273 results on '"Åke Svensson"'
Search Results
2. Cross-Cultural Validation of the RECAP of Atopic Eczema Questionnaire in a Swedish Population
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Gunnthorunn Sigurdardottir, Mikael Alsterholm, Chris D. Andersson, Maria Bradley, MariHelen Sandström Falk, Emma K. Johansson, Maria Lundqvist, Andreas Sonesson, Åke Svensson, Grigorios Theodosiou, Sophie Vrang, and Laura B. von Kobyletzki
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atopic dermatitis ,eczema ,patient-reported outcome measure ,validation study ,Dermatology ,RL1-803 - Abstract
A Swedish translation of the patient-reported outcome measure for assessing long-term control of atopic dermatitis, Recap of atopic eczema (RECAP), has not been validated. Cross-cultural translation and multi-centre validation of the translated RECAP questionnaire were therefore performed. Disease severity was assessed using the validated Investigator Global Assessment Scale for atopic dermatitis (vIGA-ADTM). The Swedish RECAP was completed by 208 individuals aged 16 years or older with a median age of 36 years (interquartile range [IQR] 27–48). The participants considered the questionnaire suitable for assessing eczema control. The median RECAP score (range 0–28) was 12 (IQR 5–19). The mean and median vIGA-ADTM scores (range 0–4) were 2 (standard deviation [SD] 2) and 3 (IQR 2–4), respectively. A correlation between RECAP and the vIGA-ADTM was observed (p
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- 2024
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3. Increasing Access to Effective Systemic Treatments in Patients with Moderate-to-Severe Psoriasis: Narrative Review
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Giampiero Girolomoni, Laura Savage, Paolo Gisondi, Åke Svensson, Emmanuel Mahé, Matthias Augustin, and Luis Puig
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Biologic drugs ,Biosimilars ,Unmet needs ,Moderate-to-severe ,Psoriasis ,Dermatology ,RL1-803 - Abstract
Abstract Psoriasis is a chronic, immune-mediated inflammatory disease with a worldwide prevalence ranging between 0.51 and 11.43%. It results in a large clinical and social burden, with patients frequently suffering from reduced quality of life, psychologic distress and debilitating comorbidities. Biologic agents are used to establish and maintain disease control in patients with moderate-to-severe psoriasis and are essential to improving quality of life. However, a substantial proportion of patients have limited access to therapy due to economics, health policies and clinical considerations, which creates clinical unmet needs that disadvantage both patients and healthcare professionals. Biosimilars are a cost-effective alternative to off-patent biologic therapies, and there is mounting evidence to suggest they offer a valuable pharmacoeconomic strategy to lower healthcare costs in patients with psoriasis. Furthermore, the introduction of biosimilars can increase the number of patients able to receive biologics, allowing these patients to be treated earlier in the disease course, potentially modifying the course of their disease and reducing the risk of comorbidities. In time, the emergence of additional data, particularly those related to long-term safety, efficacy in extrapolated indications and the effects of switching, should reassure physicians and help overcome the final hurdles for a wider implementation of biosimilars. This review aims to provide an overview of current treatment approaches for patients with moderate-to-severe psoriasis in the biosimilars era and explores both the current challenges and potential opportunities to improve access to high-quality, effective treatments.
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- 2023
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4. Comparison of Perceptions of Skin Condition, Product Use and Allergen Reactivity Between People with Psoriasis and Controls in the European Dermato-Epidemiology Network (EDEN) Fragrance Study
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Fortunato Cassalia, Simone Cazzaniga, Robert Ofenloch, Peter Elsner, Margarida Gonçalo, Marie-Louise Schuttelaar, Åke Svensson, Elena Pezzolo, Magnus Bruze, and Luigi Naldi
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psoriasis ,skin dryness ,skin sensitivity ,allergen reactivity ,patch test ,neuro-immune inflammation ,Dermatology ,RL1-803 - Abstract
Psoriasis, a chronic inflammatory skin disease, goes beyond visible symptoms and affects the general well-being of patients. The aim of this study is to understand how patients with psoriasis perceive their skin characteristics and reactivity to allergens. The study population includes 11,283 participants within the European Dermato-Epidemiology Network (EDEN) Fragrance study, covering several European regions. The study compared perceptions of skin dryness, sensitivity, product avoidance and reactivity to allergens between patients with psoriasis and controls, evaluating the potential influence of psoriasis severity. The results showed that subjects with psoriasis reported dry skin (71.1%) and sensitive skin (49.4%) more often than did controls (51.6% and 38.5%, respectively). Psoriasis patients were more likely to avoid specific products. Interestingly, there were no significant differences in patch-test results between the 2 groups and the severity of psoriasis did not have a consistent impact on these perceptions. In conclusion, people with psoriasis tend to perceive their skin as drier and more sensitive. Notably, the severity of psoriasis did not consistently influence these perceptions and objective reactivity to allergens did not align with subjective perception. Understanding these aspects is crucial for tailoring treatments to improve the well-being of patients with psoriasis, which warrants further research to explore subjective perceptions of skin well-being in patients with psoriasis.
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- 2024
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5. Increased prevalence of human papillomavirus in fresh tissue from penile cancers compared to non-malignant penile samples: a case-control study
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Sinja Kristiansen, Carina Bjartling, Christian Torbrand, Diane Grelaud, Martin Lindström, Åke Svensson, and Ola Forslund
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Penile cancer ,Human papillomavirus ,HPV. HPV16 expression ,Non-malignant penile controls ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background HPV has been detected in approximately 50% of invasive penile cancers but with a large span between 24 and 89%, most likely due to different types of tumors and various methods for HPV analysis. Most studies of HPV in penile cancer have been performed using paraffin-embedded tissue, argued to be at risk for contaminated HPV analysis. Viral activity of HPV, by the use of HPV mRNA expression is well studied in cervical cancer, but seldom studied in penile cancer. The aim was to determine prevalence of HPV types in fresh tissue of penile cancers compared to non-malignant age-matched penile controls. Additional aims were to analyze the viral expression and copy numbers of HPV16-positive tumors and 10 mm adjacent to the tumor. Methods Fresh tissue from penile cancer cases was biopsied inside the tumor and 10 mm outside the tumor. Controls were males circumcised for non-malignant reasons, biopsied at surgery. PCR and Luminex assays were used for identification of HPV types. HPV16-positive samples were investigated for copy numbers and expression of HPV16-mRNA. Results Among tumors (n = 135) and age-matched controls (n = 105), HPV was detected in 38.5% (52/135) and 11.4% (12/105), respectively (p
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- 2022
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6. Relationship between Eczema and Self-reported Difficulties Keeping up with School Education: A Cross-sectional Study
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Linda Beckman, Curt Hagquist, Åke Svensson, Sinéad M. Langan, and Laura von Kobyletzki
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achievement ,adolescents ,questionnaire ,Dermatology ,RL1-803 - Abstract
Eczema is a common chronic disease that affects both children and adults, and may have an adverse impact on school performance, as it is characteristically pruritic, and hence may lead to poor concentration and inadequate sleep. The aim of this study was to elucidate the relationship between eczema and self-reported difficulties keeping up with school education. The study was based on cross-sectional questionnaire data collected in schools among all 9th graders (15–16 years old) within a Swedish county. Logistic regression analyses were used to assess the association between having eczema and self-reported difficulties keeping up with school education. A total of 2,620 pupils participated (50.1% female). An increased odds ratio (OR) of self-reported difficulties keeping up with school education was found in adolescents with eczema compared with those without eczema after adjustment for sex and family residence (OR 2.13, 95% confidence interval (95% CI) 1.32–3.44), and with additional adjustment for sleeping problems, attention-deficit hyperactivity disorder, allergy, rhinitis, asthma, and alcohol consumption (adjusted OR 1.78, CI 1.05–3.00). Eczema may be a relevant risk factor for difficulty keeping up with school education in adolescents. However, studies that can assess temporality, based in different settings with objective reports of both eczema and self-reported difficulties at school, are needed to confirm these findings.
