1. Optimizing Choice of Skin Surrogates for Surface-Guided Stereotactic Body Radiotherapy of Lung Lesions Using Four-Dimensional Computed Tomography.
- Author
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Leipold, Vanda, Alerić, Ivana, Mlinarić, Mihaela, Kosmina, Domagoj, Stanić, Fran, Kasabašić, Mladen, Štimac, Damir, Kaučić, Hrvoje, Ursi, Giovanni, Schwarz, Karla, Nikolić, Igor, Klapan, Denis, and Schwarz, Dragan
- Subjects
STATISTICAL correlation ,PEARSON correlation (Statistics) ,RADIOTHERAPY ,ADIPOSE tissues ,DATA analysis ,T-test (Statistics) ,COMPUTED tomography ,SEX distribution ,SAMPLE size (Statistics) ,RADIOSURGERY ,MANN Whitney U Test ,CHI-squared test ,DESCRIPTIVE statistics ,SKIN ,LUNG tumors ,RESEARCH ,FRIEDMAN test (Statistics) ,STATISTICS ,CONFIDENCE intervals ,RESPIRATORY mechanics ,RIB cage - Abstract
Simple Summary: Surface tracking based on optical cameras is often used to reduce the imaging dose while maintaining precision during stereotactic ablative body radiotherapy. A region of interest (ROI) on a patient's skin is selected and monitored using harmless visible light in real time. Relying on the correlation between the skin and lesion respiratory motion, this region of interest is used as a surrogate for the tumor respiratory motion. In this study, the thoracic and abdominal skin region is segmented into nine smaller regions. For each of them, the respiratory motion magnitude and its correlation with a small structure in the lower lung (representing a lung lesion) are measured. Using the data provided by this study, a clinician can make an informed decision about which ROI to track when treating lower lung lobe lesions. Image-guided radiotherapy supported by surface guidance can help to track lower lung lesions' respiratory motion while reducing a patient's exposure to ionizing radiation. However, it is not always clear how the skin's respiratory motion magnitude and its correlation with the lung lesion's respiratory motion vary between different skin regions of interest (ROI). Four-dimensional computed tomography (4DCT) images provide information on both the skin and lung respiratory motion and are routinely acquired for the purpose of treatment planning in our institution. An analysis of 4DCT images for 57 patients treated in our institution has been conducted to provide information on the respiratory motion magnitudes of nine skin ROIs of the torso, a tracking structure (TS) representing a lower lung lobe lesion, as well as the respiratory motion correlations between the nine ROIs and the TS. The effects of gender and the adipose tissue volume and distribution on these correlations and magnitudes have been analyzed. Significant differences between the ROIs in both the respiratory motion magnitudes and their correlations with the TS have been detected. An overall negative correlation between the ROI respiratory magnitudes and the adipose tissue has been detected for ROIs with rib cage support. A weak to moderate negative correlation between the adipose tissue volume and ROI-to-TS respiratory correlations has been detected for upper thorax ROIs. The respiratory magnitudes in regions without rib support tend to be larger for men than for women, but no differences in the ROI-to-TS correlation between sexes have been detected. The described findings should be considered when choosing skin surrogates for lower lung lesion motion management. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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