The main purpose of this study is to examine the relationships among the personality traits, resilience and cognitive flexibility. The research group are students from different universities in 2021-2022 academic year in Turkey. 71.14% (n=281) of the participants are female and 28.85% (n=114) are male. Big Five Personality Traits Scale, The Brief Resilience Scale, and Cognitive Flexibility Scale were used as data collection tools in the study.T test, Pearson correlation analysis, multiple regression analysis and hierarchical regression analysis were used in the analysis of the data. According to the findings, it was determined that the psychological resilience levels of men were higher than that of women. According to the results of Pearson correlation analysis, there are a positive correlation among extraversion, conscientiousness, openness to experience which are among the personality traits and cognitive flexibility. Also there are positive and significant relationships between extraversion, openness to experience, conscientiousness which are among the personality traits and psychological resilience. Extraversion, openness to experience and conscientiousness predicted cognitive flexibility; conscientiousness and neuroticism predicted psychological resilience. The findings were discussed and interpreted within the framework of the relevant literature. [ABSTRACT FROM AUTHOR]