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INTRODUCTION The aim of the present study is to examine the effect of local administration of tranexamic acid (TXA) through lateral osteotomy line on postoperative periorbital edema and ecchymosis. MATERIALMETHOD Thirty patients underwent open technical septorhinoplasty were included. Before lateral osteotomies, the surgeon opened narrow subperiosteal tunnels on the both sides. After lateral osteotomies, the surgeon irrigated TXA into the right tunnel with the broken tip of the injection and the same amount of saline into the left tunnel. The patient's photographs were taken on the first, third, and seventh postoperative days. Periorbital edema and ecchymoses were evaluated by the blinded author. The statistical differences between the 2 sides were analyzed. RESULTS Lower Eyelid Edema values were significantly lower in the TXA(+) group than the TXA(-) group on the third day (P = 0.001). There was no statistically significant difference between the sides in terms of lower eyelid edema values on the first and seventh days (P = 0.065, P = 0.317). Upper and lower eyelid ecchymosis values were significantly lower in TXA(+) group than TXA(-) group on the first, third, and seventh days (P

Objectives: This study aims to investigate the protective effect of hyperbaric oxygen therapy HBOT as an antioxidant agent on cisplatin ototoxicity. Materials and Methods: Between June 4th, 2014 and June 13th, 2014, a total of 15 adult female Wistar albino rats were used in this study. The rats were divided into the following groups: Group A comprised of five rats and had prophylactic one course of HBOT before intraperitoneal IP cisplatin injection, followed by two more courses of HBOT. Group B comprised of five rats receiving three cycles of HBOT after 10 mg/kg of IP cisplatin administration. Group C served as the control group, including five rats, and received 10 mg/kg IP cisplatin without any additional treatment. The distortion product otoacoustic emission amplitudes of the rats were obtained before and after the study. Results: Group A and Group C showed a significant decrease in all measurements 4,004 Hz, 4,761 Hz, 5,188 Hz, 5,652 Hz, 6,726 Hz, and 7,996 Hz after cisplatin administration compared to that of baseline measurement. In Group B, a significant decrease was observed in the majority of the measurements, although no significant difference was found in 4,761 Hz. Conclusion: Our study results suggest that HBOT neither provides a protective nor therapeutic effect in a rat cisplatin-ototoxicity model.

This experement was conducted to determine the effects of different levels of dietary humate (0.0, 0.15, 0.30%) suplementation and body weight (light=1400-1500 g, medium=1500-1600, heavy=1600 < g) on laying performance and egg quality parameters of layers. A total of 216 Lohmann layers at age of 28 weeks were utilized as animal material. The experimental period lasted for 16 weeks. Except for feed consumption and feed conversion ratio, humat levels did not affect laying performance parameters. The Feed consumption and feed conversion ratio for groups of feeding humate suplementation diet (0.0, 0.15, 0.30 %) were found to be 125,8, 120,8, 123,4 g and 2,08, 2,0 and 2,0, respectively. A ll of the performance parameters were significantly affected by body weight. As body weight linearly increased, performance parameters also increased. B ut laying hens in light group consumed less feed for one kg egg pruduction than those of medium and heavy groups. Avarage daily feed intake (g), hen-day egg production (%), egg weight (g) and feed conversion ratio for light, medium and heavy groups were 119.5, 123.18, 127.3; 76.672, 82.190, 88.908 ; 61.29, 60.21, 62.69 and 1.98, 2.05, 2.08, respectively. The effect of humat level by body weight interaction on performance parameters was not found statistically significant. Except for egg yolk color and yolk index, egg quality parameters were not affected by humate levels. In addition, body weight had no significant effect on egg quality traits. Hens fed with diets including humate at differentlevels have produced more intensively coloured egg yolks than that of control group consumed feed without dietary humate. Although humat level by body weight interaction effected albumen index and Haugh unit, other egg quality parameters were not affected statistically by this interaction. As a result, groups fed with diets including dietary humate at different levels and light group consumed less feed per kg egg pruduction than those of other groups.

