM AUTHOR]

Введение: Качество и результаты клинических исследований в современной психиатрии имеют важное значение, поскольку они служат основой для клинических рекомендаций. Однако многие аспекты проведения исследований антидепрессантов и анксиолитиков в последнее время являлись предметом серьезной критики. В данном обзоре рассмотрена литература последних двух десятилетий, посвященная методологическим и методическим проблемам при изучении новых лекарственных препаратов для терапии тревожных и депрессивных расстройств. Результаты: Исследованиям анксиолитиков и антидепрессантов присущи как общие проблемы подходов к проведению клинических исследований, так и собственные особенности. Современные требования и процедура стандартизованных клинических исследований новых лекарственных препаратов решают формальные задачи с целью официальной регистрации препарата и не вполне приемлемы для психиатрии на данном этапе ее развития. Особенности классификации психических расстройств, недостаточность представлений о механизмах их патогенеза, ограничения методов психометрической оценки, недостаточно контролируемый плацебо-эффект и многие другие проблемы, возникающие у организаторов, исполнителей и субъектов клинических исследований, могут приводить к искажению получаемых результатов. Ряд других проблем, включая игнорирование оценки особенностей клинико-фармакологического действия препарата, снижает применимость результатов исследований в реальной клинической практике. Выводы: Появление более эффективных решений этих проблем позволит повысить адекватность разных аспектов исследования, начиная с выбора гипотезы, параметров эффективности (конечных точек) и популяции исследования, и получать данные, ориентированные не только на формализованную оценку результативности терапии в рамках исследований (efficacy), но и на персонифицированный/стратифицированный прогноз эффективности в реальных клинических условиях.

В статье представлен литературный обзор исследований применения методов биоуправления в терапии депрессивных расстройств. Проблема эффективной терапии, профилактики и реабилитации пациентов с депрессивными расстройствами имеет в современных условиях особую актуальность. Несмотря на появление большого количества современных антидепрессантов, число терапевтически резистентных больных составляет около 30 %. В связи с этим в настоящее время возрастает интерес специалистов к использованию в лечении депрессии методов нелекарственной терапии. Цель исследования – систематизация научных данных об эффективности применения методов биоуправления в терапии пациентов с депрессивными расстройствами. Выводы: методы биоуправления зарекомендовали себя как достаточно эффективные средства для снижения симптомов депрессии и улучшения самочувствия пациентов. Однако, несмотря на отсутствие доказательств, свидетельствующих о неэффективности методов биоуправления, необходимы дополнительные исследования, чтобы однозначно рекомендовать их к применению в клинической практике. Материал и методы исследования: по ключевым словам neurofeedback, depression, biofeedback, electroencephalography, electromyogram, respiratory training, relaxation были отобраны в базах данных (MEDLINE/PubMed и в других источниках) научные публикации с 1980 по 2020 г.

For most people regular brushing is a habit, that is forming usually from one to three months and is maintained by motivation, the stimulation of which largely depends on the information environment. Сlinical judgment of efficiency and safety of chemical bleaching were evaluated in real work with group of patients up to 25 years with acquired dental discoloration. The experiment had shown that the use of the gel with 40% hydrogen peroxide is safe and effective (8-10 shades according to VITA scale) system for teeth whitening, without using expensive lamps and additional equipment.

