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1. An international, expert-based, Delphi consensus document on controversial issues in the management of abdominal aortic aneurysms

Author

Paraskevas, Kosmas I., Schermerhorn, Marc L., Haulon, Stephan, Beck, Adam W., Verhagen, Hence J.M., Lee, Jason T., Verhoeven, Eric L.G., Blankensteijn, Jan D., Kölbel, Tilo, Lyden, Sean P., Clair, Daniel G., Faggioli, Gianluca, Bisdas, Theodosios, D'Oria, Mario, Mani, Kevin, Sörelius, Karl, Gallitto, Enrico, Fernandes e Fernandes, Jose, Katsargyris, Athanasios, Lepidi, Sandro, Vacirca, Andrea, Myrcha, Piotr, Koelemay, Mark J.W., Mansilha, Armando, Zeebregts, Clark J., Pini, Rodolfo, Dias, Nuno V., Karelis, Angelos, Bosiers, Michel J., Stone, David H., Venermo, Maarit, Farber, Mark A., Blecha, Matthew, Melissano, Germano, Riambau, Vincent, Eagleton, Matthew J., Gargiulo, Mauro, Scali, Salvatore T., Torsello, Giovanni B., Eskandari, Mark K., Perler, Bruce A., Gloviczki, Peter, Malas, Mahmoud, and Dalman, Ronald L.

Published
2025
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3. Role of gamma radiation as an agent modulator of Mucor subtilissimus UCP1262 Fibrinolytic Enzyme (MsFE)

Author

Cardoso, Kethylen Barbara Barbosa, Nascimento, Thiago Pajeú, Correia, Patyanne Carvalho, da Silva Batista, Juanize Matias, Brandão-Costa, Romero Marcos Pedrosa, Ferreira, Kétura Rhammá Cavalcante, de Carvalho-Silva, Jônatas, da Cruz Augusto Neves Petersen, Maria Teresa, Albuquerque, Wendell, Salazar e Fernandes, Thiago de, Converti, Attilio, and Porto, Ana Lúcia Figueiredo

Published
2024
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5. Why do guidelines recommend screening for abdominal aortic aneurysms, but not for asymptomatic carotid stenosis? A plea for a randomized controlled trial

Author

Paraskevas, Kosmas I., Spence, J. David, Mikhailidis, Dimitri P., Antignani, Pier Luigi, Gloviczki, Peter, Eckstein, Hans-Henning, Spinelli, Francesco, Stilo, Francesco, Saba, Luca, Poredos, Pavel, Dardik, Alan, Liapis, Christos D., Mansilha, Armando, Faggioli, Gianluca, Pini, Rodolfo, Jezovnik, Mateja K., Sultan, Sherif, Musiałek, Piotr, Goudot, Guillaume, Lavenson, George S., Jr, Jawien, Arkadiusz, Blinc, Aleš, Myrcha, Piotr, Fernandes e Fernandes, Jose, Geroulakos, George, Kakkos, Stavros K., Knoflach, Michael, Proczka, Robert M., Capoccia, Laura, Rundek, Tatjana, Svetlikov, Alexei S., Silvestrini, Mauro, Ricco, Jean-Baptiste, Davies, Alun H., Di Lazzaro, Vincenzo, Suri, Jasjit S., Lanza, Gaetano, Fraedrich, Gustav, Zeebregts, Clark J., and Nicolaides, Andrew N.

