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189 results on '"Çakar N"'

1. Timing and Modality of Kidney Replacement Therapy in Children and Adolescents

Author

Cortina, G., Arbeiter, K., Dusek, J., Harambat, J., Ranchin, B., Fischbach, M., Querfeld, U., Habbig, S., Galiano, M., Büscher, R., Gimpel, C., Kemper, M., Melk, A., Thurn, D., Schaefer, F., Doyon, A., Wühl, E., Pohl, M., Wygoda, S., Jeck, N., Kranz, B., Wigger, M., Montini, G., Lugani, F., Testa, S., Vidal, E., Matteucci, C., Picca, S., Jankauskiene, A., Azukaitis, K., Zurowska, A., Drodz, D., Tkaczyk, M., Urasinski, T., Litwin, M., Szczepanska, M., Texeira, A., Peco-Antic, A., Bucher, B., Laube, G., Anarat, A., Bayazit, A.K., Yalcinkaya, F., Basin, E., Cakar, N., Soylemezoglu, O., Duzova, A., Bilginer, Y., Erdogan, H., Donmez, O., Balat, A., Kiyak, A., Caliskan, S., Canpolat, N., Candan, C., Civilibal, M., Emre, S., Ozcelik, G., Mir, S., Sözeri, B., Yavascan, O., Tabel, Y., Ertan, P., Yilmaz, E., Shroff, R., Thumfart, Julia, Wagner, Steffen, Kirchner, Marietta, Azukaitis, Karolis, Bayazit, Aysun K., Obrycki, Lukasz, Canpolat, Nur, Bulut, Ipek Kaplan, Duzova, Ali, Anarat, Ali, Bessenay, Lucie, Shroff, Rukshana, Paripovic, Dusan, Sever, Lale, Candan, Cengiz, Lugani, Francesca, Yilmaz, Alev, Yalcinkaya, Fatos, Arbeiter, Klaus, Kiyak, Aysel, Zurowska, Aleksandra, Galiano, Matthias, Querfeld, Uwe, Melk, Anette, and Schaefer, Franz

Published
2024
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2. P027This study presents a comprehensive genetic and clinical profiling of patients with cystic fibrosis ineligible for CFTR modulator therapy, offering insights from a diverse patient cohort

Author

Yıldız, C.A., primary, Kalyoncu, M., additional, Selçuk Balcı, M., additional, Karabulut, Ş., additional, Metin Çakar, N., additional, Başer, Z.M., additional, Ergenekon, A.P., additional, Erdem Eralp, E., additional, Gökdemir, Y., additional, Ata, P., additional, Karakoç, F., additional, and Karadağ, B., additional

Published
2024
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12. Renal Autotransplantation in a Patient with Bilateral Renal Artery Stenosis Secondary to Takayasu Arteritis

Author

Mekik Akar, E., Aydin, F., Tüzüner, A., Fitöz, S., Öztürk, S., Eda Didem Kurt Şükür, Şanlidilek, U., Çelikel, E., Özçakar, Z. B., Çakar, N., and Yalçinkaya, F.

Subjects
Case Report, cardiovascular diseases, urologic and male genital diseases, skin and connective tissue diseases
Abstract

Involvement of the renal artery is common in Takayasu arteritis. We, herein, present on a patient with Takayasu arteritis causing severe renal failure and a successful auto-transplantation. This case shows that early diagnosis and immediate appropriate interventions are life-saving in patients with Takayasu arteritis. Renal auto-transplantation performed in selected cases increases dialysis-free survival.

Published
2020

30. Characteristics and determinants of outcome of hospital-acquired bloodstream infections in intensive care units: The EUROBACT International Cohort Study

Author

Tabah, A. Koulenti, D. Laupland, K. Misset, B. Valles, J. Bruzzi De Carvalho, F. Paiva, J.A. Çakar, N. Ma, X. Eggimann, P. Antonelli, M. Bonten, M.J.M. Csomos, A. Krueger, W.A. Mikstacki, A. Lipman, J. Depuydt, P. Vesin, A. Garrouste-Orgeas, M. Zahar, J.-R. Blot, S. Carlet, J. Brun-Buisson, C. Martin, C. Rello, J. Dimopoulos, G. Timsit, J.-F.

