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335 results on '"Öhman, Juha"'

10. Single-Dose Intraventricular Nimodipine Microparticles Versus Oral Nimodipine for Aneurysmal Subarachnoid Hemorrhage

Author

Carlson, Andrew P., Hänggi, Daniel, Wong, George K., Etminan, Nima, Mayer, Stephan A., Aldrich, François, Diringer, Michael N., Schmutzhard, Erich, Faleck, Herbert J., Ng, David, Saville, Benjamin R., Bleck, Thomas, Grubb, Robert, Jr, Miller, Michael, Suarez, Jose I., Proskin, Howard M., Macdonald, R. Loch, Abou-Hamden, Amal, Allan, Rodney, Altaweel, Laith, Amar, Arun, Amin-Hanjani, Sepideh, Aziz, Khaled, Bambakidis, Nicholas, Bojanowski, Michel, Bradac, Ondrej, Chou, Sherry, Clark, Wayne Marston, Darsaut, Tim, Ebersole, Koji C., Elijovich, Lucas, Freeman, William D., Goldbrunner, Roland, Graffagnino, Carmelo, Gupta, Gaurav, Habalova, Jirina, Hadani, Moshe, Harnof, Sagi, Harrigan, Mark Robert, Hatton, Kevin, Helbok, Raimund, Hrbac, Tomas, Huttner, Hagen B., Jabbour, Pascal, Jahromi, Babak, James, Robert, Jordan, Joseph Dedrick, Kelly, Michael, Kivisaari, Riku P., Ko, Nerissa, Konczalla, Jürgen, Kung, David, Lahiri, Shouri, Langer, David, Lawson, Matthew, Lay, Cappi, LeDoux, David, Lopez, George A., Lui, Wai-Man, Matouk, Charles, Mee, Edward W., Meixensberger, Jürgen, Müller, Oliver, Ng Yew Poh, Vincent, Öhman, Juha, Papadakos, Peter, Patel, Aman B., Polifka, Adam, Poon, Wai-Sang, Powers, Ciaran, Reavey-Cantwell, John, Redekop, Gary, Regelsberger, Jan, Rosenthal, Guy, Ryang, Yu-Mi, Sauvageau, Eric, Seppelt, Ian, Smrcka, Martin, Spears, Julian, Thomas, Ajith, Turner, Raymond, IV, Unterberg, Andreas, Vajkoczy, Peter, Vespa, Paul, Walzman, Daniel E., Westermaier, Thomas, Wong, John, Zaaroor, Menashe, and Zabramski, Joseph

Published
2020
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34. External Validation of the ELAPSS Score for Prediction of Unruptured Intracranial Aneurysm Growth Risk

Author

Kammen, Mayte Sánchez van, Greving, Jacoba P, Kuroda, Satoshi, Kashiwazaki, Daina, Morita, Akio, Shiokawa, Yoshiaki, Kimura, Toshikazu, Cognard, Christophe, Januel, Anne C, Lindgren, Antti, Koivisto, Timo, Jääskeläinen, Juha E, Ronkainen, Antti, Pyysalo, Liisa, Öhman, Juha, Rahi, Melissa, Kuhmonen, Johanna, Rinne, Jaakko, Leemans, Eva L, Majoie, Charles B, Vandertop, W Peter, Verbaan, Dagmar, Roos, Yvo B W E M, Berg, René van den, Boogaarts, Hieronymus D, Moudrous, Walid, Wijngaard, Ido R van den, Hove, Laura Ten, Teo, Mario, George, Edward J St, Hackenberg, Katharina A M, Abdulazim, Amr, Etminan, Nima, Rinkel, Gabriël J E, Vergouwen, Mervyn D I, Kammen, Mayte Sánchez van, Greving, Jacoba P, Kuroda, Satoshi, Kashiwazaki, Daina, Morita, Akio, Shiokawa, Yoshiaki, Kimura, Toshikazu, Cognard, Christophe, Januel, Anne C, Lindgren, Antti, Koivisto, Timo, Jääskeläinen, Juha E, Ronkainen, Antti, Pyysalo, Liisa, Öhman, Juha, Rahi, Melissa, Kuhmonen, Johanna, Rinne, Jaakko, Leemans, Eva L, Majoie, Charles B, Vandertop, W Peter, Verbaan, Dagmar, Roos, Yvo B W E M, Berg, René van den, Boogaarts, Hieronymus D, Moudrous, Walid, Wijngaard, Ido R van den, Hove, Laura Ten, Teo, Mario, George, Edward J St, Hackenberg, Katharina A M, Abdulazim, Amr, Etminan, Nima, Rinkel, Gabriël J E, and Vergouwen, Mervyn D I