Electromagnetic fields are a factor present in the life of our planet since its birth. We know many natural sources that create electromagnetic energy, such as the solar radiation that reaches us and without which life on Earth could not exist, storms and lightning and electromagnetic radiation from cosmic objects. This is how the Earth's natural electromagnetic background is formed. With the evolution of humanity and the development of science and technology, many artificial sources of EMF accompany the life of modern man. Modern medicine is unthinkable without life-saving devices such as laser systems, magnetic resonance imaging devices, life support systems and physiotherapy devices. Man-made electromagnetic smog created by base stations, WiFi, power lines, transformers, computers and TVs, electrical cables at home and at work, artificial lighting, is the modern challenge to civilization. We are exposed to the influence of different frequency non-ionizing radiations. . EMF is produced by electrically charged objects and contains electric fields (EF) and magnetic fields (MF). They are a combination of a photon and a wave and are described with a wavelength from centimeters to thousands of meters and a frequency in (Hz / s). Electric fields (EF) do not penetrate tissues due to their dielectric properties. Magnetic fields (MF) can interact with matter by affecting ionic current through membranes, or by acting on charged molecules and chemical reactions. EMFs can be potentially dangerous, and the heal th risk depends on the level of exposure. Exposure to electromagnetic fields (EMF) causes a range of neuropsychiatric symptoms such as sleep disorders, depression, anxiety, fatigue, difficulty in concentrating, oxidative damage and premature cell aging, DNA damage, carcinogenic potential and decreased fertility. Intolerance to electromagnetic fields, formulated as electromagnetic hypersensitivity (EHS), is becoming more common. The increasing use of various devices sources of electromagnetic radiation is alarming and presupposes serious work by the scientific community to develop the pathogenesis of electromagnetic hypersensitivity (EHS). Complaints presented by people identified as sensitive to electromagnetic fields (EMF) are similar to those related to idiopathic environmental sensitivity (IEI) and multiple chemical sensitivity (MCS), fibromyalgia, somatosensory disorders such as somatization syndrome (ESS), intolerance to odor and noise. People with declared electromagnetic hypersensitivity have serious personal and social problems from living in environments with EMF exposure. This requires knowledge of the clinical picture and diagnosis of electromagnetic hypersensitivity (ENS). The modern view of electromagnetic hypersensitivity considers the condition as a chronic inflammation caused by oxidative stress and associated with genetic polymorphism of the body's detoxifying systems. [ABSTRACT FROM AUTHOR]

Objective of research: To reveal the efficacy of Allium cepa used for traditional therapy of opisthorchiasis in combination with rabbit viral hemorrhagic disease by estimation of the degree of changes in internal organs. Materials and methods: Experiment was conducted on outbreed male rabbits with viral hemorrhagic disease in combination with opisthorchiasis. As traditional therapy, we used bulbs of white onion (Allium cepa L.). Each animal received daily 40-50 g of chopped onion. Pathologicoanatomic autopsy of dead animals that did not get treatment and animals that got treatment was carried out by the end of the second day after clinical manifestation of first symptoms (providing the macroscopic picture of all internal organs). Results and discussion: Macroscopic examination confirmed the presence of minimal residual changes in internal organs of experimental animals receiving traditional therapy. In opisthorchiasis combined with rabbit viral hemorrhagic disease, the use of onion as a medicine is reasonable due to decrease in structural changes of internal organs, primarily, liver. Basically the suggested traditional therapy is aimed at maintenance and repair of damaged organs of the host.

The purpose of the research - cattle dictyocaulosis studying under the conditions of dairy cattle breeding in Vologda oblast. Materials and methods. In 2006-2015, the main issues of the dictyocaulosis epizootology have been studied, and measures for effective therapy and prevention have been developed. Results and discussion. Infestation with dictyocaulus in different climatic and geographical zones of the oblast is dissimilar. The greatest infestation was noted in the northwest zone, and the lowest in the southwest one. A parasitizing of Dictyocaulus viviparus was found out. Infestation of animals occurs in the summer grazing season. Prevalence reaches maximum in September (82.4%) under the infection intensity, on average, 150.7 ± 8.8 units per animal. Dictyocaulus larvae were first found in feces in the second decade of June. The most infected are animals 1-2 years old. Preparations helmicide and fesol are the most effective for dehelminthization against dictyocaulus. Given the foregoing, measures for the therapy and prevention of cattle dictyocaulosis in the non-Chernozem zone of the Russian Federation have been developed.

