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Violation of lipid metabolism with the formation of atherogenic factors and subsequent endothelial dysfunction is one of the concepts explaining the pathogenesis of preeclampsia. Polymorphism of ApoE, CETP, and LPL genes can influence the course of pregnancy, provoking maternal dyslipidemia. The aim of the study – to study the clinical and anemnestic features of patients with preeclampsia and women with a high risk of preeclampsia; to compare the data of biochemical tests of the data of both groups of patients, as well as to determine the role of polymorphism of lipid metabolism genes as risk factors for preeclampsia. Materials and methods. A prospective cohort comparative study of 60 patients was conducted, of which the main group consisted of 30 women with moderate and severe preeclampsia and 30 patients with a high risk of developing preeclampsia according to prenatal screening of the first trimester, who made up the comparison group. In the course of the study, anamnestic factors, features of lipid metabolism and the results of genetic studies were analyzed. Conclusion. The conducted studies showed a significant difference in the features of the obstetric and gynecological anamnesis of both groups of patients, lipidogram indicators, as well as in the distribution of alleles and genotypes in the group of women with realized preeclampsia by polymorphic markers ApoE 388 T>C and CETP 1264 G>A. There was no difference in the distribution of alleles and genotypes of the LPL 447 C>G gene.

The aim of this work was to study the levels of podocalyxin and β-2-microglobulin and parameters of lipid metabolism and carbonyl stress in type 1 diabetes mellitus (T1DM) patients with different levels of albuminuria.Materials and methods. 56 men of reproductive age with T1DM were divided into two groups: 24 patients with stage A1 albuminuria (group A1) and 32 patients with stage A2 albuminuria (group A2). The control group consisted of 28 healthy men. The levels of renal function markers, lipid metabolism parameters, and methylglyoxal were assessed using enzyme immunoassay and spectrophotometric and fluorometric methods.Results. Higher values for total cholesterol, triacylglycerol, and very-low-density lipoprotein medians in both groups A1 and A2 were found. In these groups, increased podocalyxin and methylglyoxal medians were revealed. Correlation analysis in the group A1 showed the presence of a relationship between the glomerular filtration rate (GFR) and creatinine. In the group A2, correlations between the generally accepted parameters of kidney injury (the albumin / creatinine ratio and GFR) and the duration of the disease and between GFR and the creatinine and methylglyoxal levels in the blood were identified. The podocalyxin level in this group correlated with the β2- microglobulin and methylglyoxal levels and lipid metabolism parameters. The level of β2-microglobulin correlated with the lipid metabolism parameters.Conclusion. Regardless of the level of albuminuria, men with T1DM had significantly increased levels of podocalyxin, lipid metabolism parameters, and methylglyoxal, as well as strong relationships between these parameters. The data of this study can be used for development of potential strategies for prevention and early treatment of diabetic nephropathy.

Увеличение числа людей с избыточной массой тела и ожирением, наблюдаемое в последние десятилетия, явилось причиной углубленных исследований патогенеза этого состояния. Установлено, что ожирение сопровождается формированием воспалительного процесса слабой интенсивности в результате увеличения синтеза ряда провоспалительных медиаторов. Экспериментальные данные показали, что при этом некоторые из этих медиаторов способны оказывать мощное иммуномодулирующее действие, приводящее к развитию аутоиммунной патологии. В данной статье освещается роль ключевых участников липидного обмена в формировании иммунных реакций.

Introduction. In focal brain lesions, perifocal edema is a mandatory component that affects the severity of the clinical picture in most cases. Peripheral edema increases intracranial pressure and reduces perfusion pressure, contributing to the development of generalized edema and dislocation of the brain. The purpose of the article is to study the peculiarity of the pathogenesis of the peripheral edema zone in brain astrocytomas according to magnetic resonance imaging, morphological, morphometric, biochemical and histological studies. Material and methods. The study includes 430 patients operated on for brain astrocytoma. Intraoperative examination of tissue structures of peripheral edema zone and cerebral cortex vessel microcirculation over healthy and affected zones was carried out. The peripheral edema zone of the tumor was fixed in 10% formalin solution, Buena fixator. Sections are prepared and painted by standard methods. The water content of the tissues was determined by drying. Results. The highest frequency was in the anaplastic astrocyte Grade III. A high specific gravity in localization was in the astrocytomas of the temporal lobe (32.3%), parietal lobe (27.0%). The study gives a morphological assessment of the zones of perifocal edema and presents a separation of the degree of severity of the zone of perifocal edema in astrocytomas in scores. The study showed pronounced morphological changes in the waterelectrolyte composition of brain cells and intercellular space, vessels, nerve fibers in the peripheral edema zone in astrocytomas, especially in the anaplastic astrocytome Grade III. Conclusion. These studies make it possible to prevent complications, conduct adequate dehydration therapy in the pre- and postoperative periods, as well as properly plan the course of the operation. [ABSTRACT FROM AUTHOR]