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- 2023
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7. The Hairdex quality of life instrument—A translation and psychometric validation in patients with alopecia areata
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Johan Fhager, Åke Svensson, Karin Örmon, Tobias W. Fischer, and Karin Sjöström
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Dermatology ,RL1-803 - Abstract
Abstract Background The German Hairdex quality of life (QoL) instrument is specific to hair and scalp diseases, developed for self‐rating and consists of 48 statements divided into five domains: Symptoms, Functioning, Emotions, Self‐confidence and Stigmatisation. There was a need of a Swedish reliability tested, validated hair and scalp specific QoL instrument why the German Hairdex was chosen to be translated and reliability tested in a systematic way. Objectives To make a translation, a reliability test of stability, and validation of the German Hairdex QoL instrument among 100 Swedish patients with a dermatological ICD‐10 diagnosis of alopecia areata (AA). Methods An eight‐step method by Gudmundsson was used as a model with a forward and backward translation and with comments from an expert panel. A statistical test–retest (ICC (2,1)) analysis was made, followed by an internal consistency analysis. A comparison between the German and Swedish Hairdex‐S constructs by a principal component analysis was performed. Results The Hairdex‐S was very well accepted by patients. The ICC(2,1) test–retest showed a good to excellent correlation of 0.91 (CI [0.85–0.95]). Internal consistency was α = 0.92. Like the original Hairdex, Hairdex‐S showed good factorability with a Kaiser–Meyer–Olkin measure of 0.82 and with one component explaining 70% of the variance: original Hairdex instrument (69%). When tested on patients with AA, the domains Functioning and Emotions had the strongest loadings, followed by Stigmatisation and Self‐confidence. Younger AA patients at self‐assessment and patients who reported to be younger at the onset of AA, scored statistically significantly higher on the Hairdex‐S, indicating an overall lower QoL on domains Emotions and Functioning, respectively. Conclusions The Hairdex‐S is very well accepted by AA patients, shows very good psychometric properties, and a very good agreement with the original Hairdex. The Swedish Hairdex instrument can be recommended for evaluation of patients QoL as well as for research purposes.
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- 2023
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8. Establishment and Utility of SwedAD: A Nationwide Swedish Registry for Patients with Atopic Dermatitis Receiving Systemic Pharmacotherapy
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Mikael Alsterholm, Axel Svedbom, Chris D. Anderson, Lena Holm Sommar, Lina U. Ivert, Anna Josefson, Laura von Kobyletzki, Magnus Lindberg, Lena Lundeberg, Maria Lundqvist, Elisabet Nylander, MariHelen Sandström Falk, Alexander Shayesteh, Gunnthorunn Sigurdardottir, Andreas Sonesson, Åke Svensson, Marie Virtanen, Sophie Vrang, Carl-Fredrik Wahlgren, Maria Bradley, and Emma K. Johansson
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Dupilumab ,Janus Kinase Inhibitors ,Methotrexate ,Real-world data ,Registries ,Dermatology ,RL1-803 - Abstract
SwedAD, a Swedish nationwide registry for patients with atopic dermatitis receiving systemic pharmacotherapy, was launched on 1 September 2019. We describe here the establishment of a user-friendly registry to the benefit of patients with atopic dermatitis. By 5 November 2022, 38 clinics had recorded 931 treatment episodes in 850 patients with an approximate national coverage rate of 40%. Characteristics at enrolment included median Eczema Area and Severity Index (EASI) 10.2 (interquartile range 4.0, 19.4), Patient-Oriented Eczema Measure (POEM) 18.0 (10.0, 24.0), Dermatology Life Quality Index (DLQI) 11.0 (5.0, 19.0) and Peak Itch Numerical Rating Scale-11 (NRS-11) 6.0 (3.0, 8.0). At 3 months, median EASI was 3.2 (1.0, 7.3) and POEM, DLQI, and NRS-11 were improved. Regional coverage varied, reflecting the distribution of dermatologists, the ratio of public to private healthcare, and difficulties in recruiting certain clinics. This study highlights the importance of a nationwide registry when managing systemic pharmacotherapy of atopic dermatitis.
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- 2023
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9. Increased Knowledge-based Care is Indicated for Patients with Atopic Dermatitis
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Maria Bradley and Åke Svensson
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Dermatology ,RL1-803 - Abstract
Abstract is not missing (Guest Editorial)
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- 2022
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10. Incidence Rate of Hand Eczema in Different Occupations: A Systematic Review and Meta-analysis
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Wasim Jamil, Åke Svensson, Anna Josefson, Magnus Lindberg, and Laura von Kobyletzki
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hand eczema ,epidemiology ,occupation ,incidence ,Dermatology ,RL1-803 - Abstract
Hand eczema is a chronic disease that results in economic and psychosocial burdens. The aim of this study was to systematically review and assess the magnitude of the association between exposure related to occupations and the incidence rate of hand eczema. A systematic search in PubMed, EMBASE, CINAHL and Cochrane databases, from inception to September 2017, of full-text observational studies reporting incident cases of hand eczema during employment, and a supplementary search in PubMed to September 2020, were conducted. Among 2,417 screened abstracts, 15 studies fulfilled the inclusion criteria. Incidence rates were reported per 100 person-years. Based on the Newcastle-Ottawa Scale, 9 studies were good quality, 2 fair quality, and 4 poor quality. Hairdressers had a high incidence of hand eczema of 21.4 (95% confidence interval [CI] 15.3–27.4), as did nurses, 16.9 (95% CI 11.2–22.7), and metal workers, 12.4 (95% CI 3.5–21.3). Hairdressers were predominantly women, and metal worker were predominantly men. Office occupations had an incidence rate of hand eczema of 4.9 (95% CI 1.2–9.6). The high risk of hand eczema for hairdressers, nurses, and metal workers, should be considered by healthcare policymakers. Even occupations with low irritant profile, such as office workers, were at risk of developing hand eczema, and more occupations should be investigated regarding the related risk of developing hand eczema.
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- 2022
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11. Burden of Atopic Dermatitis in Swedish Adults: A Population-based Study
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Grigorios Theodosiou, Scott Montgomery, Alexandra Metsini, Florence J. Dalgard, Åke Svensson, and Laura B. Kobyletzki
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atopic dermatitis ,epidemiology ,educational status ,global burden of disease ,Dermatology ,RL1-803 - Abstract
The burden of atopic dermatitis (AD) was assessed. A population-based, cross-sectional questionnaire study was performed among 34,313 Swedish adults in 2017. The prevalence of AD was 14%. Adults with mild AD had an increased relative risk ratio (RRR) of severe depression (aRRR 1.78, 95% confidence interval (95% CI) 1.50–2.12) and anxiety (aRRR 1.97, 95% CI 1.69–2.30), which was higher for severe AD (aRRR 6.22 95% CI 4.60– 8.42, aRRR 5.62 95% CI 4.10–7.71, respectively). Persons with severe AD were less likely to have a university degree (aRRR 0.55, 95% CI 0.34–0.90) and more likely to have a lower annual income (238,000–324,000 SEK: aRRR 0.51, 95% CI 0.39–0.77; 325,000 SEK or more 0.36; 0.25–0.58) compared with individuals without AD. These results suggest that AD implies an increased prevalence of comorbid mental conditions and an adverse impact on academic achievement and work. These adverse associations increase substantially for patients with severe AD and comorbid asthma.
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- 2019
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12. IgE sensitization in a cohort of adolescents in southern Sweden and its relation to allergic symptoms
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Therese Sterner, Ada Uldahl, Åke Svensson, Magnus P. Borres, Sigrid Sjölander, Alf Tunsäter, Jonas Björk, Cecilia Svedman, Magnus Bruze, Laura von Kobyletzki, and Hampus Kiotseridis
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Adolescent ,Allergy ,Allergen components ,Asthma ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Abstract Background There is a strong and consistent association between IgE sensitization and allergy, wheeze, eczema and food hypersensitivity. These conditions are also found in non-sensitized humans, and sensitization is found among individuals without allergy-related diseases. The aim of this study was to analyse the sensitization profile in a representative sample of the population, and to relate patterns of allergens and allergen components to allergic symptoms. Methods A population of 195 adolescents took part in this clinical study, which included a self-reported questionnaire and in vitro IgE testing. Results Sensitization to airborne allergens was significantly more common than sensitization to food allergens, 43% vs. 14%, respectively. IgE response was significantly higher in airborne allergens among adolescents with rhinitis (p
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- 2019
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13. Pharmacist recommendations regarding topical steroid use may contradict the standard of care in atopic dermatitis: An international, cross-sectional study
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John C. Su, MD, Nikolay Murashkin, MD, Andreas Wollenberg, MD, Åke Svensson, MD, Pavel Chernyshov, MD, Peter Lio, MD, Dedee Murrell, MD, Audrey Nosbaum, MD, Sebastien Faure, MD, Sophie Mery, MD, and Jean-François Stalder, MD
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Dermatology ,RL1-803 - Published
- 2021
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14. Prevalence and Incidence of Atopic Dermatitis: A Systematic Review
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Simon Bylund, Laura B. von Kobyletzki, Marika Svalstedt, and Åke Svensson
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systematic review ,atopic dermatitis ,prevalence ,incidence ,Dermatology ,RL1-803 - Abstract
The primary objective of this study was to systematically review and analyse epidemiological studies of the prevalence and incidence of atopic dermatitis (AD) during childhood and adulthood, focusing on data from the 21st century. A systematic search of PubMed, EMBASE and Google (manual search) was performed in June 2019, followed by data abstraction and study quality assessment (Newcastle–Ottawa Scale). Cross-sectional and longitudinal epidemiological studies of individuals with AD (doctor-diagnosed or standardized definition) were included. Of 7,207 references reviewed, 378 moderate/good-quality studies were included: 352 on prevalence of AD and 26 on incidence of AD. In the 21st century, the 1-year prevalence of doctor-diagnosed AD ranged from 1.2% in Asia to 17.1% in Europe in adults, and 0.96% to 22.6% in children in Asia. The 1-year incidence ranged from 10.2 (95% confidence interval (95% CI) 9.9–10.6) in Italy to 95.6 (95% CI 93.4–97.9) per 1,000 person-years in children in Scotland. There were few recent studies on incidence of AD in the 21st century and no studies on adults only; most studies were conducted in Europe and the USA. Epidemiological studies on childhood and adulthood AD in different continents are still needed, especially on the incidence of AD during adulthood.