Published
2023
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7. Optimal periprocedural antithrombotic treatment in carotid interventions: An international, multispecialty, expert review and position statement

Author

Paraskevas, Kosmas I., Gloviczki, Peter, Mikhailidis, Dimitri P., Antignani, Pier Luigi, Dardik, Alan, Eckstein, Hans-Henning, Faggioli, Gianluca, Fernandes e Fernandes, Jose, Fraedrich, Gustav, Gupta, Ajay, Jawien, Arkadiusz, Jezovnik, Mateja K., Kakkos, Stavros K., Knoflach, Michael, Lal, Brajesh K., Lanza, Gaetano, Liapis, Christos D., Loftus, Ian M., Mansilha, Armando, Millon, Antoine, Pini, Rodolfo, Poredos, Pavel, Proczka, Robert M., Ricco, Jean-Baptiste, Rundek, Tatjana, Saba, Luca, Schlachetzki, Felix, Silvestrini, Mauro, Spinelli, Francesco, Stilo, Francesco, Suri, Jasjit S., Zeebregts, Clark J., Lavie, Carl J., and Chaturvedi, Seemant

Published
2022
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8. Benefits and drawbacks of statins and non-statin lipid lowering agents in carotid artery disease

Author

Paraskevas, Kosmas I., Gloviczki, Peter, Antignani, Pier Luigi, Comerota, Anthony J., Dardik, Alan, Davies, Alun H., Eckstein, Hans-Henning, Faggioli, Gianluca, Fernandes e Fernandes, Jose, Fraedrich, Gustav, Geroulakos, George, Golledge, Jonathan, Gupta, Ajay, Gurevich, Victor S., Jawien, Arkadiusz, Jezovnik, Mateja K., Kakkos, Stavros K., Knoflach, Michael, Lanza, Gaetano, Liapis, Christos D., Loftus, Ian M., Mansilha, Armando, Nicolaides, Andrew N., Pini, Rodolfo, Poredos, Pavel, Proczka, Robert M., Ricco, Jean-Baptiste, Rundek, Tatjana, Saba, Luca, Schlachetzki, Felix, Silvestrini, Mauro, Spinelli, Francesco, Stilo, Francesco, Suri, Jasjit S., Svetlikov, Alexei V., Zeebregts, Clark J., Chaturvedi, Seemant, Veith, Frank J., and Mikhailidis, Dimitri P.

Published
2022
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11. Optimal Management of Asymptomatic Carotid Stenosis in 2021: The Jury is Still Out. An International, Multispecialty, Expert Review and Position Statement

Author

Paraskevas, Kosmas I., Mikhailidis, Dimitri P., Antignani, Pier Luigi, Baradaran, Hediyeh, Bokkers, Reinoud P.H., Cambria, Richard P., Dardik, Alan, Davies, Alun H., Eckstein, Hans-Henning, Faggioli, Gianluca, e Fernandes, Jose Fernandes, Fraedrich, Gustav, Geroulakos, George, Gloviczki, Peter, Golledge, Jonathan, Gupta, Ajay, Jezovnik, Mateja K., Kakkos, Stavros K., Katsiki, Niki, Knoflach, Michael, Kooi, M. Eline, Lanza, Gaetano, Liapis, Christos D., Loftus, Ian M., Mansilha, Armando, Millon, Antoine, Nicolaides, Andrew N., Pini, Rodolfo, Poredos, Pavel, Ricco, Jean-Baptiste, Riles, Thomas S., Ringleb, Peter Arthur, Rundek, Tatjana, Saba, Luca, Schlachetzki, Felix, Silvestrini, Mauro, Spinelli, Francesco, Stilo, Francesco, Sultan, Sherif, Suri, Jasjit S., Zeebregts, Clark J., and Chaturvedi, Seemant

Published
2022
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13. α Espec-222 as a variant to the radon monitoring method using a solid state nuclear track

Author

do Nascimento Santos, Josineide Marques, dos Santos Júnior, José Araújo, dos Santos Amaral, Romilton, Cavalcanti Freire Bezerra, Mariana Brayner, de Salazar e Fernandes, Thiago, Valcárcel Rojas, Lino Angel, Fernández, Zahily Herrero, Nóbrega de Araújo, Eduardo Eudes, Isidoro de Araújo Rodrigues Azevedo, Andrey José, Lopes de Barros Correia, Filipe, and Milán, Marvic Ortueta

Published
2021
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18. Imaging Occlusive Atherosclerosis

