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The process of employing laser powder bed fusion (L-PBF) process to refractory materials, such as chromium (Cr), remains challenging because of its high ductile-brittle transition temperature. Therefore, a strategy is required to increase the processing temperature to prevent defects. The focus of this study is to clarify the effect of the preheat temperature and scan length variations on defects during the L-PBF process with an experimental and numerical study. Applying a high preheat temperature and short scan length was effective in mitigating the defects. By tuning the heat accumulation strategies, the determined relative density measured by the Archimedes principle and optical measurement of pure Cr parts increased from 97.2% to 99.8% and 97.4% to 99.2%, respectively. The numerical study indicated that deepened and elongated melt pool geometry owing to heat accumulation promoted epitaxial growth. Strong crystallographic texture formation with epitaxial growth led to higher grain size, lower high-angle grain boundary misorientation, Kernel average misorientation, and Taylor factor, which resulted in densification by preventing defects. The hardness of L-PBFed Cr samples gradually decreased with the stronger crystallographic texture formation and compressive yield strength exhibited the same phenomenon. However, the high densification sample with strong crystallographic texture promised the highest compressive strength and strain because it allows single and multi-slip operation during the compressive deformation without premature fracture. This study is a pivotal moment in heat accumulation strategies to achieve high densification for brittle materials fabricated by the L-PBF process while proposing an approach to ensure the reliability of structural applications.

Red raspberries are among the most significant wild edible fruits (WEFs) in Türkiye, thriving in cold to warm temperate regions across the country. This study focuses on 11 wild red raspberry ecotypes sampled from the Northern Anatolia region, examining their sensory, biochemical and antioxidant properties. Sensory analysis was used to compare ecotypes based on aroma, taste and juiciness. Biochemical assessments included soluble solid content (SSC), vitamin C amount, organic acids, total anthocyanins (TA), total phenolic content (TPC), total flavonoid content and total antioxidant capacity. The Ferric Reducing Antioxidant Power (FRAP) assay measured antioxidant capacity. Despite similar growing conditions, significant variations were observed among ecotypes and across years. In the first year, fruit weights ranged from 1.04 g to 1.33 g, and in the second year, they ranged from 0.97 g to 1.27 g. Fruit chroma values ranged between 26.11 and 33.70 in 2021, and 23.17 and 30.19 in 2022. Vitamin C exhibited considerable variability, ranging from 29.3 mg · 100 g−1 to 44.4 mg · 100 g−1 across ecotypes and years. TPC, total anthocyanin content (TAC) and total flavonoid content ranged from 164 mg to 390 mg gallic acid equivalent (GAE) · 100 g−1, 17.3 mg to 33.2 mg cyanidin-3-glucoside equivalent · 100 g−1 and 10.3 mg to 17.6 mg quercetin equivalent (QE) · 100 g−1, respectively, in both years. Citric acid emerged as the dominant organic acid across all ecotypes. Notably, the ecotypes V-4, V-8, V-3 and V-10 showcased larger, more appealing fruits suitable for fresh consumption, whereas V-3 and V-5 presented sweeter fruits ideal for processing. Additionally, the ecotypes V-6, V-7 and V-11 displayed higher levels of health-promoting compounds, such as TPC and antioxidant capacity, suggesting their potential as functional foods and valuable sources of natural antioxidants in the future.

IntroductionAthletes competing in weight-class sports often seek to gain an advantage by competing at lower weights. Athletes competing in weight-class sports often seek to gain an advantage by competing at lower weights. To achieve this, they aim to lose weight during the competition period, leading to various physiological and psychological changes. This study aimed to investigate the biochemical, hormonal, and psychological effects of weight reduction in elite wrestlers during the competition phase.MethodsThirty-seven elite male free style wrestlers (age: 19.02 ± 1.27) participated in the study. Samples were collected 5 days before and on the day of the match.ResultsA significant decrease in body weight was observed (p

Metals with a density of more than 5 g/cm3 are heavy metals, with more than 60 in nature. In acute and chronic exposure, they can damage many organs, such as the central nervous system, kidneys, skin, lungs, and heart. The most harmful ones to the kidney are lead, mercury, cadmium, and arsenic. They cause damage by creating some disorders in intracellular metabolic processes. The main types of kidney injury are acute tubular damage, proteinuria, and chronic kidney disease. This review discusses the basic properties of lead, mercury, cadmium, and arsenic, their nephrotoxicity mechanisms, and studies about them.