Bu calisma, diyetsel vitamini E (a-tokoferol asetat), organik selenyum (selenomethionine) ve bunlarin kombinasyonlarinin yumurta tavuklarinin bazi dokularinda bazi biyoelementlerin duzeyleri uzerine etkilerini degerlendirmek amaciyla yapildi. Calismada, 96 adet beyaz Lohman yumurta tavugu, esit sayida 4 gruba ayrildi. Gruplar sirasiyla bazal yem (Kontrol), bazal yem + 250 mg/kg Vit-E (D-I), bazal yem + 0.9 mg/kg Se (DII) ve bazal yem + 250 mg/kg Vit-E+ 0.9 mg/ kg Se (D-III) iceren rasyonlarla beslendi. Deneme sonunda, her gruptan 12 hayvan kesildi, belirtilen dokular alindi, analiz edilinceye kadar -20 oC'de saklandi ve biyoelement duzeyleri ICP-MS ile analiz edildi. Deneme gruplarinin dokularindaki Se, Zn ve Fe duzeyleri kontrol grubuna gore onemli derecede artarken (P

This study was carried out to determine the effects of addition of humate, probiotic, and their combination into diets on performance, egg quality, and yolk fatty acid composition of hens during the second laying period. Lohmann LSL white layers (n = 192), 46 weeks of age, were randomly divided into 4 groups and fed with basal diet (control, C), 0.3% humate (H), 0.3% probiotic (P), 0.15% humate + 0.15% probiotic (HP) for 18 weeks. Feed consumption and egg production were determined daily, egg weight was measured biweekly, and body weights were recorded at the beginning and the end of the experiment. Also, 12 egg samples from each group were randomly collected to determine the egg quality every 30 days. Laying performance, yolk color, and fatty acid composition were significantly (P

Bu derleme calismasi, omega-3 yag asitlerinin insan sagligi uzerine olan etkilerini belirlemek icin daha once yapilmis calismalarin incelenmesi ve konuda bir kanaate ulasilmasi amaciyla yapilmistir. Bugune kadar yapilan arastirma sonuclari, omega-3 yag asitlerinin basta kalp damar hastaliklari ve yuksek tansiyon olmak uzere Alzheimer, depresyon, sizofreni, astim, felc, romatoid artrit, osteoporoz ile prostat, gogus bagirsak ve akciger kanseri gibi cok sayida hastaligin onlenmesi ve tedavisinde hayati bir oneme sahip oldugunu ve herhangi bir yan etkinin bulunmadigini gostermistir. Keza, bu dogal fonksiyonel bilesiklerin adi gecen hastaliklarin onlenmesi ve tedavisinde terettud etmeden guvenle kullanilabilecegi sonucuna varilmistir

Turkiye yumurta uretimiyle dunyanin onemli ulkelerinden birisi olmasina ragmen, toplam uretimi mevcut potansiyeli duzeyinde degildir. Toplam yumurta uretimini artirmanin en etkin yolu verimliklik artisi saglamaktir. Bu calismada yumurtaci tavuk bazal yemine degisik oranlarda humat ilave edilerek olusturulan rasyonlarin yumurta verimine etkisi Gamma ve McNally modelleriyle analiz edilmistir. Yumurtaci tavuk yemine ilave edilen %0,15 oraninda humatin, yumurta verimine en fazla katkiyi sagladigi belirlenmistir. Sonuc olarak, yumurtaci tavuk yemlerine humat ilavesinin yumurta verimi uzerine etkisine yonelik farkli bolgelerde, farkli tur ve cins kanatlilar uzerinde daha fazla ve uzun sureli calismalarin yapilmasi onerilmektedir.

The present study envisaged the effects of different levels of dietary copper supplementation on performance, egg quality parameters, serum and yolk cholesterol and triglyceride levels, and yolk fatty acid profile in laying hens. Total 96 Lohman laying hens (38 weeks old) were randomly divided into four groups (n=24 each). Experimental diets were prepared by adding copper (0, 200, 250 or 300 mg/kg) to basal diet and feeding was lasted 12 weeks. Dietary copper supplementation decreased egg weight and feed intake but did not affect other performance parameters compared to the control diet. Shape index, shell weight, shell thickness, yolk color, yolk index, albumen index, and haugh unit were not influenced by dietary copper supplementation, whereas shell strength increased due to the inclusion of copper in the basal diet. Copper supplementation did not affect the fatty acid profile of the egg yolk. The yolk cholesterol ratio decreased by 7.22% in the presence of 250 mg/kg copper supplementation compared to control diet. Therefore, high levels of dietary copper supplementation in the diet of laying hens can be beneficial for improving shell strength and reducing the cholesterol content of the yolk.