Author

Fernandes e Fernandes, J., Pedro, L. Mendes, Fernandes e Fernandes, R., Silvestre, L., Saba, Luca, editor, Sanches, João Miguel, editor, Pedro, Luís Mendes, editor, and Suri, Jasjit S., editor

Published
2014
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22. Extracranial Carotid Artery Disease

Author

Fernandes e Fernandes, José, Pedro, Luís Mendes, Arnold, Wolfgang, editor, Ganzer, Uwe, editor, Liapis, Christos D., editor, Balzer, Klaus, editor, Benedetti-Valentini, Fabrizio, editor, and Fernandes e Fernandes, José, editor

Published
2007
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23. Invasive Diagnosis of Vascular Diseases

Author

Pedro, Luís Mendes, Fernandes e Fernandes, José, Arnold, Wolfgang, editor, Ganzer, Uwe, editor, Liapis, Christos D., editor, Balzer, Klaus, editor, Benedetti-Valentini, Fabrizio, editor, and Fernandes e Fernandes, José, editor

Published
2007
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26. Ultrasound Plaque Enhanced Activity Index for Predicting Neurological Symptoms

Author

Seabra, José, Pedro, Luís Mendes, Fernandes e Fernandes, José, Sanches, João, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Sudan, Madhu, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Vardi, Moshe Y., Series editor, Weikum, Gerhard, Series editor, Vitrià, Jordi, editor, Sanches, João Miguel, editor, and Hernández, Mario, editor

Published
2011
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31. Three-Dimensional Ultrasonic Assessment of Atherosclerotic Plaques

Author

Seabra, José, Sanches, João, Pedro, Luís M., Fernandes e Fernandes, J., Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Rangan, C. Pandu, editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Martí, Joan, editor, Benedí, José Miguel, editor, Mendonça, Ana Maria, editor, and Serrat, Joan, editor

Published
2007
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36. Position Paper on Young Vascular Surgeons Training of the Mediterranean Federation for the Advancing of Vascular Surgery (MeFAVS): State of the Art and Perspectives

Author

Bracale, Umberto Marcello, Ammollo, Raffaele Pio, Hussein, Emad A., Hoballah, Jamal J., Taurino, Maurizio, Saleem, Ben R., Setacci, Carlo, Pecoraro, Felice, Serra, Raffaele, Bracale, Giancarlo, Panagrosso, Marco, Peluso, Antonio, Petrone, Anna, Maisto, Marianna, del Guercio, Luca, Dinoto, Ettore, Bajardi, Guido, Bouayed, Mohamed N., Zeebregts, Clark J., Pulli, Raffaele, Pane, Bianca, Pratesi, Giovanni, Castelli, Patrizio, Setacci, Francesco, Gargiulo, Mauro, Stella, Andrea, Illario, Maddalena, De Luca, Vincenzo, Verhoeven, Eric L.G., Riambau, Vincent, Saratzis, Nikolaos, Cvjetko, Ivan, Resch, Timothy, Fernandes e Fernandes, José, Chiche, Laurent, and Goeau-Brissonniere, Olivier

Published
2021
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37. Comprehensive geriatric assessment in older patients suffering from infective endocarditis. A prospective multicentric cohort study

Author

E. Forestier, C. Roubaud-Baudron, T. Fraisse, C. Patry, G. Gavazzi, B. Hoen, P. Carauz-Paz, B. Moheb-Khosravi, F. Delahaye, G. Sost, M. Paccalin, P. Nazeyrollas, C. Strady, F. Alla, C. Selton-Suty, S. Schambach, d’O. Vallette, B.M. Khosravi, C. Roubaud, A. Lafargue, F. Guerville, D. Kobeh, E. Averty, L. Thiennaud, E. Soulas, T. Basileu, M. Chuzeville, M.-C. Laurain, J.L. Novella, L.A. Bertholon, Y. Jaidi, R. Guiard, J. Naturel, V. Vitrat, X. Duval, G. Wirth, P. Pavese, I. Pierre, É. Fernandes, E. Curlier, A. Boibieux, F. Goehringer, G. Béraud, Y. Nguyen, P. Tattevin, M. Revest, C. Piau, P.C. Paz, A.-C. Vançon, N. Naem, B. Richard, B. Iung, M. Dijos, A. Fluttaz, P.-V. Ennezat, C. Beaufort, F. Torossian, C. Brasselet, E. Donal, O. Pineau, N. Agrinier, M.-L. Erpelding, W.N. Sime, G. Clavère, M. Lebouc, E. Ilic-Habensus, J. Durrieu, T. Habet, C. Dupré, A.-M. Chaissac, S. Touati, A. Delahaye, E. Marquis, M. Warchol, E. Thébault, C. Jouan, C. Campagnac, and I. Petitgenêt

