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Axillary lymph node metastasis is the most important prognostic factor in breast cancer. No method exists to diagnose the metastasis of the axillary lymph nodes before surgery. Sentinel lymph node biopsy is a procedure for axillary staging. Hematological parameters and systemic inflammation play a role in cancer metastasis. This study aims to evaluate the modified Systemic Inflammation Score (mSIS) score predicting sentinel axillary lymph node positivity in early breast cancer patients and to determine if there is a need to modify it. This is a retrospective study conducted in Ankara City Hospital General Surgery Department from March 2019 to July 2021. One hundred fifty-nine patients were analyzed according to age, albumin parameters, Thrombocyte, Lymphocyte and Monocyte count, histopathological type of cancer, and lymph node metastasis status. The collected information was entered into SPSS 24.0 program. Lymph node metastasis was detected in 51 of these 159 patients. Results showed no significant difference between the lymph node metastasis group and no lymph node metastasis group after applying the mSIS score to each group. This result is due to normal albumin levels in early breast cancer patients. Platalet lymphocyte ratio (PLR) is associated with lymph node metastasis in breast cancer. PLR is applied to mSIS score instead of albumin.The new modified early-stage breast cancer SIS(mebcSIS) was established as follows: Score 0: LMR ≥ 5.7 and PLR < 141, Score 1: LMR < 5.7 or PLR ≥ 141, Score 2: LMR < 5.7 or PLR ≥ 141. The relationship between mebcSIS and LNM was statistically significant (p = 0.003). There is a positive correlation between mebcSIS score and lymph node metastasis in early breast cancer patients.

INTRODUCTION In breast cancer, the most important prognostic factor is axillary lymph node metastasis. However, there is no method which can diagnose axillary lymph node metastasis preoperatively with high sensitivity. The aim of this study was to evaluate the relationship between platelet/lymphocyte ratio (PLR) and sentinel lymph node metastasis in early-stage breast cancer. METHODS In total, 202 cases which were operated under early-stage breast cancer diagnosis in Ankara City Hospital General Surgery Department were evaluated in retrospectively. We separated the patients into two categories according to their PLR. PLR groups were evaluated for relationship with sentinel lymph node metastasis. At the last part, sentinel lymph node positive sensitivity was evaluated in PLR and preoperative USG groups. RESULTS Results showed that patients above PLR cut-off value had 0.43 times more risk of having a positive SLN in comparison with patients who had a PLR lower than cut-off (OR = 0.435, 95%CI:0.221-0.856, P

Introduction YouTube is a free video-sharing platform, which is watched by residents or specialists in order to catch up on their skills, see new techniques, and have information. In this study, our purpose is to evaluate whether or not these videos are an appropriate educational source for surgeons by analyzing their quality and content, in an environment of reduced elective operations due to the COVID-19 pandemic. Methods YouTube video search was performed by entering keywords such as CRS and HIPEC, cytoreductive surgery and hyperthermic intraperitoneal chemotherapy, cytoreductive surgery, and HIPEC. A total of 115 videos were found. Videos were divided into two groups as those containing operation videos and those that do not (slides, congress presentations, and informative videos). And then, for evaluating operation videos, a scoring system was defined based on CRS + HIPEC steps as defined by Sugarbaker and video quality. Results There were 45 operation videos and 70 videos of other content. The total number of views, number of views per day, and the total number of likes and comments were all significantly higher in the operation video group (p values 0.003-0.002-0.004-0.002). No statistically significant difference was found in the median values of the number of views, likes, and dislikes; the number of views per day; the number of comments; and the dates of uploads within different video-scoring system groups. Conclusion Our study shows that there is an increasing interest in CRS + HIPEC videos on YouTube. On the other hand, when the educational value of these videos that are receiving attention is considered, we believe it is not right to adjudicate due to the fact that the numbers are very low.

Background In-transit metastasis is considered a locoregional disease in cutaneous melanoma (CM) patients. Isolated limb perfusion (ILP) is among the treatment options in selected cases. The aim of this study was to determine the success of pre- and post-perfusion mSIS values in predicting the potential complications and the prognosis of the disease by investigating the early and long-term results of mSIS values calculated before and after ILP in CM cases with in-transit metastases. Materials and methods Patients who underwent ILP within the period from 2014 to 2020 in our department were retrospectively scanned. A total of 20 patients were found to undergo ILP. The scores obtained from modified inflammation score (mSIS) were formulated according to albumin (Alb) and lymphocyte to monocyte ratio (LMR) scores. Results The mean follow-up time was 20.47 months. Complications requiring surgical intervention developed in three patients. According to the Wieberdink local toxicity classification, the majority (70%) of the patients were found to be grade II. Based on pre-perfusion mSIS values, 8 patients were classified as mSIS 0 while six patients were classified as mSIS 1 and 2. Based on post-perfusion mSIS values, 14 patients and one patient were classified as mSIS 2 (70%) and mSIS 0, respectively. Accordingly, univariate analysis showed that mSIS 1 and mSIS 2 were negative prognostic factors for mean survival in the pre-perfusion period (HR 0.162, 95% CI 0.036–0.729; p = 0.018 and HR: 0.223, 95% CI 0.049–1.019; p = 0.053) whereas albumin (Alb) and lymphocyte to monocyte ratio (LMR) were not independent prognostic factors for mean survival. Conclusion The mSIS values calculated in the pre-perfusion period can give an opinion about the OS of the patients whereas post-perfusion mSIS values may predict potential surgical complications and local toxicities.