Esports is a natural extension of digital games. Digital games provide a platform for players to showcase their skills, thereby forming the foundation of e-sports. These two domains continuously support each other, demonstrating significant growth in popularity and establishing a solid presence in the competitive landscape. Digital games require high levels of attention, strategy, reflexes, and coordination, offering pathways to reach the pinnacle of competition. The benefits derived from digital games enhance the ability to perform effectively under stress, making them crucial for both physical and mental performance. This study investigates the effects of digital gaming on the physical performance, shoulder flexibility, muscle strength and reaction speed of female volleyball players. A total of 50 female volleyball players took part, who were divided into two groups based on their digital playing habits: Group 1 consisted of female players who played video games for at least 4 h per day in the last 6 months, while Group 2 included those who played

Abstract Aim Understanding vaccine hesitancy, as a critical concern for public health, cannot occur without the use of validated measures applicable and relevant to the samples they are assessing. The current study aimed to validate the Vaccine Hesitancy Scale (VHS) and to investigate the predictors of children’s vaccine hesitancy among parents from Australia, China, Iran, and Turkey. To ensure the high quality of the present observational study the STROBE checklist was utilized. Design A cross-sectional study. Method In total, 6,073 parent participants completed the web-based survey between 8 August 2021 and 1 October 2021. The content and construct validity of the Vaccine Hesitancy Scale was assessed. Cronbach’s alpha and McDonald’s omega were used to assess the scale’s internal consistency, composite reliability (C.R.) and maximal reliability (MaxR) were used to assess the construct reliability. Multiple linear regression was used to predict parental vaccine hesitancy from gender, social media activity, and perceived financial well-being. Results The results found that the VHS had a two-factor structure (i.e., lack of confidence and risk) and a total of 9 items. The measure showed metric invariance across four very different countries/cultures, showed evidence of good reliability, and showed evidence of validity. As expected, analyses indicated that parental vaccine hesitancy was higher in people who identify as female, more affluent, and more active on social media. Conclusions The present research marks one of the first studies to evaluate vaccine hesitancy in multiple countries that demonstrated VHS validity and reliability. Findings from this study have implications for future research examining vaccine hesitancy and vaccine-preventable diseases and community health nurses.

Abstract The data regarding primary FSGS (pFSGS) from different parts of the world differ. While the prevalence of pFSGS has been increasing in Western countries like the USA, it follows an inconsistent trend in Europe and Asia and a decreasing trend in Far Eastern countries such as China in the last two decades. There are undetermined factors to explain those national and geographic discrepancies. Herein, we aimed to reveal the current prevalence with clinical and histopathological characteristics of pFSGS in Turkish adults. This study includes the biopsy-proven pFSGS patients data recorded between 2009 and 2019, obtained from the national multicenter primary glomerulonephritis registry system of the Turkish Society of Nephrology Glomerular Diseases (TSN-GOLD) database. 850 of the 3875 primer glomerulonephritis patients(21.9%) have pFSGS. The mean age is 40.5 ± 14.2 and 435 (51.2%) of patients are male. Nephrotic syndrome is the most common biopsy indication (59.2%). 32.6% of patients have hematuria, 15.2% have leukocyturia and 7.8% have both. Serum creatinine, albumin, and proteinuria are 1.0 mg/dL (IQR = 0.7–1.4) mg/dl, 3.4 ± 0.9 g/dl, 3400 mg/day(IQR, 1774–5740), respectively. Females have lower mean arterial pressure (− 2.2 mmHg), higher eGFR (+ 10.0 mL/min/1.73 m2), and BMI (+ 1.6 kg/m2) than males. Thickened basal membrane(76.6%) and mesangial proliferation (53.5%) on light microscopy are the major findings after segmental sclerosis. IgM (32.7%) and C3 (32.9%) depositions are the most common findings on immunofluorescence microscopy. IgM positivity is related to lower eGFR, serum albumin, and higher proteinuria. The prevalence of pFSGS is stable although slightly increasing in Turkish adults. The characteristics of the patients are similar to those seen in Western countries.

