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Your search keyword '"Čemažar M"' showing total 138 results
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138 results on '"Čemažar M"'

1. Current Operating Procedure (COP) for Bleomycin ElectroScleroTherapy (BEST) of low-flow vascular malformations

Author

Muir Tobian, Wohlgemuth Walter A, Cemazar Maja, Bertino Giulia, Groselj Ales, Ratnam Lakshmi A, McCafferty Ian, Wildgruber Moritz, Gebauer Bernhard, de Terlizzi Francesca, Zanasi Alessandro, and Sersa Gregor

Subjects
low-flow vascular malformations, bleomycin sclerotherapy, bleomycin electrosclerotherapy, best, Medical physics. Medical radiology. Nuclear medicine, R895-920
Abstract

Bleomycin ElectroScleroTherapy (BEST) is a new approach in the treatment of vascular malformations. After bleomycin is administered to the malformation, electric pulses are applied to the target area to enhance the effectiveness of bleomycin. The mode of action is comparable to the effect of electrochemotherapy on tumour vasculature. For the wider and safer use of BEST in the clinical treatment of low-flow vascular malformations, this Current Operating Procedure (COP) is being prepared. It is a proposal for the clinical standardisation of BEST using the Cliniporator® as the electrical pulse generator with its associated electrodes. The electrical parameters considered in this protocol are those validated by the European Standard Operating Procedures for Electrochemotherapy (ESOPE) with the Cliniporator®.

Published
2024
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2. Combining Electrochemotherapy with Targeted Therapy Olaparib in vitro

Author

Bosnjak, M., Janzic, L., Cemazar, M., Sersa, G., Magjarevic, Ratko, Series Editor, Ładyżyński, Piotr, Associate Editor, Ibrahim, Fatimah, Associate Editor, Lackovic, Igor, Associate Editor, Rock, Emilio Sacristan, Associate Editor, Jarm, Tomaz, editor, Cvetkoska, Aleksandra, editor, Mahnič-Kalamiza, Samo, editor, and Miklavcic, Damijan, editor

Published
2021
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7. Antimetastatic Potential in Mice after Gene Therapy with Plasmid AMEP

Author

Bosnjak, M., Kamensek, U., Sedlar, A., Cemazar, M., Zavrsnik, J., Turk, B., Bouquet, Celine, Sersa, G., MAGJAREVIC, Ratko, Editor-in-chief, Ladyzynsk, Piotr, Series editor, Ibrahim, Fatimah, Series editor, Lacković, Igor, Series editor, Rock, Emilio Sacristan, Series editor, Jarm, Tomaz, editor, and Kramar, Peter, editor

Published
2016
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18. Proper Patient and Treatment Parameters Selection for Electrochemotherapy of Deep Seated Head and Neck Tumors

Author

Groselj, A., Kos, B., Cemazar, M., Urbancic, J., Kragelj, G., Bosnjak, M., Veberic, B., Jarm, T., Strojan, P., Miklavcic, D., Sersa, G., MAGJAREVIC, Ratko, Editor-in-chief, Ladyzynsk, Piotr, Series editor, Ibrahim, Fatimah, Series editor, Lacković, Igor, Series editor, Rock, Emilio Sacristan, Series editor, Jarm, Tomaz, editor, and Kramar, Peter, editor

Published
2016
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19. Technical Approach for Coupling Treatment Planning with Navigation Systems for Electroporation-Based Treatments

Author

Kos, B., Grošelj, A., Čemažar, M., Urbančič, J., Kragelj, G., Bošnjak, M., Veberič, B., Strojan, P., Miklavčič, D., Serša, G., MAGJAREVIC, Ratko, Editor-in-chief, Ladyzynsk, Piotr, Series editor, Ibrahim, Fatimah, Series editor, Lacković, Igor, Series editor, Rock, Emilio Sacristan, Series editor, Jarm, Tomaz, editor, and Kramar, Peter, editor

Published
2016
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20. Treatment of Primary Liver Tumors with Electrochemotherapy – Clinical Trial

Author

Đokic, M., Trotovsek, B., Sojar, V., Stanisavljevic, D., Jansa, R., Popovic, P., Cemazar, M., Miklavcic, D., Pozar, N., Kavcic, P., Tomazic, A., Petric, M., Sersa, G., MAGJAREVIC, Ratko, Editor-in-chief, Ladyzynsk, Piotr, Series editor, Ibrahim, Fatimah, Series editor, Lacković, Igor, Series editor, Rock, Emilio Sacristan, Series editor, Jarm, Tomaz, editor, and Kramar, Peter, editor

Published
2016
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21. Electrochemotherapy of Colorectal Liver Metastases – Trial Update

