10 results on '"Łojkowska, Anna"'
Search Results
2. Detection and localization of early- and late-stage cancers using platelet RNA
- Author
-
In ’t Veld, Sjors G.J.G., primary, Arkani, Mohammad, additional, Post, Edward, additional, Antunes-Ferreira, Mafalda, additional, D’Ambrosi, Silvia, additional, Vessies, Daan C.L., additional, Vermunt, Lisa, additional, Vancura, Adrienne, additional, Muller, Mirte, additional, Niemeijer, Anna-Larissa N., additional, Tannous, Jihane, additional, Meijer, Laura L., additional, Le Large, Tessa Y.S., additional, Mantini, Giulia, additional, Wondergem, Niels E., additional, Heinhuis, Kimberley M., additional, van Wilpe, Sandra, additional, Smits, A. Josien, additional, Drees, Esther E.E., additional, Roos, Eva, additional, Leurs, Cyra E., additional, Tjon Kon Fat, Lee-Ann, additional, van der Lelij, Ewoud J., additional, Dwarshuis, Govert, additional, Kamphuis, Maarten J., additional, Visser, Lisanne E., additional, Harting, Romee, additional, Gregory, Annemijn, additional, Schweiger, Markus W., additional, Wedekind, Laurine E., additional, Ramaker, Jip, additional, Zwaan, Kenn, additional, Verschueren, Heleen, additional, Bahce, Idris, additional, de Langen, Adrianus J., additional, Smit, Egbert F., additional, van den Heuvel, Michel M., additional, Hartemink, Koen J., additional, Kuijpers, Marijke J.E., additional, oude Egbrink, Mirjam G.A., additional, Griffioen, Arjan W., additional, Rossel, Rafael, additional, Hiltermann, T. Jeroen N., additional, Lee-Lewandrowski, Elizabeth, additional, Lewandrowski, Kent B., additional, De Witt Hamer, Philip C., additional, Kouwenhoven, Mathilde, additional, Reijneveld, Jaap C., additional, Leenders, William P.J., additional, Hoeben, Ann, additional, Verdonck-de Leeuw, Irma M., additional, Leemans, C. René, additional, Baatenburg de Jong, Robert J., additional, Terhaard, Chris H.J., additional, Takes, Robert P., additional, Langendijk, Johannes A., additional, de Jager, Saskia C., additional, Kraaijeveld, Adriaan O., additional, Pasterkamp, Gerard, additional, Smits, Minke, additional, Schalken, Jack A., additional, Łapińska-Szumczyk, Sylwia, additional, Łojkowska, Anna, additional, Żaczek, Anna J., additional, Lokhorst, Henk, additional, van de Donk, Niels W.C.J., additional, Nijhof, Inger, additional, Prins, Henk-Jan, additional, Zijlstra, Josée M., additional, Idema, Sander, additional, Baayen, Johannes C., additional, Teunissen, Charlotte E., additional, Killestein, Joep, additional, Besselink, Marc G., additional, Brammen, Lindsay, additional, Bachleitner-Hofmann, Thomas, additional, Mateen, Farrah, additional, Plukker, John T.M., additional, Heger, Michal, additional, de Mast, Quirijn, additional, Lisman, Ton, additional, Pegtel, D. Michiel, additional, Bogaard, Harm-Jan, additional, Jassem, Jacek, additional, Supernat, Anna, additional, Mehra, Niven, additional, Gerritsen, Winald, additional, de