23 results on '"Çiftci N"'
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2. Increasing the amorphous yield of {(Fe0.6Co0.4)0.75B0.2Si0.05}96Nb4 powders by hot gas atomization
- Author
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Ciftci, N., Ellendt, N., Soares Barreto, E., Mädler, L., and Uhlenwinkel, V.
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- 2018
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3. Characterization of a {(Fe60Co40)75B20Si5}96Nb4 impulse atomized glassy powder by Neutron Diffraction and Differential Scanning Calorimetry
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Bogno, A.-A., Dahlborg, U., Calvo-Dahlborg, M., Riveros, C., Ciftci, N., Henein, H., and Sediako, D.
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- 2016
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4. Evolution of the hourglass structures in the Laminaria High, Timor Sea: Implications for hydrocarbon traps
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Çiftçi, N. Bozkurt and Langhi, Laurent
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- 2012
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5. Impact of lithospheric flexure on the evolution of shallow faults in the Timor foreland system
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Langhi, Laurent, Ciftci, N. Bozkurt, and Borel, Gilles D.
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- 2011
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6. The effects of academic mentoring perceptions of research assistants on their organizational commitment
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Çiftçi Nusret, Ertürk Ebru, Doğanalp Burcu, and Kızıloğlu Esra
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Social Sciences - Abstract
Mentoring can be expressed as a supportive relationship in which an experienced person transfers his or her expertise and knowledge to someone else. Universities are one of the most appropriate environments that this process, the samples of which can be seen in many sectors, is experienced. Academicianship is one of the professions in which the mentoring process is the most intense and most-needed. This study was aimed to investigate how research assistants perceive the academic mentor and mentee relationship, how these perceptions are related to the desired working behaviour, performance, and organizational effectiveness, and how these relationships affect “organizational commitment,” which has an increasing importance. Thus, both a sample based on the academic mentoring process was obtained and the academic mentoring process, as a factor affecting the organizational commitment, was studied. As a result of the research, it was found that there was a positive relationship between perceived mentoring and organizational commitment, affective commitment from subcategories of commitment. The relationship between normative commitment and organizational commitment were also found to be positive and meaningful. However, no relationship between perceived mentoring and continuance was found, and the established regression model did not make sense either.
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- 2017
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7. The relationship between organizational commitment and whistleblowing tendency: An empirical research
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Çiftçi Nusret and Bedük Aykut
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Social Sciences - Abstract
The ethical position of organizations is of great importance to both organizations and society in general considering people spend their considerable lifespan in organizations. It is important to sustain the determination on ethics by detecting and revealing the ethical infringements inside the organization. In this context; whistleblowing, which is a concept deriving from the field of organizational psychology is defined as the action that informing the individuals and organizations for the on-going unethical and amoral activities in the organizations, has become important. The courage of individuals to report unethical, immoral or illegal activities to the authorities can be affected by the attitude of individuals towards the organization. One of the attitudes that are considered to affect that courage, which is named as whistleblowing, is organizational commitment. Organizational commitment shows the loyalty of employees to the organization. In this study it has been examined the relationship between employees’ organizational commitment and tendency to reporting immoral behaviours. The sample of the study is composed of the employees of Faculty of Economics and Administrative Sciences at Selcuk University. For this empirical study, survey method has been used, and the reached sample chosen by simply random sampling is 88 employees.
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- 2017
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8. The effect of the health belief model-based educational program on physical activity beliefs and behaviors of university students
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Hasibe Kadioglu, Necmettin ÇİFTCİ, and ÇİFTCİ N., KADIOĞLU H.