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- 2020
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15. Subjective and Objective Characteristics of Patients Seen at a Psychodermatology Unit: One-year Experience in Malmö, Sweden
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Florence J. Dalgard, Karin Sjöström, Johan Fhager, Åke Svensson, Ewa Wallin, and Inese Hauksson
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psychodermatology ,symptoms ,signs ,healthcare services ,Dermatology ,RL1-803 - Abstract
Clinical epidemiological knowledge concerning psychodermatology patients is scarce. The objective of this study was to assess morbidity in a new psychodermatology service. Information was gathered from patient records at the psychodermatology unit in Skåne University Hospital, Malmö, Sweden, from 1 February 2017 to 31 January 2018. All patients were screened with the Hospital Anxiety and Depression Scale (HADS) and the Dermatology Life Quality Index (DLQI) at baseline and after 12 months. Additional information was collated from the patient records. A total of 50 patients were treated during the 12 months, 86% were women, mean age 44 years (standard deviation (SD) 16 years). Itch was present in 72% of patients. Forty-two percent of patients were diagnosed with mood disorders, 30% with personality disorders, and 16% with delusional disorders. At baseline 40% of patients had a DLQI score >11, clinical depression was present in 14%, and clinical anxiety in 28%. These data emphasize the need for access to a multidisciplinary unit for dermatology patients.
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- 2020
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16. Risk Factors for Penile Intraepithelial Neoplasia: A Population-based Register Study in Sweden, 2000-2012
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Sinja Kristiansen, Åke Svensson, Linda Drevin, Ola Forslund, Christian Torbrand, and Carina Bjartling
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PeIN ,penile intraepithelial neoplasia ,penile cancer in situ ,CIS ,penile cancer ,risk factors ,lichen planus ,Dermatology ,RL1-803 - Abstract
Studies on risk factors for penile intraepithelial neoplasia have been small in size, have not distinguished penile intraepithelial neoplasia from invasive cancer, and have relied on self-reported information. This study investigated risk factors for penile intraepithelial neoplasia in a cohort of 580 penile intraepithelial neoplasia cases and 3,436 controls using information from 7 Swedish registers. Cases with penile intraepithelial neoplasia had increased odds ratios (ORs) for inflammatory skin diseases (14.7, 95% CI 6.5–33.4) including lichen planus (12.0, 95% CI 3.0–48.0), indicating lichen planus to be an important risk factor. Increased ORs were also observed for diseases of the prepuce (4.0, 95% CI 2.2–7.4), immunosuppressive drugs (5.0, 95% CI 2.5–9.8), penile surgical procedures (4.8, 95% CI 2.2–10.8), balanitis (9.2, 95% CI 5.0–16.8), genital warts (9.9, 95% CI 4.3−22.7) and organ transplantation (7.0, 95% CI 2.4–20.8). This study demonstrates important risk factors for penile intraepithelial neoplasia, providing knowledge that can help prevent the development of penile cancer.
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- 2018
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17. Socioeconomic Status and the Prevalence of Skin and Atopic Diseases in Five European Countries
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Robert F. Ofenloch, Marie Louise Schuttelaar, Åke Svensson, Magnus Bruze, Luigi Naldi, Simone Cazzaniga, Peter Elsner, Margarida Gonçalo, and Thomas L. Diepgen
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socioeconomic status ,health inequalities ,prevalence ,skin diseases ,European population ,Dermatology ,RL1-803 - Abstract
The aim of this study was to investigate the association between socioeconomic status and the prevalence of self-reported skin and atopic diseases in the general population of 5 European countries. A random sample was drawn from the general population aged 18–74 years, based on electoral precincts. Socioeconomic status was estimated by combining net household income with the highest education of respondents. A total of 7,904 subjects were included in this analysis. The lifetime prevalence of “contact dermatitis” ranged from 13.1% (95% confidence interval (95% CI 11.8–14.4%) in subjects with low socioeconomic status, to 19.1% (95% CI 17.5–20.8%) in those with high socioeconomic status. In younger subjects skin cancer was more prevalent in the middle or high socioeconomic status groups compared with the low socioeconomic status group (odds ratio 2.4; 95% CI 1.4–4.3); however, this effect was not found in elderly subjects. The lifetime prevalence for at least one atopic disease was 61.2% (95% CI 59.4–63.0%) in the low and 82.8% (95% CI 81.1–84.3%) in the high socioeconomic status group. Individuals with middle or high socioeconomic status reported an overall higher prevalence of skin and atopic diseases compared with those with low socioeconomic status. These findings may reflect differences in reporting, which are likely to result in an underdiagnoses, especially for skin cancer in the younger age groups with low socioeconomic status.
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- 2018
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18. Observational study on Swedish plaque psoriasis patients receiving narrowband-UVB treatment show decreased S100A8/A9 protein and gene expression levels in lesional psoriasis skin but no effect on S100A8/A9 protein levels in serum.
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Albert Duvetorp, Jan Söderman, Malin Assarsson, Marita Skarstedt, Åke Svensson, and Oliver Seifert
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Medicine ,Science - Abstract
S100A8 and S100A9 proteins are highly upregulated in patients with psoriasis and have been proposed as potential biomarkers for psoriasis. The present study was designed to analyze the effect of narrowband ultraviolet B therapy on these proteins. S100A8, S100A9 gene expression and S100A8/A9 heterocomplex protein levels were analyzed in lesional and non-lesional skin before and after narrowband-UVB treatment in patients with chronic plaque type psoriasis. In addition, disease severity was measured by psoriasis area and severity index (PASI) and serum protein levels of S100A8/A9 were repeatedly analyzed. Narrowband-UVB treatment significantly reduced S100A8, S100A9 gene expression and S100A8/A9 protein levels in lesional skin while serum levels showed no significant change. No correlation between PASI and serum S100A8/A9 protein levels was found. These results implicate a role of S100A8/A9 in the anti-inflammatory effect of narrowband-UVB. Serum S100A8/A9 levels do not respond to treatment suggesting that serum S100A8/A9 does not originate from psoriasis skin keratinocytes. Serum S100A8/A9 levels do not correlate with PASI questioning serum S100A8/A9 as a biomarker for psoriasis skin activity. Trial Registration: DRKS 00014817.