Author

Edhemovic, I., Brecelj, E., Ivanecz, A., Gasljevic, G., Music, M. Marolt, Jarm, T., Kos, B., Bosnjak, M., Cemazar, M., Miklavcic, D., Potrc, S., Gadzijev, E., Sersa, G., MAGJAREVIC, Ratko, Editor-in-chief, Ladyzynsk, Piotr, Series editor, Ibrahim, Fatimah, Series editor, Lacković, Igor, Series editor, Rock, Emilio Sacristan, Series editor, Jarm, Tomaz, editor, and Kramar, Peter, editor

Published
2016
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35. Determination of copper and other trace elements in serum samples from patients with biliary tract cancers: prospective noninterventional nonrandomized clinical study protocol

Author

Rebersek Martina, Hribernik Nezka, Markovic Katarina, Markovic Stefan, Valentinuzzi Katja Ursic, Cemazar Maja, Zuliani Tea, Milacic Radmila, and Scancar Janez

Subjects
trace elements, copper, predictive biomarkers of response, biliary tract cancer, systemic treatment, Medical physics. Medical radiology. Nuclear medicine, R895-920
Abstract

Biliary tract cancers (BTCs) are usually diagnosed at an advanced stage, when the disease is incurable. Currently used tumor biomarkers have limited diagnostic value for BTCs, so there is an urgent need for sensitive and specific biomarkers for their earlier diagnosis. Deregulation of the homeostasis of trace elements is involved in the carcinogenesis of different cancers, including BTCs. The objective of the study is to determine/compare the total concentrations of copper (Cu), zinc (Zn) and iron (Fe) and the proportions of free Cu and Cu bound to ceruloplasmin (Cp) and the isotopic ratio of 65Cu/63Cu in serum samples from healthy volunteers and cancer patients using inductively coupled plasma-mass spectrometry-based methods (ICP-MS).

Published
2024
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36. Sarcopenic obesity in cancer

Author

Jurdana Mihaela and Cemazar Maja

Subjects
sarcopenia, obesity, cancer, inflammation, Medical physics. Medical radiology. Nuclear medicine, R895-920
Abstract

Sarcopenic obesity is a relatively new term. It is a clinical condition characterized by sarcopenia (loss of muscle mass and function) and obesity (increase in fat mass) that mainly affects older adults. As the incidence of sarcopenia and obesity increases worldwide, sarcopenic obesity is becoming a greater problem also in cancer patients. In fact, sarcopenic obesity is associated with poorer treatment outcomes, longer hospital stays, physical disability, and shorter survival in several cancers. Oxidative stress, lipotoxicity, and systemic inflammation, as well as altered expression of skeletal muscle anti-inflammatory myokines in sarcopenic obesity, are also associated with carcinogenesis.

Published
2024
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39. Bleomycin electrosclerotherapy (BEST) for the treatment of vascular malformations. An International Network for Sharing Practices on Electrochemotherapy (InspECT) study group report

Author

Muir Tobian, Bertino Giulia, Groselj Ales, Ratnam Lakshmi, Kis Erika, Odili Joy, McCafferty Ian, Wohlgemuth Walter A, Cemazar Maja, Krt Aljosa, Bosnjak Masa, Zanasi Alessandro, Battista Michela, de Terlizzi Francesca, Campana Luca G, and Sersa Gregor

Subjects
vascular malformations, bleomycin electrosclerotherapy, bleomycin, electrochemotherapy, Medical physics. Medical radiology. Nuclear medicine, R895-920
Abstract

Biomedical applications of electroporation are expanding out of the field of oncology into vaccination, treatment of arrhythmias and now in the treatment of vascular malformations. Bleomycin is a widely used sclerosing agent in the treatment of various vascular malformations. The application of electric pulses in addition to bleomycin enhances the effectiveness of the drug, as demonstrated by electrochemotherapy, which utilizes bleomycin in the treatment of tumors. The same principle is used in bleomycin electrosclerotherapy (BEST). The approach seems to be effective in the treatment of low-flow (venous and lymphatic) and, potentially, even high-flow (arteriovenous) malformations. Although there are only a few published reports to date, the surgical community is interested, and an increasing number of centers are applying BEST in the treatment of vascular malformations. Within the International Network for Sharing Practices on Electrochemotherapy (InspECT) consortium, a dedicated working group has been constituted to develop standard operating procedures for BEST and foster clinical trials.