Published
2019

35. External Validation of the ELAPSS Score for Prediction of Unruptured Intracranial Aneurysm Growth Risk

Author

Cardiovasculaire Epi Team 6, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, ZL Cerebrovasculaire Ziekten Medisch, Neurologie, Brain, Kammen, Mayte Sánchez van, Greving, Jacoba P, Kuroda, Satoshi, Kashiwazaki, Daina, Morita, Akio, Shiokawa, Yoshiaki, Kimura, Toshikazu, Cognard, Christophe, Januel, Anne C, Lindgren, Antti, Koivisto, Timo, Jääskeläinen, Juha E, Ronkainen, Antti, Pyysalo, Liisa, Öhman, Juha, Rahi, Melissa, Kuhmonen, Johanna, Rinne, Jaakko, Leemans, Eva L, Majoie, Charles B, Vandertop, W Peter, Verbaan, Dagmar, Roos, Yvo B W E M, Berg, René van den, Boogaarts, Hieronymus D, Moudrous, Walid, Wijngaard, Ido R van den, Hove, Laura Ten, Teo, Mario, George, Edward J St, Hackenberg, Katharina A M, Abdulazim, Amr, Etminan, Nima, Rinkel, Gabriël J E, Vergouwen, Mervyn D I, Cardiovasculaire Epi Team 6, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, ZL Cerebrovasculaire Ziekten Medisch, Neurologie, Brain, Kammen, Mayte Sánchez van, Greving, Jacoba P, Kuroda, Satoshi, Kashiwazaki, Daina, Morita, Akio, Shiokawa, Yoshiaki, Kimura, Toshikazu, Cognard, Christophe, Januel, Anne C, Lindgren, Antti, Koivisto, Timo, Jääskeläinen, Juha E, Ronkainen, Antti, Pyysalo, Liisa, Öhman, Juha, Rahi, Melissa, Kuhmonen, Johanna, Rinne, Jaakko, Leemans, Eva L, Majoie, Charles B, Vandertop, W Peter, Verbaan, Dagmar, Roos, Yvo B W E M, Berg, René van den, Boogaarts, Hieronymus D, Moudrous, Walid, Wijngaard, Ido R van den, Hove, Laura Ten, Teo, Mario, George, Edward J St, Hackenberg, Katharina A M, Abdulazim, Amr, Etminan, Nima, Rinkel, Gabriël J E, and Vergouwen, Mervyn D I

Published
2019

41. Repeatability and variation of region-of-interest methods using quantitative diffusion tensor MR imaging of the brain

Author

Hakulinen Ullamari, Brander Antti, Ryymin Pertti, Öhman Juha, Soimakallio Seppo, Helminen Mika, Dastidar Prasun, and Eskola Hannu

Subjects
Medical technology, R855-855.5
Abstract

Abstract Background Diffusion tensor imaging (DTI) is increasingly used in various diseases as a clinical tool for assessing the integrity of the brain’s white matter. Reduced fractional anisotropy (FA) and an increased apparent diffusion coefficient (ADC) are nonspecific findings in most pathological processes affecting the brain’s parenchyma. At present, there is no gold standard for validating diffusion measures, which are dependent on the scanning protocols, methods of the softwares and observers. Therefore, the normal variation and repeatability effects on commonly-derived measures should be carefully examined. Methods Thirty healthy volunteers (mean age 37.8 years, SD 11.4) underwent DTI of the brain with 3T MRI. Region-of-interest (ROI) -based measurements were calculated at eleven anatomical locations in the pyramidal tracts, corpus callosum and frontobasal area. Two ROI-based methods, the circular method (CM) and the freehand method (FM), were compared. Both methods were also compared by performing measurements on a DTI phantom. The intra- and inter-observer variability (coefficient of variation, or CV%) and repeatability (intra-class correlation coefficient, or ICC) were assessed for FA and ADC values obtained using both ROI methods. Results The mean FA values for all of the regions were 0.663 with the CM and 0.621 with the FM. For both methods, the FA was highest in the splenium of the corpus callosum. The mean ADC value was 0.727 ×10-3 mm2/s with the CM and 0.747 ×10-3 mm2/s with the FM, and both methods found the ADC to be lowest in the corona radiata. The CV percentages of the derived measures were < 13% with the CM and < 10% with the FM. In most of the regions, the ICCs were excellent or moderate for both methods. With the CM, the highest ICC for FA was in the posterior limb of the internal capsule (0.90), and with the FM, it was in the corona radiata (0.86). For ADC, the highest ICC was found in the genu of the corpus callosum (0.93) with the CM and in the uncinate fasciculus (0.92) with FM. Conclusions With both ROI-based methods variability was low and repeatability was moderate. The circular method gave higher repeatability, but variation was slightly lower using the freehand method. The circular method can be recommended for the posterior limb of the internal capsule and splenium of the corpus callosum, and the freehand method for the corona radiata.