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- 2019
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19. The diagnosis you wish you had never operated on: Pyoderma gangrenosum misdiagnosed as necrotizing fasciitis—a case report
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Eva Hradil, Charlotte Jeppsson, Nils Hamnerius, and Åke Svensson
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Orthopedic surgery ,RD701-811 - Published
- 2017
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20. Diffuse Purpura on the Abdomen and Extremities: A Quiz
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Grigorios Theodosiou, Iva Johansson, and Åke Svensson
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scurvy ,dermoscopy ,purpura ,hair ,anemia ,Dermatology ,RL1-803 - Published
- 2019
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21. Clinical Experience of Overnight Use of a Temperature-controlled Airflow Device in a Teenager with Severe Atopic Dermatitis
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Grigorios Theodosiou and Åke Svensson
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Dermatology ,RL1-803 - Published
- 2018
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22. Banded Scalp Hair with an Unusual Glistening Appearance in a Teenager: A Quiz
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Grigorios Theodosiou, Nils Hamnerius, and Åke Svensson
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Dermatology ,RL1-803 - Published
- 2018
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23. Methotrexate-associated Sexual Dysfunction: Two Case Reports
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Grigorios Theodosiou and Åke Svensson
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Dermatology ,RL1-803 - Abstract
Abstract is missing (Short communication)
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- 2017
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24. Naevoid Malignant Melanoma: A Diagnosis of a Naevus That You Later Regret
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Grigorios Theodosiou, Iva Johansson, Nils Hamnerius, and Åke Svensson
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Dermatology ,RL1-803 - Published
- 2017
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25. Short- and Long-term Effects of Bacterial Gastrointestinal Infections
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Anders Ternhag, Anna Törner, Åke Svensson, Karl Ekdahl, and Johan Giesecke
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Gastroenteritis ,campylobacter infections ,enterobacteriaceae infections ,epidemiology ,registries ,risk ,Medicine ,Infectious and parasitic diseases ,RC109-216 - Abstract
During 1997–2004, microbiologically confirmed gastrointestinal infections were reported for 101,855 patients in Sweden. Among patients who had Salmonella infection (n = 34,664), we found an increased risk for aortic aneurysm (standardized incidence ratio [SIR] 6.4, 95% confidence interval [CI] 3.1–11.8) within 3 months after infection and an elevated risk for ulcerative colitis (SIR 3.2, 95% CI 2.2–4.6) within 1 year after infection. We also found this elevated risk for ulcerative colitis among Campylobacter infections (n = 57,425; SIR 2.8, 95% CI 2.0–3.8). Within 1 year, we found an increased risk for reactive arthritis among patients with Yersinia enteritis (n = 5,133; SIR 47.0, 95% CI 21.5–89.2), Salmonella infection (SIR 18.2, 95% CI 12.0–26.5), and Campylobacter infection (SIR 6.3, 95% CI 3.5–10.4). Acute gastroenteritis is sometimes associated with disease manifestations from several organ systems that may require hospitalization of patients.
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- 2008
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26. Validity of diagnostic codes and prevalence of physician-diagnosed psoriasis and psoriatic arthritis in southern Sweden--a population-based register study.
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Sofia Löfvendahl, Elke Theander, Åke Svensson, Katarina Steen Carlsson, Martin Englund, and Ingemar F Petersson
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Medicine ,Science - Abstract
To validate diagnostic codes for psoriasis and psoriatic arthritis (PsA) and estimate physician-diagnosed prevalence of psoriasis and PsA in the Skåne region, Sweden.In the Skåne Healthcare Register (SHR), all healthcare consultations are continuously collected for all inhabitants in the Skåne region (population 1.2 million). During 2005-2010 we identified individuals with ≥1 physician-consultations consistent with psoriasis (ICD-10). Within this group we also identified those diagnosed with PsA. We performed a validation by reviewing medical records in 100 randomly selected cases for psoriasis and psoriasis with PsA, respectively. Further, we estimated the pre- and post-validation point prevalence by December 31, 2010.We identified 16 171 individuals (psoriasis alone: n = 13 185, psoriasis with PsA n = 2 986). The proportion of ICD-10 codes that could be confirmed by review of medical records was 81% for psoriasis and 63% for psoriasis with PsA with highest percentage of confirmed codes for cases diagnosed ≥2 occasions in specialized care. For 19% and 29% of the cases respectively it was not possible to determine diagnosis due to insufficient information. Thus, the positive predicted value (PPV) of one ICD-10 code for psoriasis and psoriasis with PsA ranged between 81-100% and 63-92%, respectively. Assuming the most conservative PPV, the post-validation prevalence was 1.23% (95% CI: 1.21-1.25) for psoriasis (with or without PsA), 1.02% (95% CI: 1.00-1.03) for psoriasis alone and 0.21% (95% CI: 0.20-0.22) for psoriasis with PsA. The post-validation prevalence of PsA in the psoriasis cohort was 17.3% (95% CI: 16.65-17.96).The proportion of diagnostic codes in SHR that could be verified varied with frequency of diagnostic codes and level of care highlighting the importance of sensitivity analyses using different case ascertainment criteria. The prevalence of physician-diagnosed psoriasis and PsA confirm other population-based studies, also after adjustment due to misclassification of disease.
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- 2014
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27. Efficacy and safety of ligelizumab in adults and adolescents with chronic spontaneous urticaria: results of two phase 3 randomised controlled trials
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Rosana, Agondi, Ahmed, Al Waily, Fabio, Almerigogna, Miguel Angel Tejedor, Alonso, Alfred, Ammoury, Eng Kim, Anne Goh, Robert, Anolik, Ledit, Ardusso, Petr, Arenberger, Nandini, AS, Mohammad, Asefi, Natalia, Astafieva, Anil, Badhwar, Esther Serra, Baldrich, Christine, Bangert, Annick, Barbaud, Zsuzsanna, Bata-Csorgo, Andrea, Bauer, Frederic, Berard, Beata, Bergler-Czop, Gary D, Berman, Jonathan, Bernstein, Subhash Chandra, Bharija, Ramesh M, Bhat, Isabelle, Boccon-Gibod, Ivan, Botev, Knut, Brockow, Philipp, Buck, Paula, Busse, Regis, Campos, Giorgio Walter, Canonica, Irani, Carla, Julia Maria Del, Carmen, Jaime Del, Carpio, Mamatha, Chadalavada, Yoon-Seok, Chang, Amarjit, Cheema, Yi Hsing, Chen, Yuko, Chinuki, Soyun, Cho, Jeong-Hee, Choi, Chia-Yu, Chu, Ronit, Confino, Jonathan, Corren, Roberta, Criado, Claudia De La, Cruz, David M, Cypcar, Pramila, Daftary, Inna, Danilycheva, Kenneth, Dawes, Michelle Joy, De Vera, James, Deangelo, Stefano, Del Giacco, Diana, Deleanu, John, Delgado, Richard, DeMera, Mohamed, Denguezli, Heinrich, Dickel, Le Huu, Doanh, Sinan, Dogan, Marie Sylvie, Doutre, Anne