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Objective: We aimed to assess the frequency of Y-chromosome microdeletions (YCMs) in a non-multiethnic urban population in our region, define predictive factors, and determine a new clinical threshold for YCMs in infertile men. Materials and Methods: A total of 281 patients with a sperm concentration ≤5 million/mL were retrospectively evaluated. Oligozoospermic and/or azoospermic patients with a sperm concentration of ≤5 million/mL were screened for the YCM analysis. Results: Y-chromosome microdeletion was detected in 9 (3.2%) of the 281 patients. All patients with YCM were azoospermic. The presence of azoospermia, a high folliclestimulating hormone level, and a high luteinizing hormone level were found to be important determinants for the identification of a microdeletion (P = .002, P = .002, and P=.021, respectively). If the presence of azoospermia and a sperm concentration threshold of

OBJECTIVE: In this study, the effect of tocilizumab (TCZ) on lung tissue in lung ischemia-reperfusion (I/R) injury in rats was investigated. MATERIAL AND METHODS: A total of 24 Wistar rats were divided into 4 equal groups, with 6 rats in each group: Left lung I/R was applied to I/R groups. In the I/R groups, the left lung hilum was clamped for 45 minutes, and then the clamp was removed and reperfused for 120 minutes. In the TCZ groups, 4 mg/kg and 8 mg/kg of TCZ were administered intraperitoneally to the rats 30 minutes before surgery. RESULTS: The tumor necrosis factor-alpha mean value was not statistically significant between the groups (P = .091). Statistically significant results were observed between group I/R-TCZ (8 mg/kg) and group I/R for catalase. (P = .005). Statistically significant results were observed between group I/R-TCZ (8 mg/kg) and group I/R for malondialdehyde. (P = .009). The difference in total ischemia score between group I/R-TCZ (4 mg/kg) and group I/R-TCZ (8 mg/kg) and group I/R was statistically significant (P < .001). In terms of alveolar hemorrhage, there was a statistically significant difference between group I/R-TCZ (4 mg/kg) and group I/R-TCZ (8 mg/kg) and group I/R (P = .01 and P = .002, respectively). There was a statistically significant difference between group I/R-TCZ (8 mg/kg) and group I/R in terms of neutrophil accumulation (P = .01). In terms of interstitial edema, there was a statistically significant difference between group I/R-TCZ (4 mg/kg) and group I/R-TCZ (8 mg/kg) and group I/R (P = .006 and P = .001, respectively). In terms of pulmonary edema, there was a statistically significant difference between group I/R-TCZ (4 mg/kg) and group I/R-TCZ (8 mg/kg) and group I/R (P = .01 and P = .009, respectively). CONCLUSION: Lung tissue may be affected by I/R injury and this damage can be reversed with the use of TCZ. [ABSTRACT FROM AUTHOR]

Background: Double-J stents are widely used in urology practice, and removal of these stents can sometimes be forgotten. Aims: To investigate whether indwelling time of double-J stent can predict which treatment modality is required for removal of the stent from the body. Study Design: A multicentre, retrospective observational study. Methods: The data of 57 patients who were treated for forgotten ureteral stents between January 2007 and December 2014 were evaluated retrospectively. Patients were classified into four groups according to indwelling time of the stents: 6-12 months, 13-24 months, 25-36 months, and >36 months. Encrustation and associated stone burden of the stents were evaluated with non-contrast stone protocol computerised tomography. Results: Patients were classified according to their duration of the stent indwelling time. Simple cystoscopic stent retrieval was performed in 71.4% of patients in the 6-12 months group, 44% of patients in the 13-24 months group, 6.2% of patients in the 25-36 months group, and 11.1% of patients in the >36 months group. A percutaneous or open surgery was required in no patients with an indwelling time of double-J stent shorter than 30 months. Conclusion: Transurethral and/or percutaneous combined endo-urological approaches are usually sufficient for the removal of forgotten double-J stents. Transurethral procedures are sufficient for the treatment of patients with double-J stent indwelling times less than 30 months

Objectives: Respiratory complications are an important contributor to morbidity and mortality following lung resection. The surgical techniques used and the patient’s pre-operative medical condition determine the severity of complications. The aim of this study is to evaluate the relationship between the perioperative characteristics of patients undergoing lung resection and the development of pulmonary complications (PC). Methods: We retrospectively reviewed the records of 1186 patients who underwent lung resections between 2017 and 2020 and identified 124 patients who developed PC. A group of 215 consecutive patients who underwent surgery during the same period and did not develop complications were included as the control group. The groups were compared to evaluate risk factors for PC. Results: The patients had a mean age of 58.9±12.1 (range, 18-83) years and 82% were men (n=278). Factors significantly associated with PC were age over 65 years, male sex, presence of chronic heart failure, coronary artery disease, and chronic obstructive pulmonary disease, undergoing pneumonectomy, intraoperative use of blood products, reoperation due to bleeding, operative time longer than 4 h, and intraoperative inotrope use. Independent variables for PC were intraoperative inotrope use, preoperative anticoagulant use, revision due to hemorrhage, high Sequential Organ Failure Assessment (SOFA) score, low Forced Expiratory Volume in the 1st s (FEV1), and low preoperative hemoglobin values. Conclusion: This study demonstrated the presence of many risk factors for PC after lung resection. In our study, independent risk factors for PC; intraoperative inotropic use, preoperative anticoagulant use, revision due to bleeding, high SOFA score, low FEV1, and low preoperative hemoglobin values were observed. [ABSTRACT FROM AUTHOR]

Paraganglioma can be found in different parts of the body. In this case report, a rare case of anterior mediastinal paraganlioma was examined. Pheochromocytoma can pose problems in intraoperative anesthesia management. A 17-year-old male patient with an anterior mediastinal mass was first scheduled for thoracoscopic tumor resection, and then proceeded with open thoracotomy. The patient, who was diagnosed with preoperative pheochromocytoma, had a history of dual antihypertensive drug use. The patient, who showed an intraoperative labile course, had episodes of hypertension (270/140 mmHg) and tachycardia (200 bpm). Esmolol and nitroglycerin infusion was applied and intervened. Diagnosis of paraganglioma-related pheochromocytoma can be challenging. Risks can be minimized by making appropriate decisions and interventions before and during the operation. [ABSTRACT FROM AUTHOR]

BACKGROUND: We evaluated the importance and efficacy of 'stepped procedure' in laparoscopic cyst decortication as an initial experience in it. MATERIALS AND METHODS: A 36 renal cyst cases were included. The stepped retroperitonoscopic cyst excision divided into three groups. First step, doing the incisions to place the ports and expanding the retroperitoneal space with balloon distension, second step, placement of trocars and reach to the cyst, third step, aspiration and decortication of the cyst. The difficulty of the sessions was measured with the Visual Analog Scale (VAS) scoring system. Score was determined according to the difficulty of the surgical step ranging from '0' to '10', '0', too easy, '10' too difficult'. The durations were measured. One-way ANOVA test was used for statistical analysis. RESULTS: The mean age was 52.0 (20-75) years. The mean operation time was 52.0 min. The mean duration of the first step was 12.5, second, 26.0 and third, 22.5 min. The mean VAS of first step, 3.2, second, 6.0 and third, 3.6 There were only significant differences in duration time and VAS score for second step among the surgeons (P<0.05). CONCLUSIONS: Laparoscopic cyst decortication may provide gaining experience to approach the kidney laparoscopically. The side, size and localization of cysts were not found associated with the difficulty of the method. [ABSTRACT FROM AUTHOR]