This study investigated the oxidation of wastewater generated during the production of glass fiber manufacturing material, which contains high organic carbon (18.32 g/L) and has a pH of 8.8, by chemical coagulation, electrocoagulation and electro-advanced oxidation techniques. It was determined that the total organic content (TOC) of wastewater was reduced by 53% using the chemical coagulation method. After electrocoagulation with Al/Al electrode pair for 300 minutes at 500 mA, 73% TOC removal was achieved at pH 8.8. While 50% TOC removal was completed in 2 h at 400 mA in electrocoagulation with Fe/Fe electrode pair, 71% TOC removal was obtained in the combined electrocoagulation/electro-Fenton process by adding hydrogen peroxide to the medium under the same conditions. In addition, it was also observed that the success of the anodic oxidation methods alone was lower. The electro-Fenton application after electrocoagulation was effective and provided 78% TOC but required work at pH 3 and a longer treatment time.

Objective: The current study aimed to investigate the prevalence of adult separation anxiety disorder and specific phobia in the general population, along with identifying the factors associated with these two disorders. Material and Method: The study was carried out in the Selçuklu district, encompassing 28 of the 34 family health centers selected through a simple random sampling method. The study sample included 1,218 individuals over 18, chosen using a systematic sampling approach by skipping one resident from each neighborhood covered by the family health unit. After collecting the sociodemographic data, face-to-face diagnostic interviews were performed using the Structured Clinical Interviews for Separation Anxiety Symptoms (SCI-SAS) for ASAD and the Structured Clinical Interview for DSM-5 (SCID-5) for specific phobia assessment. Results: The study revealed that the lifetime prevalence of ASAD was 5.9%, with a point prevalence of 1.5%, while the lifetime prevalence of specific phobia was 11.3%. The application rates for the treatment of both disorders were very low and clinicians demonstrated limited recognition of ASAD. ASAD was correlated with female gender, low income, childhood traumatic experiences, migraine presence, and family history of serious illness. On the other hand, specific phobia was associated with female gender and family history of psychiatric disease. Conclusion: Despite the high prevalence of both disorders, the alarming rates of clinical recognition and treatment underscore the need to develop health policies and awareness programs aimed at promoting early diagnosis and treatment.

The 2D double arrow-headed (DAH) lattice structures, which are promising cellular structures for impact mitigation, remain relatively unexplored in terms of their compression response when manufactured using the powder bed fusion process with Ti6Al4V (Ti64) alloy. This study aims to investigate the effects of build orientation and beam scan speed of Electron Beam Powder Bed Fusion (PBF-EB) process on the energy absorption of 2D Ti64 DAH lattice structures. Additionally, potential microstructural variations due to adjusted process parameters can be linked to different levels of energy absorption. For the compressions, the lattice structures were manufactured at two build orientations (0° and 45°), using three different beam scan speeds: speed function (SF), low speed (LS), high speed (HS). In micro-characterizations, the unit cells of 0deg-LS exhibited the lowest micro-porosity level at 0.12 %. Based on KAM values, thin struts at unit cells had higher residual stresses than thick struts, contributing to the initiation of failure locations. The compressions revealed that the 0deg-LS group absorbed 21.6 % and 24 % more energy than 0deg-SF and 0deg-HS groups, respectively, at compressions of 33 %. 45° samples absorbed approximately 10 % more energy than 0° samples except HS groups. The lowest micro-porosity of 0deg-LS contributed to having the highest energy absorption among 0deg samples. As the residual stresses in KAM values did not differ strongly with varying beam speed, varied energy absorptions were not linked to them. An optimization of the numerical compressions helped obtain designs with higher energy absorption and less relative volume. This study provides valuable insights into Ti64 cellular applications constrained with 2D-type designs.

The metal-based 2D auxetic lattice structures hold the potential for multifunctional tasks in aerospace applications. However, the compression response of those manufactured by powder bed fusion process is underexplored. This study proposes a comprehensive comparison of in-plane quasi-static compression performance of 2D auxetic lattice structures, utilizing three designs (anti-tetrachiral (ATC), double arrow-headed (DAH), and tree-like re-entrant (TLR)), manufactured with stiff Ti6Al4V by the electron beam powder bed fusion process (PBF-EB) with various manufacturing speeds. The results revealed unique failure patterns and superior energy absorptions among 2D lattice structures in the literature. TLR design enhanced energy absorption by overcoming failures between DAH columns and exhibited the lowest standard deviations in specific energy absorption (SEA) values (9.75 %–12.62 %). Besides, Kernel average misorientation (KAM) values followed the order of DAH, TLR, and ATC, and inversely correlated with SEA values. ATC structures with the lowest KAM outperformed DAH and TLR by 47.5 % and 6.44 %, respectively. Scan speed variations affected SEA and porosity values differently for each lattice design while exhibiting similar microstructure characteristics. The findings in this study propose a significant contribution to the development of aerospace sandwich structures where harsh environments exist and employment of 2D topologies are required.