Sophie, Dupond, Anton, Edin, Kent, EDWARD, Swarna, Ekanayake-Bohling, Daniel, Elbirt, David, Elkayam, Anne, Ellis, Shaunagh, Emanuel, Alexander, Emeliyanov, Burhan, Engin, Luis Felipe, Ensina, Ignacio Antepara, Ercoreca, Safiye, Ergun, Jose Luis Lopez, Estebaranz, Rustem, Fassakhov, Daria, Fomina, Linda, Ford, Mariangela, Francomano, Todd, Funkhouser, Remi, Gagnon, Ricardo, Galimberti, Cesar Alberto, Galvan Calle, Clovis, Galvao, Gabriel, Gattolin, Pierre-Dominique, Ghislain, Ana Maria, Gimenez Arnau, Elliot, Ginchansky, Francoise, Giordano-Labadie, Stanislav, Givirovsky, Kiran, Godse, Shaila, Gogate, Alan, Goldsobel, Francisca, Gomez, Rene Maximiliano, Gomez, Erika, Gonzalez, Paula Ribo, Gonzalez, Dimitar, Gospodinov, Clive, Grattan, Martine, Grosber, Gary, Gross, Francisco Jose Gomez, Guimera Martin-Neda, Rolland, Gyulai, Svetlana, Hadvabova, Suzana Ljubojevic, Hadzavdic, Hadi, Hamam, Daniela, Hasicova, Koremasa, Hayama, Pravin, Hissaria, Anna, Hjerppe, Ivan, Hlinka, Moises Labrador, Horrillo, Connie, Hsu, Yu-Huei, Huang, Iftikhar, Hussain, Atsuyuki, Igarashi, Beata, IMKO-WALCZUK, Huseyin Serhat, Inaloz, Rossella, Intravaia, Neal, Jain, Sanjeev, Jain, Thilo, Jakob, Ruth Cerino, Javier, Antonio, João, Luiza Marek, Jozefowicz, Chang-Gyu, Jung, Martin, Kaatz, Nida, Kacar, Henry, Kanarek, Iva, Karlova, Alexander, Kastanayan, Jana, Kazandjieva, Johannes, Kern, Aharon, Kessel, Neena, Khanna, HeeJoo, Kim, Nancy, Kim, Sang-Ha, Kim, Tae-bum, Kim, Kulli, Kingo, Andreas, Kleinheinz, Janka, Komova, Evangelia, Kompoti, Tomas, Kopal, Peter, Kozub, Dorota, Krasowska, Beata, Krecisz, Burkhard, Kreft, Satsuki, Kubota, Hitoshi, Kudo, Teja, Kulkarni, Kanokvalai, Kulthanan, Akihiro, Kume, Maciej, Kupczyk, Edward, Lain, Bobby, Lanier, Hilde, Lapeere, Griselle Ortiz, Lasanta, Svetlana, Lazareva, Laura, Lazzeri, Dennis, Ledford, Donghun, Lee, Haur Yueh, Lee, Jeffrey, Leflein, Nicolas, Leitz, Nancy, Levin, Hermenio, Lima, Undine, Lippert, Brian, Lipson, Paula, Luna, Gabriel, Magarinos, Satyaprakash, Mahajan, Michail, Makris, Alejandro, Malbran, Ahmed Manjra, Manjra, Michael, Manning, Maria, Manrique, Adriana, Marcipar, Mariano, Marini, Veronique Del, Marmol, Jorge, Maspero, Tomoko, Matsuda, Jonathan, Matz, Marcus, Maurer, Wendy, McFalda, Anne, Mclaughlin, Iris, Medina, Rajesh Dutt, Mehta, Stephan, Meller, Steven, MELTZER, Raisa, Meshkova, Dorin, Mihalache, Francisco Javier, Miquel, Mourad, Mokni, J, Molhoek, Efrain, Montano, Sabine, Mueller, Javier Pedraz, Munoz, Toshikazu, Nagakura, Joanna, Narbutt, Ignasi Figueras, Nart, Ma. Lourdes M, Nebrida-Idea, Trong Hao, Nguyen, Johannes, Niesmann, Violeta Zaragoza, Ninet, Hiromitsu, Noguchi, Yuko Chinuki, Nomura, Roman, Nowicki, Tokuya, Omi, Robert, Onder, Ivan, Orojan, Francisco Javier, Ortiz de Frutos, Kim, Papp, Claudio, Parisi, Chun Wook, Park, Heungwoo, Park, Jungwon, Park, Young Min, Park, Viviana, Parra, Thierry, Passeron, Justine, Pasteur, Shivakumar, Patil, Vergil, Patrascu, Sylvia, Pauser, Anna Wojas, Pelc, Jonathan Grant, Peter, Wolfgang, Pfuetzner, Nicola, Pimpinelli, Andreas, Pinter, Cristian, Pizarro, Karel, Pizinger, Jarmila, Plutinska, Todor, Popov, Veronika, Popova, Marta Ferrer, Puga, Lara Ferrandiz, Pulido, Anca, Purcaru, Ulrike, Raap, Anna, Rajchel, John, Ramey, Ma Deanna Santos, Ramiscal, German Dario, Ramon, Syed, Rehman, Adam, Reich, Norbert, Reider, Krista, Ress, Dimitrios, Rigopoulos, Enrique, Rivas, Heike, Rockmann, Pierre-Paul, Roquet-Gravy, Menachem, Rottem, Vermen Verallo, Rowell, Franziska, Rueff, Juan Alberto Ruano, Ruiz, Juan, Russo, Ronald, Saff, Sarbjit, Saini, Maria, Salazar, Juan Francisco Silvestre, Salvador, Jorge, Sanchez, Florica, Sandru, Mark, Scarupa, Knut, Schaekel, Sibylle, Schliemann, Rik, Schrijvers, Beate, Schwarz, Andreas, Schwinn, Sudhir, Sekhsaria, Nilgun, Senturk, Seong Jun, Seo, Mercedes Rodriguez, Serna, Faradiba, Serpa, Paul A, Shapero, Eriko, Shinkawa, Jan-Christoph, Simon, Rodney, Sinclair, Ralfi, Singer, Dareen D, Siri, Karl, Sitz, Adam, Smialowski, Andrew, Smith, Morten, Soerensen, Wiebke, Sondermann, Haejun, Song, Dmitrii, Sonin, Weily, Soong, Daniel, Soteres, Maria, Staevska-Kotasheva, Petra, Staubach-Renz, Nisha Su Yien, Subash, Gordon, Sussman, Ake Svensson, Svensson, Ekaterini, Syrigou, Andrea, Szegedi, Jacek, Szepietowski, Shunsuke, Takahagi, Yuval, Tal, Neetu, Talreja, Wooi Chiang, Tan, Ricardo, Tan, Jyh Jong, Tang, Tonny, Tanus, Martha, Tarpay, Shang Ian, Tee, Craig, Teller, Florence, Tetart, Aurelie Du, Thanh, Suganthi, Thevarajah, Simon Francis, Thomsen, Carl, Thornblade, Milan, Tjioe, Alberto, Tolcachier, Celeste, Tolentino, Athanasios, Tsianakas, Ilia, Tsingov, Hamida, Turki, Olga, Ukhanova, Jens, Ulrich, Meltem, Uslu, Fernando, Valenzuela, Solange, Valle, Martijn, van Doorn, Jirina, Vankova, Suneel, Vartak, Christine, Vidouria, Sebastian, Volc, Gerald, Volcheck, Nicola, Wagner, Irena, Walecka-Herniczek, Penpun, Wattanakrai, Bettina, Wedi, Steven, Weinstein, Vesarat, Wessagowit, Hugh, Windom, Akiko, Yagami, Aisaku, Yamamoto, Shinichiro, Yasumoto, Young Min, Ye, Jose Cevallos, Yepez, Sang Woong, Youn, Hana, Zelenkova, Oleg, Ziganshin, Matthew, Zook, Maurer, Marcus, Ensina, Luis Felipe, Gimenez-Arnau, Ana Maria, Sussman, Gordon, Hide, Michihiro, Saini, Sarbjit, Grattan, Clive, Fomina, Daria, Rigopoulos, Dimitrios, Berard, Frederic, Canonica, Giorgio Walter, Rockmann, Heike, Szepietowski, Jacek C, Leflein, Jeffrey, Bernstein, Jonathan A, Peter, Jonny G, Kulthanan, Kanokvalai, Godse, Kiran, Ardusso, Ledit, Ukhanova, Olga, Staubach, Petra, Sinclair, Rodney, Gogate, Shaila, Thomsen, Simon Francis, Tanus, Tonny, Ye, Young Min, Burciu, Alis, Barve, Avantika, Modi, Darshna, Scosyrev, Emil, Hua, Eva, Letzelter, Kerstin, Varanasi, Vineeth, Patekar, Manmath, and Severin, Thomas
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- 2024
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28. Atopy patch testing and associations with atopic conditions and specific IgE tests: a population-based study in adolescents
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Ada, Uldahl, Therese, Sterner, Magnus, Bruze, Jakob, Dahlin, Laura, Von Kobyletzki, Åke, Svensson, Hampus, Kiotseridis, Alf, Tunsäter, and Cecilia, Svedman
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Quality of Life ,Humans ,Allergens ,Immunoglobulin E ,Patch Tests ,Dermatitis, Atopic - Abstract
The clinical usefulness of the atopy patch test (APT) is unclear for investigating aeroallergen- and food-triggered atopic dermatitis (AD).This study aimed to assess the prevalence of positive APT reactions in a population of adolescents and investigate possible associations between the APT, specific serum (s) immunoglobulin E (IgE) tests, self-reported atopic conditions and health-related quality of life.A population-based study was performed on 211 adolescents (13-14 years old). Collected data included questionnaires, an APT with food and aeroallergens and s-IgE tests.Positive APT reactions were observed in 9.0% (19/211) of the adolescents. Timothy grass was the top allergen with 11 (5.2%) positive reactions, followed by cat dander (2.8%) and house dust mites (2.4%). Rhinoconjunctivitis increased the odds of any positive APT (crude odds ratio: 3.32; 95% confidence interval [CI]: 1.17–9.40), particularly when an APT was positive for aeroallergens (odds ratio: 5.02, 95% CI: 1.54-16.42). There was no association between a positive APT and AD. Four adolescents without AD and no IgE-sensitization had a positive APT.Based on a population of adolescents, the APT is associated with rhinoconjunctivitis but not AD. This finding should be taken into consideration in further attempts to clarify the role of the APT in the clinical setting.