Subjects
Male, 0301 basic medicine, Microbiology (medical), Pediatrics, medicine.medical_specialty, 030106 microbiology, Nutritional Status, Comorbidity, 03 medical and health sciences, 0302 clinical medicine, Older patients, medicine, Humans, Prospective Studies, 030212 general & internal medicine, Prospective cohort study, Geriatric Assessment, Aged, Aged, 80 and over, Old patients, Endocarditis, business.industry, Mean age, Geriatric assessment, General Medicine, medicine.disease, Survival Analysis, Hospitalization, Infectious Diseases, Infective endocarditis, Female, Functional status, France, business, Cohort study
Abstract

The aim was to describe the impact of infective endocarditis (IE) on functional, cognitive and nutritional statuses, and to estimate the influence of these parameters on surgical management and mortality.This was a prospective study over 13 months in 14 French hospitals, including patients ≥75 years of age with definite or possible IE. A comprehensive geriatric assessment (CGA) was performed during the first week of hospitalization, including a retrospective estimation of functional status 2 months before hospitalization, and 3 months after.A total of 120 patients were included (mean age 83.1 ± 5.0 (75-101) years). IE was associated with a dramatic impairment of functional status between 2 months prior hospitalization and the first geriatric evaluation (90.8% able to walk vs. 35.5% (p 0.0001), ADL (Activities in Daily Living) 5.0 ± 1.7 vs. 3.1 ± 2.1 (p 0.0001)). The 19 operated patients (15.8%) had less comorbidities (cumulative illness rating scale geriatric 10.8 ± 8.2 vs. 15.3 ± 7.1 (p 0.0176)), better functional (ADL 5.9 ± 0.4 vs. 4.9 ± 1.8 (p 0.0171) and nutritional (mini nutritional assessment 20.4 ± 5.0 vs. 17.3 ± 6.2 (p 0.0501)) statuses than non-operated patients. Among all infectious, cardiac and geriatric parameters, body mass index (HR 0.9, range 0.8-1, p 0.05) and ADL at the time of the first evaluation (HR 0.7, range 0.6-0.9, p 0.002) were the sole independent predictors of the 3-month (32.5%) and 1-year mortality (42.5%). Three months later, the 57 assessed patients only partially recovered their ADL (3.7 ± 1.9 vs. 5.3 ± 1.4 2 months prior hospitalization and 4.6 ± 1.9 at the first CGA; p 0.0001).Functional and nutritional abilities are crucial components that can be accurately explored through a CGA when managing IE in oldest patients.

Published
2019
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40. Clarifying the rationale supporting selective screening for asymptomatic carotid artery stenosis

Author

Paraskevas, Kosmas I., Nicolaides, Andrew N., Spence, J. David, Mikhailidis, Dimitri P., Lanza, Gaetano, Liapis, Christos D., Goudot, Guillaume, Faggioli, Gianluca, Pini, Rodolfo, Musiałek, Piotr, Suri, Jasjit S., Silvestrini, Mauro, Fernandes e Fernandes, Jose, Eckstein, Hans-Henning, Jawien, Arkadiusz, Spinelli, Francesco, Stilo, Francesco, Myrcha, Piotr, Rundek, Tatjana, Kakkos, Stavros K., Di Lazzaro, Vincenzo, Svetlikov, Alexei, Antignani, Pier Luigi, Poredos, Pavel, Saba, Luca, Jezovnik, Mateja K., Blinc, Aleš, Sultan, Sherif, Knoflach, Michael, Capoccia, Laura, Proczka, Robert M., Fraedrich, Gustav, Zeebregts, Clark J., Davies, Alun H., Geroulakos, George, Ricco, Jean-Baptiste, Mansilha, Armando, Dardik, Alan, and Gloviczki, Peter