Kroon, Cornelis D., additional, Lok, Christianne A.R., additional, Piek, Jurgen M.J., additional, Steeghs, Neeltje, additional, van Houdt, Winan J., additional, Brakenhoff, Ruud H., additional, Sonke, Gabe S., additional, Verheul, Henk M., additional, Giovannetti, Elisa, additional, Kazemier, Geert, additional, Sabrkhany, Siamack, additional, Schuuring, Ed, additional, Sistermans, Erik A., additional, Wolthuis, Rob, additional, Meijers-Heijboer, Hanne, additional, Dorsman, Josephine, additional, Oudejans, Cees, additional, Ylstra, Bauke, additional, Westerman, Bart A., additional, van den Broek, Daan, additional, Koppers-Lalic, Danijela, additional, Wesseling, Pieter, additional, Nilsson, R. Jonas A., additional, Vandertop, W. Peter, additional, Noske, David P., additional, Tannous, Bakhos A., additional, Sol, Nik, additional, Best, Myron G., additional, and Wurdinger, Thomas, additional
- Published
- 2022
- Full Text
- View/download PDF
3. Abstract LB168: Platelet RNA signature enables early and accurate detection of ovarian cancer: An intercontinental, biomarker identification study
- Author
-
Gao, Yue, primary, Liu, Chun-Jie, additional, Li, Hua-Yi, additional, Xiong, Xiao-Ming, additional, In ‘t Veld, Sjors G.j.g., additional, Li, Gui-Ling, additional, Liu, Jia-Hao, additional, Cai, Guang-Yao, additional, Xie, Gui-Yan, additional, Zeng, Shao-Qing, additional, Wu, Yuan, additional, Chi, Jian-Hua, additional, Zhang, Qiong, additional, Jiao, Xiao-Fei, additional, Shi, Lin-Li, additional, Lu, Wan-Rong, additional, Lv, Wei-Guo, additional, Yang, Xing-Sheng, additional, Piek, Jurgen M.j., additional, de Kroon, Cornelis D, additional, Lok, C.a.r., additional, Supernat, Anna, additional, Łapińska-Szumczyk, Sylwia, additional, Łojkowska, Anna, additional, Żaczek, Anna J., additional, Jassem, Jacek, additional, Tannous, Bakhos A., additional, Sol, Nik, additional, Post, Edward, additional, Best, Myron G., additional, Kong, Bei-Hua, additional, Xie, Xing, additional, Ma, Ding, additional, Wurdinger, Thomas, additional, Guo, An-Yuan, additional, and Gao, Qing-Lei, additional
- Published
- 2022
- Full Text
- View/download PDF
4. Detection and localization of early- and late-stage cancers using platelet RNA
- Author
-
In ’t Veld, Sjors G.J.G., Arkani, Mohammad, Post, Edward, Antunes-Ferreira, Mafalda, D'Ambrosi, Silvia, Vessies, Daan C.L., Vermunt, Lisa, Vancura, Adrienne, Muller, Mirte, Niemeijer, Anna Larissa N., Tannous, Jihane, Meijer, Laura L., Le Large, Tessa Y.S., Mantini, Giulia, Wondergem, Niels E., Heinhuis, Kimberley M., van Wilpe, Sandra, Smits, A. Josien, Drees, Esther E.E., Roos, Eva, Leurs, Cyra E., Tjon Kon Fat, Lee Ann, van der Lelij, Ewoud J., Dwarshuis, Govert, Kamphuis, Maarten J., Visser, Lisanne E., Harting, Romee, Gregory, Annemijn, Schweiger, Markus W., Wedekind, Laurine E., Ramaker, Jip, Zwaan, Kenn, Verschueren, Heleen, Bahce, Idris, de Langen, Adrianus J., Smit, Egbert F., van