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Social Sciences and Humanities ,Health (social science) ,Social Sciences (SOC) ,FITNESS ,Sosyal Bilimler ve Beşeri Bilimler ,Epidemiology ,SOCIAL SCIENCES, GENERAL ,EXERCISE ,Nursing ,Sağlık Bilimleri ,Sociology ,Occupational Therapy ,Epidemiyoloji ,Health Sciences ,Genel Sosyal Bilimler ,Sosyal ve Beşeri Bilimler ,Social Sciences & Humanities ,Sosyoloji ,Halk, Çevre ve İş Sağlığı ,Güvenlik Araştırması ,PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH ,Physical activity ,Public Health, Environmental and Occupational Health ,General Social Sciences ,Sosyal Bilimler Genel ,EFFICACY ,Exercise Health Belief Model Scale ,KAMU, ÇEVRE VE İŞ SAĞLIĞI ,PREVALENCE ,İş Sağlığı ve Terapisi ,RELIABILITY ,Sosyal Bilimler (SOC) ,Safety Research ,INTERVENTION ,Sağlık (sosyal bilimler) ,Health Belief Model - Abstract
Aim This study was conducted to determine the effect of the education program based on the Health Belief Model (HBM) on the physical activity beliefs and behaviors of university students. Subject and methods This quasi-experimental study was carried out with one experiment and one control group where a pre-test and post-test were applied to the participant. The study included 129 participants (experimental group = 61, control group = 68) studying at two universities between March-September 2019. A 4-week HBM-based training program was applied to the students in the experimental group. Data were collected with the \"Personal Information Form,\" \"International Physical Activity Questionnaire (IPAQ)\" and \"Exercise Health Belief Model Scale (EHBMS).\" Chi-square test, T-test for dependent and independent groups, Wilcoxon sign test, and Mann-Whitney U tests were used in the evaluation of the data. Result The EHBMS (p = 0.009) and MET (p=0.000) total score averages of the experimental group were found to be statistically significantly higher than the control group in the post-test. Conclusion We determined that the HBM-based education program implemented within the scope of this study positively affects the physical activity beliefs and behaviors of the students. Nurses studying with students can use this program as a guide.
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- 2022
9. Effect of Environmental Awareness-Based Education on Environmental Attitudes of Nursing Students: A Randomized Controlled Study.
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Evcimen H, Çiftci N, and Yıldız M
- Abstract
Objective: This study was conducted to determine the effect of environmental awareness-based education given to nursing students on their environmental attitudes., Method: This study was designed in a parallel-group 1:1 single-blind randomized controlled experimental design. The study was conducted with 110 nursing students studying at a state university in Turkey between November 1, 2023, and March 15, 2024. Data were collected using a personal information form and the Environmental Attitude Scale. Data were analyzed using SPSS 25.0 and G Power 3.1.9.7 software., Results: After the training program was applied to the students, it was found that the mean score of the environmental attitude scale of the experimental group was significantly higher than the control group (p < 0.05). It was found that the posttest mean score of the experimental group's environmental attitude scale was higher than the pretest (p < 0.05)., Conclusion: It was observed that the environmental awareness-based education program given to nursing students had a positive effect on environmental attitude. Longitudinal studies on environmental attitude are recommended., Trial Registration: ClinicalTrials.gov identifier: NCT06169189., (© 2024 Wiley Periodicals LLC.)
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- 2024
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10. The relationship between satisfaction with life, dietary attitude, and comfort level in hemodialysis patients: Analysis with machine learning approach.
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Çiftci N, Yıldız M, and Yildirim Z
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- Humans, Female, Male, Cross-Sectional Studies, Middle Aged, Personal Satisfaction, Aged, Adult, Patient Comfort methods, Diet methods, Surveys and Questionnaires, Renal Dialysis psychology, Machine Learning, Quality of Life
- Abstract
Introduction: Hemodialysis (HD) patients have become a serious public health problem, the number of which is increasing every year worldwide. This study aimed to determine the relationship between satisfaction with life, dietary attitude, and comfort level in patients receiving HD treatment., Methods: This research was conducted in a relational cross-sectional descriptive design. The research was conducted with 174 patients (85% of the population) receiving HD treatment between March 20 and September 30, 2023. In the study, hierarchical regression analysis was performed with SPSS 25.0. Machine learning analysis and prediction were performed using R programming language, version 4.1.3., Results: The model used to determine the factors affecting satisfaction with life was significant and usable (F(2,171) = 25.855, p = 0.001). Attitudes of HD patients toward dietary therapy and their HD comfort levels together explained 22.3% of the total variance of satisfaction with life. In the regression model, according to the results of the t-test regarding the significance of the regression coefficient, the increase in the HD comfort levels of the participants (t = 2.668, p = 0.008) and the increase in the attitude of the HD patients toward dietary therapy (t = 5.897, p = 0.001) caused a statistical increase in "satisfaction with life." According to Shapley values, the most important variable in the prediction of satisfaction with life variable is attitude for the dietary attitude., Conclusion: It was determined that the increase in the comfort levels of HD patients and their positive dietary attitudes increased satisfaction with life. It is recommended to provide education to increase patients' diet attitudes and comfort levels., (© 2024 International Society for Apheresis and Japanese Society for Apheresis.)
