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Collaboration between enterprises and public research organisations (PROS) is an important factor in the economic performance and development of a country. The said relates to the objective of the present study, in which we identified the effects, results, reasons for (non-)collaboration, and advantages/disadvantages of collaboration among enterprises and pros from the perspective of enterprises and business clusters. Our results show that the reason behind enterprises and pros working together is to achieve breakthrough results rather than financial gain. The obstacles hindering such university-industry collaboration include red tape, inadequate staff, low financial incentives, unawareness of calls for projects, and lack of initiative on behalf of pros in establishing contacts. Among the most important effects of such collaboration are entry into new markets, progress in the field of human resources, and establishment of new partnerships. Less important effects include the establishment of start-ups and profits arising from patents and licenses. While the development of new products/services and their offer on the market are considered important, scientific achievements and granted patents are regarded as less significant results. University-industry cooperation should thus be improved by way ofmore frequent collaborations, knowledge exchange, liaison officers, streamlined administration, proper management of intellectual property rights, and increased public visibility. [ABSTRACT FROM AUTHOR]