Mussels Mytilus edulis L. living on the littoral are traditional objects for monitoring the state of coastal ecosystems. In the process of ecological and biochemical studies of some littoral settlements of these mussels in the Kandalaksha Nature Reserve, some modifications have been identified in the structure of local populations, and biochemical markers have also been searched at the level of lipid composition reflecting the chronic action of environmental factors. Investigations of the size and age structure of some intertidal settlements of the Mytilus edulis L. have shown inter-annual dynamics reflecting the natural processes associated with the regime of replenishment by juveniles and the elimination of generations. The revealed significant differences in the density and biomass of Mytilus edulis L. settlements probably reflect the influence of anthropogenic load on their livelihoods (first of all, prolonged discharge of fresh water from the hydroelectric station system). The composition of lipids and fatty acids in the gills of littoral mussels has been determined using thin-layer, gas-liquid and high-performance liquid chromatography methods. Evaluation of the lipid status of mussel gills inhabiting biotopes with different hydrodynamic regimes and anthropogenic load (the pollution level, fresh water discharge) has shown inter-annual dynamics in the content of lipids and their fatty acids. At the same time, there are significant differences in the content of membrane and storage lipids in the mussel gills exposed to fresh water on the littoral zone of Biotope 1. Prolonged ecological and biochemical monitoring studies of coastal mussel settlements reveal the characteristic features of their size and age structure, density and biomass, as well as the lipid status of the gills of mollusks formed under conditions of long-term environmental factors

Aim of investigation. To study lipid composition of blood and bile at diabetes mellitus (DM) of the 1st and 2nd type. Material and methods. Overall 70 patients with the first type DM, 67 patients with the second type DM, 44 patients of the control group #1 and 43 patients of the control group #2 were investigated. All patients underwent diagnostics for the presence of DM and cholelithiasis, blood lipid levels and blood­to­duodenal bile ratio was assessed by biochemical methods. Results. Patients with type II DM and cholelithiasis had total cholesterol level in blood serum 25% higher, triglyceride level - 80% higher and Thomas­Hofmann index in duodenal bile portion B 20% higher, than patients was gallstone disease and type I DM. Conclusions. Type II DM is followed by more pronounced lipidemia and increase in bile cholesterol saturation, type I DM, but the latter is also associated with lipid metabolism disorders and the risk of gallstone disease development.

The aim of the work is to study the state of health and peculiarities of metabolic reactions in adolescents, representatives of the small Siberian ethnos - tofalars and caucasians.Materials and methods. Clinico-biochemical examination of children and adolescents, representatives of a small ethnic group – Тofalars and Caucasians, permanently residing in the territory of Tofalaria in the Irkutsk region. The metabolic status of adolescents was assessed using spectrophotometric (total cholesterol, diene conjugates), fluorometric (superoxide dismutase activity, α-tocopherol and retinol levels), immunoenzymes (determination of thyroid-stimulating hormone concentrations, free fractions of triiodothyronine and thyroxine, cortisol).Results. An increased incidence of diseases of the musculoskeletal system and connective tissue, as well as diseases of the endocrine system and eating disorders – among Тofalars; diseases of the genitourinary system – among Сaucasians. For practically healthy Тofalar teenagers, in contrast to Сaucasians of the newcomer population, adaptive metabolism reactions are characteristic, which is expressed by a reduced level of total cholesterol and increased values of antioxidant factors (the level of fat-soluble vitamins – α-tocopherol and retinol), and adaptive changes in the system of neuroendocrine regulation.Сonclusion. An assessment of the health status of children and adolescents in Tofalaria has shown the need for more intensive monitoring of the incidence rate in the specified region, with the obligatory consideration of the ethnic factor for the development of regional ethno-specific preventive measures.