den Heuvel, Michel M., Hartemink, Koen J., Kuijpers, Marijke J.E., oude Egbrink, Mirjam G.A., Griffioen, Arjan W., Rossel, Rafael, Hiltermann, T. Jeroen N., Lee-Lewandrowski, Elizabeth, Lewandrowski, Kent B., De Witt Hamer, Philip C., Kouwenhoven, Mathilde, Reijneveld, Jaap C., Leenders, William P.J., Hoeben, Ann, Verdonck-de Leeuw, Irma M., Leemans, C. René, Baatenburg de Jong, Robert J., Terhaard, Chris H.J., Takes, Robert P., Langendijk, Johannes A., de Jager, Saskia C., Kraaijeveld, Adriaan O., Pasterkamp, Gerard, Smits, Minke, Schalken, Jack A., Łapińska-Szumczyk, Sylwia, Łojkowska, Anna, Żaczek, Anna J., Lokhorst, Henk, van de Donk, Niels W.C.J., Nijhof, Inger, Prins, Henk Jan, Zijlstra, Josée M., Idema, Sander, Baayen, Johannes C., Teunissen, Charlotte E., Killestein, Joep, Besselink, Marc G., Brammen, Lindsay, Bachleitner-Hofmann, Thomas, Mateen, Farrah, Plukker, John T.M., Heger, Michal, de Mast, Quirijn, Lisman, Ton, Pegtel, D. Michiel, Bogaard, Harm Jan, Jassem, Jacek, Supernat, Anna, Mehra, Niven, Gerritsen, Winald, de Kroon, Cornelis D., Lok, Christianne A.R., Piek, Jurgen M.J., Steeghs, Neeltje, van Houdt, Winan J., Brakenhoff, Ruud H., Sonke, Gabe S., Verheul, Henk M., Giovannetti, Elisa, Kazemier, Geert, Sabrkhany, Siamack, Schuuring, Ed, Sistermans, Erik A., Wolthuis, Rob, Meijers-Heijboer, Hanne, Dorsman, Josephine, Oudejans, Cees, Ylstra, Bauke, Westerman, Bart A., van den Broek, Daan, Koppers-Lalic, Danijela, Wesseling, Pieter, Nilsson, R. Jonas A., Vandertop, W. Peter, Noske, David P., Tannous, Bakhos A., Sol, Nik, Best, Myron G., Wurdinger, Thomas, In ’t Veld, Sjors G.J.G., Arkani, Mohammad, Post, Edward, Antunes-Ferreira, Mafalda, D'Ambrosi, Silvia, Vessies, Daan C.L., Vermunt, Lisa, Vancura, Adrienne, Muller, Mirte, Niemeijer, Anna Larissa N., Tannous, Jihane, Meijer, Laura L., Le Large, Tessa Y.S., Mantini, Giulia, Wondergem, Niels E., Heinhuis, Kimberley M., van Wilpe, Sandra, Smits, A. Josien, Drees, Esther E.E., Roos, Eva, Leurs, Cyra E., Tjon Kon Fat, Lee Ann, van der Lelij, Ewoud J., Dwarshuis, Govert, Kamphuis, Maarten J., Visser, Lisanne E., Harting, Romee, Gregory, Annemijn, Schweiger, Markus W., Wedekind, Laurine E., Ramaker, Jip, Zwaan, Kenn, Verschueren, Heleen, Bahce, Idris, de Langen, Adrianus J., Smit, Egbert F., van den Heuvel, Michel M., Hartemink, Koen J., Kuijpers, Marijke J.E., oude Egbrink, Mirjam G.A., Griffioen, Arjan W., Rossel, Rafael, Hiltermann, T. Jeroen N., Lee-Lewandrowski, Elizabeth, Lewandrowski, Kent B., De Witt Hamer, Philip C., Kouwenhoven, Mathilde, Reijneveld, Jaap C., Leenders, William P.J., Hoeben, Ann, Verdonck-de Leeuw, Irma M., Leemans, C. René, Baatenburg de Jong, Robert J., Terhaard, Chris H.J., Takes, Robert P., Langendijk, Johannes A., de Jager, Saskia C., Kraaijeveld, Adriaan O., Pasterkamp, Gerard, Smits, Minke, Schalken, Jack A., Łapińska-Szumczyk, Sylwia, Łojkowska, Anna, Żaczek, Anna J., Lokhorst, Henk, van