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1. Early neonatal outcomes of very-low-birth-weight infants in Turkey: a prospective multicenter study of the Turkish Neonatal Society

Author

Gürsoy, Tuğba (ORCID 0000-0002-6084-4067 & YÖK ID 214691), Koç, Esin; Demirel, Nihal; Baş, Ahmet Yağmur; Işık, Dilek Ulubaş; Hirfanoğlu, İbrahim Murat; Tunc, Turan; Sarı, Fatma Nur; Karatekin, Güner; Özdemir, Ramazan; Altunhan, Hüseyin; Çetinkaya, Merih; Özcan, Beyza; Özkiraz, Servet; Çalkavur, Sebnem; Tekgündüz, Kadir Şerafettin; Taştekin, Ayhan; Özlü, Ferda; Özyurt, Banu Mutlu; Özdemir, Ahmet; Çetinkaya, Bilin; Demirelli, Yaşar; Köklü, Esad; Çelik, Ülker; Tarakçı, Nuriye; Armangil, Didem; Okulu, Emel; Narter, Fatma; Mutlu, Birgul; Mert, Mustafa Kurthan; Bülbül, Ali; Asker, Hüseyin Selim; Uygur, ÖzgÜn; Uslu, İlker Sait; Ertuğrul, Sabahattin; Aydemir, Cumhur; Çelik, Hasan Tolga; Küçüktaşçı, Kazım; Arslan, Selda; Ergin, Hacer; Zenciroğlu, Aysegül; Yurttutan, Sadık; Orman, Ayşen; Tuncer, Oğuz; Yaşa, Beril; Acunas, Betül; Takci, Şahin; Gökmen, Zeynel; Özkan, Hilal; Cömert, Serdar; Üstün, Nuran; Mutlu, Mehmet; Bayraktar, Bilge Tanyeri; Bilgin, Leyla; Tuzun, Funda; Aydemir, Özge; Akdağ, Arzu; Memisoğlu, Aslı; Can, Emrah; Terek, Demet; Beken, Serdar; Turan, Özden; Güzoğlu, Nilüfer; Örs, Rahmi; Kale, Yusuf; Hekimoğlu, Berna; Aylanc, Hakan; Eroğlu, Funda; Şahin, Suzan; Konak, Murat; Sarıcı, Dilek; Kılıç, İlknur; Hakan, Nilay, School of Medicine, Gürsoy, Tuğba (ORCID 0000-0002-6084-4067 & YÖK ID 214691), Koç, Esin; Demirel, Nihal; Baş, Ahmet Yağmur; Işık, Dilek Ulubaş; Hirfanoğlu, İbrahim Murat; Tunc, Turan; Sarı, Fatma Nur; Karatekin, Güner; Özdemir, Ramazan; Altunhan, Hüseyin; Çetinkaya, Merih; Özcan, Beyza; Özkiraz, Servet; Çalkavur, Sebnem; Tekgündüz, Kadir Şerafettin; Taştekin, Ayhan; Özlü, Ferda; Özyurt, Banu Mutlu; Özdemir, Ahmet; Çetinkaya, Bilin; Demirelli, Yaşar; Köklü, Esad; Çelik, Ülker; Tarakçı, Nuriye; Armangil, Didem; Okulu, Emel; Narter, Fatma; Mutlu, Birgul; Mert, Mustafa Kurthan; Bülbül, Ali; Asker, Hüseyin Selim; Uygur, ÖzgÜn; Uslu, İlker Sait; Ertuğrul, Sabahattin; Aydemir, Cumhur; Çelik, Hasan Tolga; Küçüktaşçı, Kazım; Arslan, Selda; Ergin, Hacer; Zenciroğlu, Aysegül; Yurttutan, Sadık; Orman, Ayşen; Tuncer, Oğuz; Yaşa, Beril; Acunas, Betül; Takci, Şahin; Gökmen, Zeynel; Özkan, Hilal; Cömert, Serdar; Üstün, Nuran; Mutlu, Mehmet; Bayraktar, Bilge Tanyeri; Bilgin, Leyla; Tuzun, Funda; Aydemir, Özge; Akdağ, Arzu; Memisoğlu, Aslı; Can, Emrah; Terek, Demet; Beken, Serdar; Turan, Özden; Güzoğlu, Nilüfer; Örs, Rahmi; Kale, Yusuf; Hekimoğlu, Berna; Aylanc, Hakan; Eroğlu, Funda; Şahin, Suzan; Konak, Murat; Sarıcı, Dilek; Kılıç, İlknur; Hakan, Nilay, and School of Medicine

Abstract

Objective: to investigate the early neonatal outcomes of very-low-birth-weight (VLBW) infants discharged home from neonatal intensive care units (NICUs) in Turkey. Material and methods: a prospective cohort study was performed between April 1, 2016 and April 30, 2017. The study included VLBW infants admitted to level III NICUs. Perinatal and neonatal data of all infants born with a birth weight of.1500 g were collected for infants who survived. Results: data from 69 NICUs were obtained. The mean birth weight and gestational age were 1137 +/- 245 g and 29 +/- 2.4 weeks, respectively. During the study period, 78% of VLBW infants survived to discharge and 48% of survived infants had no major neonatal morbidity. VLBW infants who survived were evaluated in terms of major morbidities: bronchopulmonary dysplasia was detected in 23.7% of infants, necrotizing enterocolitis in 9.1%, blood culture proven late-onset sepsis (LOS) in 21.1%, blood culture negative LOS in 21.3%, severe intraventricular hemorrhage in 5.4% and severe retinopathy of prematurity in 11.1%. Hemodynamically significant patent ductus arteriosus was diagnosed in 24.8% of infants. Antenatal steroids were administered to 42.9% of mothers. Conclusion: the present investigation is the first multicenter study to include epidemiological information on VLBW infants in Turkey. Morbidity rate in VLBW infants is a serious concern and higher than those in developed countries. Implementation of oxygen therapy with appropriate monitoring, better antenatal and neonatal care and control of sepsis may reduce the prevalence of neonatal morbidities. Therefore, monitoring standards of neonatal care and implementing quality improvement projects across the country are essential for improving neonatal outcomes in Turkish NICUs., Turkish Neonatal Society

Published
2019

2. Comparison of cut and intact cord milking regarding cerebral oxygenation, hemodynamic and hematological adaptation of term infants.