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- 2024
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11. Relationship of Cryptocurrency Trading to Quality of Life, Sleep and Stress Levels in Academics
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Uçar, Yildiz M, Çiftci N, and Aylaz R
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- Humans, Cross-Sectional Studies, Male, Female, Adult, Turkey, Universities, Stress, Psychological, Sleep, Young Adult, Middle Aged, Commerce, Surveys and Questionnaires, Quality of Life psychology
- Abstract
Background: Cryptocurrency trading has become popular with a large section of society, and the number of investors is increasing daily. It is critical to address the health impacts of cryptocurrency trading. Of particular importance is the issue of how such trading affects mental health. Research should be conducted on this topic, and where necessary, national governments should develop policies to combat these effects., Aims: This study was conducted to examine the relationship of cryptocurrency trading to quality of life, sleep, and stress levels in academics., Methods: This descriptive and cross-sectional study was conducted with 437 academics working at a state university in Turkey. A Personal Information Form, the SF-12 Quality of Life Scale, the Scopa Sleep Scale, and the Perceived Stress Scale were used to collect data. These data were analyzed using SPSS 25.0 and G*Power 3.1 programs., Results: The data obtained in this study were analyzed using SPSS program (SPSS-25). The effect size and r-effect size were calculated with Cohen’s d value. It was found that the mean scores for the SF-12 Quality of Life Scale were statistically lower in academics who traded cryptocurrency than in those who did not. The results showed that the mean scores for the Scopa Sleep Scale and Perceived Stress Scale were statistically higher in academics who traded cryptocurrency than in those who did not (p<0.05)., Discussion: The academics who traded cryptocurrency had more negative health outcomes when compared to those who did not. Social awareness should be raised on the negative effects of cryptocurrency trading. A limitation of the study is that only data obtained from the statements of the participants were included in the study. The study may have some generalizability to other academics, but has less generalizability to populations other than academics., Implications for Health Care Provision and Use: Cryptocurrency trading is a significant public health problem. Although cryptocurrency trading has been found to profoundly affect mental health (sleep, stress, and quality of life), the current policies that address these problems are generally inadequate in terms of implementing and sustaining mental healthcare systems. The limitations of these health policies prevent many individuals in society from receiving high quality services., Implications for Health Policies: Health systems alone cannot solve the systemic problems that lead to the population’s dependence of mental health services and institutions. In order to solve this basic problem, it may be necessary for governments to increase individuals’ basic incomes and develop specific mental health policies for people engaged in cryptocurrency trading., Implications for Further Research: Future studies should examine expert perspectives on mental health services in different contexts (e.g., behavioral addiction services), collect targeted feedback, and explore issues such as strategic planning and funding stability. Effective decisions should be made regarding the implementation and maintenance of treatment for behavioral addictions.
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- 2024
12. Relationship Between Posttraumatic Stress Disorder, Death Anxiety, and Insomnia in Adults After the Earthquake.
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Çiftci N, Yildiz M, and Uçar M
- Abstract
This study aimed to determine the relationship between posttraumatic stress disorder, death anxiety, and insomnia in adults after the earthquake. This study, designed in a relational-cross-sectional-descriptive model, was conducted with 624 adult individuals living in a province affected by the earthquake that occurred in Turkey on February 6, 2023. The study data were collected using a personal information form, Posttraumatic Stress Disorder Checklist, Turkish Death Anxiety Scale, and Bergen Insomnia Scale. The analysis of the study data was performed by using SPSS 25.0, AMOS 24.0, and G*Power 3.1 Statistical package software. A significant positive correlation was found between posttraumatic stress disorder and Insomnia and Death Anxiety ( p < .05). There was a significant positive correlation between Death Anxiety and Insomnia ( p < .05). It was determined that Death Anxiety has a mediating role in the impact of posttraumatic stress disorder on insomnia (95% Confidence Interval: 0.572/1.407) ( p < .05). It was determined that the model created in line with the hypotheses was compatible and the model fit indices were within the desired limits, with x
2 /df = 1.795, RMSEA = 0.03, CFI = 0.95, GFI = 0.946, AGFI = 0.93, IFI = 0.95. It was determined that posttraumatic stress disorder increased death anxiety and insomnia after the earthquake. Conducting longitudinal studies on the post-earthquake period is recommended., Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.- Published
- 2024
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13. Segmentation and classification of skin burn images with artificial intelligence: Development of a mobile application.