Toxic erythema of newborns is referred to borderline states and is considered as the first manifestation of allergy. The formation of a complete epidermal skin barrier depends on the lipid and vitamin composition of the surface hydrolyzed film (SHLF) of the skin. The purpose of the study – to study the peculiarities of the lipid and fat-solvable vitamins content in the SHLF of the skin of newborns and infants with toxic erythema in the anamnesis. Materials and methods. There was carried out a complex clinical and laboratory study of 46 healthy children and 34 children with elements of toxic erythema on the body and extremities. Biochemical analysis of the superficial lipid skin film was carried out on the 1st and 6th days of life, as well as at the end of 1, 6, 9 and 12 months. Results and conclusions. When comparing the parameters of SHLF skin of children with manifestations of toxic erythema with those in healthy children, significant differences were found on the first day of life. Changes in the lipid and vitamin spectrum of SHLF in children with manifestations of toxic erythema observed in the early neonatal period were expressed in a high level of triacylglycerols, fat acids, phospholipids and β-carotene and a low percentage of cholesterol, α-palmitate and α-tocopherol. By the end of the first year of life, the composition of the SHLF of the skin of children with manifestations of toxic erythema in the anamnesis practically did not differ from the one in the group of healthy children.

Lipid fatty acids composition for muscle tissue of pacific saury is determined in dependence on the fish body size. The percentage is 40.97 % of monounsaturated fatty acids and 34.20 % of polyunsaturated fatty acids for small-sized fish and 43.87 % and 31.09 %, respectively, for large-sized fish. The summary content of EPA and DHA is 2.30 g per 100 g of muscle tissue for small-sized fish and 3.77 g/100 g for large-sized fish. Decreasing of the omega-3 fatty acids content in the process of the canned food sterilization does not exceed 5.2 % of the initial amount. The saury of various size could be processed to the canned goods of pate type that excludes the fat losses in the process of broth and fat separation under high temperature. The portion of omega-3 polyunsaturated fatty acids in the canned food from saury is 42.1-46.7%, with average content of EPA and DHA 1.73-2.71 g per 100 g that corresponds to daily requirements of human organism.

The brief review presents the main provisions of the molecular-genetic theory of carcinogenesis. The data on the presence of overcelled mechanisms regulating of tissue homeostasis has done, which can be explained by molecular genetic approach. The data of the interpretation of the theory of the oncogene based on different pathogenetic concepts is considered and it allows you to continue the development of tissue theory of carcinogenesis. The current understanding of the structural and functional characteristics of the microvasculature is described. Compelling author’s data on the effect of oxygen therapy is provided (normobaric and hyperbaric oxygen therapy), and the modulation of antioxidant activity of plasma by controlled differentiation of malignant cells with surgery (the change in the retrograde antegrade flow through the vascular reverse ).The significance of microcirculation of tissue homeostasis has determined. The updated position of the ground tissue microcirculatory theory of carcinogenesis has formulated.

High priority in the pathogenesis and treatment of non-alcoholic steatohepatitis (NASH) is given to disorders of lipid-phospholipid fractions, which are directly related to the functioning of hepatocytes. The aim of the study was to evaluate the effect of various complex treatment regimens on lipid-phospholipid fractions in patients with NASH in combination with obesity (OB) and pathology of the biliary tract (BT) according to a 6-month follow-up. 52 patients with NASH in combination with OB and BT pathology were examined. The control group consisted of 20 practically healthy individuals. The effect of complex treatment (preventive and therapeutic measures) on the indicators of lipid-phospholipid fractions in patients with NASH in combination with obesity and pathology of the biliary tract was studied. Changes in the indicators of serum lipid-phospholipid fractions were detected before treatment in all observation groups, which were accompanied by decrease in phospholipids (PL), phosphatidylcholine and sphingomyelin content and a significant increase in PL lysoforms – lysophosphatidylcholine and phosphatidylethanolamine, triglycerides, cholesterol esters (from p<0.05 to p<0.001). Combination therapy with the inclusion in the standard treatment of ursodeoxycholic acid and arginine glutamate in the comorbid course of NASH can be considered as a promising direction in the treatment of this category of patients, this allows to improve indicators of lipid-phospholipid fractions and stabilize the hepatocytes' membrane (from p<0.05 to p<0.001). [ABSTRACT FROM AUTHOR]