Author

Orpak, Ümmühan Seda, Ergin, Hacer, Çıralı, Ceren, Özdemir, Özmert M. A., Koşar Can, Özlem, and Çelik, Ülker

Subjects
UMBILICAL cord clamping, INFANTS, HEMODYNAMICS, BLOOD volume, UMBILICAL cord
Abstract

Although both delayed umbilical cord clamping and intact umbilical cord milking (I-UCM) provide the effective placental transfusion at birth, these procedures may not be used in neonates needing resuscitation. The aim of this study is to investigate the effect of cut umbilical cord milking (C-UCM), which permits resuscitation during an immediate transition period (ITP). Sixty-two healthy term infants were randomly divided into C-UCM and I-UCM groups at birth. Approximately 30-cm length of cord was milked towards the baby 2–4 times within 20 seconds after birth in both C-UCM and I-UCM groups while the umbilical cord was cut in the former, and intact in the latter. Heart rate, arterial oxygen saturation (SpO2), cerebral regional oxygen saturation (crSO2) (2nd–15th min), blood pressure (BP) (within 15–30 min), residual placental blood volume (RPBV), and hemoglobin levels (at the sixth hour) were monitored during ITP. There were no significant differences in terms of mean gestational age (w) [(39.0 ± 1.2) versus (38.8 ± 1.1)], birth weight (g) [(3351.45 ± 254.30) versus (3256.94 ± 285.52)], Apgar scores at the 5th min (10 ± 0 versus 10 ± 0), first breathing time (sec) (5.4 ± 3.8 versus 5.7 ± 4.1), SpO2, crSO2, BP (mmHg) [(52.9 ± 6.9) versus (51.8 ± 5.7)], hemoglobin levels (g/dl) [(17.7 ± 1.8) versus (18.4 ± 1.4)], and RPBV (ml/kg) [(23.9 ± 4.7) versus (22.9 ± 5.4)] between C-UCM and I-UCM groups (p >.05). This study showed that C-UCM is as effective as I-UCM on cerebral oxygenation, hemodynamic and hematological adaptation of term infants in ITP. We suggest that C-UCM can provide additional placental transfusion in term neonates exposed to early cord clamping. [ABSTRACT FROM AUTHOR]

Published
2021
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4. Incidence, risk factors and severity of retinopathy of prematurity in Turkey (TR-ROP study): a prospective, multicentre study in 69 neonatal intensive care units