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Yıldız M, Sarpdağı Y, Okuyar M, Yildiz M, Çiftci N, Elkoca A, Yildirim MS, Aydin MA, Parlak M, and Bingöl B
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- Humans, Photography methods, Burns classification, Burns diagnostic imaging, Burns pathology, Mobile Applications, Artificial Intelligence
- Abstract
Aim: This study was conducted to determine the segmentation, classification, object detection, and accuracy of skin burn images using artificial intelligence and a mobile application. With this study, individuals were able to determine the degree of burns and see how to intervene through the mobile application., Methods: This research was conducted between 26.10.2021-01.09.2023. In this study, the dataset was handled in two stages. In the first stage, the open-access dataset was taken from https://universe.roboflow.com/, and the burn images dataset was created. In the second stage, in order to determine the accuracy of the developed system and artificial intelligence model, the patients admitted to the hospital were identified with our own design Burn Wound Detection Android application., Results: In our study, YOLO V7 architecture was used for segmentation, classification, and object detection. There are 21018 data in this study, and 80% of them are used as training data, and 20% of them are used as test data. The YOLO V7 model achieved a success rate of 75.12% on the test data. The Burn Wound Detection Android mobile application that we developed in the study was used to accurately detect images of individuals., Conclusion: In this study, skin burn images were segmented, classified, object detected, and a mobile application was developed using artificial intelligence. First aid is crucial in burn cases, and it is an important development for public health that people living in the periphery can quickly determine the degree of burn through the mobile application and provide first aid according to the instructions of the mobile application., Competing Interests: Declaration of Competing Interest The author(s) declared no potential conflicts of interest concerning the research, authorship, and/or publication of this article., (Copyright © 2024 Elsevier Ltd and International Society of Burns Injuries. All rights reserved.)
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- 2024
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14. Relationship between social media addiction and appearance-related social media consciousness in Turkish adolescents.
- Author
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Sarman A and Çiftci N
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- Humans, Adolescent, Female, Turkey, Male, Cross-Sectional Studies, Behavior, Addictive psychology, Surveys and Questionnaires, Internet Addiction Disorder psychology, Social Media, Adolescent Behavior psychology
- Abstract
Purpose: This study was aimed to investigate the relationship between social media addiction and appearance-related social media consciousness in adolescents., Design and Methods: This study was conducted in a relational-cross-sectional-descriptive model. The population of the study consists of high schools located in a provincial center in the eastern of Turkey. Cluster sampling method was applied, and the study was completed with 1009 adolescents. The research data were collected by using personal information form, Bergen Social Media Addiction Scale and Adolescents' Appearance-Related Social Media Consciousness Scale., Results: It was determined that the mean scores of adolescents' social media addiction and appearance-related social media consciousness were at a moderate level. It was determined that female adolescents had higher mean scores of social media addiction and appearance-related social media consciousness. The model established with structural equation modelling was found to be compatible with social media usage time, which was found to be related to the level of social media addiction and appearance-related social media consciousness., Conclusions: It was found that there was a significant positive relationship between social media addiction and appearance-related social media consciousness. Time spent using social media was found to be a predictor of addiction and social media consciousness about appearance., Practice Implications: Pediatric nurses can educate adolescents about the potential risks of excessive use of social media and help them to act consciously. Suggest implementing school-based interventions to educate adolescents, especially females, about healthy social media use., Competing Interests: Declaration of competing interest The authors declare that they have no competing interests., (Copyright © 2024 Elsevier Inc. All rights reserved.)
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- 2024
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15. Relationship between smartphone addiction, loneliness, and depression in adolescents: A correlational structural equation modeling study.