The purpose of the research is to analyze situation with control measures against animals with ectoparasitoses by the means of bringing environmentally safe and easy to use medicinal products to animal industry. Materials and methods. Literature has been studied and situation on extension of the major parasitic arthopods in animals have been analyzed in the Republic of Belarus. Evaluation of results of administration of Stomozan, Ektocin-5, Ratoks, Pharmacidol-600 as well as Rivertin, Univerm, aversectin paste and Pharmacine. Results and discussion. It is necessary to carry out disinfestation of outer walls, summer sheds, fences by the means of Stomozan, Ektocin-5, Ratoks, Pharmacidol-600 in order to eliminate parasitic insects and mites. Animals might be treated by these drugs. During the winter animals are treated by insect-powder, unctures, liniments. At the onset of warm weather animals are treated by liquid acaricides at all times. Drugs from the pyrethroids, macrocyclic lactone, organic sulphur-containing compound groups are administered more frequent. But summer spraying do not guarantee 100 % impact against gadfly diseases. For horse treatment Rivertin can be used in the dose of 0.1 mg per kg of animal body weight per os with food dualfold in 24 hours; Univerm can be used in the dose of 0.1 mg per kg per os with food dualfold in 24 hours; 2% Aversectin paste can be used in the dose of 1 g per 100 kg of body weight per os dualfold every other day. Pharmacine in the single dose of 0.4 ml (2 injections of 0.2 ml) intradermally in the neck is recommended to use for treatment of hypodermatosis. Intradermal administration of Pharmacine is effective during the period from September, 15 to March (as far as swellings are appeared under the skin). If larvae formed velum under the skin, the dose should be increased.

Депрессия является одним из наиболее распространенных сопутствующих синдромов при шизофрении,ассоциированным с ухудшением каче ства жизни,утяжелением течения заболевания и повышенным уровнем смертности.Выявление и лечение даннои патологии связано с рядом трудностеи,в частности необходимы дифференциальная диагностика и подбор как лекарственных,так и нефармакогенных методов терапии.В даннои статье выполнен краткии обзор актуальных данных литературы(систематические обзоры,метаанализы)и приведены клинические рекомендации международных экспертных групп(в частности,Всемирнои федерации обществ биологическои психиатрии WFSBP)с указа нием степени доказательности и уровня рекомендации для различных диагностических и терапевтических опции.Предложена графическая схема алгоритма диагностики и терапии депрессии при шизофрении с ее описанием.

Tulathromycin is a semi-synthetic antimicrobial substance from the group of macrolides. It differs in that it has a longer period of action due to three amino groups. That’s why it is classified in the subgroup “triamylides”. The product has high activity against Gram-negative and Grampositive pathogens and suitable pharmacological characteristics for high and tissue-retaining levels in domestic animals. In addition, have not been reported resistant strains, with the exception of a few of P. multocida and M. haemolitica. The product is intended for cattle, pigs and sheep. Tulathromycin has been evaluated as a bacteriostatic in therapeutic concentrations, but may also be a slow bacteriocide against streptococci. The review presents the results of its tests in swine and pigs affected by various bacterial diseases, the doses used and the therapeutic efficacy. It is considered to be highly effective against diseases caused by A. pleuropneumoniae, B. bronhiseptica, P. multocida, H. parasuis and M. hyopneumoniae, alone or in various combinations between them, in a therapeutic mode with a single intramuscular administration of a low-volume dose of 2.5 mg/kg b.w. [ABSTRACT FROM AUTHOR]

The risk of deep vein thrombosis and pulmonary embolism is more than 5 times higher in pregnant women. The incidence of venous thromboembolism (VTE) according to various studies is about 0.5-2 per 1000, with pulmonary embolism (PE) being one of the leading causes of maternal mortality. Аim: Тo specify the leading risk factors for VTE in pregnant women and the latest recommendations for prevention and treatment based on the shared scientific experience. Materials and Methods: We conducted a literature review of published studies on the prevention and therapy of VTE in pregnancy, highlighting recent updates of guideline recommendations. Results: The standards for prevention and treatment of VTE in developed countries are set by the recommendations of the American College of Chest Physicians, American College of Obstetricians and Gynecologists, American Society of Hematology, and Royal Society of Obstetricians and Gynecologists. Despite the numerous studies in recent decades, the results related to the assessment of the statistics found a low quality of reliability of the obtained results regarding risk factors, prevention and therapy of VTE in pregnancy. Conclusion: We have access to the most current recommendations for the prevention and treatment of VTE during pregnancy. We need the introduction of an unified multidisciplinary strategy and medical database as a source of quality, accessible statistics for more credibility in VTE risk assessment and treatment. [ABSTRACT FROM AUTHOR]

