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This article discusses a case study of a 35-year-old female patient who presented with symptoms of myalgia, weakness, dyspnea, dysphagia, and cold-induced pallor in the hands. The patient was diagnosed with overlap syndrome, specifically systemic sclerosis-polymyositis, based on physical examination findings, laboratory analysis, and imaging results. The patient also had coexisting conditions of ulcerative colitis and papillary thyroid carcinoma, which is a rare combination. The article highlights the importance of vigilance for malignancy in patients with inflammatory myopathy and systemic sclerosis, particularly in younger patients. [Extracted from the article]