Background and aimThe correlation between eating attitudes, positive body image, and body esteem is a pivotal area of research that has garnered substantial attention in recent years, given its implications for both mental and physical well-being. The objective of this study was to examine the interplay between positive body image, body esteem, and eating attitudes within an Iranian population.Materials and methodsThis study employed a cross-sectional study design and was conducted in the year 2022. A convenience sample of 752 participants residing in Tehran, Iran, was included in the study. The data collection tools were comprised of a demographic registration form, the Adolescence/Adults Scale (PBIAS), the Eating Attitudes Test (EAT), and the Body Esteem Scale (BES) as measurement instruments.ResultsMean age of participants was 26.36 (SD = 8.49). Significant relationships were found among positive body image (B = − 0.095, β = −0.150, p

Abstract In the human gut, there is a metabolically active microbiome whose metabolic products reach various organs and are used in the physiological activities of the body. When dysbiosis of intestinal microbial homeostasis occurs, pathogenic metabolites may increase and one of them is trimethyl amine-N-oxide (TMAO). TMAO is thought to have a role in the pathogenesis of insulin resistance, diabetes, hyperlipidemia, atherosclerotic heart diseases, and cerebrovascular events. TMAO level is also associated with renal inflammation, fibrosis, acute kidney injury, diabetic kidney disease, and chronic kidney disease. In this review, the effect of TMAO on various kidney diseases is discussed.

The need for accurate measurement of constructs and understanding of diverse phenomena has prompted researchers to investigate the validity and reliability of developed measures in a continuous effort to improve our understanding of their psychometric properties. However, at times, these endeavors are flawed by serious methodological inadequacies. In this article, we discussed one example of a psychometric study that appears to be deeply flawed, providing some recommendations for remediating the issue.

This study developed a non-equiatomic Ti28.33Zr28.33Hf28.33Nb6.74Ta6.74Mo1.55 super-solid solutionized BioHEA using laser powder bed fusion (LPBF) to reach the full potential as BioHEA. We succeeded in significant suppression of elemental segregation, thus, resulting in a single crystalline-like texture by activating layer-to-layer epitaxial growth. Relatively low Young’s modulus was achieved in the single crystalline-like BioHEA. Moreover, LPBF-fabricated BioHEA exhibited significantly higher yield stress (1355–1426 MPa) due to the effective solid solution hardening compared to as-cast counterpart with marked segregation (949 MPa), and good biocompatibility. This is first report achieving BioHEA with low modulus, excellent strength-ductility balance, and good biocompatibility via LPBF.

Aim: Among the hand functions, grasping is an important function for the continuity of daily living activities. The assessment of grip strength is crucial for identifying athletic prowess, neuromuscular illnesses, assessing potential side effects following hand surgery, and treatment plans. It was aimed to examine whether bioimpedance analysis (BIA) and upper extremity anthropometric measurements are effected grip strength in young adults. Material and Methods: The study was conducted on 110 young adults, 55 males and 55 females, aged 18-25 years. Individuals with a history of trauma, musculoskeletal problems, and cardiac, respiratory, metabolic, or systemic diseases were not included in the study. Non-flexible tape measure, Harpenden anthropometric set, digital caliper, hand dynamometer, and skinfold caliper were used for anthropometric measurements. Body fat percentage and lean body mass, muscle mass, basal metabolic rate, and total body fluid parameters were investigated by bioelectrical impedance measurement. Three measurements were taken to reduce the error rate, and the average of these measurements was considered. Results: Excluding arm circumference, forearm length, and wrist circumference from anthropometric measurements, and mineral from BIA parameters; anthropometric measurements and BIA results were found to be statistically significantly correlated with grip strength. Conclusion: Upper extremity anthropometric measurements and BIA were associated with grip strength and varied according to gender. Significant correlations were found between grip strength with most of the anthropometric parameters and BIA.

