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This study investigates the influence of temperature variations on the buckling properties of thin-walled omega-profiles fabricated from carbon-epoxy composite materials. Utilizing a MTS testing machine, compression tests were conducted on these profiles at temperatures ranging from-20°C to 80°C, in 20°C increments. The primary objective was to assess how temperature fluctuations impact the buckling load and load-bearing capacity of these composite profiles under axial compression. The experimental setup allowed for precise measurement of load-displacement and load-deflection characteristics, and the critical load at which buckling initiation occurred. Observations revealed that the buckling resistance of the profiles exhibited a complex dependence on temperature. At lower temperatures, the composite material demonstrated enhanced stiffness and strength, marginally increasing buckling resistance. Conversely, at elevated temperatures, a noticeable degradation in mechanical properties was observed, leading to a reduced buckling load and altered failure modes. To complement the experimental findings, a comprehensive finite element (FE) analysis was conducted for sample in room temperature. The FE model, developed to replicate the experimental conditions closely, employed an eigenvalue-based approach to predict the buckling initiation and progression accurately. The presented results are the results of only preliminary tests and they will be expand about more samples number as well as to determine material properties for various temperatures. [ABSTRACT FROM AUTHOR]

Introduction: Tuberous sclerosis complex (TSC) is a genetic disease resulting from mutation in TSC1 or TSC2 and subsequent hyperactivation of mammalian Target of Rapamycin (mTOR). Common TSC features include brain lesions, such as cortical tubers and subependymal giant cell astrocytomas (SEGAs). However, the current treatment with mTOR inhibitors has critical limitations. We aimed to identify new targets for TSC pharmacotherapy. Results: The results of our shRNA screen point to glutamate-cysteine ligase catalytic subunit (GCLC), a key enzyme in glutathione synthesis, as a contributor to TSC-related phenotype. GCLC inhibition increased cellular stress and reduced mTOR hyperactivity in TSC2-depleted neurons and SEGA-derived cells. Moreover, patients’ brain tubers showed elevated GCLC and stress markers expression. Finally, GCLC inhibition led to growth arrest and death of SEGA-derived cells. Conclusions: We describe GCLC as a part of redox adaptation in TSC, needed for overgrowth and survival of mutant cells, and provide a potential novel target for SEGA treatment. Electronic supplementary material The online version of this article (doi:10.1186/s40478-015-0225-z) contains supplementary material, which is available to authorized users.

The work concerns the experimental analysis of the process of destruction of sandwich structures as a result of circumferential shearing. The aim of the research was to determine the differences that occur in the destruction mechanism of such structures depending on the thickness and material of the core used. Specimens with a Rohacell foam core and a honeycomb core were made for the purposes of the research. The specimen destruction process was carried out in a static loading test with the use of a system introducing circumferential shear stress. The analysis of the tests results was made based on the load-displacement curves, the maximum load, and the energy absorbed by individual specimens. The tests indicated significant differences in the destruction mechanism of specimens with varied core material. The specimen with the honeycomb core was characterized by greater stiffness, which caused the damage to occur locally in the area subjected to the pressure of the punch. In specimens with the foam core, due to the lower stiffness of that core, the skins of the structure were bent, which additionally transfers compressive and tensile loads. This led to a higher maximum force that the specimens obtained at the time of destruction and greater energy absorption. [ABSTRACT FROM AUTHOR]