Published
2023
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41. Screening for asymptomatic carotid stenosis in patients with non-valvular atrial fibrillation

Author

Paraskevas, Kosmas I., Eckstein, Hans-Henning, Mansilha, Armando, Ricco, Jean-Baptiste, Geroulakos, George, Di Lazzaro, Vincenzo, Rundek, Tatjana, Lanza, Gaetano, Fraedrich, Gustav, Svetlikov, Alexei S., Suri, Jasjit S., Zeebregts, Clark J., Davies, Alun H., Capoccia, Laura, Proczka, Robert M., Myrcha, Piotr, Antignani, Pier Luigi, Fernandes e Fernandes, Jose, Spence, J. David, Dardik, Alan, Jezovnik, Mateja K., Knoflach, Michael, Lavenson, George S., Jr., Kakkos, Stavros K., Jawien, Arkadiusz, Silvestrini, Mauro, Blinc, Aleš, Spinelli, Francesco, Stilo, Francesco, Musiałek, Piotr, Sultan, Sherif, Goudot, Guillaume, Liapis, Christos D., Saba, Luca, Faggioli, Gianluca, Pini, Rodolfo, Poredos, Pavel, Mikhailidis, Dimitri P., Gloviczki, Peter, and Nicolaides, Andrew N.

Published
2023
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45. Immunovirological status in people with perinatal and adult-acquired HIV-1 infection: a multi-cohort analysis from FranceResearch in context