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Sarman A and Çiftci N
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- Humans, Female, Adolescent, Male, Turkey, Cross-Sectional Studies, Smartphone, Internet Addiction Disorder psychology, Internet Addiction Disorder epidemiology, Behavior, Addictive psychology, Latent Class Analysis, Loneliness psychology, Depression epidemiology, Depression psychology, Adolescent Behavior psychology
- Abstract
Purpose: This study was aimed to investigate the relationship between smartphone addiction, loneliness, and depression in adolescents., Design and Methods: This study was designed in a correlational-cross-sectional-descriptive model and was conducted with 1041 adolescents attending high schools in a provincial center in Eastern Turkey. The data were collected through face-to-face interviews using a personal information form, Smartphone Addiction Scale-Short Version for Adolescents, UCLA Loneliness Scale, and Kutcher Adolescent Depression Scale., Results: The average scores for smartphone addiction were found to be higher among females, individuals with low academic success, and those with a high-income level. Similarly, the average scores for loneliness were higher among individuals residing in broken families and those with parents who have limited literacy. Additionally, the mean scores for depression were higher among individuals with low academic success and those with a high-income level. Furthermore, a significant positive correlation was observed between the duration of smartphone use and levels of smartphone addiction, loneliness, and depression., Conclusion: Smartphone addiction, loneliness, and depression were found to be prevalent above the moderate level in adolescents. Additionally, a significant positive correlation was observed between the depression and loneliness scores of adolescents., Practice Implications: Pediatric and school nurses should assess children's phone use. Nurses are well-positioned to establish a follow-up program aimed at monitoring adolescents' efforts in managing smartphone use, offering continuous support, and providing guidance when necessary. The implementation of such programs enables prompt intervention in addressing any arising issues., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Inc. All rights reserved.)
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- 2024
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16. The relationship between fear of old age, loneliness and death anxiety in adults.
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Çiftci N, Yildiz M, Durmuş M, and Çoban M
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- Humans, Male, Female, Aged, Turkey epidemiology, Cross-Sectional Studies, Middle Aged, Aged, 80 and over, Adult, Loneliness psychology, Fear psychology, Attitude to Death, Anxiety psychology, Aging psychology
- Abstract
Background: The increase in the number of elderly people in the world, individuals' perspectives on older adults, and false beliefs and ideas about old age negatively affect adults in terms of ageing. This study was conducted to determine the relationship between fear of old age, loneliness and death anxiety in adults., Method: This study, which was designed in a correlational cross-sectional descriptive model, was conducted with 1074 adult individuals living in one province in eastern Turkey. Data were collected using Personal Information Form, Fear of Old Age Scale, UCLA Loneliness Scale and Turkish Death Anxiety Scale. Data were analyzed using SPSS 25.0, AMOS 24.0, G*Power 3.1 statistical package programs., Results: In our study, it was determined that the model created in line with the hypotheses was compatible and the model fit indices were within the desired limits as χ
2 /df = 4.737, root mean square error of approximation = 0.05, comparative fit index = 0.93, goodness-of-fit index = 0.92, adjusted goodness-of-fit index = 0.90, IFI = 0.93. There is a significant relationship between loneliness and death anxiety (P < 0.05). There is a significant relationship between loneliness and fear of old age (P < 0.05). There is a significant relationship between death anxiety and fear of old age (P < 0.05). It was determined that death anxiety has a mediating role in the effect of loneliness on fear of old age (95% confidence interval: 0.112-0.226; P < 0.05)., Conclusion: As the level of loneliness increases, the level of death anxiety and fear of old age increases. Fear of old age also increases in the mediating role of death anxiety. It is recommended to conduct intervention studies to reduce fear of old age. Longitudinal study on fear of old age is recommended., (© 2024 Japanese Psychogeriatric Society.)- Published
- 2024
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17. The mediating role of social ostracism in the effect of social media addiction on loneliness in adolescents.
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Çiftci N, Yıldız M, and Çiftci K
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- Humans, Adolescent, Loneliness, Ostracism, Cross-Sectional Studies, Internet Addiction Disorder, Behavior, Addictive, Social Media
- Abstract
Objective: This study aimed to determine the mediating role of social ostracism in the effect of social media addiction on loneliness in adolescents., Methods: This descriptive and cross-sectional study was conducted with 1225 adolescent students attending high school in a province in Eastern Turkey between 30 May 2023 and 01 August 2023. The study data were collected using the "Personal Information Form", "Bergen Social Media Addiction Scale", "UCLA Loneliness Scale-Short Form" and "Ostracism Experience Scale for Adolescents". The analysis of the study data was performed by using SPSS 22.0, AMOS V 24.0, and G*Power 3.1 Statistical package software., Results: It was determined that the model created in line with the determining the mediating role of social ostracism in the effect of social media addiction on loneliness in adolescents was compatible and the model fit indices were within the desired limits x
2 /df = 4.481, RMSEA = 0.05, CFI = 0.96, GFI = 0.96, AGFI = 0.94, IFI = 0.96. Social media addiction has been found to affect loneliness and social ostracism (p < 0.05). It was found that social ostracism affected the level of loneliness (p < 0.05). It was determined that social ostracism had a mediating role in the effect of social media addiction on loneliness (p < 0.05)., Conclusion: As the level of social media addiction increases, the level of loneliness and social ostracism increases. As the level of social ostracism increases, the level of loneliness increases. Longitudinal studies on the factors affecting loneliness are recommended., Practice Implications: In order to reduce the loneliness and social ostracism levels of adolescents, their access to social media should be controlled. Programs to reduce social ostracism should be designed., Competing Interests: Declaration of Competing Interest The authors declare that there is no conflict of interest., (Copyright © 2023 Elsevier Inc. All rights reserved.)- Published
- 2023
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18. The effect of health literacy and health empowerment on quality of life in the elderly.