Homocystinuria is a rare inherited metabolic disorder of methionine metabolism leading to increased plasma, urine and tissue accumulation of homocysteine. Increased homocysteine causes various complications, especially vascular. We report a 17-year-old boy with homocystinuria, presenting with marfanoid habitus, neurological complications and anxiety. The patient is treated with a low methionine diet, methionine free L-AA mixture, pyridoxine, folat and vitamin B12 supplementation, betaine anhydrous and rehabilitation. Significant improvement has been occurred with the use of betaine anhydrous. [ABSTRACT FROM AUTHOR]

Purpose. To compare hypotensive efficiency and safety of fixed combinations of drugs treating primary open-angle glaucoma (POAG). Material and methods. We conducted a randomized prospective clinical trial which involved 80 patients (158 eyes) divided into 4 groups) and lasted six months. The patients received timolol 0.5 % + travoprost 0.004 % (group1), timolol 0.5 % + brimonidine 0.2 % (group 2), timolol 0.5 %+brinzolamide 1 % (group 3) and timolol 0.5 % + pilocarpin 2 % (group 4). Results. All fixed drug combinations compared were found to produce a hypotensive effect in the treatment of POAG patients. Over 6 months, IOP dropped by 20.6 % to 33.1 % against the initial level. The best and the longest-lasting effect was achieved when the first combination, timolol+travoprost (jointly called duotrav), was used. Conclusion. The Duotrav combination should be prescribed for long-term treatment of POAG and ocular hypertension. Timolol + brimonidine and timolol + brinzolamide are the most effective in short-term therapy of POAG and ocular hypertension, as well as in the pre-operative period prior to surgeries of glaucoma with high IOP. After normal IOP values have been obtained, the patient should be prescribed Duotrav, which is a more stable combination. Travoprost 0.004 %/timolol with 0.5 % is more effective, stabile and safe combination and recommend for long-term therapy of. Even though the combination of timolol and pilocarpin is not generally recommended for POAG therapy, it can be used for short-term inexpensive POAG and ocular hypertension treatment // Russian Ophthalmological Journal, 2016; 4: 5-10. doi: 10.21516/2072-0076-2016-9-4-5-10.

Purpose: to estimate the change of uveitis activity using Behcet’s disease ocular attack score 24 (BOS24) during anti-inflammatory and immunosuppressive therapy of Behcet's disease (BD) patients. Material and methods. 144 out of 205 patients (70.2 %) with confirmed BD diagnosis (according to the criteria set out in ISGBD, 1990) had ocular lesions, 83 of 144 (57.6 %) had acute uveitis, 145 eyes displayed active inflammation. Uveitis activity was estimated in dynamics using BOS24 score, which consisted of 6 parameters with the maximum level of 24 points. Results. The initial average BOS24 score for 145 eyes with active uveitis was 7.38 ± 0.71 points. The most pronounced inflammatory changes were revealed in posterior pole areas - mostly in retina periphery, less frequently in the area of fovea and the optic disc. All patients with uveitis exacerbation received systemic therapy including glucocorticoids, cyclosporine and/or azathioprine. After 9.43 ± 2.47 months of therapy, the average BOS24 score dropped significantly (р < 0.001) to 1.86 ± 0.48. The most notable positive changes were revealed in the anterior chamber (р < 0.001), the vitreous (р = 0.002) and in retinal periphery (р < 0.001). Conclusion. BOS24 is a reliable tool allowing a quantitative assessment of uveitis activity in BD patients and its change after anti-inflammatory and immunosuppressive therapy. For citations: Neroev V.V., Davydova G.A., Katargina L.A., Lisitsyna T.A., Khatagova Z.R., Alekberova Z.S. Evaluation of uveitis activity in Behcet's disease patients using BOS24. Russian ophthalmological journal. 2017; 10 (4): 30-7. doi: 10.21516/2072-0076-2017-10-4-30-37 (In Russian).

В половом акте женщины играют роль такие аспекты, как ее внутреннее сексуальное состояние, внешний сексуальный образ, а также такие составляющие факторы, как семья, общество, культура и окружающая среда. Определенное значение в этом принадлежит опыту сексуальных отношений, имевшиеся партнеры, психическое состояние, заболевания, гормональный статус, психогенные и органические причины нарушений сексуального влечения, возбуждения, оргазма и половых болевых нарушений, вызывающих у человека стресс. Нет оснований считать, что большинство женщин увязывают удовлетворение половым актом с количеством достигнутых оргазмов или даже с вероятностью достижения оргазма при данном половом акте. В настоящее время разрабатываются 6 основных путей медикаментозного лечения нарушений сексуальных функций и/или симптомов менопаузы у женщин.

