Search

Your search keyword '"Åkerblom, Hans K."' showing total 318 results
Start Over Author "Åkerblom, Hans K."
318 results on '"Åkerblom, Hans K."'

1. Avoidance of Cow's Milk–Based Formula for At-Risk Infants Does Not Reduce Development of Celiac Disease: A Randomized Controlled Trial

Author

Åkerblom, H.K., Eskola, V., Haavisto, H., Hämäläinen, A.-M., Holm C, C., Järvenpää, A.-L., Jokisalo, R., Käär, M.-L., Kaski, U., Komulainen, J., Korpela, P., Lautala, P., Niemi, K., Nuuja, A., Rantanen, P., Renko, R., Renlund, M., Salo, M., Talvitie, T., Uotila, T., Wetterstrand, G., Hyöty, H., Ilonen, J., Klemetti, P., Knip, M., Kulmala, P.K., Paronen, J., Reunanen, A., Saukkonen, T., Savilahti, E., Savola, K., Teramo, K., Vaarala, O., Virtanen, S.M., Hyytinen, Mila, Savilahti, Erkki, Virtanen, Suvi M., Härkönen, Taina, Ilonen, Jorma, Luopajärvi, Kristiina, Uibo, Raivo, Vaarala, Outi, Åkerblom, Hans K., and Knip, Mikael

Published
2017
Full Text
View/download PDF

2. Early Nutrition and Later Diabetes Risk

Author

Knip, Mikael, Åkerblom, Hans K., Back, Nathan, editor, Cohen, Irun R., editor, Kritchevsky, David, editor, Lajtha, Abel, editor, Paoletti, Rodolfo, editor, Koletzko, Berthold, editor, Dodds, Peter, editor, Akerblom, Hans, editor, and Ashwell, Margaret, editor

Published
2005
Full Text
View/download PDF

3. Effect of Hydrolyzed Infant Formula vs Conventional Formula on Risk of Type 1 Diabetes: The TRIGR Randomized Clinical Trial

Author

Knip, Mikael, Åkerblom, Hans K., Al Taji, Eva, Becker, Dorothy, Bruining, Jan, Castano, Luis, Danne, Thomas, de Beaufort, Carine, Dosch, Hans-Michael, Dupre, John, Fraser, William D., Howard, Neville, Ilonen, Jorma, Konrad, Daniel, Kordonouri, Olga, Krischer, Jeffrey P., Lawson, Margaret L., Ludvigsson, Johnny, Madacsy, Laszlo, Mahon, Jeffrey L., Ormisson, Anne, Palmer, Jerry P., Pozzilli, Paolo, Savilahti, Erkki, Serrano-Rios, Manuel, Songini, Marco, Taback, Shayne, Vaarala, Outi, White, Neil H., Virtanen, Suvi M., and Wasikowa, Renata

Published
2018
Full Text
View/download PDF

4. Growth and development of islet autoimmunity and type 1 diabetes in children genetically at risk

Author

Nucci, Anita M., Virtanen, Suvi M., Cuthbertson, David, Ludvigsson, Johnny, Einberg, Ulle, Huot, Celine, Castano, Luis, Aschemeier, Bärbel, Becker, Dorothy J., Knip, Mikael, Krischer, Jeffrey P., Mandrup-Poulsen, Thomas, Arjas, Elias, Läärä, Esa, Lernmark, Åke, Schmidt, Barbara, Åkerblom, Hans K., Hyytinen, Mila, Koski, Katriina, Koski, Matti, Pajakkala, Eeva, Salonen, Marja, Shanker, Linda, Bradley, Brenda, Dosch, Hans Michael, and Dupré, John

Subjects
Male, 0301 basic medicine, Pediatric Obesity, Heredity, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Breastfeeding, Autoimmunity, Overweight, Child Development, 0302 clinical medicine, Risk Factors, Weight management, Medicine, Child, Randomized Controlled Trials as Topic, education.field_of_study, Incidence, Age Factors, Childhood growth, Beta cell autoimmunity, Prognosis, Infant Formula, Pedigree, Europe, Type 1 diabetes, Phenotype, Child, Preschool, Female, medicine.symptom, medicine.medical_specialty, Adolescent, Length, Population, 030209 endocrinology & metabolism, Risk Assessment, Article, Islets of Langerhans, 03 medical and health sciences, Internal medicine, Internal Medicine, Humans, Genetic Predisposition to Disease, education, Genetic risk, business.industry, Proportional hazards model, Insulin, Australia, Infant, Newborn, Autoantibody, Infant, Adolescent Development, Weight, medicine.disease, Bottle Feeding, Diabetes Mellitus, Type 1, 030104 developmental biology, North America, business
Abstract