Author

Rémonie Seng, Pierre Frange, Albert Faye, Catherine Dollfus, Jérôme le Chenadec, Faroudy Boufassa, Asma Essat, Tessa Goetghebuer, Elisa Arezes, Véronique Avettand-Fènoël, Jean-Joël Bigna, Stéphane Blanche, Cécile Goujard, Laurence Meyer, Josiane Warszawski, Jean-Paul Viard, H. Aumaitre, E. Froguel, F. Caby, S. Dellion, L. Gerard, F. Lucht, C. Chirouze, M. Dupon, Jl Schmit, C. Goujard, T. Allegre, B. Cazenave, G. Hittinger, P. De Truchis, J. Cailhol, C. Duvivier, A. Canestri, O. Bouchaud, M. Karmochkine, D. Salmon-Ceron, D. Zucman, E. Mortier, R. Tubiana, P.M. Girard, C. Pintado, A. Cabie, V. Rabier, P. Morlat, D. Neau, C. Genet, D. Makhloufi, S Bregigeon Ronot, J. Ghosn, V. Reliquet, P. Perré, Jl Pellegrin, C. Arvieux, C. Cheneau, L. Bernard, P. Delobel, R. Verdon, C. Jacomet, L. Piroth, F. Ajana, S. Bevilacqua, Y. Debab, A.L. Lecapitaine, L. Cotte, S. Mokhtari, P. Mercie, P. Poubeau, V. Garrait, Ma Khuong, G. Beck-Wirth, L. Blum, S. Blanche, F. Boccara, T. Prazuck, C. Barbuat, J.P. Viard, S. Stegmann-Planchard, B. Martha, J.M. Treluyer, E. Dore, C. Gaud, M. Niault, E. Fernandes, H. Hitoto, A. Compagnucci, N. Elenga, A. Faye, C. Dollfus, A. Chace, M. Levine, S.A. Martha, C. Floch-Tudal, K. Kebaïli, N. Entz-Werle, J. Tricoire, F. Mazingue, P. Bolot, P. Brazille, T. Goetghebuer, A.F. Gennotte, D. Van Der Linden, V. Schmitz, M. Moutschen, C. Crenn-Hebert, F. Habibi, A. Coursol, E. Guesdon, P.F. Ceccaldi, M. Dehlinger – Paul, E. Pannier, V. Marcou, C. Elleau, M. Achkar, M.O. Vareil, S. Couderc, C. Routier, M.A. Bouldouyre, L. Selleret, A. Chabrol, C. Bellahcene, C. Pluchart, A. Yangui, D. Vignes, A. Alissa, A. Johnson, E. Lachassinne, A. Benbara, L. Karaoui, A. Bongain, B. Yakeu, J.L. Schmit, L. Cravello, C. Hubert, P. Faucher, D. Pinquier, C. Borie, D. Rocchi, C. Brunet-Cartier, C. Briandet, J. Brouard, A. Chalvon-Demersay, M. Rajguru, K. Billiemaz, A. Fresard, A. Moulin, P. Fialaire, L. Mesnard, E. Werner, E. Vintejoux, J. Marian, S. Ranaivojaona, F. Bissuel, M. Abdelhadi, Y. Hammou, C. Genet-Villeger, Y. Hatchuel, G. Bachelard, M. Medus, J. Dendale – Nguyen, T.S. Guimard, A. Martha, M. Rouha, P. Perfezou, L. De Saint Martin, S. Jaffuel, R. Buzele, M. Gousseff, C. Cudeville, V. Vitrat, C. Michau, G. Palenzuela, M. Driessen, B. Heller-Roussin, J.M. Labaune, B. Muanza, J. Massardier, M. Partisani, I. Hau, C. Runel-Belliard, C. Brehin, K. Kebaili, M. Lalande, M. Lagree, K. Lacombe, J.-M. Molina, J. Reynes, O. Robineau, F. Raffi, A. Becker, L. Weiss, T. Allègre, G. Pialoux, F. Souala, A. Rami, C. Katlama, A. Cabié, J.-P. Viard, F. Bastides, C. Michel, D. Salmon, J-D Le Lièvre, A. Sotto, E. Rouveix, A. Naqvi, S. Brégigeon, R. Rodet, A. Simon-Coutelier, J.-L. Esnault, R. Buzelé, A. Stein, C. Godin-Colet, G. Pichancourt, P. Caraux-Paz, M Mohseni Zadeh, L. Gérard, C. Lascaux-Cametz, L. Bodard, J.-L. Pellegrin, N. Ettahar, A. Uludag, E. Rosenthal, F. Prevoteau du Clary, S. Jaureguiberry, P. Philibert, A.-L. Lecapitaine, E. Chakvetadze, H. Champagne, V. Daneluzzi, J. Goupil de Bouillé, A. Leprêtre, I. Lamaury, I. Darasteanu, B. Abraham, D. Garipuy, J.-L. Berger, J.-L. Schmit, K. Diallo, F. Gourdon, O. Vaillant, V. Gaborieau, J. Doll, D. Quinsat, L. Geffray, J.-J. Girard, D. Houlbert, V. Perronne, E. Klement, O. Antioniotti, C. Rouzioux, V. Avettand-Fenoel, O. Lortholary, S. Boucly, A. Maignan, R. Thiebaut, L. Meyer, F. Boufassa, M.A. Charles, R. Dray-Spira, C. Legeai, V. Amon, N. Benammar, R. Seng, L. Slama, P. Bonnard, C. Chakvetadze, T. L’Yavanc, J. Capeau, C. Vigouroux, S. Fellahi, J.P. Bastard, E. Oksenhendler, J.F. Bourge, V. Bajzik, D. Sereni, C. Lascoux-Combe, O. Taulera, L.V. Dien, J. Delgado, J.M. Molina, T. Saint-Marc, S. Ferret, J. Pavie, J.F. Bergmann, M. Parrinello, BLefebvre, C. Boudraa, B. Diallo, C. Lupin, S. Herson, A. Simon, N. Edeb, L. Guillevin, T. Tahi, M.P. Pietri, D. Tisne-Dessus, C. Jalbert, P. Yeni, S. Matheron, G. Pahlavan, B. Phung, N. El-Alami Talbi, Z. Ramani, G. Catalano, C. Godard, F. Boue, V. Chambrin, D. Bornarel, H. Schoen, R. Carlier, B. Fantin, C. Poder, R. Dhote, M. Bentata, P. Honore, Xuan Tuyet, J.F. Delfraissy, F. Chaix, M.T. Rannou, Y. Levy, A. Sobel, C. Dumont, S. Abel, S. Pierre-François, V. Beaujolais, I. Poizot-Martin, O. Zaegel-Faucher, C. Debreux, J. Moreau, E. Van Der Gheynst, M.C. Thiebaut-Drobacheff, A. Foltzer, B. Hoen, J.F. Faucher, H. Gil, J.M. Ragnaud, I. Raymond, I. Louis, M. Hessamfar, V. Baillat, C Merle De Boever, C. Tramoni, A. Soufflet, P. Guadagnin, P. Choutet, O. Mounoury, D. Brosseau, H. Hue, T. May, S. Wassoumbou, M. Stenzel, M.P. Bouillon, Y. Yazdanpanah, T. Huleux, E. Aissi, S. Pavel, D. Rey, P. Fischer, G. Blaison, M. Martinot, A. Pachart, F. Jeanblanc, J.L. Touraine, C. Trepo, P. Miailhes, K. Kouadjo, V. Thoirain, C. Brochier, P. Perre, S. Leautez, J.L. Esnault, and I. Suaud