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- 2022
29. Validation of questionnaire algorithm based on repeated open application testing with the constituents of fragrance mix II: the EDEN Fragrance Study
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Peter Elsner, Åke Svensson, Luigi Naldi, Magnus Bruze, Malin Engfeldt, Marielouise Schuttelaar, Robert Ofenloch, Margarida Gonçalo, Cecilia Svedman, and Public Health Research (PHR)
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Allergy ,Population ,Dermatology ,Patch testing ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Surveys and Questionnaires ,Humans ,Medicine ,Positive test ,Fragrance mix ,education ,Allergic contact dermatitis ,education.field_of_study ,business.industry ,Patch test ,Allergens ,Patch Tests ,medicine.disease ,Perfume ,ALLERGY ,Infectious Diseases ,DOSE-RESPONSE RELATIONSHIP ,Contact allergy ,030220 oncology & carcinogenesis ,Dermatitis, Allergic Contact ,Odorants ,QUANTITATIVE ASPECTS ,business ,Algorithm ,Algorithms - Abstract
Background In a European study on contact allergy in the general population, it has been hypothesized that the combination of contact allergy to a fragrance together with a history indicating dermatitis at exposure and thereafter subsequent avoidance of scented products implied a diagnosis of allergic contact dermatitis.Objectives The primary aim of this study was to validate this hypothesis/algorithm. The secondary aim was to investigate whether there was any association between the outcome of the recent repeated open application test (ROAT) and the patch test reactivity.Methods One hundred nine subjects with and without contact allergy to fragrance mix II (FM II) were recruited. Volunteers from six European dermatology clinics participated in the study including a patch test and a ROAT.Results Twenty-four positive ROAT reactions were noted in total including 20 of those 32 with contact allergy to FM II. None of the volunteers reacted to the vehicle (P < 0.001). More individuals with a positive algorithm had positive ROATs when compared with those with a negative algorithm. However, the difference was not statistically significant (P = 0.12). The lower the patch test concentration eliciting a positive test reaction, the more likely was a positive ROAT and the more likely that the positive ROAT appeared early during the investigative period.Conclusions The algorithm used in this study was not validated but it was indicated in this ROAT setup. The stronger the patch test reactivity the more likely was a positive ROAT and the more likely it was that the positive ROAT appeared early during the application period.
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- 2021
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30. European Task Force on Atopic Dermatitis
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Thomas Werfel, Carsten Flohr, Uwe Gieler, Alain Taieb, M. Deleuran, Michael J. Cork, B. Kunz, J. Gutermuth, Z. Szalai, L. De Raeve, Carlo Gelmetti, A. Wollenberg, Pavel V Chernyshov, Åke Svensson, S. Weidinger, L.B. von Kobyletzki, Dagmar Simon, Magdalena Trzeciak, Ph.I. Spuls, Jacob P. Thyssen, DirkJan Hijnen, R. Fölster-Holst, Christian Vestergaard, Sébastien Barbarot, M S de Bruin-Weller, Christine Bangert, Ulf Darsow, Antonio Torrelo, Julien Seneschal, J. F. Stalder, Carle Paul, T. Bieber, Annice Heratizadeh, J. Ring, Stéphanie Christen-Zaech, Dermatology, AII - Inflammatory diseases, APH - Methodology, APH - Quality of Care, Surgical clinical sciences, Skin function and permeability, Artificial Intelligence supported Modelling in clinical Sciences, and Gerontology
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Adult ,medicine.medical_specialty ,macromolecular substances ,Disease ,Dermatology ,Asymptomatic ,Dermatitis, Atopic ,SDG 3 - Good Health and Well-being ,Internal medicine ,Diabetes mellitus ,Pandemic ,Medicine ,Humans ,Respiratory system ,Letters to the Editor ,Letter to the Editor ,Biological Products ,atopic dermatitis ,business.industry ,SARS-CoV-2 ,musculoskeletal, neural, and ocular physiology ,Vaccination ,COVID-19 ,Atopic dermatitis ,medicine.disease ,Pneumonia ,Infectious Diseases ,nervous system ,medicine.symptom ,business ,Vaccine - Abstract
The coronavirus disease 2019 (COVID-19) pandemic is caused by rapid spread of different strains of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The severity of infection ranges from mild, or even asymptomatic, to very severe. Signs and symptoms include fatigue, fever, exanthemas, upper respiratory illness, loss of smell and taste, pneumonia, severe acute respiratory syndrome, and multi-organ failure. Risk factors for a severe or lethal course include age, male gender, obesity, diabetes, cardiovascular disease, and immune suppression1 .
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- 2021
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31. Disease burden and treatment history among adults with atopic dermatitis receiving systemic therapy
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Ana Giménez-Arnau, E. Rizova, Shyamalie Jayawardena, Tove Agner, Zafer E. Ozturk, Åke Svensson, Marius Ardeleanu, Annalisa Patrizi, Petr Arenberger, Laurent Eckert, Marie L A Schuttelaar, Marjolein S. de Bruin-Weller, Andrew Pink, Silvia Ferrucci, Audrey Nosbaum, Pierre Paul Roquet-Gravy, and Public Health Research (PHR)
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Adult ,Male ,Pediatrics ,medicine.medical_specialty ,Adolescent ,Dermatology ,Comorbidity ,Systemic therapy ,Severity of Illness Index ,Dermatitis, Atopic ,systemic therapy ,030207 dermatology & venereal diseases ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Quality of life (healthcare) ,Cost of Illness ,Adrenal Cortex Hormones ,medicine ,Prevalence ,Humans ,Prospective Studies ,Treatment history ,Health policy ,Disease burden ,Aged ,Atopic dermatitis ,030203 arthritis & rheumatology ,Aged, 80 and over ,business.industry ,Middle Aged ,medicine.disease ,body regions ,quality of life ,patient-reported outcomes ,Baseline characteristics ,Cyclosporine ,Observational study ,Female ,Dermatologic Agents ,business - Abstract
Background: Insights into the real-world treatment paradigm and long-term burden of atopic dermatitis (AD) are needed to inform clinical and health policy decisions.Methods: The prospective, observational EUROSTAD study enrolled adults with moderate-to-severe AD starting or switching systemic therapy (51 sites in 10 European countries). We report the baseline characteristics, treatment patterns, and outcomes of these patients using descriptive statistics.Results: A 12-month enrollment period of EUROSTAD was completed and 308 patients were enrolled: average age 37 years, AD duration 25 years, 43% were female. Most patients reported use of systemic therapy (93%) and >= 1 atopic comorbidity (82%). Mean [standard deviation] disease severity/burden measures were high: Investigator's Global Assessment (3.1 [0.8]), Eczema Area and Severity Index (16.2 [10.9]), Peak Pruritus Numerical Rating Scale (5.5 [2.5]), sleep impairment Visual Analog Scale (49.8 [31.6]) scores, and time lost from work (4.1 [13.7] days/year) or usual activities (16.8 [38.7] days/year). Most patients showed borderline or clinical levels of anxiety (59%) and/or depression (63%) using the Hospital Anxiety and Depression Scale.Conclusions: Adults with moderate-to-severe AD starting/switching systemic treatment enrolled in EUROSTAD have a high burden of longstanding disease despite continuous use of topical drugs, emollients, and systemic therapies.
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- 2021
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32. Curettage and electrodessication combined with photodynamic therapy in the treatment of large squamous cell carcinomas in unfit and frail patients
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Henrik, Luu, Måns, Cornefjord, Åke, Svensson, and Henry, Svensson
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Skin Neoplasms ,Photochemotherapy ,Frail Elderly ,Carcinoma, Squamous Cell ,Humans ,Female ,Aged ,Curettage - Abstract
A Caucasian female patient in her 90s was referred to the department of plastic and reconstructive surgery for surgical removal of a large invasive squamous cell carcinoma on the anterior chest wall. A skin biopsy prior to the referral indicated that the tumour was moderately differentiated. The patient suffered from severe congestive heart failure with a mechanical valve prosthesis and atrial fibrillation, and was therefore treated with anticoagulants. Hence, a surgical procedure would be hazardous. Therefore, other treatment options were considered. The principal aim was to reduce the amount of tumour tissue to an appropriate size suitable for later excision with primary wound closure. After interdisciplinary discussions, curettage and electrodessication combined with photodynamic therapy was judged the best alternative treatment in this case. At the 1.5 years follow-up after the intervention there was no indication for further surgery. The patient was at that stage content with the treatment and its outcome.