Author

Uludağ, Günay (ORCID & YÖK ID 175586); Gürsoy, Tuğba (ORCID 0000-0002-6084-4067 & YÖK ID 214691), Baş, Ahmet Yağmur; Demirel, Nihal; Koç, Esin; Işık, Dilek Ulubaş; Hirfanoğlu, İbrahim Murat; Tunç, Turan; Sarı, Fatma Nur; Karatekin, Güner; Köklü, Esad; Altunhan, Hüseyin; Turgut, Hatice; Narter, Fatma; Tarakçı, Nuriye; Tekgündüz, Kadir Şerafettin; Özkiraz, Servet; Aydemir, Cumhur; Özdemir, Ahmet; Çetinkaya, Bilin; Kazancı, Ebru; Taştekin, Ayhan; Calkavur, Şebnem; Özyurt, Banu Mutlu; Demirelli, Yaşar; Asker, Hüseyin Selim; Mutlu, Birgul; Uygur, Özgün; Özkan, Hilal; Armangil, Didem; Özlü, Ferda; Mert, Mustafa Kurthan; Ergin, Hacer; Özcan, Beyza; Baş, Evrim Kıray; Okulu, Emel; Acunas, Betül; Çelik, Ülker; Uslu, Sait İlker; Mutlu, Mehmet; Demir, Nihat; Eroğlu, Funda; Gökmen, Zeynel; Beken, Serdar; Bayraktar, Bilge Tanyeri; Hakan, Nilay; Küçüktaşçı, Kazım; Orman, Ayşen; Cömert, Serdar; Ertuğrul, Sabahattin; Üstün, Nuran; Şahin, Özlem; Terek, Demet; Kale, Yusuf; Konak, Murat; Yurttutan, Sadık; Aydemir, Özge; Zenciroğlu, Aysegül; Sarıcı, Dilek; Güzoğlu, Nilüfer; Hamilçıkan, Şahin; Tüzün, Funda; Örs, Rahmi; Arslan, Selda; Akdağ, Arzu; Memişoğlu, Aslı; Yasa, Beril; Hekimoğlu, Berna; Turan, Özden; Aylanc, Hakan; Takçı, Şahin; Çelik, Tolga; Şahin, Suzan; Kılıç, İlknur; Kara, Caner; Tunay, Zuhal Özen; Çelik, Gökhan; Gözen, İbrahim; Satırtav, Günhal; Polat, Nihat; Oral, Ayşe Yeşim; Tokgöz, Mine; Keleş, Sadullah; Bilgin, Burak; Uğurbaş, Silay Cantürk; Karaca, Çağatay; Keşkek, Nedime Şahinoğlu; Ekinci, Dilbade Yıldız; Balcı, Özlem; Altan, Emir Volkan; Bakbak, Sevda; Ceylan, Nihan Aksu; Kimyon, Sabit; Alyamaç, Günay; Türe, Gamze; Yıldız, Meral; Çalış, Feyza; Sızmaz, Selçuk; Sukgen, Emine; Çetin, Ebru Nevin; Özçimen, Muammer; Demir, Semra Tiryaki; Atila, Huban; Özal, Altan; Tufaner, Gökhan; Yücel, Özlem Eski; Kola, Mehmet; Seven, Erbil; Özdek, Şengül; Durukan, Ali Hakan; Kal, Ali; Çelebi, Ali Riza Cenk; Koytak, İbrahim Arif; Alaçamlı, Göksu; Esme, Arif; Çatak, Onur; Perente, İrfan; Şahin, Alparslan; Akçakaya, Aylin Ardagil; Kıray, Gülünay; Nalçacı, Serhat; Aksoy, Ümit; Bakbak, Ber, School of Medicine, Department of Internal Medicine, Uludağ, Günay (ORCID & YÖK ID 175586); Gürsoy, Tuğba (ORCID 0000-0002-6084-4067 & YÖK ID 214691), Baş, Ahmet Yağmur; Demirel, Nihal; Koç, Esin; Işık, Dilek Ulubaş; Hirfanoğlu, İbrahim Murat; Tunç, Turan; Sarı, Fatma Nur; Karatekin, Güner; Köklü, Esad; Altunhan, Hüseyin; Turgut, Hatice; Narter, Fatma; Tarakçı, Nuriye; Tekgündüz, Kadir Şerafettin; Özkiraz, Servet; Aydemir, Cumhur; Özdemir, Ahmet; Çetinkaya, Bilin; Kazancı, Ebru; Taştekin, Ayhan; Calkavur, Şebnem; Özyurt, Banu Mutlu; Demirelli, Yaşar; Asker, Hüseyin Selim; Mutlu, Birgul; Uygur, Özgün; Özkan, Hilal; Armangil, Didem; Özlü, Ferda; Mert, Mustafa Kurthan; Ergin, Hacer; Özcan, Beyza; Baş, Evrim Kıray; Okulu, Emel; Acunas, Betül; Çelik, Ülker; Uslu, Sait İlker; Mutlu, Mehmet; Demir, Nihat; Eroğlu, Funda; Gökmen, Zeynel; Beken, Serdar; Bayraktar, Bilge Tanyeri; Hakan, Nilay; Küçüktaşçı, Kazım; Orman, Ayşen; Cömert, Serdar; Ertuğrul, Sabahattin; Üstün, Nuran; Şahin, Özlem; Terek, Demet; Kale, Yusuf; Konak, Murat; Yurttutan, Sadık; Aydemir, Özge; Zenciroğlu, Aysegül; Sarıcı, Dilek; Güzoğlu, Nilüfer; Hamilçıkan, Şahin; Tüzün, Funda; Örs, Rahmi; Arslan, Selda; Akdağ, Arzu; Memişoğlu, Aslı; Yasa, Beril; Hekimoğlu, Berna; Turan, Özden; Aylanc, Hakan; Takçı, Şahin; Çelik, Tolga; Şahin, Suzan; Kılıç, İlknur; Kara, Caner; Tunay, Zuhal Özen; Çelik, Gökhan; Gözen, İbrahim; Satırtav, Günhal; Polat, Nihat; Oral, Ayşe Yeşim; Tokgöz, Mine; Keleş, Sadullah; Bilgin, Burak; Uğurbaş, Silay Cantürk; Karaca, Çağatay; Keşkek, Nedime Şahinoğlu; Ekinci, Dilbade Yıldız; Balcı, Özlem; Altan, Emir Volkan; Bakbak, Sevda; Ceylan, Nihan Aksu; Kimyon, Sabit; Alyamaç, Günay; Türe, Gamze; Yıldız, Meral; Çalış, Feyza; Sızmaz, Selçuk; Sukgen, Emine; Çetin, Ebru Nevin; Özçimen, Muammer; Demir, Semra Tiryaki; Atila, Huban; Özal, Altan; Tufaner, Gökhan; Yücel, Özlem Eski; Kola, Mehmet; Seven, Erbil; Özdek, Şengül; Durukan, Ali Hakan; Kal, Ali; Çelebi, Ali Riza Cenk; Koytak, İbrahim Arif; Alaçamlı, Göksu; Esme, Arif; Çatak, Onur; Perente, İrfan; Şahin, Alparslan; Akçakaya, Aylin Ardagil; Kıray, Gülünay; Nalçacı, Serhat; Aksoy, Ümit; Bakbak, Ber, School of Medicine, and Department of Internal Medicine

Abstract

Background to evaluate the prevalence, risk factors and treatment of retinopathy of prematurity (ROP) in Turkey and to establish screening criteria for this condition. Methods: a prospective cohort study (TR-ROP) was performed between 1 April 2016 and 30 April 2017 in 69 neonatal intensive care units (NICUs). Infants with a birth weight (BW)=1500 g or gestational age (GA)<= 32 weeks and those with a BW> 1500 g or GA> 32 weeks with an unstable clinical course were included in the study. Predictors for the development of ROP were determined by logistic regression analyses. Results: the TR-ROP study included 6115 infants: 4964 (81%) with a GA <= 32 weeks and 1151 (19%) with a GA>32 weeks. Overall, 27% had any stage of ROP and 6.7% had severe ROP. A lower BW, smaller GA, total days on oxygen, late-onset sepsis, frequency of red blood cell transfusions and relative weight gain were identified as independent risk factors for severe ROP in infants with a BW=1500 g. Of all infants, 414 needed treatment and 395 (95.4%) of the treated infants had a BW <= 1500 g. Sixty-six (16%) of the treated infants did not fulfil the Early Treatment for Retinopathy of Prematurity requirements for treatment. Conclusions: screening of infants with a GA <= 34 weeks or a BW<1700 g appears to be appropriate in Turkey. Monitoring standards of neonatal care and conducting quality improvement projects across the country are recommended to improve neonatal outcomes in Turkish NICUs., NA

Published
2018

6. Çocuk kan hastalıkları bilim dalında vitamin B12 eksikliği tanısıyla takipli hastaların retrospektif olarak incelenmesi

Author

Çelik, Ülker, Albayrak, Canan, and Çocuk Sağlığı ve Hastalıkları Anabilim Dalı

Subjects
Retrospective studies, Vitamin B 12, Anemia-megaloblastic, Hematoloji, Hematologic diseases, Anemia, Child diseases, Hematology, Children, Çocuk Sağlığı ve Hastalıkları, Child Health and Diseases
Abstract