This experiment was designed to evaluate the effects of the processing method of common vetch seed (CVS) (Vicia sativa) on laying performance, egg quality, metabolic parameters and liver histopatology during the peak production period in hens. Lohman layers, 46 wk of age in 6 replicate cages each containing 4 hens, were allocated randomly to one of four dietary treatments. Diets were control (C) diet containing no common vetch and experimental diets containing 25% raw common vetch (RCV), 25% soaked in water for 72 h with exchange of water every 24 h (SCV) and 25% soaked&boiled at 100°C for 30 minute common vetch (SBCV). Inclusion of RCV into the diet deteriorated all laying performance variables. SCV did not alleviate the adverse effect of raw common vetch on feed intake, egg weight, feed conversion, final weight and weight change. SCV partially alleviated egg production (p

To examine the effects of supplemental fat on fatty acid (FA) compositions of some tissues, laying hens were fed diets containing different fat sources (tallow, mixture of tallow and flaxseed oil [1:1], sunflower oil, flaxseed oil) and levels (2% or 4%); 360 Isa Brown hens were assigned to one of the nine diets. The dietary FA composition was reflected in the FA composition of tissue lipids. The supplemental tallow oil increased concentrations of saturated fatty acids. The proportions of linoleic and arachidonic acids in all tissues for laying hens fed a diet containing sunflower oil (SO) were higher than the other diets. Moreover, increasing the SO level increased the n-6 FAs content. Also, dietary flaxseed oil significantly increased the content of linolenic and other n-3 FAs in most studied tissues. These results indicated that desirable changes can be achieved in FA compositions of poultry meats by using various animal and plant fats in poultry diets.

Celebi, S. and Macit, M. 2009. Effects of feeding tallow and plant fat to laying hens on performance, egg quality and fatty acid composition of egg yolk. J. Appl. Anim. Res., 36: 49–52. To determine the effects of sources of supplemental fat 200 Isa Brown layers were equally divided in 5 groups and assigned randomly to be fed ad libitum a standard commercial layer feed (BD), BD+ 4% tallow (T), BD+ mixture of 2% tallow and 2% flaxseed oil (MTFO), BD+ 4% sunflower oil (SO) and BD+ 4% flaxseed oil (FO) for 8 weeks. Dietary fat supplemantion affected the laying performance, but had no (P>0.05) effect on egg quality parameters. The supplemental tallow increased concentration of saturated fatty acids (palmitic: 29.10%, stearic: 10.17%). The proportions of linoleic and arachidonic acids in egg yolks for layers fed the diet containing 4% sunflower oil were higher than other diets. The concentration of oleic acid (40.08%) was the highest in layers receiving 2% tallow + 2% flaxseed oil diet. In addition, d...

BACKGROUND: The objective of this study was to determine the effects of humate on performance, egg quality and egg yolk fatty acid (FA) composition in laying hens. RESULTS: Six hundred and thirty White Lohmann layers at 46 weeks of age were assigned randomly to seven groups, each with 18 replicate cages of five hens. Control diet (C) and C supplemented with 0.10 (H1), 0.15 (H2), 0.20 (H3), 0.25 (H4), 0.30 (H5) and 0.35 (H6) wt% humate were offered for 25 weeks. Humate supplementation improved performance variables and egg quality indices including shape index, yolk colour, albumen index, yolk index and Haugh unit, but not specific gravity, shell strength and shell thickness. Average feed intake (g), egg production (%), egg weight (g) and feed efficiency for the groups were 118.9, 87.2, 68.1 and 2.07 (C), 118.8, 87.7, 66.3 and 2.08 (H1), 119.3, 89.8, 66.6 and 2.03 (H2), 119.5, 88.9, 66.9 and 2.05 (H3), 118.3, 86.5, 66.9 and 2.11 (H4), 119.3, 90.6, 66.9 and 2.02 (H5) and 123.6, 88.5, 66.1 and 2.16 (H6) respectively. Palmitoleic acid concentration increased from 4.34% (C) to 7.65% (H5) and stearic acid concentration decreased from 7.39% (C) to 5.39% (H6) of total FA. CONCLUSION: Dietary humate supplementation improved performance, inner egg quality parameters and egg yolk fatty acid composition. Copyright © 2008 Society of Chemical Industry