Aim: Molecular subtypes in invasive breast cancer is a classification system based on tumor biology rather than tumor morphology. The aim of this study is to find out whether the age of 65, which is accepted as the elderly population limit, could be an independet risf factor on the molecular basis in invasive breast cancer.Materials and Methods: 512 patients who underwent mastectomy with a diagnosis of breast cancer between 2012 and 2021 at the Department of General Surgery of Ankara City Hospital were retrospectively analyzed. The patients were divided into two groups as elderly (≥65 years old) and young (, Amaç: Meme kanserinde moleküler alt tiplendirme, tümör morfolojisi yerine tümör biyolojisinin temel alınmasına dayalı sınıflama sistemidir. Bu çalışmanın amacı, yaşlı nüfus sınırı olarak kabul edilen 65 yaşın, meme kanserinde moleküler düzeyde bağımsız bir risk faktörü olup olamayacağını bulmaktır.Gereç ve Yöntemler: Ankara Şehir Hastanesi Genel Cerrahi Anabilim Dalında 2012 ve 2021 yılları arasında meme kanseri tanısı ile mastektomi operasyonu yapılan 512 hasta retrospektif incelendi. Hastalar dünya sağlık örgütü (DSÖ) verilerine göre yaşlı ( ≥65 yaş) ve genç (

Giriş: Memede ele gelen kitle, kadınlarda en sık görülen meme kanserini akla getirir. Ancak meme kitlelerinin iyi huylu olup olmadığının teşhisinin doğru yapılması önemlidir. Bu kitlelerin teşhisinde en sık kullanılan görüntüleme yöntemi mamografidir. Meme Görüntüleme Raporlama ve Veri Sistemi (BI-RADS) kullanılmasının kitlelerin benign veya malign olduğunu ayırmada faydalı olduğu bilinmektedir. Biz bu çalışmamızda, BI-RADS sınıflamasının meme kanseri risk faktörlerini ne oranda karşıladığını ve hematolojik parametrelerle ilişkisini bulmayı amaçladık. Materyal ve Metot: Hastanemiz meme ve endokrin cerrahisi polikliniğine meme rahatsızlığı şikayetleri ile başvuran mamografi tetkiki sonrası kliniğimize (meme kanseri şüphesi ve/veya tanısıyla) yatırılarak opere edilmiş toplam 380 kadın dahil edildi. Bu retrospektif kohort çalışmada kadınlara yaşı, boyu, kilosu, eğitim durumu, medeni durumu ve ilk adet yaşı soruldu. Ayrıca adet görüp görmediği, gebe kalıp kalmadığı, gebe kaldıysa sayısı, ailede meme kanseri öyküsü olup olmadığı, doğum kontrol hapı veya hormon replasman tedavisi (HRT) kullanıp kullanmadığı soruldu. Bulgular: Meme kanseri risk faktörlerinden hasta yaşının ≥51 olması (OR 3.1, %95 CI 1.6-6.1) , vücut kitle indeksi (VKİ) ≥27.88 kg/m2 olması (OR 2.7, %95 CI 1.4-5.2), ilk gebelik yaşının ≥30 olması (OR 2.8, %95 CI 1.4-5.8), tam süreli olmayan gebelik sayısının ≥3 olması (OR 4.4, %95 CI 1.7-11.2) ve yoğun meme dokusuna sahip olmanın (OR 5.0, %95 CI 2.6-9.7) BI-RADS 4-5-6 olarak raporlamayı ve meme kanseri olma riskini arttırdı. Nötrofil lökosit/ Lenfosit oranının (NLR) 2.19 ve Trombosit/Lenfosit oranının (PLR) 146.81 ve üzerindeki kadınların mamografilerinin BI-RADS 5-6 olarak raporlamasının anlamlı olarak yüksek olduğu saptandı (Sırasıyla p

Purpose The aim of this study is to evaluate the relation between LVI and molecular subtypes in invasive breast cancers and to find out whether LVI which is a histopathologic indicator has a role in subtype classification or not. Methods One hundred and seventy-six patients who had mastectomy for breast cancer between 2013 and 2018 in the Department of Surgical Oncology, Faculty of Medicine, Ankara University were retrospectively analysed. One hundred and thirty-two patients who had LVI, ER, PR, Her 2 and Ki-67 index status information provided in their pathology results were included in the study. The relationship between molecular subtypes and LVI was investigated. Results One hundred and thirty-two patients were analysed retrospectively. Eighty-two patients had LVI and 50 patients had not. We found a relationship between Luminal B with Her2(-) and LVI, basal like and LVI (P = .00). No significant statistical difference was found between LVI and other molecular subtypes. We confirmed these results with multiple variable analysis (%77.3 correlation). Conclusions As a result, we found that LVI can affect molecular subtypes. This showed that a histopathological factor may affect tumour biology. In other words, breast cancer is a heterogeneous disease with many different predictors and prognostic variables.