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The prevalence of urinary stone disease (USD) depends on geographic, climatic, ethnic, dietary, and genetic factors. USD of the upper urinary tract occurs 2-3 times more often in men than in women. The risk of stone formation during the human life is from 5% to 10 %, and the prevalence of USD in different regions varies from 1% to 20%. In the countries with a high life standard (for example, Sweden, Canada, the USA), the prevalence of this disease is very high and is more than 10 %. Unfortunately, in some regions there is the increased indices more than 37 % over the past 20 years. In Ukraine, USD ranks the second place among all urological diseases, more than 52000 patients are registered annually for the first time, and the frequency of occurrence varies from 30% to 45% of all urological pathologies. Mostly young people are affected, the disease progresses with symptoms of acute and chronic pyelonephritis and frequent recurrence of USD (30-80%). This course of USD leads to the development of kidney failure, disability and mortality of patients. The formation of calculi in the kidneys is a complex and polyetiological process that includes endogenous (age, sex and heredity) and exogenous factors (geographical conditions, climate, nutrition). USD has been well known for centuries. It has been proven that humanity has been suffering from this disease for over 7000 years. This is clearly confirmed by various archaeological finds, as well as writings about painful stones and therapeutic procedures that were carried out to remove them. Taking into account the importance and spread of USD, the article presents an overview of the historical development of diagnosis and treatment of this pathology in different regions of the world, an analysis of diagnostic and treatment methods, starting from early antiquity and up to the most modern approaches. [ABSTRACT FROM AUTHOR]

Benign prostatic hyperplasia (BPH) is one of the most common benign diseases in men, as it leads to an enlarged prostate, the development of lower urinary tract symptoms, and worsens the quality of patient’s life. Surgical treatment is indicated to patients after non-effective drug treatment. Most often, transurethral resection of the prostate (TURP) is used. The objective: to improve the results of TURP in patients with BPH and acute urinary retention by optimizing antibacterial prophylaxis of postoperative complications in the early postoperative period. Materials and methods. An analysis of the surgical treatment of 179 patients with BPH with acute urinary retention after TURP was performed. The age of the patients varied from 51 to 84 years old, the average age was 64.9±5.1 years. All patients had a complex urological examination in the preoperative period. The patients were divided into two groups: I group – 85 patients after operation who were prescribed ceftriaxone in the early postoperative period; II group – 94 patients who received levofloxacin in the early postoperative period. Results. It was determined that complications occurred in 43 (24.1%) patients in the early postoperative period. Long-term macrohematuria was found in 23 (12.9%) patients, exacerbation of chronic pyelonephritis was in 13 (7.3%) patients after operation, acute urethritis developed in 7 (3.9%) patients, acute orchiepididymitis – in 9 (5, 0%) patients. It has been proven that the total frequency of complications in patients with BPH who received levofloxacin in the early postoperative period was statistically significantly lower than in the patients who were prescribed ceftriaxone. Conclusions. The use of levofloxacin for the prevention of early postoperative complications after TURP in patients with BPH complicated by acute urinary retention improves the results of surgical treatment by reducing the frequency of postoperative complications by 60%. [ABSTRACT FROM AUTHOR]