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Tulathromycin is a semi-synthetic antimicrobial substance from the group of macrolides. It differs in that it has a longer period of action due to three amino groups. That’s why it is classified in the subgroup “triamylides”. The product has high activity against Gram-negative and Grampositive pathogens and suitable pharmacological characteristics for high and tissue-retaining levels in domestic animals. In addition, have not been reported resistant strains, with the exception of a few of P. multocida and M. haemolitica. The product is intended for cattle, pigs and sheep. Tulathromycin has been evaluated as a bacteriostatic in therapeutic concentrations, but may also be a slow bacteriocide against streptococci. The review presents the results of its tests in swine and pigs affected by various bacterial diseases, the doses used and the therapeutic efficacy. It is considered to be highly effective against diseases caused by A. pleuropneumoniae, B. bronhiseptica, P. multocida, H. parasuis and M. hyopneumoniae, alone or in various combinations between them, in a therapeutic mode with a single intramuscular administration of a low-volume dose of 2.5 mg/kg b.w. [ABSTRACT FROM AUTHOR]