de Donk, Niels W.C.J., Nijhof, Inger, Prins, Henk Jan, Zijlstra, Josée M., Idema, Sander, Baayen, Johannes C., Teunissen, Charlotte E., Killestein, Joep, Besselink, Marc G., Brammen, Lindsay, Bachleitner-Hofmann, Thomas, Mateen, Farrah, Plukker, John T.M., Heger, Michal, de Mast, Quirijn, Lisman, Ton, Pegtel, D. Michiel, Bogaard, Harm Jan, Jassem, Jacek, Supernat, Anna, Mehra, Niven, Gerritsen, Winald, de Kroon, Cornelis D., Lok, Christianne A.R., Piek, Jurgen M.J., Steeghs, Neeltje, van Houdt, Winan J., Brakenhoff, Ruud H., Sonke, Gabe S., Verheul, Henk M., Giovannetti, Elisa, Kazemier, Geert, Sabrkhany, Siamack, Schuuring, Ed, Sistermans, Erik A., Wolthuis, Rob, Meijers-Heijboer, Hanne, Dorsman, Josephine, Oudejans, Cees, Ylstra, Bauke, Westerman, Bart A., van den Broek, Daan, Koppers-Lalic, Danijela, Wesseling, Pieter, Nilsson, R. Jonas A., Vandertop, W. Peter, Noske, David P., Tannous, Bakhos A., Sol, Nik, Best, Myron G., and Wurdinger, Thomas
- Abstract
Cancer patients benefit from early tumor detection since treatment outcomes are more favorable for less advanced cancers. Platelets are involved in cancer progression and are considered a promising biosource for cancer detection, as they alter their RNA content upon local and systemic cues. We show that tumor-educated platelet (TEP) RNA-based blood tests enable the detection of 18 cancer types. With 99% specificity in asymptomatic controls, thromboSeq correctly detected the presence of cancer in two-thirds of 1,096 blood samples from stage I–IV cancer patients and in half of 352 stage I–III tumors. Symptomatic controls, including inflammatory and cardiovascular diseases, and benign tumors had increased false-positive test results with an average specificity of 78%. Moreover, thromboSeq determined the tumor site of origin in five different tumor types correctly in over 80% of the cancer patients. These results highlight the potential properties of TEP-derived RNA panels to supplement current approaches for blood-based cancer screening.
- Published
- 2022
5. Detection and localization of early- and late-stage cancers using platelet RNA
- Author
-
Pharmaceutics, Sub Membrane Biochemistry & Biophysics, Afd Pharmaceutics, In ’t Veld, Sjors G.J.G., Arkani, Mohammad, Post, Edward, Antunes-Ferreira, Mafalda, D'Ambrosi, Silvia, Vessies, Daan C.L., Vermunt, Lisa, Vancura, Adrienne, Muller, Mirte, Niemeijer, Anna Larissa N., Tannous, Jihane, Meijer, Laura L., Le Large, Tessa Y.S., Mantini, Giulia, Wondergem, Niels E., Heinhuis, Kimberley M., van Wilpe, Sandra, Smits, A. Josien, Drees, Esther E.E., Roos, Eva, Leurs, Cyra E., Tjon Kon Fat, Lee Ann, van der Lelij, Ewoud J., Dwarshuis, Govert, Kamphuis, Maarten J., Visser, Lisanne E., Harting, Romee, Gregory, Annemijn, Schweiger, Markus W., Wedekind, Laurine E., Ramaker, Jip, Zwaan, Kenn, Verschueren, Heleen, Bahce, Idris, de Langen, Adrianus J., Smit, Egbert F., van den Heuvel, Michel