5 results on '"Ökdemir D"'
Search Results
2. Management of Thyrotoxicosis in Children and Adolescents: A Turkish Multi-center Experience
- Author
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Esen İ, Bayramoğlu E, Yıldız M, Aydın M, Karakılıç Özturhan E, Aycan Z, Bolu S, Önal H, Kör Y, Ökdemir D, Ünal E, Önder A, Evliyaoğlu O, Çayır A, Taştan M, Yüksel A, Kılınç A, Büyükinan M, Özcabı B, Akın O, Binay Ç, Kılınç S, Yıldırım R, Aytaç EH, and Sağsak E
- Subjects
- Adolescent, Child, Child, Preschool, Combined Modality Therapy, Disease Management, Female, Follow-Up Studies, Humans, Infant, Male, Retrospective Studies, Treatment Outcome, Antithyroid Agents therapeutic use, Thyroidectomy methods, Thyrotoxicosis therapy
- Abstract
Objective: To determine the demographic and biochemical features of childhood and juvenile thyrotoxicosis and treatment outcome., Methods: We reviewed the records of children from 22 centers in Turkey who were diagnosed with thyrotoxicosis between 2007 to 2017., Results: A total of 503 children had been diagnosed with thyrotoxicosis at the centers during the study period. Of these, 375 (74.6%) had been diagnosed with Graves’ disease (GD), 75 (14.9%) with hashitoxicosis and 53 (10.5%) with other less common causes of thyrotoxicosis. The most common presenting features in children with GD or hashitoxicosis were tachycardia and/or palpitations, weight loss and excessive sweating. The cumulative remission rate was 17.6% in 370 patients with GD who had received anti-thyroid drugs (ATDs) for initial treatment. The median (range) treatment period was 22.8 (0.3-127) months. No variables predictive of achieving remission were identified. Twenty-seven received second-line treatment because of poor disease control and/or adverse events associated with ATDs. Total thyroidectomy was performed in 17 patients with no recurrence of thyrotoxicosis and all became hypothyroid. Ten patients received radioiodine and six became hypothyroid, one remained hyperthyroid and restarted ATDs and one patient achieved remission. Two patients were lost to follow up., Conclusion: This study has demonstrated that using ATDs is the generally accepted first-line approach and there seems to be low remission rate with ATDs in pediatric GD patients in Turkey.
- Published
- 2019
- Full Text
- View/download PDF
3. The Role of Irisin, Insulin and Leptin in Maternal and Fetal Interaction
- Author
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Ökdemir D, Hatipoğlu N, Kurtoğlu S, Siraz ÜG, Akar HH, Muhtaroğlu S, and Kütük MS
- Subjects
- Adult, Birth Weight, Female, Gestational Age, Humans, Infant, Newborn, Infant, Small for Gestational Age blood, Male, Obesity blood, Pregnancy, Pregnancy Complications blood, Young Adult, Fetal Blood metabolism, Fibronectins blood, Insulin blood, Leptin blood
- Abstract
Objective: Insulin is an important hormone for intrauterine growth. Irisin is an effective myokine in the regulation of physiological insulin resistance in pregnancy. Leptin and insulin are associated with fetal growth and fetal adiposity. In this study, we aimed to investigate the relationships between irisin, insulin and leptin levels and maternal weight gain, as well as anthropometric measurements in the newborn., Methods: Eighty-four mothers and newborns were included in the study. Irisin, leptin and insulin levels were measured in the mothers and in cord blood. Anthropometric measurements in the newborn, maternal weight at the beginning of the pregnancy and at delivery were recorded., Results: Birth weight were classified as small for gestational age (SGA), appropriate for gestational age (AGA) and large for gestational age (LGA). There was no difference in irisin levels among the groups. Leptin and insulin levels were found to change significantly according to birth weight (p=0.013, and p=0.012, respectively). There was a negative correlation between the anthropometric measurements of the AGA newborns and irisin levels. This correlation was not observed in SGA and LGA babies. Leptin levels were associated with fetal adiposity., Conclusion: While irisin levels are not affected by weight gain during pregnancy nor by birth weight, they show a relationship with anthropometric measurements in AGA infants. These results may lead to the understanding of metabolic disorders that will occur in later life.
- Published
- 2018
- Full Text
- View/download PDF
4. ROHHAD Syndrome, a Rare Cause of Hypothalamic Obesity: Report of Two Cases
- Author
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Şiraz ÜG, Ökdemir D, Direk G, Akın L, Hatipoğlu N, Kendirci M, and Kurtoğlu S
- Subjects
- Child, Child, Preschool, Female, Humans, Rare Diseases diagnosis, Syndrome, Weight Gain, Autonomic Nervous System Diseases diagnosis, Hypothalamic Diseases diagnosis, Hypoventilation diagnosis, Obesity diagnosis
- Abstract
Rapid-onset obesity with hypoventilation, hypothalamic dysfunction and autonomic dysregulation (ROHHAD) syndrome is a rare disease that is difficult to diagnosis and distinguish from genetic obesity syndromes. The underlying causes of the disease have not been fully explained. Hypothalamic dysfunction causes endocrine problems, respiratory dysfunction and autonomic alterations. Currently there are around 80 reported patients although this is likely due to underdiagnosis due to lack of recognition. We present two female patients suspected of ROHHAD due to weight gain starting in early childhood. Clinical and biochemical findings such as respiratory and circulatory dysfunction, hypothalamic hypernatremia, central hypothyrodism, hyperprolactinemia and central early puberty in these patients matched the criteria for ROHHAD syndrome. ROHHAD syndrome should be considered in the differential diagnosis of monogenic obesity.
- Published
- 2018
- Full Text
- View/download PDF
5. A patient developing anaphylaxis and sensitivity to two different GnRH analogues and a review of literature.
- Author
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Ökdemir D, Hatipoğlu N, Akar HH, Gül Ü, Akın L, Tahan F, and Kurtoğlu S
- Subjects
- Adult, Anaphylaxis drug therapy, Child, Female, Humans, Prognosis, Anaphylaxis chemically induced, Antineoplastic Agents, Hormonal adverse effects, Leuprolide adverse effects, Puberty, Precocious drug therapy, Triptorelin Pamoate adverse effects
- Abstract
Gonadotropin-releasing hormone analogues are used in the treatment of prostate cancer, breast cancer, endometriosis, and uterine leiomyomas in adults and often in the treatment of precocious puberty in children. Many adverse effects have been reported for gonadotropin-releasing hormone analogues, but anaphylaxis is rarely reported as an adverse effect. Frequent cross-reactions, particularly during childhood, and diversity of the time of onset of anaphylactic manifestations complicate the diagnosis. A patient who exhibited anaphylactic allergic reactions to two different agents used in the treatment of central precocious puberty presented here because the case has an atypical course and is the first in the literature.
- Published
- 2015
- Full Text
- View/download PDF
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