Subjects
Perinatal HIV infection, Cohort, Viral failure, Immunological outcome, Epidemiology, Public aspects of medicine, RA1-1270
Abstract

Summary: Background: No study has compared the virological and immunological status of young people with perinatally-acquired HIV infection (P-HIV) with that of people with HIV adulthood (A-HIV) having a similar duration of infection. Methods: 5 French cohorts of P-HIV and A-HIV patients with a known date of HIV-infection and receiving antiretroviral treatment (ART), were used to compare the following proportions of: virological failure (VF) defined as plasma HIV RNA ≥ 50 copies/mL, CD4 cell percentages and CD4:CD8 ratios, at the time of the most recent visit since 2012. The analysis was stratified on time since infection, and multivariate models were adjusted for demographics and treatment history. Findings: 310 P-HIV were compared to 1515 A-HIV (median current ages 20.9 [IQR:14.4–25.5] and 45.9 [IQR:37.9–53.5] respectively). VF at the time of the most recent evaluation was significantly higher among P-HIV (22.6%, 69/306) than A-HIV (3.3%, 50/1514); p ≤ 0.0001. The risk of VF was particularly high among the youngest children (2–5 years), adolescents (13–17 years) and young adults (18–24 years), compared to A-HIV with a similar duration of infection: adjusted Odds-Ratio (aOR) 7.0 [95% CI: 1.7; 30.0], 11.4 [4.2; 31.2] and 3.3 [1.0; 10.8] respectively. The level of CD4 cell percentages did not differ between P-HIV and A-HIV. P-HIV aged 6–12 and 13–17 were more likely than A-HIV to have a CD4:CD8 ratio ≥ 1: 84.1% vs. 58.8% (aOR = 3.5 [1.5; 8.3]), and 60.9% vs. 54.7% (aOR = 1.9 [0.9; 4.2]) respectively. Interpretation: P-HIV were at a higher risk of VF than A-HIV with a similar duration of infection, even after adjusting for treatment history, whereas they were not at a higher risk of immunological impairment. Exposure to viral replication among young patients living with HIV since birth or a very early age, probably because of lower adherence, could have an impact on health, raising major concerns about the selection of resistance mutations and the risk of HIV transmission. Funding: Inserm - ANRS MIE.

Published
2024
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