M., Hartemink, Koen J., Kuijpers, Marijke J.E., oude Egbrink, Mirjam G.A., Griffioen, Arjan W., Rossel, Rafael, Hiltermann, T. Jeroen N., Lee-Lewandrowski, Elizabeth, Lewandrowski, Kent B., De Witt Hamer, Philip C., Kouwenhoven, Mathilde, Reijneveld, Jaap C., Leenders, William P.J., Hoeben, Ann, Verdonck-de Leeuw, Irma M., Leemans, C. René, Baatenburg de Jong, Robert J., Terhaard, Chris H.J., Takes, Robert P., Langendijk, Johannes A., de Jager, Saskia C., Kraaijeveld, Adriaan O., Pasterkamp, Gerard, Smits, Minke, Schalken, Jack A., Łapińska-Szumczyk, Sylwia, Łojkowska, Anna, Żaczek, Anna J., Lokhorst, Henk, van de Donk, Niels W.C.J., Nijhof, Inger, Prins, Henk Jan, Zijlstra, Josée M., Idema, Sander, Baayen, Johannes C., Teunissen, Charlotte E., Killestein, Joep, Besselink, Marc G., Brammen, Lindsay, Bachleitner-Hofmann, Thomas, Mateen, Farrah, Plukker, John T.M., Heger, Michal, de Mast, Quirijn, Lisman, Ton, Pegtel, D. Michiel, Bogaard, Harm Jan, Jassem, Jacek, Supernat, Anna, Mehra, Niven, Gerritsen, Winald, de Kroon, Cornelis D., Lok, Christianne A.R., Piek, Jurgen M.J., Steeghs, Neeltje, van Houdt, Winan J., Brakenhoff, Ruud H., Sonke, Gabe S., Verheul, Henk M., Giovannetti, Elisa, Kazemier, Geert, Sabrkhany, Siamack, Schuuring, Ed, Sistermans, Erik A., Wolthuis, Rob, Meijers-Heijboer, Hanne, Dorsman, Josephine, Oudejans, Cees, Ylstra, Bauke, Westerman, Bart A., van den Broek, Daan, Koppers-Lalic, Danijela, Wesseling, Pieter, Nilsson, R. Jonas A., Vandertop, W. Peter, Noske, David P., Tannous, Bakhos A., Sol, Nik, Best, Myron G., Wurdinger, Thomas, Pharmaceutics, Sub Membrane Biochemistry & Biophysics, Afd Pharmaceutics, In ’t Veld, Sjors G.J.G., Arkani, Mohammad, Post, Edward, Antunes-Ferreira, Mafalda, D'Ambrosi, Silvia, Vessies, Daan C.L., Vermunt, Lisa, Vancura, Adrienne, Muller, Mirte, Niemeijer, Anna Larissa N., Tannous, Jihane, Meijer, Laura L., Le Large, Tessa Y.S., Mantini, Giulia, Wondergem, Niels E., Heinhuis, Kimberley M., van Wilpe, Sandra, Smits, A. Josien, Drees, Esther E.E., Roos, Eva, Leurs, Cyra E., Tjon Kon Fat, Lee Ann, van der Lelij, Ewoud J., Dwarshuis, Govert, Kamphuis, Maarten J., Visser, Lisanne E., Harting, Romee, Gregory, Annemijn, Schweiger, Markus W., Wedekind, Laurine E., Ramaker, Jip, Zwaan, Kenn, Verschueren, Heleen, Bahce, Idris, de Langen, Adrianus J., Smit, Egbert F., van den Heuvel, Michel M., Hartemink, Koen J., Kuijpers, Marijke J.E., oude Egbrink, Mirjam G.A., Griffioen, Arjan W., Rossel, Rafael, Hiltermann, T. Jeroen N., Lee-Lewandrowski, Elizabeth, Lewandrowski, Kent B., De Witt Hamer, Philip C., Kouwenhoven, Mathilde, Reijneveld, Jaap C., Leenders, William P.J., Hoeben, Ann, Verdonck-de Leeuw, Irma M., Leemans, C. René, Baatenburg de Jong, Robert J., Terhaard, Chris H.J., Takes, Robert P., Langendijk, Johannes A., de Jager, Saskia C., Kraaijeveld, Adriaan O., Pasterkamp, Gerard, Smits, Minke, Schalken, Jack A., Łapińska-Szumczyk, Sylwia, Łojkowska, Anna, Żaczek, Anna