Copyright of Gastroenterologia (2308-2097) is the property of Zaslavsky O.Yu and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Levitsky A. P., Tkachuk V. V., Velichko V. I., Vasyuk V. L. Профилактика ожирения и неалкогольного стеатогепатита у крыс антидисбиотическим средством = Prevention and treatment effect of antidysbiotic formulation on obesity and nonalcoholic steatohepatitis in rats. Journal of Education, Health and Sport. 2016;6(4):281-286. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.50200 http://ojs.ukw.edu.pl/index.php/johs/article/view/3471 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 755 (23.12.2015). 755 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Author (s) 2016; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 20.03.2016. Revised 17.04.2016. Accepted: 17.04.2016. УДК 517.112:612.8+615.462 ПРОФИЛАКТИКА ОЖИРЕНИЯ И НЕАЛКОГОЛЬНОГО СТЕАТОГЕПАТИТА У КРЫС АНТИДИСБИОТИЧЕСКИМ СРЕДСТВОМ А. П. Левицкий1, В. В. Ткачук2, В. И. Величко2, В. Л. Васюк3 1ГУ «Институт стоматологии НАМН Украины» (г. Одесса, Украина) e-mail: flavan@mail.ru 2Одесский национальный медицинский университет (Украина) 3Буковинский государственный медицинский университет (г. Черновцы, Украина) Резюме Сочетание высокожирового рациона и кишечного дисбиоза вызывает у крыс развитие ожирения и неалкогольного стеатогепатита (НАСГ). Введение антидисбиотического средства «Квертулин» (кверцетин + инулин + цитрат кальция) предотвращает развитие ожирения и НАСГ. Ключевые слова: ожирение, неалкогольный стеатогепатит, липиды, высокожировое питание, дисбиоз, антидисбиотическое средство. PREVENTION AND TREATMENT EFFECT OF ANTIDYSBIOTIC FORMULATION ON OBESITY AND NONALCOHOLIC STEATOHEPATITIS IN RATS A. P. Levitsky1, V. V. Tkachuk2,V. I. Velichko2, V. L. Vasyuk3 1SE«The Institute of Stomatology of the National academie of medical science of Ukraine» (Odessa, Ukraine) e-mail: flavan@mail.ru 2Odessa National Medical University (Ukraine) 3Bukovina State Medical University (Chernovtsy, Ukraine) Abstract Aim: To determine of prevention and treatment effect of antidysbiotic formulation on obesity and NASH in rats. Methods: The experimental obesity and NASH were induced by feeding rats with a high fat diet (HFD) (fodder, plus 15 % sunflower oil – 40 days) and driaking water with lincomycin at a dose of 60 mg/kg day for 5 days. The duration of experiment was 41 days. One group of rats received HFD and lincomycin, received antidysbiotic formulation Quertulin (quercetine + inuline + Ca-citrate) in dose 300 mg/kg 40 days. Determined morphometric parameters like body mass, body mass index, content of triglyceride (TG) and cholesterine (Ch) of liver and serum cjntent of bilirubine and activity of ALT and in serum, alkaline phosphatase (AP). Results: At obesity and NASH body mass, body mass index, content of TR, Ch, in liver and serum were increased; in serum content to bilirubine and activity to ALT and AP were increased. Taking quertulin normalized morphometric and biochemic indexis in liver and serum. Conclusion: Antidysbiotic formulation quertulin made of prevention and treatment effect on obesity and NASH. Key words: obesity, nonalcoholic steatohepatitis, lipids, high fat nutrition, dysbiosis, antidysbiotic formulation.