Amaç: Bu çalışmada, bölümümüzdevitamin B12eksikliği tanısıyla takipli hastalarınsıklığı, demografik özellikleri, eksiklik nedenleri, eşlik eden hastalıkları, klinik ve laboratuar özelliklerinin incelenmesi ve tedavi sonuçlarının değerlendirilmesi amaçlanmıştır.Method:Ondokuz Mayıs Üniversitesi Tıp Fakültesi Çocuk Kan Hastalıkları Bilim Dalında Ocak 2006-Aralık 2010 tarihleri arasında vitamin B12eksikliği tanısıyla takip ve tedavi edilen 0-18 yaş grubu (0-215 ay) 145 hastanın dosyası geriye dönük olarak incelendi.Bulgular:Vitamin B12 eksikliği sıklığı en az %2,8 olarak saptandı. Hastaların 82'si (%57) kız, 63'ü (%43) erkekti ve kızlarda sıklık artmıştı. Vitamin B12 eksikliği 0-2 yaş ve 12-17 yaş aralığında (adölesanlarda) sık görülüyordu. Süt çocuklarının ek gıdalara başlama zamanı ortalama9,6±3,81 aydı ve ek gıdalara başlama zamanı gecikmişti. Süt çocuklarının annelerinin %77'sinde vitamin B12 eksikliği tespit edildi. Süt çocukları ile annelerinin vitamin B12 düzeyleri arasında korelasyon yoktu. Hastaların en sık başvuru semptomları;Solukluk(%43), halsizlik(%40), iştahsızlık(%32), kilo alamama (%23), kusma (%18)idi. Hastaların %43'ünde cilt ve mukozalarda solukluk, %29'unda büyüme geriliği, %18'inde gelişme geriliği, %15'inde apati-irritabilite tespit edildi. Hastaların, vitamin B12ortalaması 145±37,3 pg/ml, hemoglobin ortalaması 9,82±2,96 g/dl, MCV ortalaması 81,8±15,46 flidi.Hastaların %57'sinde anemi, %16'sında nötropeni, %17'sinde bisitopeni, %9'unda trombositopeni, %4'ünde pansitopeni ve %30'unda makrositoz tespit edildi.Hastaların %57'sine demir eksikliği, %5'ine parazit enfestasyonu, %5'ine Helikobakter Pilorienfeksiyonu, %3'üne çölyak hastalığı, %2'sine Ailevi Akdeniz Ateşi ve kolşisin kullanım öyküsü eşlik ediyordu. Hastaların %97'sinde vitamin B12 eksikliğinin nedeni nutrisyoneldi.Tüm hastalarda vitamin B12 eksikliği olmasına rağmen yalnızca %44'ünde homosistein yüksekliği tespit edildi.Tedavi verilen hastaların %51'ine oral yolla, %49'una intramusküler yollasiyanokobalamin tedavisi verildi. İntramuskuler tedavi oral tedaviye göre daha etkindi.Takibine devam eden 116 hastanın 4'ünde (%3,5) tedavi sonrası komplikasyon gelişti.Sonuç:Bu çalışma, Samsun ve çevre illerde çocuklarda vitamin B12 eksikliğinin sık görüldüğünü göstermiştir. Hastalığın ilk 2 yaş ve 12-17 yaş arasında yoğunlaşması bu yaş gruplarının risk altında olduğuna işaret etmektedir. İnfantlardaki vitamin B12 eksikliğini önlemek için gebelerin ve süt çocuklarının annelerinin vitamin B12 düzeylerine bakılmalı ve hayvansal gıdalar önerilmelidir. Adölesanlarda ihtiyaç artışı göz önüne alınarak hayvansal gıdalar tavsiye edilmelidir.Vitamin B12 eksikliği bir halk sağlığı problemi olarak değerlendirilip, ülke çapında ve bölgesel prevalans çalışmaları yapılmalı ve bu konuda yeni çözümler üretilmelidir. Aim: In this study, the analysis of the frequency, demographic features, causes of deficiency, other diseases, the clinical and laboratory features of the patients with vitamin B12 deficiency and the evaluation of the outcome of treatment are aimed.Method: The records of the 145 patients with vitamin B12 deficiency aged 0-18 years (0-215 months) followed between January 2006 and December 2010 in Ondokuz Mayis University Faculty of medicine, department of PediatricHematology analyzed retrospectively.Results: The frequencyof vitamin B12 deficiency was observed at least 2.8%82 (57%) patients were female, 63 (43%) patients were male and the frequency was higher in females and between 0-2 years and 12-17 years (in adolescents). The mean of weaning theof infants was 9.6±3.81 months and it delayed. 77% of the mothers had vitamin B12 deficiency. There was no correlation between the vitamin B12 levels of infants and their mothers. The most frequent symptoms on admission of patients were pallor (43%), fatigue (40%), anorexia (32%), insufficient weight gain (23%), vomiting (18%). 43% of the patients had pallor on skin and mucosa, 29% had growth failure, 18% had development delay, 15% had apathy-irritability. The mean vitamin B12 level was 145±37.3 pg/ml, the mean hemoglobin level was 9.82±2.96 g/dl, theMCV was 81.8±15.46 fl. The 57% of patients had anemia, 16% had neutropenia, 17% had bicytopenia, 9% had thrombocytopenia, 4% had pancytopenia, and 30% had macrocytosis. The 57% of patients had iron deficiency, 5% had parasite infestation, 5% had Helicobacter Pylori infection, 3% had celiac disease, 2% had Familial Mediterranean Fever and history of colchicum use. The 97% cause of vitamin B12 deficiency was nutritional. Even though all patients had vitamin B12 deficiency, only 44% of them had higher homocystein levels. In treatment group, 51% of patients received cyanocobalamine oral route, 49% received Intramuscular. The Intramusculartreatment was more effective than oral route. The four of 116 patients (3.5%) had complication after treatment.Conclusion: This study showed that vitamin B12 deficiency is frequent in children in Samsun andsurrounding counties. The disease becomes widespread first two years and between 12-17 years. This indicates that these ages are at risk. To prevent vitamin B12 deficiency in infants, its level must be evaluated in pregnant and mothers of infants and foods of animal origin must be suggested. Animal foods are advised adolescent because of growing necessity.Vitamin B12deficiency must be evaluated as a public health problem and the prevalence studies must performed regional and in country and new solutions must produced 122

Published
2011

7. Early neonatal outcomes of very-low-birthweight infants in Turkey: A prospective multicenter study of the Turkish Neonatal Society