Высокий процент выявления хронических заболеваний вен в современном мире заставляет профессиональное сообщество совершенствовать подходы к их лечению и профилактике. Определение диагностических, лечебных и профилактических мероприятий подробно описывают в клинических рекомендациях, способствующих выбору оптимальной тактики при ведении пациентов. Основная задача экспертов при подготовке клинических рекомендаций - утвердить необходимые методы лечения, включая хирургические и фармакотерапию, опираясь на доказательную клиническую практику, эффективность и высокий профиль безопасности. Динамика развития фармакотерапии и положительные результаты клинических исследований позволяют включать в российские клинические рекомендации новые препараты, отвечающие международным требованиям. Более подробно о новой редакции клинических рекомендаций по лечению ХВН, выход которых ожидается в 2018 году, мы попросили рассказать члена Российского общества ангиологов и сосудистых хирургов, д.м.н., профессора Вадима Юрьевича Богачёва.

Copyright of International Journal of Endocrinology / Mìžnarodnij Endokrinologìčnij Žurnal is the property of Zaslavsky O.Yu and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of International Journal of Endocrinology / Mìžnarodnij Endokrinologìčnij Žurnal is the property of Zaslavsky O.Yu and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Доказова медицина відіграє провідну роль у сучасній клі- нічній практиці. Найвідомішими шкалами оцінювання якос- ті доказів і рекомендацій на їхній основі є ОCEBM (Oxford Centre for Evidence-based Medicine), GRADE (Gradingof Recommendations Assessment, Development and Evaluation),NICE (National Institute for Health and Care excellence). Мета: ознайомити читачів із сучасними клінічними реко- мендаціями щодо консервативного лікування остеоартрозу (ОА), розробленими на підставі принципів доказової меди- цини. Для їхнього створення найчастіше використовують шкалу GRADE. Серед рекомендацій найбільший автори- тет мають спільноти: ACR (Американський коледж рев- матологів), EULAR (Європейська антиревматична ліга), OARSI (Міжнародне товариство дослідників остеоартри- ту), AAOS (Американська академія хірургів-ортопедів), ESCEO (Європейське товариство з клінічних і економічних аспектів остеопорозу, остеоартриту і кістково-м'язових захворювань). Відмінності між рекомендаціями пов'язані, зокрема, із використанням різних шкал оцінювання рівнів доказовості та сили рекомендацій і стосуються засто- сування SYSADOA (симптоматичних повільнодіючих пре- паратів для лікування ОА), внутрішньосуглобових ін'єкцій різних засобів (кортикостероїдів, PRP, гіалуронової кисло- ти тощо) і т. п. В статті наводяться строго та умовно ре- комендовані методи консервативного лікування остеоартроза кисті, колінного та кульшового суглобів. Висновки: сучас- ні клінічні рекомендації створюються на основі об'єктивних шкал оцінювання доказів і рекомендацій, відповідно, ймо- вірність систематичних помилок знижена. Тому, призна- чаючи згідно з ними пацієнту з ОА методики лікування, ми впевнені, що вибираємо найбільш ефективні серед усіх наяв- них підходів. [ABSTRACT FROM AUTHOR]

This systematic review presents the data on using the Safocid complex drug for the treatment of a combination or unknown pathology of the urogenital tract as well as for the prevention of pre- and post-surgical complications in case of urologic and gynecologic interventions. According to the review of 39 articles, the authors of most of the publications assess the drug efficacy as high while the amount of adverse effects is minimum.

The article presents the clinical observation effectiveness of TNF-a inhibitor etanercept in patients with generalized pustular psoriasis and PsA, resistant to treatment by other drugs of this class. It presents the current recommendations for the management of patients with pustular psoriasis.