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Çiftci N, Yıldız M, and Yıldırım Ö
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- Aged, Humans, Quality of Life, Cross-Sectional Studies, Health Status, Health Promotion, Surveys and Questionnaires, Health Literacy
- Abstract
Background: This study was conducted to determine the effect of health literacy and health promotion on quality of life in the elderly., Method: This descriptive and cross-sectional study was conducted with 981 elderly individuals aged 65 years and older in Turkey. 'Introductory Information Form', 'Health Literacy Scale', 'Elderly Health Empowerment Scale' and 'Quality of Life Scale for the Elderly' were used to collect data. The research data were analyzed by Structural Equation Modelling using SPSS 22.0, AMOS V 24.0, G*Power 3.1 statistical package programs., Results: Health literacy level increased health empowerment level (t = 5.929 R
2 = 0.035, P < 0.05). Health literacy level increased quality of life level (t = 13.439 R2 = 0.156, P < 0.05). Health empowerment level was found to affect quality of life level (t = 17.746 R2 = 0.243, P < 0.05). Health empowerment was found to have a mediating role in the effect of health literacy on quality of life (β = 0.502, 95% confidence interval (lower bound-upper bound) = 0.013-1.038). It was determined that the model created in line with the hypotheses was compatible and the model fit indices x2 /SD = 4.919, root mean square error of approximation = 0.06, comparative fit index = 0.91, fit index = 0.95, adjusted fit index = 0.93, incremental fit index = 0.91 were within the desired limits., Conclusions: As the level of health literacy increases, so does the level of health empowerment and quality of life. As the level of health empowerment increases, so does the level of quality of life. It is recommended to design policies that will help to increase the health literacy and health empowerment levels of the elderly. Longitudinal studies on quality of life in the elderly are recommended., (© 2023 Japanese Psychogeriatric Society.)- Published
- 2023
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19. Clinical Characteristics and Genetic Analyses of Patients with Idiopathic Hypogonadotropic Hypogonadism
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Çiftci N, Akıncı A, Akbulut E, Çamtosun E, Dündar İ, Doğan M, and Kayaş L
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- Humans, Female, Child, Adolescent, Mutation, Phenotype, Heterozygote, Hypogonadism genetics, Hypogonadism diagnosis
- Abstract
Objective: Idiopathic hypogonadotropic hypogonadism (IHH) is classified into two groups-Kalman syndrome and normosmic IHH (nIHH). Half of all cases can be explained by mutations in >50 genes. Targeted gene panel testing with nexrt generation sequencing (NGS) is required for patients without typical phenotypic findings. The aim was to determine the genetic etiologies of patients with IHH using NGS, including 54 IHH-associated genes, and to present protein homology modeling and protein stability analyzes of the detected variations., Methods: Clinical and demographic data of 16 patients (eight female), aged between 11.6-17.8 years, from different families were assessed. All patients were followed up for a diagnosis of nIHH, had normal cranial imaging, were without anterior pituitary hormone deficiency other than gonadotropins, had no sex chromosome anomaly, had no additional disease, and underwent genetic analysis with NGS between the years 2008-2021. Rare variants were classified according to the variant interpretation framework of the American College of Medical Genetics and Genomics (ACMG)/Association for Molecular Pathology. Changes in protein structure caused by variations were modeled using RoseTTAFold and changes in protein stability resulting from variation were analyzed., Results: Half of the 16 had no detectable variation. Three (18.75%) had a homozygous (pathogenic) variant in the GNRHR gene, one (6.25%) had a compound heterozygous [likely pathogenic-variants of uncertain significance (VUS)] variant in PROK2 and four (25%) each had a heterozygous (VUS) variant in HESX1, FGF8, FLRT3 and DMXL2 . Protein models showed that variants interpreted as VUS according to ACMG could account for the clinical IHH., Conclusion: The frequency of variation detection was similar to the literature. Modelling showed that the variant in five different genes, interpreted as VUS according to ACMG, could explain the clinical IHH., (©Copyright 2023 by Turkish Society for Pediatric Endocrinology and Diabetes | The Journal of Clinical Research in Pediatric Endocrinology published by Galenos Publishing House.)