OBJECTIVE: The pathogenesis of primary hypertension (HT) is still not completely clear, although autoimmunity has been implicated in recent years. Carbonic anhydrase (CA) is an enzyme involved in a number of important metabolic processes. CA I and II autoantibodies have been linked to various autoimmune diseases. However, CA I and II autoantibody levels in primary HT have not been previously investigated. The purpose of this study was, therefore, to investigate levels of CA I and II autoantibodies in primary HT. PATIENTS AND METHODS: Fifty-six patients newly diagnosed with primary HT and 33 healthy individuals were included in the study. Twenty- four-hour ambulatory blood pressure monitoring was performed following office controls. Blood specimens were collected under appropriate conditions for CA I and II autoantibody level investigation and biochemical tests. Urine sodium and protein excretion were measured after 24 h. Demographic and biochemical parameters and CA I and II autoantibody levels were then compared between the patient and healthy groups. RESULTS: CA II autoantibody and uric acid levels were significantly higher in the hypertensive group than in the control group (p=0.005, and p<0.001, respectively). CA II autoantibody (exp ß: 79.06 CI: 4.44-1407.02) (p=0.003) and uric acid elevation (exp ß: 2.10 CI: 1.31- 3.34) (p=0.002) were identified as independent predictors of HT development at logistic regression analysis. CONCLUSIONS: CA II autoantibody levels were higher in hypertensive patients, and this elevation is an independent predictor of HT development. [ABSTRACT FROM AUTHOR]

Aim: Free radical formation increases due to hyperglycemia occurring in the pathogenesis of diabetes mellitus (DM), and as a result, oxidative stress occurs. Hyperglycemia-mediated oxidative stress plays an important role in the pathogenesis of diabetic nephropathy. The antihyperglycemic, antioxidative, anti-apoptotic, and anti-inflammatory effects of ellagic acid (EA) have been demonstrated by many studies. In this study, it was aimed to demonstrate the antifibrotic effect of EA on TGFβ1/Smad signaling in rats with streptozotocin induced diabetic nephropathy. Material and Methods: A total of 24 male Sprague Dawley rats, weighing 200-250 g, were used in this study. The animals were divided into four groups as control, EA, DM, and DM+EA. The kidney tissues were used for histological and immunohistochemical procedures. While the collagen density in kidney tissues was revealed by Masson's trichrome staining, the expression levels of fibrotic markers TGFβ1, p-Smad3, and αSMA were determined by the immunocytochemical method. Results: It was shown that the collagen density in the renal tissue of the DM group increased significantly in the intertubular area, while the collagen density in the EA-treated DM group was statistically significantly decreased. When TGFβ1, p-Smad3, and αSMA immunopositivity in kidney tissue sections of all groups were evaluated, the highest staining intensity was in the DM group, while the intensity of staining was close to the control group in the treatment group. It was observed that αSMA, TGFβ1, and p-Smad3 protein expression were down-regulated with EA treatment. Conclusion: EA reduced fibrosis in diabetic nephropathy by returning profibrotic parameters to normal levels.

During the follow-up of patients with renal failure, many medications may be required due to the clinical condition and comorbidities. Care should be taken in terms of the nephrotoxic effect of these drugs used or the accumulation of renally excreted drugs in the body and causing toxic effects. One of the most important side effects of carbapenems is neurotoxicity. Although Imipenem is the most frequently mentioned in this respect, similar side effects can be seen due to other carbapenems. Even if the dose is adjusted according to the glomerular filtration rate, these side effects can be seen. When the literature is examined, it has been determined that neurotoxicity due to ertapenem is seen more frequently than expected. In this study, we wanted to draw attention to this issue by presenting our case of visual hallucination observed after the use of ertapenem in a patient with chronic renal failure.

Abstract Background Skin conditions often considerably impact the older patients’ psycho-social health and quality of life (QoL). The present study was aimed to examine the validity and reliability of the Persian version of Skindex-16 among older people with skin diseases. Methods In this validation study, 260 older patients suffering from a range of skin conditions were recruited from a dermatology clinic in Rasht, Iran. Data were collected using a checklist for demographic and clinical characteristics and the Skindex-16 questionnaire. In this study, validity (face, content, and construct) and reliability (Cronbach’s alpha) of the Skindex-16 were assessed and reported. Results The mean age of participants was 64.51 ± 5.04 years. The results of confirmatory factor analysis showed that the model had acceptable fitness into the expected three-factor structure [χ 2 /df = 249.363, P