Aim. To estimate antihypertensive, organ protective and metabolic efficiency of angiotensin converting enzyme (ACE) inhibitor spirapril in patients with arterial hypertension (AH).Material and methods. 30 patients with AH of I-II grade with different cardiovascular risk were included into the study. Spirapril was prescribed in the dose of 3 mg once daily. If necessary, daily dose could be increased to 6 mg after two weeks, and after next 4 weeks hydrochlorothiazide in daily dose 12,5-25 mg could be added. Treatment lasted 16 weeks. Before and after 16-week treatment ambulatory blood pressure monitoring (ABPM) was carried out. At the same time vasodilatation tests for reactive hyperemia and nitroglycerin were held, microalbuminuria and β2-microglobulinuria levels were defined, figures of lipid and glucose metabolism were studied, questionnaires for quality of life were filled in.Results. 27 patients with AH finished the study according to protocol. Treatment with spirapril within 16 weeks caused normalization of blood pressure in 60% of patients, decreased levels of microalbuminuria (pConclusion. Spirapril is a highly efficient antihypertensive drug with organ protective effect and metabolic neutrality. According to the revealed qualities it can be recommended to patients with AH with high cardiovascular risk.

The lipid and fatty acid spectrum of juvenile atlantic salmon (aged 0+, 1+, 2+, 3+ (smolts)) from the Varzuga River (Porokushka rapid) was studied in the summer period. a high content of polyunsaturated fatty acids with the dominance of docosahexaenoic 22:6(n-3) and eicosapentaenoic 20:5(n-3) fatty acids was revealed. Smolts (3+) had an elevated proportion of physiologically active 22:6(n-3), 20:5(n-3) and 20:4(n-6) fatty acids, which is characteristic of marine fish and is associated with their preparation for smoltification and transition to life in the sea. an increased level of monounsaturated fatty acids with the dominance of 18:1(n-9), 16:1(n-7) and 18:1(n-7) acids was shown for juveniles aged 0+, 1+ and 2+. In smolts, however, the level of these fatty acids was reduced, which positively correlates with changes in TaG storage and is characteristic of salmon smolts. as compared to 1+ and 2+ parr, fingerlings (0+) and smolts (3+) had a low content of storage TaGs and the TaG/PL index, which is most likely due to a high metabolic rate. The early development and completion of the preparation of salmon smolts for transition to the marine environment were facilitated by ‘launching’ the mechanisms of biochemical adaptations, including those involving individual lipids and fatty acids that play an important role in maintaining homeostasis in an organism exposed to changing environmental conditions.

Background. According to the some studies tocilizumab therapy (TCZ) in patients with rheumatoid arthritis (RA) is accompanied by deterioration of blood lipid profile. Aim. To study changes in serum lipid parameters in patients with RA treated with a combination of tocilizumab and methotrexate compared with methotrexate alone for 24 weeks of observation. Material and methods. Patients (n=72) with RA were included into the pilot non-randomized 24-week study and divided in two groups: 1) TCZ+MTX group (n=39; women 30; median age 51 [43-55] years; 6 i.v. infusions of TCZ 8 mg/kg + МТX 10-20 mg/week); 2) MTX group (n=33; women 23; mеdian age 56 [48-63] years; MTX 7.5-20 mg/week). Results. At the baseline, similar proatherogenic blood profile was observed in both groups. The patients of MTX group more frequently took statins (n=19; 57.6%) compared with the group TCZ+MTX (n=7; 18%), (p Conclusions. TCZ+MTX combined therapy as well as MTX monotherapy are associated with similar improvement in lipid parameters. Adjusted statin doses may be needed to achieve target serum lipid profile in RA patients.

Aim. To study the efficacy of rosuvastatin in dyslipidemia correction in patients after Q-wave myocardial infarction (Q-MI).Material and methods. 40 patients (aged 52.7±9.4 years old) were included into the study after 10-14 days of the acute Q-MI onset. Determination of blood lipids profile, alanine and asparagine transaminase levels was included into the initial examination. Rosuvastatin in a fixed dose of 20 mg/day was prescribed to the patients as a part of the standard therapy. Depending on the dynamics of the investigated parameters the individual doses of rosuvastatin were adjusted from 10 to 40 mg/day after 1 month of therapy. Final evaluation of blood lipids profile and transaminase levels was performed in the next 2 months of therapy.Results. Rosuvastatin 20 mg/day for 1 month in patients with an acute Q-MI provides a significant decrease in low-density lipoprotein (LDL) cholesterol level by 21.4%, and achievement of target levels of this parameter in 59.5% of patients. Rosuvastatin dose adjustment was required in 48.6% of patients after 1 month of therapy. Individually adjusted rosuvastatin doses provided the achievement of LDL cholesterol target levels by the end of the third month of treatment in 91% of patients. Elevated liver transaminase levels were observed in 7.5% of patients after 1 month of treatment. There were no new cases of adverse events after 3 months of therapy.Conclusion. Rosuvastatin 10-40 mg/day is effective and safe medicine for the treatment of dyslipidemia in patients after acute Q-MI.