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- 2022
33. Penile intraepithelial neoplasia, penile cancer precursors and human papillomavirus prevalence in symptomatic preputium: a cross‐sectional study of 351 circumcised men in Sweden
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Sinja Kristiansen, Carina Bjartling, Ola Forslund, Åke Svensson, and Christian Torbrand
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Adult ,Male ,medicine.medical_specialty ,#uroonc ,Cross-sectional study ,Urology ,Foreskin ,030232 urology & nephrology ,preputium ,Lichen sclerosus ,Alphapapillomavirus ,Malignancy ,circumcision ,03 medical and health sciences ,lichen sclerosus ,0302 clinical medicine ,Biopsy ,medicine ,Prevalence ,Penile cancer ,Humans ,#PenileCancer ,human papillomavirus ,Penile Neoplasms ,Sweden ,medicine.diagnostic_test ,business.industry ,Papillomavirus Infections ,penile intraepithelial neoplasia ,Odds ratio ,Original Articles ,Middle Aged ,medicine.disease ,Dermatology ,medicine.anatomical_structure ,Cross-Sectional Studies ,Circumcision, Male ,030220 oncology & carcinogenesis ,histopathology ,Penile Intraepithelial Neoplasia ,Original Article ,business ,Carcinoma in Situ - Abstract
Objectives: To investigate the prevalence of pathological disease and spectrum of human papillomavirus (HPV) types among symptomatic foreskin tissue. Patients and Methods: Consecutively excised symptomatic foreskins from 351 men were sent for histopathological evaluation. During the surgical procedure, a fresh biopsy was taken for HPV analysis by modified general primer polymerase chain reaction. A medical questionnaire regarding medication, smoking habits, number of lifetime sexual partners, former diseases and surgery performed on penis was completed by all participants. Results: The most common clinical diagnosis and cause for circumcision was phimosis, seen in 85.2%. Histopathologically inflammatory dermatological conditions were present in 87% of the men. The most common histopathological diagnosis was lichen sclerosus (LS) observed among 58.7%. Notably, penile intraepithelial neoplasia (PeIN) was present in 2% without former clinical suspicion. Overall, HPV was detected in 17.1% of the men and 28 different HPV types were found. High-risk (HR) HPV types were identified in 9.1% and HPV16 was present in 2.3%. Current smoking increased the risk of HPV (crude odds ratio [OR] 2.8, confidence interval [CI] 1.4–5.6; P = 0.005). Having >15 lifetime sexual partners increased the risk of HPV (crude OR 2.6, 95% CI 1.4–5.1; P = 0.003) and when adjusted for current smoking the OR was substantially increased (OR 6.0, 95% CI CI 2.2–16.8; P < 0001). Conclusions: Histopathological evaluation of circumcised symptomatic foreskin revealed PeIN in 2% of the men without any clinical suspicion of malignancy and that treatable dermatological conditions were present in 87%, LS being the most common. HR-HPV types were present in 9%. Due to risk of malignant development both in PeIN and in inflammatory skin diseases we recommend sending all excised foreskins from patients with symptoms for histopathological evaluation as guidance for further clinical management. (Less)
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- 2020
34. Position statement of the European Academy of Dermatology and Venereology Task Force on Quality of Life and Patient Oriented Outcomes on quality of life issues in dermatologic patients during the COVID‐19 pandemic
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Åke Svensson, Christine Blome, Françoise Poot, Mir-saeed Salek, Servando E Marron, Alina Suru, Andrew Yule Finlay, Jacek C Szepietowski, Francesca Sampogna, Dennis Linder, Lucia Tomas-Aragones, Florence J Dalgard, Carmen Salavastru, Andrea W M Evers, Damiano Abeni, N. Pustišek, L. Manolache, Pavel V Chernyshov, Matthias Augustin, and Anthony Bewley
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medicine.medical_specialty ,Infectious Disease Transmission, Patient-to-Professional ,Venereology ,Advisory Committees ,Pneumonia, Viral ,Population ,MEDLINE ,Dermatology ,Skin Diseases ,SARS‐CoV‐2 ,Betacoronavirus ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Quality of life ,COVID‐19 ,Health care ,Pandemic ,medicine ,Humans ,Infection control ,030212 general & internal medicine ,Position Statement ,education ,Pandemics ,Societies, Medical ,Infection Control ,education.field_of_study ,treatment ,SARS-CoV-2 ,business.industry ,COVID-19 ,humanities ,Europe ,Infectious Diseases ,quality of life ,Periodicals as Topic ,Coronavirus Infections ,business ,Psychosocial - Abstract
The pandemic of COVID‐19 is a global challenge for health care and dermatologists are not standing apart from trying to meet this challenge. The European Academy of Dermatology and Venereology (EADV) has collected recommendations from its Task Forces (TFs) related to COVID‐19. The Journal of the EADV has established a COVID‐19 Special Forum giving free access to related articles. The psychosocial effects of the pandemic, an increase in contact dermatitis and several other skin diseases because of stress, disinfectants and protective equipment use, especially in health care workers, the temporary limited access to dermatologic care, the dilemma whether or not to pause immunosuppressive therapy, and, finally, the occurrence of skin lesions in patients infected by COVID‐19 all contribute to significant quality of life (QoL) impairment. Here we present detailed recommendations of the EADV TF on QoL and Patient Oriented Outcomes on how to improve QoL in dermatologic patients during the COVID‐19 pandemic for several different groups of patients and for the general population.
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- 2020
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35. Intervention study to evaluate the importance of information given to patients with contact allergy: a randomized, investigator‐blinded clinical trial*
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Ingrid Siemund, Åke Svensson, W. Troensegaard, A. Dizdarevic, Ada Uldahl, Ola Bergendorff, and Andreas Sonesson
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Adult ,Male ,medicine.medical_specialty ,Allergy ,Dermatology ,medicine.disease_cause ,Affect (psychology) ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Allergen ,Surveys and Questionnaires ,Intervention (counseling) ,medicine ,Humans ,Aged ,Response rate (survey) ,business.industry ,Patch test ,Allergens ,Middle Aged ,Patch Tests ,medicine.disease ,Clinical trial ,Research Design ,Dermatitis, Allergic Contact ,Physical therapy ,business ,Contact dermatitis - Abstract
Background: In contact dermatitis, it is crucial to understand and remember the outcome of patch testing. Unfortunately, many patients do not remember the results of their patch tests. Objectives: Our aim was to evaluate the effects of an intervention programme in which extensive information on specific contact allergy was provided, in individuals with positive patch test reactions. Methods: The study was designed as a randomized, investigator-blinded clinical trial. Participants with positive test reactions were randomized into two groups that received either standard information according to clinical routine or standard information and a reminder letter. Knowledge of contact allergies was evaluated using questionnaires 12 months after inclusion. Results: There were 184 adults included in the trial and the response rate at 1-year follow-up was 78% (143 of 184). Sixty-five per cent (45 of 69) in the intervention group and 54% (40 of 74) in the control group reported the correct name of the allergen (P = 0·23). Participants with several – as opposed to few – positive patch test reactions had difficulty in remembering the correct names of the allergens (P = 0·001). Moreover, the type of allergy had an influence on their ability to remember the name of the allergen correctly and their ability to make changes in lifestyle. Conclusions: The intervention performed did not significantly affect the participants’ ability to remember their contact allergy. To achieve better knowledge and changes in lifestyle, efforts to inform should concentrate on individuals with several positive patch test reactions, those with particular allergens, individuals over 60 years of age, and – concerning changes in lifestyle – males. (Less)
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- 2020
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36. Hidradenitis Suppurativa in Sweden: A Registry-Based Cross-Sectional Study of 13,538 Patients
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Karin Sartorius, Lennart Emtestam, Hassan Killasli, and Åke Svensson
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Adult ,Male ,medicine.medical_specialty ,Adolescent ,Cross-sectional study ,Population ,Subgroup analysis ,Comorbidity ,Dermatology ,Overweight ,Young Adult ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Pregnancy ,Internal medicine ,medicine ,Humans ,Hidradenitis suppurativa ,Registries ,Child ,education ,Life Style ,Aged ,Aged, 80 and over ,Sweden ,education.field_of_study ,business.industry ,Infant, Newborn ,Infant ,Middle Aged ,medicine.disease ,Hidradenitis Suppurativa ,Pregnancy Complications ,Cross-Sectional Studies ,Socioeconomic Factors ,Child, Preschool ,030220 oncology & carcinogenesis ,Cohort ,Female ,medicine.symptom ,business ,Record linkage - Abstract
Background: Hidradenitis suppurativa (HS) is a chronic, inflammatory skin condition with nodules and fistula formation and scarring. It is a debilitating disease with a severe negative impact on quality of life. There is a need for increased knowledge about the social and lifestyle characteristics of patients with HS in general, and pregnant women in particular. Objectives: The aims of this study were to investigate and describe social characteristics and comorbidity in all HS patients in Sweden as well as to study the prevalence of lifestyle factors associated with negative impact on health and pregnancy in Swedish pregnant women with HS. Methods: A registry-based cross-sectional study was performed by record linkage between Swedish registers covering the entire population. A cohort of 13,538 HS patients diagnosed with HS in specialised care during the years 2001–2014 and a subgroup of 1,368 HS patients who had undergone pregnancy during 2010–2015 were defined and described. Aggregated public data on the entire Swedish population and all pregnancies in 2014 were described for reference. Results: The HS population had an average age of 44 years on December 31, 2014. The prevalence of HS was 0.14%. In comparison to the Swedish reference population the HS patients were more often women, unmarried (36 vs. 44% married), and had lower education (68 vs. 82% with an upper-secondary school degree or higher) and lower income (39 vs. 16% made SEK Conclusions: The results from this comprehensive characterisation of Swedish HS patients may be used to improve preventive measures, information, and care for this vulnerable group.