Published
2023
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41. Treatment of vulvar cancer recurrences with electrochemotherapy – a detailed analysis of possible causes for unsuccessful treatment

Author

Vivod Gregor, Jesenko Tanja, Gasljevic Gorana, Kovacevic Nina, Bosnjak Masa, Sersa Gregor, Merlo Sebastjan, and Cemazar Maja

Subjects
electrochemotherapy, bleomycin, vulvar cancer, recurrence, Medical physics. Medical radiology. Nuclear medicine, R895-920
Abstract

Electrochemotherapy has good local effectiveness in the treatment of vulvar cancer. Most studies have reported the safety and effectiveness of electrochemotherapy for palliative treatment of gynecological cancers and mostly vulvar squamous cell carcinoma. Some tumors, however, fail to respond to electrochemotherapy. The biological features/determinants for the nonresponsiveness are not determined yet.

Published
2023
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45. Treatment of skin tumors with intratumoral interleukin 12 gene electrotransfer in the head and neck region: a first-in-human clinical trial protocol

Author

Groselj Ales, Bosnjak Masa, Jesenko Tanja, Cemazar Maja, Markelc Bostjan, Strojan Primoz, and Sersa Gregor

Subjects
gene therapy, interleukin 12, gene electrotransfer, basal cell carcinoma, head and neck region, Medical physics. Medical radiology. Nuclear medicine, R895-920
Abstract

Immune therapies are currently under intensive investigation providing in many cases excellent responses in different tumors. Other possible approach for immunotherapy is a targeted intratumoral delivery of interleukin 12 (IL-12), a cytokine with anti-tumor effectiveness. Due to its immunomodulatory action, it can be used as an imunostimulating component to in situ vaccinating effect of local ablative therapies. We have developed a phIL12 plasmid devoid of antibiotic resistance marker with a transgene for human IL-12 p70 protein. The plasmid can be delivered intratumorally by gene electrotransfer (GET).

Published
2022
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47. Expression of DNA-damage response and repair genes after exposure to DNA-damaging agents in isogenic head and neck cells with altered radiosensitivity

Author

Todorovic Vesna, Groselj Blaz, Cemazar Maja, Prevc Ajda, Zakelj Martina Niksic, Strojan Primoz, and Sersa Gregor

Subjects
head and neck cancer, squamous cell carcinoma, radioresistance, irradiation, dna-damaging agents, gene expression profiles, Medical physics. Medical radiology. Nuclear medicine, R895-920
Abstract

Increased radioresistance due to previous irradiation or radiosensitivity due to human papilloma virus (HPV) infection can be observed in head and neck squamous cell carcinoma (HNSCC). The DNA-damage response of cells after exposure to DNA-damaging agents plays a crucial role in determining the fate of exposed cells. Tightly regulated and interconnected signaling networks are activated to detect, signal the presence of and repair the DNA damage. Novel therapies targeting the DNA-damage response are emerging; however, an improved understanding of the complex signaling networks involved in tumor radioresistance and radiosensitivity is needed.

Published
2022
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48. Sunitinib potentiates the cytotoxic effect of electrochemotherapy in pancreatic carcinoma cells

Author

Bosnjak Masa, Jesenko Tanja, Markelc Bostjan, Cerovsek Anja, Sersa Gregor, and Cemazar Maja

Subjects
electrochemotherapy, ect, pancreas, sunitinib, bleomycin, tyrosine-kinase inhibitors, pancreatic cancer, Medical physics. Medical radiology. Nuclear medicine, R895-920
Abstract

One of the new treatment options for unresectable locally advanced pancreatic cancer is electrochemotherapy (ECT), a local ablative therapy that potentiates the entry of chemotherapeutic drugs into the cells, by the application of an electric field to the tumor. Its feasibility and safety were demonstrated in preclinical and clinical studies; however, there is a lack of preclinical studies assessing the actions of different drugs used in ECT, their mechanisms and interactions with other target drugs that are used in clinical practice.

Published
2022
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49. MitomiRs: their roles in mitochondria and importance in cancer cell metabolism

Author

Rencelj Andrej, Gvozdenovic Nada, and Cemazar Maja

Subjects
micrornas, mitomir, mitochondria, cancer, cancer cell metabolism, Medical physics. Medical radiology. Nuclear medicine, R895-920
Abstract

MicroRNAs (miRNAs) are short non-coding RNAs that play important roles in almost all biological pathways. They regulate post-transcriptional gene expression by binding to the 3’untranslated region (3’UTR) of messenger RNAs (mRNAs). MitomiRs are miRNAs of nuclear or mitochondrial origin that are localized in mitochondria and have a crucial role in regulation of mitochondrial function and metabolism. In eukaryotes, mitochondria are the major sites of oxidative metabolism of sugars, lipids, amino acids, and other bio-macromolecules. They are also the main sites of adenosine triphosphate (ATP) production.

Published
2021
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