BACKGROUND: The objective of this study was to determine the effects of sources of supplemental fat on laying performance, egg quality, and fatty acid composition of egg yolk. RESULTS: Two hundreds Isa Brown layers were assigned randomly to be fed ad libitum a standard commercial layer feed (BD), basal diet plus 2% tallow (T), basal diet plus a mixture of 1% tallow and 1% flaxseed oil (MTFO), basal diet plus 2% sunflower oil (SO), or basal diet plus 2% flaxseed oil (FO), which were offered for 8 weeks. Each diet was given to five groups, each containing 10 hens. The feed efficiency and egg production were 2.78 and 53.51% for BD; 2.30 and 63.47% for T; 2.45 and 60.14% for MTFO; 2.29 and 64.30% for SO, and 2.62 and 61.18% for FO groups, respectively. Dietary fat supplementation affected the laying performance but had no significant effects on egg quality parameters. The fatty acid composition of egg yolk lipids were significantly affected by dietary fatty acid composition. The supplemental tallow increased palmitic fatty acid. The proportions of linoleic and arachidonic fatty acids in egg yolks for layers fed the SO diet were higher than in the BD group and those on diets containing other fats. Concentrations of oleic and omega-3 fatty acids were the highest in layers fed the FO diet during the laying period. CONCLUSION: The results indicated that dietary animal and plant fats changed the fatty acid composition of egg yolk. Copyright © 2008 Society of Chemical Industry

2 Abstract: This experimental was conducted to determine the effects of the dietary animal fat and vegetable oils on performance and lipid metabolism in serum of laying hens. Two hundred Isabrown hens at 67 weeks of age were randomly divided into five groups containing 40 hens each therefore there were five dietary treatments groups, control group (CO) was fed basal diet without fat supplementation. Experimental groups were offered diets having 4 % tallow (TO), 4 % mixture of tallow and flaxseed oil (1:1) (MTFO), 4 % sunflower oil (SO) and 4 % flaxseed oil (FO) respectively. Fat supplementation effected laying performance and serum lipid parameters were significantly (p

This study was carried out to determine the influence of ram horn hydrolysate (RHH) supplementation on the growth performance and slaughter traits of broilers. A total of 240 male broiler chicks (Ross 308), received from a commercial hatchery at 1 day of age, were allocated to four dietary treatments (H0, H1, H2 and H3 groups) in a completely randomized experimental design. Feed and water were offered ad libitum and lighting was continuous throughout the experimental period. The H0 group was fed with basal diet plus normal drinking water. The H1, H2 and H3 groups were fed with basal diet plus 1%, 2% and 3% RHH-added water, respectively, in place of normal drinking water to meet the daily water requirements of broiler chicks from 1 to 28 days of age. All birds were housed in batteries from 1 to 21 days, and in grower broiler pens to 49 days. Feed intake and body weight gain were recorded weekly per pen. The average final body weights were 2524.9, 2601.2, 2441.7 and 2424.9 g for the H0, H1, H2 and H3 groups, respectively, and the difference was significant (P 0.05). At the end of the trial all birds were slaughtered to determine the slaughter traits. The hot carcass weights and yields were 1874.0, 1934.7, 1767.0, 1845.3 g and 75.78, 77.80, 75.00, 77.41%, respectively, and the difference was significant (P < 0.01). In addition, offal weights were determined and it was observed that there was no difference among the groups. Abdominal fat pad weights were similar in all groups. The H1 group experienced more effects on some performance and slaughter traits than the control and the other RHH-treated groups, and the supplementation of diets with RHH at a level of 1% improved broiler performance. Copyright © 2005 Society of Chemical Industry