Aims/hypothesis: We aimed to evaluate the relationship between childhood growth measures and risk of developing islet autoimmunity (IA) and type 1 diabetes in children with an affected first-degree relative and increased HLA-conferred risk. We hypothesised that being overweight or obese during childhood is associated with a greater risk of IA and type 1 diabetes. Methods: Participants in a randomised infant feeding trial (N = 2149) were measured at 12 month intervals for weight and length/height and followed for IA (at least one positive out of insulin autoantibodies, islet antigen-2 autoantibody, GAD autoantibody and zinc transporter 8 autoantibody) and development of type 1 diabetes from birth to 10–14 years. In this secondary analysis, Cox proportional hazard regression models were adjusted for birthweight and length z score, sex, HLA risk, maternal type 1 diabetes, mode of delivery and breastfeeding duration, and stratified by residence region (Australia, Canada, Northern Europe, Southern Europe, Central Europe and the USA). Longitudinal exposures were studied both by time-varying Cox proportional hazard regression and by joint modelling. Multiple testing was considered using family-wise error rate at 0.05. Results: In the Trial to Reduce IDDM in the Genetically at Risk (TRIGR) population, 305 (14.2%) developed IA and 172 (8%) developed type 1 diabetes. The proportions of children overweight (including obese) and obese only were 28% and 9% at 10 years, respectively. Annual growth measures were not associated with IA, but being overweight at 2–10 years of life was associated with a twofold increase in the development of type 1 diabetes (HR 2.39; 95% CI 1.46, 3.92; p < 0.001 in time-varying Cox regression), and similarly with joint modelling. Conclusions/interpretation: In children at genetic risk of type 1 diabetes, being overweight at 2–10 years of age is associated with increased risk of progression from multiple IA to type 1 diabetes and with development of type 1 diabetes, but not with development of IA. Future studies should assess the impact of weight management strategies on these outcomes. Trial registration: ClinicalTrials.gov NCT00179777 Graphical abstract: [Figure not available: see fulltext.]

Published
2021
Full Text
View/download PDF

17. Cohort Profile: The Cardiovascular Risk in Young Finns Study

Author

Raitakari, Olli T, Juonala, Markus, Rönnemaa, Tapani, Keltikangas-Järvinen, Liisa, Räsänen, Leena, Pietikäinen, Matti, Hutri-Kähönen, Nina, Taittonen, Leena, Jokinen, Eero, Marniemi, Jukka, Jula, Antti, Telama, Risto, Kähönen, Mika, Lehtimäki, Terho, Åkerblom, Hans K, and Viikari, Jorma SA

Published
2008

21. Dietary Compliance in Diabetes Prevention Project in Finland

Author

Bärlund, Sonja, Uusitalo, Ulla, Kleemola, Päivi, Knip, Mikael, Åkerblom, Hans K., Virtanen, Suvi M., Back, Nathan, editor, Cohen, Irun R., editor, Kritchevsky, David, editor, Lajtha, Abel, editor, Paoletti, Rodolfo, editor, Koletzko, Berthold, editor, Dodds, Peter, editor, Akerblom, Hans, editor, and Ashwell, Margaret, editor

Published
2005
Full Text
View/download PDF

37. Dietary compliance in a randomized double‐blind infant feeding trial during infancy aiming at prevention of type 1 diabetes.

Author

Virtanen, Suvi M., Cuthbertson, David, Nucci, Anita M., Hyytinen, Mila, Ormisson, Anne, Salonen, Marja, Turrini, Tania, Cummings, Elizabeth A., Bradley, Brenda, Tanner‐Blasiar, Marilyn, Becker, Dorothy J., Åkerblom, Hans K., Savilahti, Erkki, Krischer, Jeffrey P., and Knip, Mikael

Subjects
TYPE 1 diabetes, INFANT formulas, INFANTS, NEWBORN infants, MILK proteins, PREMATURE infants, INFANT nutrition, CHILD nutrition
Abstract

