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Background/aim: A subset of melanocytic tumors with spitzoid morphology may lead to potential inaccurate diagnosis and lack of assessment of malignancy potential. In this study, we aimed to evaluate melanocytic tumors with spitzoid morphology using conventional melanoma FISH (RREB-1, CCND1, MYB and CEP6) and 9p21 FISH (CDKN2A) probes and compare the probe results with clinical and histopathological features. Materials and methods: This study is a multicentric retrospective study including three centers, İstanbul University-Cerrahpaşa, Cerrahpaşa School of Medicine, Department of Pathology, Acıbadem University, School of Medicine, Department of Pathology and ETA Pathology Laboratory. The pathology reports in archives of these three centers between 2015 and 2017 have been reviewed for cases diagnosed as atypical Spitz tumor or melanoma with Spitzoid features. These cases were selected for the study. We analyzed 39 cases of atypical Spitz tumor (AST), 10 cases of melanomas with spitzoid features for clinicopathological data and chromosomal alterations, targeting RREB-1 (6p25), CCND1 (11q13), MYB (6q23), together with 9p21 (CDKN2A), using FISH methodology. Conclusion: These data suggest that 9p21 FISH positivity correlated with more worrisome histopathologic and clinical features, such as deep mitosis, increased mitotic activity, epidermal consumption, and larger lesion size, so these features are precious, pointing out spitzoid lesions with higher risk. However, there is a need for further studies using FISH or similar techniques in order to provide more accurate prognostic information in lesions Blank morphology. [ABSTRACT FROM AUTHOR]

This article examines Sephardic identity formation in the North American context through Sephardic Jews' encounter with their co-religionists, Ashkenazi Jews. It explores the shifting cultural, linguistic and traditional boundaries between Ashkenazi Jews and North African and Turkish Jews in Montreal and Toronto to understand the North American dynamics of this inter-ethnic encounter. Given that they are a minority in relation to Yiddish and English-speaking Ashkenazim who started to settle in Canada in the 19th century, how then did the relationship between Sephardim and Ashkenazim develop and what specific role did language play in shaping this inter-ethnic encounter in North America? After a historical overview of encounters between these two groups in North America, drawing on twenty life-story interviews with Moroccan, Tunisian, and Turkish Jews, this article presents an empirical portrait of these relationships in contemporary Canada from a relational sociology perspective. Providing an historical contextualization from a selective literature on the Jewish migration from Ottoman lands, the Middle East and North Africa to North America helps formulate the question of how this encounter relates to the current context in Canada. By paying specific attention to both the continuities and the ruptures in the relations between Sephardic and Ashkenazic groups in North America since the 1910s, this article argues that the encounter between these two groups in Montreal and Toronto shows how the linguistic pluralism in Quebec, which is different from the United States and Toronto, illuminates a unique context. As such, the collective experiences of North African and Turkish Jews I interviewed in this study reveals Canadian pluralism through the interplay between language, ethnicity, and religion. [ABSTRACT FROM AUTHOR]