Recessive dystrophic epidermolysis bullosa (RDEB) is a severe inherited disease developing due to genetic abnormalities in the synthesis of Type VII collagen by fibroblasts. A low production rate of Type VII collagen and abnormalities related to the formation of anchoring fibrils weaken the epidermis and derma adhesion strength, which results in the formation of blisters or erosions in case of any mechanical injury. Fibroblasts and keratinocytes belong to the key sources of Type VII collagen in the skin. Application of allogeneic fibroblasts is a promising cell technique for treating RDEB patients. The therapeutic effect of fibroblasts intradermal administration is stipulated by high stability of newly synthesized Type VII collagen and its ability to form anchoring fibrils in the area of the dermoepidermal junction. According to experimental and clinical studies, it is possible to boost the content of Type VII collagen in the dermoepidermal junction area and heal long-term skin defects in RDEB patients by means of intradermal administration of allogeneic fibroblasts.

The article presents data on clinical forms of warts associated with different types of human papillomavirus. The authors analyze the following wart treatment methods: excision, chemical and immune. Based on literature sources, the authors assess the efficacy, advantages and disadvantages of well-known treatment methods. The authors describe their own experience of treating primary and recurrent vulgar and plantar warts with an up-to-date chemical destruction drug - Mardil Zinc Max, a solution containing a complex compound of 1.5% zinc 2-chloropropionate in 2-chloropropionic acid. The efficacy of treatment of vulgar warts was 100%, and that of plantar ones - 62.5%. Clinical recovery was observed both in case of primary and recurrent processes. The treatment had no adverse effects or complications and was characterized by a low injury rate, good tolerance and full tissue recovery without any cosmetic defects.

Modern data of the acne pathogenesis, including the role of Propionibacterium acnes in the early stages of the acne formation and their provocative role in the development of the inflammatory process are presented. Priority importance of topical retinoids and combination products containing fixed combinations adapalene with benzoyl peroxide or antibiotic clindamycin in the acne treatment are shown. There are presented the facts of the effectiveness of Clenzit gel (adapalene 0.1%) and Clenzit-C (adapalene 0.1% and clindamycin phosphate 1.0%) and an algorithm for the choice of drug depending on clinical and morphological features of the skin process that allows to optimize the treatment of patients with various forms of acne.

Goal. The authors conducted a comparative assessment of the efficacy and safety of 2% silver sulfathiazole in a prospective parallel-group observational study of patients with microbial eczema at the exacerbation stage. Materials and methods. The efficacy of the therapy was assessed on Day 7 and Day 14 based on dynamic calculations of the EASI index and ultrasonic assessment of the intensity of pathological processes in the epidermis and derma; the life quality was assessed based on DLQI and EQ-5D indices, respectively. The microbial composition in the lesions was assessed based on bacterioscopy tests of the contents of blains and erosion fluids. The safety of the therapy was assessed based on the frequency of adverse effects. Results. The administration of 2% silver sulfathiazole arrested both eczematous and pyogenic processes in the lesions within a short period of time, which was confirmed by ultrasonic tests: the depth and density of epidermis and derma were normalized. When applications were performed twice a day, the efficacy with regard to gram-positive bacteria was higher as compared to “classical” topical antibiotics. An evident therapeutic effect with regard to gram-positive bacteria and absence of adverse effects substantially improved the life quality of patients suffering from microbial eczema.

The study involved 80 adult psoriatic patients with scalp affections at the dermatosis progressing stage. The authors compared scalp psoriasis topical treatment options such as using 0.05% clobetasol propionate in the form of a shampoo, and successive administration of the 2% salicylic acid ointment and aforesaid short-term topical product in patients with vulgar or exudative dermatoses using dynamic scores such as mPASI, DLQI and itching intensity degree. It was demonstrated that 0.05% clobetasol propionate used in the form of a shampoo is characterized by a high efficacy and safety profile for patients with vulgar or exudative psoriasis of the scalp. At the same time, in case of exudative dermatosis successive topical treatment with the use of the 2% salicylic acid ointment and 0.05% clobetasol propionate in the form of a shampoo contributes to the clearance of psoriatic foci from accumulated scales and enables a potent topical corticosteroid such as clobetasol to efficiently reduce principal clinical symptoms of scalp psoriasis such as erythema, infiltration, exfoliation and itching. Using the clobetasol shampoo reduces the scalp itching intensity as the key psoriatic symptom preventing an isomorphic reaction as a result of foci traumatization related to scratching.