Author

Hüseyin Selim Asker, Emrah Can, Cumhur Aydemir, Betül Acunaş, Ali Bulbul, Turan Tunc, Kadir Şerafettin Tekgündüz, Hasan Tolga Çelik, Şahin Takcı, Ramazan Ozdemir, Ahmet Ozdemir, Mehmet Mutlu, Ferda Özlü, Yasar Demirelli, Beyza Ozcan, Rahmi Ors, Fatma Nur Sari, Ilknur Kilic, Guner Karatekin, Dilek Ulubas Isik, Banu Mutlu Özyurt, Berna Hekimoğlu, Sabahattin Ertuğrul, Murat Konak, Selda Arslan, Nuriye Tarakci, Ozgun Uygur, Serdar Cömert, Sadık Yurttutan, Kazim Kucuktasci, Emel Okulu, Arzu Akdag, Nilay Hakan, Nilüfer Güzoğlu, Tugba Gursoy, Hakan Aylanç, Şebnem Çalkavur, Asli Memisoglu, Ayşegül Zenciroğlu, Bilin Cetinkaya, Serdar Beken, Ozge Aydemir, Hacer Ergin, Ibrahim Murat Hirfanoglu, Yusuf Kale, Didem Armangil, Suzan Sahin, Bilge Tanyeri Bayraktar, Özden Turan, Huseyin Altunhan, Servet Ozkiraz, İlker Uslu, Nihal Demirel, Funda Eroglu, Zeynel Gokmen, Aysen Orman, Leyla Bilgin, Esin Koç, Beril Yasa, Demet Terek, Funda Tuzun, Esad Koklu, Nuran Üstün, Birgul Mutlu, Ahmet Yagmur Bas, Merih Cetinkaya, Hilal Özkan, Fatma Narter, Mustafa Kurthan Mert, Ayhan Tastekin, Ulker Celik, Dilek Sarici, Oğuz Tuncer, KOÇ E., DEMİREL N., BAŞ A. Y., Isik D. U., HIRFANOĞLU İ. M., Tunc T., Sari F. N., Karatekin G., ÖZDEMİR R., Altunhan H., et al., Ege Üniversitesi, MÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Hakan, Nilay, Dicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı, Ertuǧrul, Sabahattin, Selçuk Üniversitesi, OMÜ, Gürsoy, Tuğba (ORCID 0000-0002-6084-4067 & YÖK ID 214691), Koç, Esin, Demirel, Nihal, Baş, Ahmet Yağmur, Işık, Dilek Ulubaş, Hirfanoğlu, İbrahim Murat, Tunc, Turan, Sarı, Fatma Nur, Karatekin, Güner, Özdemir, Ramazan, Altunhan, Hüseyin, Çetinkaya, Merih, Özcan, Beyza, Özkiraz, Servet, Çalkavur, Sebnem, Tekgündüz, Kadir Şerafettin, Taştekin, Ayhan, Özlü, Ferda, Özyurt, Banu Mutlu, Özdemir, Ahmet, Çetinkaya, Bilin, Demirelli, Yaşar, Köklü, Esad, Çelik, Ülker, Tarakçı, Nuriye, Armangil, Didem, Okulu, Emel, Narter, Fatma, Mutlu, Birgul, Mert, Mustafa Kurthan, Bülbül, Ali, Asker, Hüseyin Selim, Uygur, ÖzgÜn, Uslu, İlker Sait, Ertuğrul, Sabahattin, Aydemir, Cumhur, Çelik, Hasan Tolga, Küçüktaşçı, Kazım, Arslan, Selda, Ergin, Hacer, Zenciroğlu, Aysegül, Yurttutan, Sadık, Orman, Ayşen, Tuncer, Oğuz, Yaşa, Beril, Acunas, Betül, Takci, Şahin, Gökmen, Zeynel, Özkan, Hilal, Cömert, Serdar, Üstün, Nuran, Mutlu, Mehmet, Bayraktar, Bilge Tanyeri, Bilgin, Leyla, Tuzun, Funda, Aydemir, Özge, Akdağ, Arzu, Memisoğlu, Aslı, Can, Emrah, Terek, Demet, Beken, Serdar, Turan, Özden, Güzoğlu, Nilüfer, Örs, Rahmi, Kale, Yusuf, Hekimoğlu, Berna, Aylanc, Hakan, Eroğlu, Funda, Şahin, Suzan, Konak, Murat, Sarıcı, Dilek, Kılıç, İlknur, School of Medicine, Acibadem University Dspace, KKÜ, and Kırıkkale Üniversitesi

Subjects
Male, Turkey, Temel Bilimler (SCI), very low birth weight, ÇOK DİSİPLİNLİ BİLİMLER, Pathology and Laboratory Medicine, blood culture, Pediatrics, Infant, Newborn, Diseases, lung dysplasia, sepsis, Families, 0302 clinical medicine, newborn, Pregnancy, Birth Weight, Medicine, Prospective Studies, Children, [Anahtar Kelime Yok], Organic Compounds, adult, steroid, Pregnancy Outcome, clinical trial, Retinopathy of prematurity, cohort analysis, Bronchopulmonary dysplasia, Necrotizing enterocolitis, Morbidity, Mortality, Health, Prematurity, Infections, Countries, Distress, Sepsis, Physical Sciences, disease severity, prospective study, survival rate, medicine.medical_specialty, Science, Article, patent ductus arteriosus, 03 medical and health sciences, Signs and Symptoms, turkey (bird), Intensive Care Units, Neonatal, Intensive care, Humans, Retinopathy of Prematurity, human, Retinopathy, necrotizing enterocolitis, MULTIDISCIPLINARY SCIENCES, Chemical Compounds, Biology and Life Sciences, Neonates, Doğa Bilimleri Genel, medicine.disease, major clinical study, neonatal intensive care unit, Health Care, hospital discharge, Ophthalmology, Low birth weight, multicenter study, NATURAL SCIENCES, GENERAL, Population Groupings, Health Statistics, Neonatology, Developmental Biology, genetic structures, morbidity, hemodynamics, Neonatal Care, Turkey (republic), Medicine and Health Sciences, Infant, Very Low Birth Weight, 030212 general & internal medicine, gestational age, Prospective cohort study, Science and technology, Multidisciplinary, Temel Bilimler, Gestational age, newborn disease, Chemistry, female, Natural Sciences (SCI), brain hemorrhage, Retinal Disorders, Steroids, Female, Neonatal Sepsis, newborn morbidity, medicine.symptom, Natural Sciences, Infants, Research Article, Adult, Birth weight, Gestational Age, Turkish Neonatal Society, Diagnostic Medicine, 030225 pediatrics, retinopathy, controlled study, outcome assessment, perinatal period, Multidisipliner, business.industry, Organic Chemistry, prematurity, Infant, Newborn, infant, Age Groups, People and Places, Study, business, Early Neonatal Outcomes
Abstract