Celebi, S. and Utlu, N. 2004. Laying performance, serum lipoproteins, cholesterol and triglyceride of hens as influenced by dietary fat sources. J. Appl. Anim. Res., 25: 121–124. There were five dietary treatment groups. Control group was fed with basal diet without added fat (CO), experimental groups were fed on a diet supplemented with 2% of either of tallow (TO), a mixture of tallow and flaxseed oil (1:1 w/w) (MTFO), sunflower oil (SO) and flaxseed oil (FO). Fat supplementation improved egg production (P

Utlu, N. and Celebi, S. 2003. Effect of different fat sources on some enzyme activities in laying hens. J. Appl. Anim. Res., 24: 159–164. To examine the effects of different vegetable and animal fat sources on some enzyme activities and protein metabolism, 270 laying hens were randomly divided into 9 groups of 30 each (one control and 8 experimental groups). In experiment 1 and 2, four experimental groups (II, III, TV and V) each were fed with a diet supplemented with 2% or 4% tallow (TO), mixture of tallow-flaxseed oil (1:1 w/w) (MTFO), sunflower (SO) and flaxseed oils (FO), respectively for 8 wks. The serum AST, ALP, ALT and LDH activities in groups of 4% TO and MTFO were higher than that of control group (POM). The 2% level of TO, MTFO (1:1 w/w), SO and FO and 4% of SO and FO did not affect various tissues. However, 4% TO and MTFO (1:1 w/w) significantly affected various tissues. It is concluded that 4% TO and MTFO, used as energy sources in diet of layers, are harmful for laying hens.

In this prospective, multicenter, randomized, controlled, double-blind study, we investigated the impact of a mobile patient engagement application on health outcomes and quality of life in allergic rhinitis (AR) and asthma patients.In total, 327 patients with diagnoses of persistent AR or mild-to-severe persistent asthma were randomized into 2 intervention groups and 2 control groups upon their admission at outpatient clinics. The intervention groups (POPET-AR and POPET-Asthma) received a mobile phone application ("physician on call patient engagement trial" [POPET]), enabling them to communicate with their physician, and record their health status and medication compliance. The AR groups completed the Rhinitis Quality of Life Questionnaire (RQLQ) at initiation and at the first month of the study. The asthma groups completed the Asthma Control Test (ACT) at initiation and at the third month of the study.The POPET-AR group showed better clinical improvement than the control group in terms of the overall RQLQ score as well in measures of general problems, activity, symptoms other than nose/eye, and emotion domains (p0.05). In the POPET-Asthma group, more patients (49%) achieved a well-controlled asthma score (ACT19) compared with the control group (27%); this was statistically significant (p0.05).Use of a mobile engagement platform, such as POPET, can have a significant impact on health outcomes and quality of life in both AR and asthma, potentially decreasing the number of hospital admissions, repeat doctor visits, and losses in productivity. Improvements were seen in domains related to activity, productivity, perception of disease, and emotion.

Bu çalışma, yumurta tavuğu karma yemlerine sarımsak tozu ilavesinin karaciğer, göğüs, but, kan ve yumurtada bazı antioksidan enzimlerin (Glutatyon peroksidaz (GSH Px), Süperoksit dismutaz (SOD), Glutatyon s-transferaz (GST) ve Katalaz (CAT)) düzeyleri üzerine etkilerini incelemek amacıyla yapılmıştır. Bu amaçla, 38 haftalık yaşta 96 adet Lohmann ırkı ticari yumurta tavuğu her biri 6 alt grup ve her alt grupta 4 hayvan olacak şekilde 4 ana gruba ayrılmış ve karma yeme sırasıyla; %0, 2, 4 ve 6 seviyelerinde sarımsak tozu ilave edilerek oluşturulan rasyonlarla 12 hafta süreyle beslenmişlerdir. Deneme sonunda her gruptan şansa bağlı olarak 6 yumurta ve hayvan seçilmiş, hayvanlardan karaciğer, göğüs, but ve kan örnekleri alınarak bunlarda; GSH Px, SOD, GST ve CAT düzeyleri tespit edilmiştir. Rasyona sarımsak tozu ilavesi, yalnızca yumurta sarısı CAT düzeylerinde istatistiksel olarak önemli bulunmayan bir düşüşe neden olması dışında, incelenen tüm enzim düzeylerini ele alınan diğer tüm dokularda önemli derecede etkilediği (P