Published
2012
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42. External Validation of the ELAPSS Score for Prediction of Unruptured Intracranial Aneurysm Growth Risk

Author

Sánchez van Kammen, Mayte, primary, Greving, Jacoba P., additional, Kuroda, Satoshi, additional, Kashiwazaki, Daina, additional, Morita, Akio, additional, Shiokawa, Yoshiaki, additional, Kimura, Toshikazu, additional, Cognard, Christophe, additional, Januel, Anne C., additional, Lindgren, Antti, additional, Koivisto, Timo, additional, Jääskeläinen, Juha E., additional, Ronkainen, Antti, additional, Pyysalo, Liisa, additional, Öhman, Juha, additional, Rahi, Melissa, additional, Kuhmonen, Johanna, additional, Rinne, Jaakko, additional, Leemans, Eva L., additional, Majoie, Charles B., additional, Vandertop, W. Peter, additional, Verbaan, Dagmar, additional, Roos, Yvo B.W.E.M., additional, Berg, René van den, additional, Boogaarts, Hieronymus D., additional, Moudrous, Walid, additional, Wijngaard, Ido R. van den, additional, Hove, Laura ten, additional, Teo, Mario, additional, George, Edward J. St, additional, Hackenberg, Katharina A.M., additional, Abdulazim, Amr, additional, Etminan, Nima, additional, Rinkel, Gabriël J.E., additional, and Vergouwen, Mervyn D.I., additional

Published
2019
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45. Texture analysis of MR images of patients with Mild Traumatic Brain Injury

Author

Wäljas Minna, Dastidar Prasun, Harrison Lara, Holli Kirsi K, Liimatainen Suvi, Luukkaala Tiina, Öhman Juha, Soimakallio Seppo, and Eskola Hannu

Subjects
Medical technology, R855-855.5
Abstract

Abstract Background Our objective was to study the effect of trauma on texture features in cerebral tissue in mild traumatic brain injury (MTBI). Our hypothesis was that a mild trauma may cause microstructural changes, which are not necessarily perceptible by visual inspection but could be detected with texture analysis (TA). Methods We imaged 42 MTBI patients by using 1.5 T MRI within three weeks of onset of trauma. TA was performed on the area of mesencephalon, cerebral white matter at the levels of mesencephalon, corona radiata and centrum semiovale and in different segments of corpus callosum (CC) which have been found to be sensitive to damage. The same procedure was carried out on a control group of ten healthy volunteers. Patients' TA data was compared with the TA results of the control group comparing the amount of statistically significantly differing TA parameters between the left and right sides of the cerebral tissue and comparing the most discriminative parameters. Results There were statistically significant differences especially in several co-occurrence and run-length matrix based parameters between left and right side in the area of mesencephalon, in cerebral white matter at the level of corona radiata and in the segments of CC in patients. Considerably less difference was observed in the healthy controls. Conclusions TA revealed significant changes in texture parameters of cerebral tissue between hemispheres and CC segments in TBI patients. TA may serve as a novel additional tool for detecting the conventionally invisible changes in cerebral tissue in MTBI and help the clinicians to make an early diagnosis.

Published
2010
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46. Spinal cord injury induces widespread chronic changes in cerebral white matter

Author

Ilvesmäki, Tero, Koskinen, Eerika, Brander, Antti, Luoto, Teemu, Öhman, Juha, and Eskola, Hannu

Subjects
nervous system, Research Articles
Abstract

Traumatic spinal cord injuries (SCIs) lead to axonal damage at the trauma site, as well as disconnections within the central nervous system. While the exact mechanisms of the long-term pathophysiological consequences of SCIs are not fully understood, it is known that neuronal damage and degeneration are not limited to the direct proximity of the trauma. Instead, the effects can be detected even in the cerebrum. We examined SCI-induced chronic brain changes with a case-control design using 32 patients and 70 control subjects. Whole-brain white matter (WM) tracts were assessed with diffusion tensor imaging (DTI). In addition, we analysed associations between DTI metrics and several clinical SCI variables. Whole-brain analyses were executed by tract-based spatial statistics (TBSS), with an additional complementary atlas-based analysis (ABA). We observed widespread, statistically significant (P ≤ 0.01) changes similar to neural degeneration in SCI patients, both in the corticospinal tract (CST) and beyond. In addition, associations between DTI metrics and time since injury were found with TBSS and ABA, implying possible long-term post-injury neural regeneration. Using the ABA approach, we observed a correlation between SCI severity and DTI metrics, indicating a decrease in WM integrity along with patient sensory or motor scores. Our results suggest a widespread neurodegenerative effect of SCI within the cerebrum that is not limited to the motor pathways. Furthermore, DTI-measured WM integrity of chronic SCI patients seemed to improve as time elapsed since injury. Hum Brain Mapp 38:3637-3647, 2017. © 2017 Wiley Periodicals, Inc.

Published
2017

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