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28 results on '"ŽEMLIČKA, Milan"'

9. Webová počítačová hra jako edukační nástroj

Author

Žemlička, Milan, Vaňková, Petra, and Novák, Jaroslav

Subjects
ComputingMilieux_PERSONALCOMPUTING, ComputingMilieux_COMPUTERSANDEDUCATION, didaktická webová hra, informační a komunikační technologie, evaluation of an educational applications, Didactic games, webová aplikace ve školním prostředí
Abstract

This diploma thesis focuses on a didactic game and its usage within an educational process. The subject of the thesis is, on the basis of the study of the expert literature and expertly focused primary resources from various fields, to create and test a functional web computer game with didactic content. The theoretical part focuses on the very phenomenon of a game; from a historical and philosophical point of view as well as from the current interpretation of electronic games and a game in the context of didactic methods. In the empirical investigation, the thesis contains the whole development of the game, possibilities of its modification depending on users and the implementation of the didactic game in teaching. In the conclusion, the results of the research are given and recommendations for the research area of the development of other educational tools using Web applications as games are made.

Published
2017

15. Flow injection analysis coupled with carbon electrodes as the tool for analysis of naphthoquinones with respect to their content and functions in biological samples

Author

Babula, Petr, Húska, Dalibor, Hanuštiak, Pavel, Baloun, Jiří, Křížková, Soňa, Adam, Vojtěch, Hubálek, Jaromír, Havel, Ladislav, Žemlička, Milan, Horna, Aleš, Beklová, Miroslava, Kizek, René, Babula, Petr, Húska, Dalibor, Hanuštiak, Pavel, Baloun, Jiří, Křížková, Soňa, Adam, Vojtěch, Hubálek, Jaromír, Havel, Ladislav, Žemlička, Milan, Horna, Aleš, Beklová, Miroslava, and Kizek, René

Abstract

Naphthoquinones are one of the groups of secondary metabolites widespread in nature, where they mostly appear as chromatic pigments. They embody broad-range of biological actions from phytotoxic to fungicidal. An anticancer effect of naphthoquinones stimulates an interest in determination and characterization of single derivatives of 1,2- and 1,4-quinones in biological samples. The main aim of this work was to suggest a technique suitable to determine lawsone, juglone and/or plumbagin in biological samples and to study of their influence on BY-2 tobacco cells. The BY-2 tobacco cells were cultivated in the presence of the naphthoquinones of interest ( 500 mu g.l(-1)) for 24 h and then the morphological changes were observed. We found out that naphthoquinones triggered the programmed cell death at BY-2 cells, which can be confirmed by the apoptotic bodies in nucleus. After that we suggested and optimized different electrochemical techniques such differential pulse voltammetry ( DPV) coupled with hanging mercury drop ( HMDE) and carbon paste electrode, micro flow device coupled with carbon screen printed electrodes and flow injection analysis coupled with Coulochem III detector to determine them. The detection limits of naphthoquinones of interest were expressed as 3S/N and varied from units to hundreds of ng per millilitres according to methods used. Moreover, we utilized DPV coupled with HMDE and micro flow device to determine content of juglone in leaves Persian walnut ( Juglans regia). We determined that the leaves contained juglone tenths of g per 100 g of fresh weight. The results obtained show the convincing possibilities of using of these methods in analysis of plant secondary metabolites.

Published
2006

17. Natural Compound Cudraflavone B Shows Promising Anti-inflammatory Properties in Vitro

Author

Hošek, Jan, primary, Bartos, Milan, additional, Chudík, Stanislav, additional, Dall’Acqua, Stefano, additional, Innocenti, Gabbriella, additional, Kartal, Murat, additional, Kokoška, Ladislav, additional, Kollár, Peter, additional, Kutil, Zsófia, additional, Landa, Přemysl, additional, Marek, Radek, additional, Závalová, Veronika, additional, Žemlička, Milan, additional, and Šmejkal, Karel, additional

Published
2011
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19. Evaluation of the Antiradical Activity of Schisandra Chinensis Lignans Using Different Experimental Models

Author

Šmejkal, Karel, primary, Šlapetová, Tereza, additional, Krmenčík, Pavel, additional, Kubínová, Renata, additional, Suchý, Pavel, additional, Dall´Acqua, Stefano, additional, Innocenti, Gabbriella, additional, Vančo, Ján, additional, Kalvarová, Karolína, additional, Dvorská, Margita, additional, Slanina, Jiří, additional, Kramářová, Eva, additional, Muselík, Jan, additional, and Žemlička, Milan, additional

Published
2010
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23. Osajin

Author

Lišková, Margita, primary, Marek, Jaromír, additional, Jankovská, Dagmar, additional, Sukupová, Lada, additional, Žemlička, Milan, additional, and Vančo, Ján, additional

Published
2005
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24. Pomiferin

Author

Marek, Jaromír, primary, Veselá, Dagmar, additional, Lišková, Margita, additional, and Žemlička, Milan, additional

Published
2003
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27. Antioxidative and EROD activities of osajin and pomiferin

Author

Veselá, Dagmar, Kubínová, Renáta, Muselík, Jan, Žemlička, Milan, and Suchý, Václav

Subjects
*FRUIT development, *ISOFLAVONES, *MATERIA medica, *WOOD
Abstract

The major constituents of fruits of Maclura pomifera are the prenylated isoflavones, osajin (1) and pomiferin (2). Since significant biological activities of extracts from the wood of M. pomifera were previously reported, the peroxynitrite scavenging activity, inhibition of lipid peroxidation, scavenging of DPPH and EROD activity of these two major substances were studied. [Copyright &y& Elsevier]

Published
2004
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28. Schisandra chinensis and its phytotherapeutical applications.

Author

Rybnikář M, Šmejkal K, and Žemlička M

Subjects
Phytotherapy, Plant Extracts pharmacology, Schisandra chemistry
Abstract

Schisandra (Schisandra chinensis) has been used for centuries as a plant of traditional Chinese medicine. Its biological activity and pharmacological use are associated with dibenzocyclooctadiene lignans, while specific polysaccharides may also be involved. The lignans of schisandra are genus-specific. Their activity has been investigated in hundreds of studies that have confirmed adaptogenic effects, central nervous system stimulation, hepatoprotective effects and potential anticancer potential. This summary review of the literature synthesizes the current state-of-the-art in research on bioactivities of schisandra constituents, description of folk use of extracts, overview of clinical studies and additional information on in vitro tests bringing insight into mechanisms of action.

Published
2019

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