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- 2023
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20. Chronic Disease Management of Children Followed with Type 1 Diabetes Mellitus
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Güven Baysal Ş, Çiftci N, Dündar İ, Büyükavcı MA, Yağın FH, Çamtosun E, Gümüş Doğan D, and Akıncı A
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- Humans, Child, Male, Female, Child, Preschool, Adolescent, Mothers, Chronic Disease, Disease Management, Melanoma, Cutaneous Malignant, Diabetes Mellitus, Type 1 therapy, Diabetes Mellitus, Type 1 psychology
- Abstract
Objective: With the diagnosis of chronic illness in children, a stressful period is likely to begin for both the affected child and their families. The aim of this study was to investigate the factors affecting chronic disease management by the parents of children diagnosed with type 1 diabetes mellitus (T1DM)., Methods: The sample consisted of 110 children, aged between 4-17 years and their mothers. The patients had been diagnosed with T1DM for at least one year, and had attended pediatric endocrinology outpatients or were hospitalized in a single center. First, sociodemographic information about the child with T1DM were obtained. Then, the “Family Management Measure” (FaMM) was applied. The FaMM is constructed to measure family functioning and management in families who have a child with a chronic illness., Results: Paternal years of education (p=0.036), family income (p=0.008), insulin pump use (p=0.011), and time elapsed after diagnosis (p=0.048) positively affected both the management of T1DM and the child’s daily life. However, presence of chronic diseases in addition to T1DM (p=0.004) negatively affected diabetes management. Higher maternal education year (p=0.013) and family income level (p=0.001) increased parental mutuality scores. However, as the time after diagnosis increased, parental mutuality scores decreased., Conclusion: It is important to evaluate the child with chronic disease with a biopsychosocial approach. This approach aims to evaluate the problems of the child and his/her family who experience the disease with a holistic approach., (©Copyright 2023 by Turkish Society for Pediatric Endocrinology and Diabetes | The Journal of Clinical Research in Pediatric Endocrinology published by Galenos Publishing House.)
- Published
- 2023
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21. 46,XY Sex Development Defect due to a Novel Homozygous (Splice Site) c.673_1G>C Variation in the HSD17B3 Gene: Case Report
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Çiftci N, Kayaş L, Çamtosun E, and Akıncı A
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- Androstenedione, Female, Humans, Infant, Mutation, Sexual Development, 17-Hydroxysteroid Dehydrogenases genetics, Disorder of Sex Development, 46,XY diagnosis, Disorder of Sex Development, 46,XY genetics
- Abstract
The enzyme 17-β-hydroxysteroid dehydrogenase type 3 (17β-HSD3) catalyzes the biosynthesis of testosterone (T) from Δ4-androstenedione, and plays an important role in the final steps of androgen synthesis. 17β-HSD3 deficiency originates from mutations in the HSD17B gene, causing an autosomal recessive 46,XY sex developmental disorder (DSD). Patients with 46,XY karyotype can exhibit a wide phenotypic spectrum, varying from complete external female genitalia to male genitalia with hypospadias. Here we report a case of 17β-HSD3 deficiency diagnosed in the infantile period who was later found to have a novel HSD17B3 gene variation. The 14-month old patient, who exhibited a female phenotype, presented with a bilateral lump in the inguinal area. Imaging revealed bilateral testicular gonads in the inguinal area. Hormonal evaluation showed low levels of basal and stimulated serum T, a high level of androstenedione (A), and a low T/A ratio. Chromosomal analysis showed 46,XY karyotype. Sequence analysis of the HSD17B3 gene revealed a c.673_1G>C homozygous class 2 (splice site) variation in intron 9. The consanguineous parents were sequenced, and both were heterozygous for the same mutation. This variation has not been previously reported in the literature. In conclusion, a 46,XY DSD should be considered in patients with a female phenotype who exhibit gonad(s) in the inguinal area at an early age. Furthermore, in patients with insufficient T synthesis and high levels of androstenedione, 17β-HSD3 should be considered, and molecular analysis should be done for a definitive diagnosis and subsequent genetic counseling.