Goal. To assess the effect of a combined cytostatic therapy and sulodexide on the functional condition of the vascular endothelium in psoriatic patients. Materials and methods. The authors examined 74 patients suffering from psoriasis vulgaris and exudative form of psoriasis. Depending on the treatment option, the patients were subdivided into two groups: Group I (n = 41) receiving a cytostatic therapy and Group II where patients received sulodexide as well. The severity of the endothelium dysfunction was assessed based on laboratory assessments such as nitrogen oxide and endothelin 1 in the blood serum. Results. Prior to the treatment, the level of nitrogen oxide was reduced and endothelin 1 was increased in the blood serum of most patients. Substantial improvement of the pathological process was observed in patients from Group I after the cytostatic therapy (total dose of methotrexate: 100 mg); no normalization of laboratory assessments was observed. In patients from Group II receiving methotrexate (total dose: 40 mg) along with sulodexide, improvement or recovery was observed after the completion of the treatment; endothelium dysfunction was normalized. Conclusion. The inclusion of sulodexide in a complex therapy normalizes endothelial dysfunction in case of psoriasis and reduces the dose and duration of methotrexate treatment.

The article discusses current approaches to management of adult patients suffering from the gonococcal infection according to federal (national) clinical recommendations of the Russian Society of Dermatovenerologists and Cosmetologists (2013), European Guideline on the Diagnoses and Treatment of Gonorrhoeae in Adults (2012) and Sexually Transmitted Diseases Treatment Guidelines (CDC, 2010). The article describes indications for gonococcal infection examinations and diagnostics methods presented in Russian and foreign recommendations. The article describes the treatment regimen based on N. gonorrhoeae antibacterial resistance monitoring results.

Настоящая статья посвящена проблеме диагностики и дифференцированной терапии депрессий в рамках различных нозологических категорий. Обсуждаются сложности диагностики и систематики депрессивных состояний, предлагается алгоритм обследования больного с депрессией. Показаны различия в терапевтических подходах к депрессии при рекуррентном депрессивном расстройстве, биполярном расстройстве и ши зофрении.

Copyright of Nanosistemi, Nanomateriali, Nanotehnologii is the property of G.V. Kurdyumov Institute for Metal Physics, N.A.S.U and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Rotavirus infections predominantly affect children up to 5 years of age. The article presents a brief review of the scientific literature. Epidemiology, clinical presentation, therapy and vaccine prophylaxis of rotavirus gastroenteritis have been presented. The increasing knowledge of rotavirus infections is an important step in their management [ABSTRACT FROM AUTHOR]

The skill to communicate is extremely important in every moment of human life. The interpersonal communication is a complex process that first takes place within the individual when he or she wishes to share his or her ideas with someone. The profession of the medical specialists is associated with intense communication activity and empathy. In the medical practice of the rehabilitation therapist, empathy requires an intellectual understanding of the patient, sharing his feelings, effective communication, and a positive attitude towards the patient. Mastering and applying the tools of communication in the medical practice have a favorable effect on the patient's behavior and support the patient. The effectiveness of communication depends on the extent to which the relationship between the rehabilitation therapist and the patient is built on the principles of collaboration, mutual respect and trust, empathy and responsibility. Empathic professional behavior extends the patient's understanding beyond the history and symptoms of his or her illness and is a prerequisite for achieving an effective therapeutic outcome. Communication is the activity of people for the purpose of developing psychological contact, characterized by the exchange of information, mutual understanding and empathy. Good communication is part of the role of the healthcare professional. When dealing with suffering people, it is important to support both the patient and his or her environment, and to overcome the health problem and its consequences more easily. The purpose of this study is to analyze the psychological aspects of communication and empathy in the work of the medical specialist - rehabilitation therapist. Conclusion: As a profession with a strong social element, it cannot be practiced without having theoretical knowledge and practical communication skills. Sick people are always looking for contacts with professionals, expecting human communication, understanding, sympathy, empathy and support. The effective communication and interaction are the main factors for achieving good therapeutic results. [ABSTRACT FROM AUTHOR]