Abstract

Purpose: The recent increase in drug-resistant microorganisms complicates the management of hospital-acquired bloodstream infections (HA-BSIs). We investigated the epidemiology of HA-BSI and evaluated the impact of drug resistance on outcomes of critically ill patients, controlling for patient characteristics and infection management. Methods: A prospective, multicentre non-representative cohort study was conducted in 162 intensive care units (ICUs) in 24 countries. Results: We included 1,156 patients [mean ± standard deviation (SD) age, 59.5 ± 17.7 years; 65 % males; mean ± SD Simplified Acute Physiology Score (SAPS) II score, 50 ± 17] with HA-BSIs, of which 76 % were ICU-acquired. Median time to diagnosis was 14 [interquartile range (IQR), 7-26] days after hospital admission. Polymicrobial infections accounted for 12 % of cases. Among monomicrobial infections, 58.3 % were gram-negative, 32.8 % gram-positive, 7.8 % fungal and 1.2 % due to strict anaerobes. Overall, 629 (47.8 %) isolates were multidrug-resistant (MDR), including 270 (20.5 %) extensively resistant (XDR), and 5 (0.4 %) pan-drugresistant (PDR). Micro-organism distribution and MDR occurrence varied significantly (p < 0.001) by country. The 28-day all-cause fatality rate was 36 %. In the multivariable model including micro-organism, patient and centre variables, independent predictors of 28-day mortality included MDR isolate [odds ratio (OR), 1.49; 95 % confidence interval (95 %CI), 1.07-2.06], uncontrolled infection source (OR, 5.86; 95 %CI, 2.5-13.9) and timing to adequate treatment (before day 6 since blood culture collection versus never, OR, 0.38; 95 %CI, 0.23-0.63; since day 6 versus never, OR, 0.20; 95 %CI, 0.08-0.47). Conclusions: MDR and XDR bacteria (especially gram-negative) are common in HA-BSIs in critically ill patients and are associated with increased 28-day mortality. Intensified efforts to prevent HA-BSIs and to optimize their management through adequate source control and antibiotic therapy are needed to improve outcomes. © Copyright jointly held by Springer and ESICM 2012.

Published
2012

31. Developing of a new scale for assessing the adherence to colchicine treatment in pediatric patients with FMF

Author

Yesilkaya, S, primary, Acikel, C, additional, Fidanci, BE, additional, Sozeri, B, additional, Ayaz, NA, additional, Akıncı, N, additional, Kavukçu, S, additional, Özçelik, G, additional, Aydogan, U, additional, Ozenç, S, additional, Emre, S, additional, Donmez, O, additional, Delibaş, A, additional, Yüksel, S, additional, Berdelli, A, additional, Poyrazoğlu, H, additional, Saldır, M, additional, Çakar, N, additional, Peru, H, additional, Bakkaloğlu, S, additional, Tabel, Y, additional, Sarı, O, additional, Polat, A, additional, Basbozkurt, G, additional, Unsal, E, additional, Kasapcopur, O, additional, Gok, F, additional, Ozen, S, additional, and Demirkaya, E, additional

Published
2015
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32. Familial Mediterranean fever-associated diseases in children.

Author

Özçakar, Z. B., Çakar, N., Uncu, N., Çelikel, B. A., and Yalçınkaya, F.

Subjects
*FAMILIAL Mediterranean fever, *GENES, *PYRIN (Protein), *INFLAMMATION, *DISEASE nomenclature
Abstract

Background: MEditerranean FeVer (MEFV) gene encodes for the pyrin protein and a mutated pyrin is associated with a prolonged or augmented inflammation. Hence, various diseases were reported to be associated with familial Mediterranean fever (FMF) or carriers of MEFV mutations. However, systematic evaluation of all associated diseases in children with FMF has not been done previously. Aim: The aim of this study was to investigate the frequency and type of FMF-associated diseases in children. Design and Methods: Files of FMF patients who had been seen in two reference hospitals in Ankara, in the last two years, were retrospectively evaluated. Patients with FMF and concomitant diseases were included to the study. Results: Among 600 FMF patients, 77 were found to have a concomitant disease (12.8%). Thirty patients (5%) had vasculitis; 21 (3.5%) had juvenile idiopathic artritis (JIA); 7 (1.16%) had inflammatory bowel disease (IBD) and 19 had other diseases including 5 patients with isolated sacroiliitis. Overall, 13 (2.17%) patients had sacroiliitis in our cohort. The most frequent mutation was M694V/M694V (44%) and 81% of the patients had at least one M694V mutation. Majority of the patients (74%) developed associated diseases while they were not receiving colchicine therapy. Conclusions: Certain inflammatory diseases including vasculitis, chronic arthritis and IBD were more frequently detected in patients with FMF during childhood. M694V mutation is a susceptibility factor for associated diseases. In countries where FMF is prevalent, clinicians dealing with FMF and other inflammatory diseases should be aware of these associations. [ABSTRACT FROM AUTHOR]

Published
2017
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37. The value of the levels of acute phase reactants for the prediction of familial Mediterranean fever associated amyloidosis: a case control study

Author

Yalçınkaya, F., primary, Çakar, N., additional, Acar, B., additional, Tutar, E., additional, Güriz, H., additional, Elhan, A. H., additional, Öztürk, S., additional, Kansu, A., additional, İnce, E., additional, Atalay, S., additional, Girgin, N., additional, Doğru, Ü., additional, Aysev, D., additional, and Ekim, M., additional

Published
2006
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