J., Lokhorst, Henk, van de Donk, Niels W.C.J., Nijhof, Inger, Prins, Henk Jan, Zijlstra, Josée M., Idema, Sander, Baayen, Johannes C., Teunissen, Charlotte E., Killestein, Joep, Besselink, Marc G., Brammen, Lindsay, Bachleitner-Hofmann, Thomas, Mateen, Farrah, Plukker, John T.M., Heger, Michal, de Mast, Quirijn, Lisman, Ton, Pegtel, D. Michiel, Bogaard, Harm Jan, Jassem, Jacek, Supernat, Anna, Mehra, Niven, Gerritsen, Winald, de Kroon, Cornelis D., Lok, Christianne A.R., Piek, Jurgen M.J., Steeghs, Neeltje, van Houdt, Winan J., Brakenhoff, Ruud H., Sonke, Gabe S., Verheul, Henk M., Giovannetti, Elisa, Kazemier, Geert, Sabrkhany, Siamack, Schuuring, Ed, Sistermans, Erik A., Wolthuis, Rob, Meijers-Heijboer, Hanne, Dorsman, Josephine, Oudejans, Cees, Ylstra, Bauke, Westerman, Bart A., van den Broek, Daan, Koppers-Lalic, Danijela, Wesseling, Pieter, Nilsson, R. Jonas A., Vandertop, W. Peter, Noske, David P., Tannous, Bakhos A., Sol, Nik, Best, Myron G., and Wurdinger, Thomas
- Published
- 2022
6. imPlatelet classifier: image‐converted RNA biomarker profiles enable blood‐based cancer diagnostics
- Author
-
Pastuszak, Krzysztof, primary, Supernat, Anna, additional, Best, Myron G., additional, In 't Veld, Sjors G.J.G., additional, Łapińska‐Szumczyk, Sylwia, additional, Łojkowska, Anna, additional, Różański, Robert, additional, Żaczek, Anna J., additional, Jassem, Jacek, additional, Würdinger, Thomas, additional, and Stokowy, Tomasz, additional
- Published
- 2021
- Full Text
- View/download PDF
7. Platelet RNA Signature Enables Early and Accurate Detection of Ovarian Cancer: An Intercontinental, Biomarker Identification Study
- Author
-
Gao, Yue, primary, Liu, Chun-Jie, additional, Xiong, Xiaoming, additional, In ‘t Veld, Sjors G.J.G., additional, Li, Guiling, additional, Li, Huayi, additional, Liu, Jiahao, additional, Cai, Guangyao, additional, Xie, Gui-Yan, additional, Zeng, Shaoqing, additional, Wu, Yuan, additional, Chi, Jianhua, additional, Zhang, Qiong, additional, Jiao, Xiaofei, additional, shi, linli, additional, lu, wanrong, additional, Lu, Weiguo, additional, Yang, Xingsheng, additional, M.J. Piek, Jurgen, additional, D de Kroon, Cornelis, additional, Lok, C.A.R., additional, Supernat, Anna, additional, Łapińska-Szumczyk, Sylwia, additional, Łojkowska, Anna, additional, J Żaczek, Anna, additional, Jassem, Jacek, additional, Tannous, Bakhos A., additional, Sol, Nik, additional, Post, Edward, additional, G. Best, Myron, additional, Kong, Beihua, additional, Xie, Xing, additional, Ma, Ding, additional, Wurdinger, Thomas, additional, Guo, An-yuan, additional, and Gao, Qinglei, additional
- Published
- 2021
- Full Text
- View/download PDF
8. Chemosensitivity testing in ovarian cancer – prospects for the future
- Author
-
Pogońska, Paulina, primary, Wydra, Dariusz, additional, Kobierski, Juliusz, additional, Łojkowska, Anna, additional, and Serkies, Krystyna, additional