Beken, Serdar/0000-0002-8609-2684; BAS, AHMET YAGMUR/0000-0002-1329-2167; Bulbul, Ali/0000-0002-3510-3056; Karatekin, Guner/0000-0001-7112-0323, WOS: 000534242500056, PubMed: 31851725, Objective To investigate the early neonatal outcomes of very-low-birth-weight (VLBW) infants discharged home from neonatal intensive care units (NICUs) in Turkey. Material and methods A prospective cohort study was performed between April 1, 2016 and April 30, 2017. the study included VLBW infants admitted to level III NICUs. Perinatal and neonatal data of all infants born with a birth weight of.1500 g were collected for infants who survived. Results Data from 69 NICUs were obtained. the mean birth weight and gestational age were 1137 +/- 245 g and 29 +/- 2.4 weeks, respectively. During the study period, 78% of VLBW infants survived to discharge and 48% of survived infants had no major neonatal morbidity. VLBW infants who survived were evaluated in terms of major morbidities: bronchopulmonary dysplasia was detected in 23.7% of infants, necrotizing enterocolitis in 9.1%, blood culture proven late-onset sepsis (LOS) in 21.1%, blood culture negative LOS in 21.3%, severe intraventricular hemorrhage in 5.4% and severe retinopathy of prematurity in 11.1%. Hemodynamically significant patent ductus arteriosus was diagnosed in 24.8% of infants. Antenatal steroids were administered to 42.9% of mothers. Conclusion the present investigation is the first multicenter study to include epidemiological information on VLBW infants in Turkey. Morbidity rate in VLBW infants is a serious concern and higher than those in developed countries. Implementation of oxygen therapy with appropriate monitoring, better antenatal and neonatal care and control of sepsis may reduce the prevalence of neonatal morbidities. Therefore, monitoring standards of neonatal care and implementing quality improvement projects across the country are essential for improving neonatal outcomes in Turkish NICUs., Turkish Neonatal Society [2-2016]; Turkish Neonatal Society, This study was supported by the Turkish Neonatal Society, http://www.neonatology.org.tr, number 2-2016, received by AYB. Turkish Neonatal Society funded the study's online registry system. the funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Published
2019

8. Incidence, risk factors and severity of retinopathy of prematurity in Turkey (TR-ROP study): a prospective, multicentre study in 69 neonatal intensive care units