It was revealed that melancholic and phlegmatic had the lowest content of high-density lipoprotein and the highest content atherogenic lipid fractions combined with maximum activity and weight of lipoprotein-associated phospholipase A2 as well as the highest quantity of people with complications of hypertension among the examined patients. The ratio of people with complications in groups of choleric and sanguine with high level of anxiety and phlegmatic and melancholic with high level of anxiety was 1: 2.

Copyright of International Journal of Endocrinology / Mìžnarodnij Endokrinologìčnij Žurnal is the property of Zaslavsky O.Yu and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of International Journal of Endocrinology / Mìžnarodnij Endokrinologìčnij Žurnal is the property of Zaslavsky O.Yu and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Remote radiobiological effects in male rats prenatally exposed by 131I in different periods of gestation were studied. It was established that the negative effects of irradiation of 131I in utero in the distant period are manifested by disorders of the functioning of the pituitary-thyroid link of endocrine regulation, pro-antioxidant equilibrium, changes in the lipid- lipoprotein spectrum of blood serum. As a result of irradiation of 131I in utero throughout the period of gestation, discoordination in the functioning of the pituitary-thyroid link of endocrine regulation, a violation of the pro-antioxidant balance by increasing the intensity of lipoperoxidation processes and the activity reducing of enzymes of antioxidant defense, the atherogenic orientation of changes in the lipid-lipoprotein spectrum was established. As a result of irradiation by 131I in utero during the third trimester of gestation, the development of hypothyroidism, changes in proantioxidant balance due to the activation of antioxidant defense, and the reduction of the concentration of the main classes of lipids have been established. [ABSTRACT FROM AUTHOR]

Levitsky A. P., Makarenko O. A., Khodakov I. V., Lukanin A. S., Lukanina M. A. Гепатопротекторные свойства полифенольных веществ экстракта «Дубовый» = Hepatoprotective properties of polyphenols substances of Oak extract. Journal of Education, Health and Sport. 2016;6(11):537-547. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.192393 http://ojs.ukw.edu.pl/index.php/johs/article/view/4039 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 755 (23.12.2015). 755 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Author (s) 2016; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 02.11.2016. Revised 22.11.2016. Accepted: 30.11.2016. УДК 615.07+615.015+616.98 ГЕПАТОПРОТЕКТОРНЫЕ СВОЙСТВА ПОЛИФЕНОЛЬНЫХ ВЕЩЕСТВ ЭКСТРАКТА «ДУБОВЫЙ» А. П. Левицкий1, О. А. Макаренко1, И. В. Ходаков1, А. С. Луканин2, М. А. Луканина3 1ГУ «Институт стоматологии и челюстно-лицевой хирургии Национальной академии медицинских наук Украины» (г. Одесса) E-mail: flavan@mail.ru 2Лаборатория мониторинга сырьевых ресурсов для виноделия (г. Киев) 3ГП «Государственный центр сертификации и экспертизы сельскохозяйственной продукции Минагрополитики Украины» (г. Киев) Резюме Экстракт «Дубовый» обладает гепатопротекторным действием при токсическом гепатите. Ключевые слова: гепатит, полифенолы дуба, гепатопротектор, ферменты, липиды. HEPATOPROTECTIVE PROPERTIES OF POLYPHENOLS SUBSTANCES OF OAK EXTRACT A. P. Levitsky, O. A. Makarenko, I. V. Khodakov, A. S. Lukanin, M. A. Lukanina 1SE «The Institute of Stomatology and Maxillo-Facial Surgery of the NAMS of Ukraine» (Odessa, Ukraine) flavan@mail.ru 2The Laboratory of monitoring of raw materials for wine-making (Kiev, Ukraine) 3The state of sertification and expertise agriculture products of Ministry of agropolitics (Kiev, Ukraine) Summary Purpose of work: To determine of hepatoprotective properties of oak extract. Materials and methods: The oak extract, wich contained 1,3 % polyphenols, was used. The hepatoprotective properties were determined using rats with hydrazine hepatitis. The oak extract was introduced in dose of 10 ml/kg from the first day of the experiment during 13 days. The liver state was estimated by inflammation indices (elastase, MDA) index of microbe sowing (urease), index of non-specific immunity (lysozyme), index of cholestasis (alkaline phosphotase, AlPh). The liver markers (bilirubine, ALT, AlPh) were determined into serum. The levels of triglycerides and total cholesterine were determined into liver and serum. Results: The oak extract reduced of inflammation indices, the activaties of urease, AlPh into liver and the degree of dysbiosis into liver and serum. The conclusion: The oak extract has hepatoprotective action. Key words: hepatite, polyphenols of oak, hepatoprotectore, enzymes, lipids.