- Published
- 2022
- Full Text
- View/download PDF
22. The Effect of COVID -19 Crisis on Hopelessness, Loneliness and Spiritual Well-Being of Patients with Type 1 and Type 2 Diabetes in Turkey.
- Author
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Durmuş M, Çiftci N, Gerçek A, and Durmuş Y
- Subjects
- Humans, Loneliness, Spirituality, Turkey epidemiology, COVID-19, Diabetes Mellitus, Type 2
- Abstract
This study aims to examine the relationship between the levels of hopelessness, loneliness, and spiritual well-being of patients with Type 1 and Type 2 diabetes during the process of COVID-19 outbreak. The study was carried out with diabetic patients living in three different cities that are in the Eastern Anatolia region of Turkey between the dates of 15 of November and 30 of November 2020. The sample of the study consisted of 500 (Type 1, n = 218, Type 2, n = 282) diabetes patients. Data were collected using a demographic information form, Beck Hopelessness Scale (BHS), Loneliness Scale (UCLA-LS), and Spiritual Well-being Scale (FACIT-Sp). While the mean scores of hopelessness and loneliness of type 1 patients were below the moderate level, the mean scores of their spiritual well-being were found to be above the moderate level. Moreover, while the mean scores of hopelessness and loneliness in type 2 patients were below the moderate level, the mean scores of their spiritual well-being were found above the moderate level. A significant relationship was found between Type 1 and Type 2 diabetes patients' levels of hopelessness, loneliness, and spiritual well-being during the COVID-19 outbreak. It was found that as the spiritual well-being levels of Type 1 and Type 2 diabetic patients increased, the levels of their loneliness and hopelessness decreased. It is recommended that mass communication that includes spiritual care practices can be used effectively to reduce diabetes patients' levels of loneliness and hopelessness during the pandemic. In addition, while providing care to diabetes patients, it can be suggested that health professionals offer a holistic approach with initiatives that will increase diabetes patients' spiritual well-being., (© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
- Published
- 2022
- Full Text
- View/download PDF
23. Pediatric Primary Adrenal Insufficiency: A 21-year Single Center Experience
- Author
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Çamtosun E, Dündar İ, Akıncı A, Kayaş L, and Çiftci N
- Subjects
- Adolescent, Adrenal Hyperplasia, Congenital complications, Child, Child, Preschool, Female, Humans, Infant, Male, Retrospective Studies, Tertiary Care Centers, Addison Disease diagnosis, Addison Disease etiology
- Abstract
Objective: Primary adrenal insufficiency (PAI) is a rare but potentially life-threatening condition. In childhood, PAI is usually caused by monogenic diseases. Although congenital adrenal hyperplasia (CAH) is the most common cause of childhood PAI, numerous non-CAH genetic causes have also been identified., Methods: Patients aged 0-18 years and diagnosed with PAI between 1998 and 2019 in a tertiary care hospital were retrospectively evaluated. After the etiologic distribution was determined, non-CAH PAI patients were evaluated in detail., Results: Seventy-three PAI patients were identified. The most common etiology was CAH (69.9%, n=51). Non-CAH etiologies accounted for 30.1% (n=22) and included adrenoleukodystrophy (ALD; n=8), familial glucocorticoid deficiency (n=3), Triple A syndrome (n=5), autoimmune adrenalitis (n=1), adrenal hypoplasia congenital (n=1), IMAGe syndrome (n=1), and other unknown etiologies (n=3). The median age at the time of AI diagnosis for non-CAH etiologies was 3.52 (0.03-15.17) years. The most frequent symptoms/clinical findings at onset were hyperpigmentation of skin (81.8%), symptoms of hypoglycemia (40.9%), and weakness/fatigue (31.8%). Hypoglycemia (50.0%), hyponatremia (36.4%) and hyperkalemia (22.7%) were prominent biochemical findings. Diagnosis of specific etiologies were proven genetically in 13 of 22 patients. A novel p.Q301* hemizygous frameshift mutation of the DAX1 gene was identified in one patient., Conclusion: Etiology was determined in 86.3% of children with non-CAH PAI through specific clinical and laboratory findings with/ without molecular analysis of candidate genes. ALD was the most common etiology. Currently, advanced molecular analysis can be utilized to establish a specific genetic diagnosis for PAI in patients who have no specific diagnostic features.
- Published
- 2021
- Full Text
- View/download PDF
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