- Published
- 2014
- Full Text
- View/download PDF
9. Platelet RNA enables accurate detection of ovarian cancer: an intercontinental, biomarker identification study.
- Author
-
Gao Y, Liu CJ, Li HY, Xiong XM, Li GL, In 't Veld SGJG, Cai GY, Xie GY, Zeng SQ, Wu Y, Chi JH, Liu JH, Zhang Q, Jiao XF, Shi LL, Lu WR, Lv WG, Yang XS, Piek JMJ, de Kroon CD, Lok CAR, Supernat A, Łapińska-Szumczyk S, Łojkowska A, Żaczek AJ, Jassem J, Tannous BA, Sol N, Post E, Best MG, Kong BH, Xie X, Ma D, Wurdinger T, Guo AY, and Gao QL
- Subjects
- Humans, Female, Biomarkers, Tumor genetics, China, Blood Platelets pathology, Ovarian Neoplasms diagnosis, Ovarian Neoplasms genetics, Ovarian Neoplasms pathology
- Abstract
Platelets are reprogrammed by cancer via a process called education, which favors cancer development. The transcriptional profile of tumor-educated platelets (TEPs) is skewed and therefore practicable for cancer detection. This intercontinental, hospital-based, diagnostic study included 761 treatment-naïve inpatients with histologically confirmed adnexal masses and 167 healthy controls from nine medical centers (China, n = 3; Netherlands, n = 5; Poland, n = 1) between September 2016 and May 2019. The main outcomes were the performance of TEPs and their combination with CA125 in two Chinese (VC1 and VC2) and the European (VC3) validation cohorts collectively and independently. Exploratory outcome was the value of TEPs in public pan-cancer platelet transcriptome datasets. The AUCs for TEPs in the combined validation cohort, VC1, VC2, and VC3 were 0.918 (95% CI 0.889-0.948), 0.923 (0.855-0.990), 0.918 (0.872-0.963), and 0.887 (0.813-0.960), respectively. Combination of TEPs and CA125 demonstrated an AUC of 0.922 (0.889-0.955) in the combined validation cohort; 0.955 (0.912-0.997) in VC1; 0.939 (0.901-0.977) in VC2; 0.917 (0.824-1.000) in VC3. For subgroup analysis, TEPs exhibited an AUC of 0.858, 0.859, and 0.920 to detect early-stage, borderline, non-epithelial diseases and 0.899 to discriminate ovarian cancer from endometriosis. TEPs had robustness, compatibility, and universality for preoperative diagnosis of ovarian cancer since it withstood validations in populations of different ethnicities, heterogeneous histological subtypes, and early-stage ovarian cancer. However, these observations warrant prospective validations in a larger population before clinical utilities., (©The Author(s) 2022. Published by Oxford University Press on behalf of Higher Education Press.)
- Published
- 2023
- Full Text
- View/download PDF
10. [Chemosensitivity testing in ovarian cancer--prospects for the future].
- Author
-
Pogońska P, Wydra D, Serkies K, Kobierski J, and Łojkowska A
- Subjects
- Antineoplastic Agents pharmacology, Antineoplastic Combined Chemotherapy Protocols pharmacology, Disease-Free Survival, Drug Screening Assays, Antitumor methods, Female, Humans, Prognosis, Antineoplastic Agents therapeutic use, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Drug Resistance, Neoplasm, Ovarian Neoplasms drug therapy
- Abstract
Individualization of treatment on the basis of in vitro chemosensitivity testing constitutes one of the aims of contemporary oncology Although previous studies report advantages resulting from chemosensitivity laboratory tests, the issue remains an area of interest. The aim of this study was to discuss chemosensitivity assay methods of ovarian cancer cells. ATP-TCA (ATP-based tumor chemosensitivity assay) is the most investigated chemosensitivity test in ovarian cancer with well-documented efficacy Potentially it is possible to use the xCELLigence system to evaluate chemosensitivity of ovarian cancer cells by measuring their colony volume but application of this method remains in the experimental phase. Optimization of ovarian cancer treatment would improve chemotherapy results, thus increasing the overall survival, improving the quality of patient life, decreasing chemotherapy-related toxicity and resulting in economic benefits owing to better drug use.
- Published
- 2014
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.