Copyright of Likarska Sprava is the property of J. Likarska Sprava and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Zdorov'ye Rebenka is the property of Zaslavsky O.Yu and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Glial tumors are the most common form of primary brain tumors that can grow into a malignant glioblastoma multiforme (GBM) during growth. In recent years, molecular mechanisms that promote oncogenesis have become increasingly apparent, but much remains to be learned. MicroRNAs (miRNAs) are short non-coding RNAs with 18-22 nucleotides in length which function as key regulators of various biological processes through negative control over gene expression at the post-transcriptional level. New evidence suggests that miRNAs play an important role in the development of human tumors. In recent years, significant progress has been made in research on the role of miRNA in the oncogenesis of brain tumors, especially in gliomas and its malignant forms. MicroRNAs regulate a wide range of tumor processes including cell proliferation, differentiation, angiogenesis, invasion and apoptosis. Profiling miRNA expression in various human pathological conditions is a rapidly growing field, and it is likely that the knowledge gained from these studies regarding the genesis of gliomas will have the potential in the field of minimally invasive therapy with miRNA to improve the prognosis of patients with this pathology. [ABSTRACT FROM AUTHOR]

Copyright of Mezdunarodnyj Nevrologiceskij Zurnal is the property of Zaslavsky O.Yu and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Mezdunarodnyj Nevrologiceskij Zurnal is the property of Zaslavsky O.Yu and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Sensory integration (SI) is a complex process, the theory of which is based on a number of studies in the field of neuroscience. The greatest contribution to the development of this theory has Dr. A. Jean Ayres, who began her research on the subject back in 1950. SI can be defined as an effective interaction between man and the everchanging environment that is based on the successful interpretation of sensory impressions. These impressions come into the nervous system in the form of information from sensory systems (visual, auditory, olfactory, taste, tactile, proprioceptive, vestibular and interoceptive). There the information is processed and arranged, and as a result the nervous system is ready to answer. This response is called an adaptive response and helps the individual to succeed successfully in terms of his/hers inner sensation, movement, emotions and behavior. When the SI process is disturbed at one of its stages, making an adaptive response is difficult. This condition is called sensory integrative dysfunction (SID) or also sensory processing disorder (SPD). Clinically sensory integrative dysfunctions may be related to manifestations of delayed psycho-motor development in the child, emotional imbalance, behavioral problems and difficulties in learning, communication and social skills. Signs of SID are most common in the following conditions: high-risk infants; autistic spectrum disorders; attention-deficit/hyperactivity disorder (ADHD); fragile X syndrome; children with learning disabilities; brain damage; some genetic syndromes and others. The aim of the present study is to highlight the importance of building a good SI in every child and the need to carry out prevention and early intervention at the first signs of SID. The tasks of the study are: 1) to track the main stages of SI development during the first seven years of child's life; 2) to differentiate the main types of difficulty with regard to sensory processing; 3) describe the main symptoms of SID typical of the relevant age groups; 4) to offer some validated methods and tests for assessment of the condition; 5) give guidance on the therapeutic approach. This study is aimed at parents, teachers, medical and non-medical specialists working within or outside the nosological unit. It aims not only to help them recognize and understand the signs of SID, but also to guide them: how to support the specific needs of children through their personal and professional competencies and when it is necessary to redirect them to a specialized sensory integrative therapy (SIT). There is a number of scientific evidence that therapeutic interventions at the age of three years in children with different development deficits are more successful. Understanding children with SID, timely and accurate assessment, and appropriate therapy, would help improve their condition and prevent future complications. [ABSTRACT FROM AUTHOR]

Copyright of International Journal of Endocrinology / Mìžnarodnij Endokrinologìčnij Žurnal is the property of Zaslavsky O.Yu and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Respiratory mycoplasmosis is a group of infectious and inflammatory diseases of the respiratory system caused by pathogenic microorganisms - Mycoplasma species. It was found that the major causative agent is Mycoplasma pneumoniae (M. pneumoniae). The role of other mycoplasma pathogens in the development of respiratory infections still remains a subject of debate. Hence, the term "respiratory mycoplasmosis" is generally associated with M-pneumoniae infection [5, 7, 15, 22].

In 2008, the European Society of Pediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) in conjunction with the European Society for Paediatric Infectious Diseases (ESPID) published guidelines for the management of acute gastroenteritis in children [1] (Slide 5). When the new evidence-based data emerged in 2014, the document was updated. [2]