The relationships of risk factors with hypertension in workers of coal enterprises were studied. Based on the identified predictors developed risk prediction scale of this disease in miners.Surveyed 792 employees of the mine “Polosukhinskaya”. Along with a complete clinical, anthropometric and laboratory testing, conducted settlement criterion relative risk of developing hypertension.The most important factors determining the increased risk of disease in workers of coal enterprises were: increased body weight, age, waist circumference, and the index “waist/hip”, elevated levels of total cholesterol, triglycerides, low density lipoprotein cholesterol, atherogenic index. These signs and have the greatest prognostic factors that increase the risk of developing the disease.

In contrast to the empirical anti-hypertensive therapy, the targeted antihypertensive therapy was combined with the earlier (6 months) and more pronounced approach of the lipid content of blood and magnesium to those in healthy individuals of appropriate temperament and anxiety; lower was the proportion of people with the areterial hypertension complications.

Copyright of International Journal of Endocrinology / Mìžnarodnij Endokrinologìčnij Žurnal is the property of Zaslavsky O.Yu and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Eastern-European Journal of Enterprise Technologies is the property of PC TECHNOLOGY CENTER and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Eastern-European Journal of Enterprise Technologies is the property of PC TECHNOLOGY CENTER and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The purpose of work was studying of a role of systemic lipid metabolism disturbances in a pathogenesis of homeostasis disorders in the early posttraumatic period at fractures of pelvic bones in experiment and clinic. Pilot and clinical studies are put in a basis of work with application of the techniques estimating structure phospholipid membranes of erythrocytes, cells of a liver, kidneys, heart, lungs, and also intensity of the processes participating in a regulation of a lipid metabolism. Results. It is established that at a pelvic trauma change of lipids structure arise not only in a blood, but also other tissues structures (a liver, kidneys, lungs, heart) that is caused by activization of phosfolipaze systems, an intensification of lipids peroxidation process. There is a systemic lipid distress syndrome. The arisen changes - one of significant in a pathogenesis of traumatic illness. At modification of lipid structure of a biomembrane the morphological and functional condition of a cell starts suffering. It is substrate of emergence of disregulation pathologies. The received scientific facts can be the base for intelligent medical actions for the purpose of the prevention of emergence of a "favorable" background of disregulation conditions by vectorial impact on one of its main pathogenetic links - a systemic lipide distress syndrome.

In the review the current understanding of some clinically and pathogenetically meaningful features of the lipid and carbohydrate metabolism in the indigenous and migrant population of the North and equivalent areas of Siberia are stated. Physiological and pathophysiological importance of the changes in human metabolism in the North are discussed in connection with the processes of adaptation and disadaptation to extreme climatic and geographical factors.

Проведено исследование фенольного и липидного состава вторичных ресурсов экологически чистой сосны (Pinus Sylvestris) (sosnowskyi), распространённой на охраняемой территории Тушети (регион северо-восточной части Грузии), в частности, коры, древесных обрезков и смолы. Выявлены различия по содержанию липидной и фенольной фракций исследуемых объектов. Полученные данные указывают на то, что древесные обрезки, кора и смола как вторичные продукты из экологически чистой местности могут быть использованы для комплексной переработки, с целью получения полезных для здоровья природных биологически активных соединений.