Author

Bas, Ahmet Yagmur, Demirel, Nihal, Koc, Esin, Isik, Dilek Ulubas, Hirfanoglu, Ibrahim Murat, Tunc, Turan, Sari, Fatma Nur, Karatekin, Guner, Koklu, Esad, Altunhan, Huseyin, Turgut, Hatice, Narter, Fatma, Tarakci, Nuriye, Tekgunduz, Kadir Serafettin, Ozkiraz, Servet, Aydemir, Cumhur, Ozdemir, Ahmet, Cetinkaya, Bilin, Kazanci, Ebru, Tastekin, Ayhan, Calkavur, Sebnem, Ozyurt, Banu Mutlu, Demirelli, Yasar, Asker, Huseyin Selim, Mutlu, Birgul, Uygur, Ozgun, Ozkan, Hilal, Armangil, Didem, Ozlu, Ferda, Mert, Mustafa Kurthan, Ergin, Hacer, Ozcan, Beyza, Bas, Evrim Kiray, Okulu, Emel, Acunas, Betul, Celik, Ulker, Uslu, Sait Ilker, Mutlu, Mehmet, Demir, Nihat, Eroglu, Funda, Gokmen, Zeynel, Beken, Serdar, Bayraktar, Bilge Tanyeri, Hakan, Nilay, Kucuktasci, Kazim, Orman, Aysen, Comert, Serdar, Ertugrul, Sabahattin, Ustun, Nuran, Sahin, Ozlem, Terek, Demet, Kale, Yusuf, Konak, Murat, Yurttutan, Sadik, Aydemir, Ozge, Zenciroglu, Aysegul, Sarici, Dilek, Guzoglu, Nilufer, Hamilcikan, Sahin, Gursoy, Tugba, Tuzun, Funda, Ors, Rahmi, Arslan, Selda, Akdag, Arzu, Memisoglu, Asli, Yasa, Beril, Hekimoglu, Berna, Turan, Ozden, Aylanc, Hakan, Takci, Sahin, Celik, Tolga, Sahin, Suzan, Kilic, Ilknur, Kara, Caner, Tunay, Zuhal Ozen, Celik, Gokhan, Gozen, Ibrahim, Satirtav, Gunhal, Polat, Nihat, Oral, Ayse Yesim, Tokgoz, Mine, Keles, Sadullah, Bilgin, Burak, Ugurbas, Silay Canturk, Karaca, Cagatay, Keskek, Nedime Sahinoglu, Ekinci, Dilbade Yildiz, Balci, Ozlem, Altan, Emir Volkan, Bakbak, Sevda, Ceylan, Nihan Aksu, Kimyon, Sabit, Alyamac, Gunay, Ture, Gamze, Yildiz, Meral, Calis, Feyza, Sizmaz, Selcuk, Sukgen, Emine, Cetin, Ebru Nevin, Ozcimen, Muammer, Demir, Semra Tiryaki, Atila, Huban, Ozal, Altan, Tufaner, Gokhan, Yucel, Ozlem Eski, Kola, Mehmet, Seven, Erbil, Ozdek, Sengul, Durukan, Ali Hakan, Kal, Ali, Celebi, Ali Riza Cenk, Koytak, Ibrahim Arif, Alacamli, Goksu, Esme, Arif, Catak, Onur, Perente, Irfan, Sahin, Alparslan, Akcakaya, Aylin Ardagil, Kiray, Gulunay, Nalcaci, Serhat, Aksoy, Umit, Bakbak, Berker, Comez, Aysegul, Gursoy, Huseyin, Kabatas, Emrah Utku, Petricli, Ikbal Seza, Yumusak, Mehmet Erhan, Kirgiz, Ahmet, Uludag, Gunay, Yaman, Aylin, Dadaci, Zeynep, Karatas, Ali, Celiker, Hande, Cebeci, Zafer, Esenulku, Mahmut Cenap, Akkoyun, Imren, Ersan, Ismail, Demir, Selim, Kadayifcilar, Sibel, Unsal, Ayse Ipek Akyuz, Hocaoglu, Mumin, Grp, T. R.-R.O.P. Study, Ege Üniversitesi, Zonguldak Bülent Ecevit Üniversitesi, Çukurova Üniversitesi, Çocuk Sağlığı ve Hastalıkları, KOYTAK, İBRAHİM ARİF, Uludağ, Günay (ORCID & YÖK ID 175586), Gürsoy, Tuğba (ORCID 0000-0002-6084-4067 & YÖK ID 214691), Baş, Ahmet Yağmur, Demirel, Nihal, Koç, Esin, Işık, Dilek Ulubaş, Hirfanoğlu, İbrahim Murat, Tunç, Turan, Sarı, Fatma Nur, Karatekin, Güner, Köklü, Esad, Altunhan, Hüseyin, Turgut, Hatice, Narter, Fatma, Tarakçı, Nuriye, Tekgündüz, Kadir Şerafettin, Özkiraz, Servet, Aydemir, Cumhur, Özdemir, Ahmet, Çetinkaya, Bilin, Kazancı, Ebru, Taştekin, Ayhan, Calkavur, Şebnem, Özyurt, Banu Mutlu, Demirelli, Yaşar, Asker, Hüseyin Selim, Mutlu, Birgul, Uygur, Özgün, Özkan, Hilal, Armangil, Didem, Özlü, Ferda, Mert, Mustafa Kurthan, Ergin, Hacer, Özcan, Beyza, Baş, Evrim Kıray, Okulu, Emel, Acunas, Betül, Çelik, Ülker, Uslu, Sait İlker, Mutlu, Mehmet, Demir, Nihat, Eroğlu, Funda, Gökmen, Zeynel, Beken, Serdar, Bayraktar, Bilge Tanyeri, Hakan, Nilay, Küçüktaşçı, Kazım, Orman, Ayşen, Cömert, Serdar, Ertuğrul, Sabahattin, Üstün, Nuran, Şahin, Özlem, Terek, Demet, Kale, Yusuf, Konak, Murat, Yurttutan, Sadık, Aydemir, Özge, Zenciroğlu, Aysegül, Sarıcı, Dilek, Güzoğlu, Nilüfer, Hamilçıkan, Şahin, Tüzün, Funda, Örs, Rahmi, Arslan, Selda, Akdağ, Arzu, Memişoğlu, Aslı, Yasa, Beril, Hekimoğlu, Berna, Turan, Özden, Aylanc, Hakan, Takçı, Şahin, Çelik, Tolga, Şahin, Suzan, Kılıç, İlknur, Kara, Caner, Tunay, Zuhal Özen, Çelik, Gökhan, Gözen, İbrahim, Satırtav, Günhal, Polat, Nihat, Oral, Ayşe Yeşim, Tokgöz, Mine, Keleş, Sadullah, Bilgin, Burak, Uğurbaş, Silay Cantürk, Karaca, Çağatay, Keşkek, Nedime Şahinoğlu, Ekinci, Dilbade Yıldız, Balcı, Özlem, Altan, Emir Volkan, Bakbak, Sevda, Ceylan, Nihan Aksu, Kimyon, Sabit, Alyamaç, Günay, Türe, Gamze, Yıldız, Meral, Çalış, Feyza, Sızmaz, Selçuk, Sukgen, Emine, Çetin, Ebru Nevin, Özçimen, Muammer, Demir, Semra Tiryaki, Atila, Huban, Özal, Altan, Tufaner, Gökhan, Yücel, Özlem Eski, Kola, Mehmet, Seven, Erbil, Özdek, Şengül, Durukan, Ali Hakan, Kal, Ali, Çelebi, Ali Riza Cenk, Koytak, İbrahim Arif, Alaçamlı, Göksu, Esme, Arif, Çatak, Onur, Perente, İrfan, Şahin, Alparslan, Akçakaya, Aylin Ardagil, Kıray, Gülünay, Nalçacı, Serhat, Aksoy, Ümit, Bakbak, Berker, Çömez, Ayşegül, Gürsoy, Hüseyin, Kabataş, Emrah Utku, Petricli, İkbal Seza, Yumuşak, Mehmet Erhan, Kırgız, Ahmet, Yaman, Aylin, Dadacı, Zeynep, Karataş, Ali, Çeliker, Hande, Cebeci, Zafer, Esenülkü, Mahmut Cenap, Akkoyun, İmren, Ersan, İsmail, Demir, Selim, Kadayıfçılar, Sibel, Ünsal, Ayşe İpek Akyüz, Hocaoğlu, Mümin, School of Medicine, Department of Internal Medicine, MÜ, Kırıkkale Üniversitesi, Selçuk Üniversitesi, Bas, Ahmet Yagmur, Koc, Esin, Isik, Dilek Ulubas, Hirfanoglu, Ibrahim Murat, Tunc, Turan, Sari, Fatma Nur, Karatekin, Guner, Koklu, Esad, Altunhan, Huseyin, Tarakci, Nuriye, Tekgunduz, Kadir Serafettin, Ozkiraz, Servet, Ozdemir, Ahmet, Cetinkaya, Bilin, Kazanci, Ebru, Tastekin, Ayhan, Calkavur, Sebnem, Ozyurt, Banu Mutlu, Demirelli, Yasar, Asker, Huseyin Selim, Uygur, Ozgun, Ozkan, Hilal, Ozlu, Ferda, Ozcan, Beyza, Bas, Evrim Kiray, Acunas, Betul, Celik, Ulker, Uslu, Sait Ilker, Eroglu, Funda, Gokmen, Zeynel, Kucuktasci, Kazim, Orman, Aysen, Comert, Serdar, Ertugrul, Sabahattin, Ustun, Nuran, Sahin, Ozlem, Yurttutan, Sadik, Aydemir, Ozge, Zenciroglu, Aysegul, Sarici, Dilek, Guzoglu, Nilufer, Hamilcikan, Sahin, Gursoy, Tugba, Tuzun, Funda, Ors, Rahmi, Akdag, Arzu, Memisoglu, Asli, Hekimoglu, Berna, Turan, Ozden, Takci, Sahin, Celik, Tolga, Sahin, Suzan, Kilic, Ilknur, Tunay, Zuhal Ozen, Celik, Gokhan, Gozen, Ibrahim, Satirtav, Gunhal, Oral, Ayse Yesim, Tokgoz, Mine, Keles, Sadullah, Ugurbas, Silay Canturk, Karaca, Cagatay, Keskek, Nedime Sahinoglu, Ekinci, Dilbade Yildiz, Balci, Ozlem, Alyamac, Gunay, Ture, Gamze, Yildiz, Meral, Calis, Feyza, Sizmaz, Selcuk, Cetin, Ebru Nevin, Ozcimen, Muammer, Ozal, Altan, Tufaner, Gokhan, Yucel, Ozlem Eski, Ozdek, Sengul, Celebi, Ali Riza Cenk, Koytak, Ibrahim Arif, Alacamli, Goksu, Catak, Onur, Perente, Irfan, Sahin, Alparslan, Akcakaya, Aylin Ardagil, Kiray, Gulunay, Nalcaci, Serhat, Aksoy, Umit, Comez, Aysegul, Gursoy, Huseyin, Kabatas, Emrah Utku, Petricli, Ikbal Seza, Yumusak, Mehmet Erhan, Kirgiz, Ahmet, Uludag, Gunay, Dadaci, Zeynep, Karatas, Ali, Celiker, Hande, Esenulku, Mahmut Cenap, Akkoyun, Imren, Ersan, Ismail, Kadayifcilar, Sibel, Unsal, Ayse Ipek Akyuz, Hocaoglu, Mumin, OMÜ, Tıp Fakültesi, and Acibadem University Dspace