The international Trial to Reduce IDDM in the Genetically at Risk (TRIGR) tested the hypothesis whether extensively hydrolyzed casein‐based versus regular cow's milk‐based infant formula reduces the risk of type 1 diabetes. We describe dietary compliance in the trial in terms of study formula intake, feeding of nonrecommended foods, and serum cow's milk antibody concentration reflecting intake of cow's milk protein among 2,159 eligible newborn infants with a biological first‐degree relative affected by type 1 diabetes and with HLA‐conferred susceptibility to type 1 diabetes. The participating infants were introduced to the study formula feeding at the median age of 15 days with a median duration of study formula use of 63 days. During the intervention, 80% of the infants received study formula. Of these, 57% received study formula for at least 2 months. On average, 45.5 l of study formula were used per infant. Only 13% of the population had received a nonrecommended food by the age of 6 months. The dietary compliance was similar in the intervention and control arm. The reported cow's milk consumption by the families matched very well with measured serum casein IgA and IgG antibody concentration. To conclude, good compliance was observed in this randomized infant feeding trial. Compliance varied between the regions and those infants who were breastfed for a longer period of time had a shorter exposure to the study formula. High dietary compliance in infant feeding trial is necessary to allow accurate interpretation of study results. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

47. Regional differences in milk and complementary feeding patterns in infants participating in an international nutritional type 1 diabetes prevention trial

Author

Nucci, Anita M., Virtanen, Suvi M., Sorkio, Susa, Bärlund, Sonja, Cuthbertson, David, Uusitalo, Ulla, Lawson, Margaret L., Salonen, Marja, Berseth, Carol L., Ormisson, Anne, Lehtonen, Eveliina, Savilahti, Erkki, Becker, Dorothy J., Dupré, John, Krischer, Jeffrey P., Knip, Mikael, Åkerblom, Hans K., Mandrup-Poulsen, Thomas, Arjas, Elias, Läärä, Esa, and Lernmark, Åke

Subjects
endocrine system diseases, infant feeding, breastfeeding, type 1 diabetes, infant formula, breastfeeding duration, complementary feeding
Abstract

Differences in breastfeeding, other milk feeding and complementary feeding patterns were evaluated in infants at increased genetic risk with and without maternal type 1 diabetes (T1D). The Trial to Reduce IDDM in the Genetically at Risk is an international nutritional primary prevention double-blinded randomized trial to test whether weaning to extensively hydrolyzed vs. intact cow's milk protein formula will decrease the development of T1D-associated autoantibodies and T1D. Infant diet was prospectively assessed at two visits and seven telephone interviews between birth and 8 months. Countries were grouped into seven regions: Australia, Canada, Northern Europe, Southern Europe, Central Europe I, Central Europe II and the United States. Newborn infants with a first-degree relative with T1D and increased human leukocyte antigen-conferred susceptibility to T1D were recruited. A lower proportion of infants born to mothers with than without T1D were breastfed until 6 months of age in all regions (range, 51% to 60% vs. 70% to 80%). Complementary feeding patterns differed more by region than by maternal T1D. In Northern Europe, a higher proportion of infants consumed vegetables and fruits daily compared with other regions. Consumption of meat was more frequent in all European regions, whereas cereal consumption was most frequent in Southern Europe, Canada and the United States. Maternal T1D status was associated with breastfeeding and other milk feeding patterns similarly across regions but was unrelated to the introduction of complementary foods. Infant feeding patterns differed significantly among regions and were largely inconsistent with current recommended guidelines.

Published
2017

49. Avoidance of Cow's Milk–Based Formula for At-Risk Infants Does Not Reduce Development of Celiac Disease: A Randomized Controlled Trial

Author

Hyytinen, Mila, primary, Savilahti, Erkki, additional, Virtanen, Suvi M., additional, Härkönen, Taina, additional, Ilonen, Jorma, additional, Luopajärvi, Kristiina, additional, Uibo, Raivo, additional, Vaarala, Outi, additional, Åkerblom, Hans K., additional, Knip, Mikael, additional, Åkerblom, H.K., additional, Eskola, V., additional, Haavisto, H., additional, Hämäläinen, A.-M., additional, Holm C, C., additional, Järvenpää, A.-L., additional, Jokisalo, R., additional, Käär, M.-L., additional, Kaski, U., additional, Komulainen, J., additional, Korpela, P., additional, Lautala, P., additional, Niemi, K., additional, Nuuja, A., additional, Rantanen, P., additional, Renko, R., additional, Renlund, M., additional, Salo, M., additional, Talvitie, T., additional, Uotila, T., additional, Wetterstrand, G., additional, Hyöty, H., additional, Ilonen, J., additional, Klemetti, P., additional, Knip, M., additional, Kulmala, P.K., additional, Paronen, J., additional, Reunanen, A., additional, Saukkonen, T., additional, Savilahti, E., additional, Savola, K., additional, Teramo, K., additional, Vaarala, O., additional, and Virtanen, S.M., additional

Published
2017
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results