Subjects
Male, BLOOD-TRANSFUSION, Pediatrics, Turkey, INFANTS, Logistic regression, 0302 clinical medicine, Risk Factors, FOR-GESTATIONAL-AGE, Prevalence, Birth Weight, Infant, Very Low Birth Weight, Prospective Studies, Prospective cohort study, [Anahtar Kelime Yok], Neovascularisation, Incidence, Incidence (epidemiology), Gestational age, Retinopathy of prematurity, Clinical Science, Sensory Systems, Female, Infant, Premature, Child health (paediatrics), Retina, Treatment medical, congenital, hereditary, and neonatal diseases and abnormalities, medicine.medical_specialty, Birth weight, Gestational Age, Sepsis, 03 medical and health sciences, Cellular and Molecular Neuroscience, Neonatal Screening, Intensive Care Units, Neonatal, 030225 pediatrics, Intensive care, medicine, Humans, Retinopathy of Prematurity, business.industry, Child Health (paediatrics), Infant, Newborn, [No Keywords], Infant, medicine.disease, eye diseases, Ophthalmology, For-Gestational-Age, TR-ROP Study, 030221 ophthalmology & optometry, Treatment Medical, Blood-Transfusion, WEIGHT, Weight, Infants, Severity of Retinopathy, business, Medicine
Abstract

Background To evaluate the prevalence, risk factors and treatment of retinopathy of prematurity (ROP) in Turkey and to establish screening criteria for this condition., Methods A prospective cohort study (TR-ROP) was performed between 1 April 2016 and 30 April 2017 in 69 neonatal intensive care units (NICUs). Infants with a birth weight (BW)=1500 g or gestational age (GA) 1500 g or GA> 32 weeks with an unstable clinical course were included in the study. Predictors for the development of ROP were determined by logistic regression analyses., Results The TR-ROP study included 6115 infants: 4964 (81%) with a GA 32 weeks. Overall, 27% had any stage of ROP and 6.7% had severe ROP. A lower BW, smaller GA, total days on oxygen, late-onset sepsis, frequency of red blood cell transfusions and relative weight gain were identified as independent risk factors for severe ROP in infants with a BW=1500 g. Of all infants, 414 needed treatment and 395 (95.4%) of the treated infants had a BW, Conclusions Screening of infants with a GA

Published
2018

9. Retinopathy of Prematurity in Triplets.

Author

Şekeroğlu MA, Hekimoğlu E, Çelik Ü, Kale Y, and Baş AY

Abstract

Objectives: To investigate the incidence, severity and risk factors of retinopathy of prematurity (ROP) in triplets., Materials and Methods: The medical records of consecutive premature triplets who had been screened for ROP in a single maternity hospital were analyzed and presence and severity of ROP; birth weight, gender, gestational age of the infant; route of delivery and the mode of conception were recorded., Results: A total of 54 triplets (40 males, 14 females) who were screened for ROP between March 2010 and February 2013 were recruited for the study. All triplets were delivered by Caesarean section and 36 (66.7%) were born following an assisted conception. During follow-up, seven (13%) of the infants developed ROP of any stage and two (3.7%) required laser photocoagulation. The mean gestational age of triplets with ROP was 27.6±1.5 (27-31) weeks whereas it was 32.0±1.5 (30-34) weeks in those without ROP (p=0.002). The mean birth weights of triplets with and without ROP were 1290.0±295.2 (970-1600) g and 1667.5±222.2 (1130-1960) g, respectively (p<0.001). The presence of ROP was not associated with gender (p=0.358) or mode of conception (p=0.674)., Conclusion: ROP in triplets seems to be mainly related to low gestational age and low birth weight. Further prospective randomized studies are necessary to demonstrate risk factors of ROP in triplets and to determine if and how gemelarity plays a role in the development of ROP., Competing Interests: No conflict of interest was declared by the authors. Financial Disclosure: The authors declared that this study received no financial support.

Published
2016
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