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- 2020
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37. Validation of a questionnaire algorithm based on repeated open application testing with the constituents of fragrance mix I
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Peter Elsner, Thomas L. Diepgen, Margarida Gonçalo, Marie L A Schuttelaar, Robert Ofenloch, Åke Svensson, Malin Engfeldt, Marléne Isaksson, Magnus Bruze, Luigi Naldi, and Public Health Research (PHR)
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Population ,Dermatology ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,ELICITATION ,Surveys and Questionnaires ,medicine ,Humans ,EXPERIMENTAL PROVOCATION ,Positive test ,Fragrance mix ,education ,Allergic contact dermatitis ,ATRANOL ,education.field_of_study ,Dose-Response Relationship, Drug ,business.industry ,CONTACT-DERMATITIS ,Patch test ,PATCH TEST ,Allergens ,Patch Tests ,DEODORANTS ,medicine.disease ,Perfume ,PRODUCTS ,ALLERGY ,Contact allergy ,DOSE-RESPONSE RELATIONSHIP ,Dermatitis, Allergic Contact ,Odorants ,QUANTITATIVE ASPECTS ,business ,Algorithm ,Algorithms - Abstract
Background: In a European study on contact allergy in the general population, it was hypothesized that the combination of contact allergy to a fragrance together with a history indicating dermatitis at exposure, and thereafter subsequent avoidance of scented products, implied a diagnosis of allergic contact dermatitis. Objectives: The primary aim of this study was to validate this hypothesis and algorithm. The secondary aim was to investigate whether there was any association between the outcome of the repeated open application test (ROAT) and the patch test reactivity. Methods: In total, 109 patients with and without contact allergy to fragrance mix (FM) I were recruited. Volunteers from six European dermatology clinics participated in the study including a patch test and a ROAT. Results: Positive ROAT reactions were noted in 26 of the 44 volunteers with contact allergy to FM I. None of the volunteers reacted to the vehicle (P < 0·001). More individuals with a positive algorithm had positive ROATs than those with a negative algorithm. However, the difference was not statistically significant. The lower the patch test concentration eliciting a positive test reaction, the more likely a positive ROAT and the more likely that the positive ROAT appeared early during the investigative period. Conclusions: The algorithm used in this study was not substantiated in this ROAT set-up. The stronger the patch test reactivity the more likely was a positive ROAT and the more likely it was that the positive ROAT appeared early during the application period. What's already known about this topic?. To the best of our knowledge, a scientifically designed and conducted repeated open application test (ROAT) has never been performed before to validate a diagnosis of allergic contact dermatitis partly based on a questionnaire. What does this study add?. This is the largest controlled, randomized and blinded ROAT performed to date. Higher patch test reactivity to fragrance mix I indicated a greater likelihood of a positive ROAT. What are the clinical implications of this work?. Further refinement of the questions is required in order to diagnose allergic contact dermatitis from fragrances based on a questionnaire.
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- 2020
38. Prevalence of contact allergies in the population compared to a tertiary referral patch test clinic in Jena/Germany
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Magnus Bruze, Robert Ofenloch, Åke Svensson, Peter Elsner, Wolfgang Uter, Anica Zetzmann, Sibylle Schliemann, Marielouise Schuttelaar, Luigi Naldi, Margarida Gonçalo, and Public Health Research (PHR)
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Adult ,Male ,medicine.medical_specialty ,Allergy ,Referral ,Population ,MULTICENTER ,Dermatology ,medicine.disease_cause ,Allergen ,Nickel ,Germany ,Internal medicine ,Epidemiology ,Prevalence ,medicine ,Humans ,Immunology and Allergy ,EPIDEMIOLOGY ,education ,RRID ,Allergic contact dermatitis ,patch testing ,GENERAL-POPULATION ,education.field_of_study ,business.industry ,Patch test ,Cobalt ,clinical epidemiology ,Allergens ,Middle Aged ,Patch Tests ,medicine.disease ,SERIES ,Perfume ,SENSITIZATION ,DERMATITIS ,Contact allergy ,PHENYLENEDIAMINE ,Population Surveillance ,METHYLCHLOROISOTHIAZOLINONE/METHYLISOTHIAZOLINONE ,Dermatitis, Allergic Contact ,EUROPEAN SURVEILLANCE SYSTEM ,contact allergy ,surveillance ,SCR_001905 ,business ,TRUE TEST(R) - Abstract
Background The contact allergy prevalences in patch-tested patients are usually higher than those in the population, owing to morbidity-driven selection. Objectives To examine the differences between two samples, one from the population, one from the patch test clinic, in one area of Germany (Jena, Thuringia). Methods Between August 2008 and October 2011, a total of 519 participants of the population-based european dermato-epidemiology network (EDEN) fragrance study were patch tested in Jena using a TRUE Test baseline series extended with some pet.-based (fragrance) allergen preparations. Between 2007 and 2012 (inclusive), 1906 routine patients were patch tested for suspected allergic contact dermatitis (ACD) in the Jena University Hospital Department; of these 1694 (83.2%) with the German baseline series using pet./aq.-based, investigator-loaded allergens. Results In the population (clinical) sample, 19.6% (41.1%) were sensitized to at least one of the allergens considered. The most common baseline series allergens in the population/clinical sample were nickel (10.5%/13.2%), fragrance mix (FM) II (2.9%/6.7%), FM I (2.3%/8.3%), and cobalt (1.6%/5%). The clinical sample was slightly older (71.5% vs 55.9% age 40+) and included less males (36% vs 49.3%). Conclusions Results are quite similar, although prevalences are usually higher in the clinical setting, with the exception of p-tert-butylphenol formaldehyde resin.
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- 2021
39. Recent changes in the frequency of plant species and vegetation types in Scania, S Sweden, compared to changes during the twentieth century
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Torbjörn Tyler, Åke Svensson, Stefan Andersson, Lars Fröberg, Ola Olsson, and Kjell-Arne Olsson
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0106 biological sciences ,Flora ,geography ,geography.geographical_feature_category ,010504 meteorology & atmospheric sciences ,Ecology ,Land use ,Biodiversity ,Wetland ,Vegetation ,010603 evolutionary biology ,01 natural sciences ,Grassland ,Ruderal species ,Arable land ,Ecology, Evolution, Behavior and Systematics ,0105 earth and related environmental sciences ,Nature and Landscape Conservation - Abstract
Based on data from three surveys of the vascular flora of the province of Scania, southernmost Sweden, conducted 1938–1971, 1987–2006 and 2008–2015, we analyse the change in frequency of individual species and groups of species associated with particular vegetation types. A majority of all species have experienced a change in frequency since 1938, and this turnover has continued in recent decades. The species showing the most dramatic declines since 1987 represent a mixture of arable weeds, grassland species and ruderals, but excludes forest species. In contrast, a majority of the most increasing species are escapes from cultivation that thrive under shaded conditions. The vegetation types showing the largest decreases since 1987 are all open seminatural grasslands and wetlands, while the vegetation types performing best are wooded. All vegetation types increasing since 1987 also increased during the 1900s; however, species of wooded types performed relatively better in recent decades, as opposed to the minimal increase observed for species of vegetation strongly influenced by human activities. Among decreasing vegetation types, those that have received much attention from conservationists, e.g. sand-steppe and calcareous fens tend to perform relatively better now than during the 1900s, while those that have received less attention, e.g. poor fens, oligotrophic waters and heaths, now comprise the most rapidly declining vegetation types. A majority of the species that decreased 1938–1996 also decreased 1987–2015, but, in general, species shown to have increased during the 1900s have not continued to increase.
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- 2019
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40. Burden of Atopic Dermatitis in Swedish Adults: A Population-based Study
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Åke Svensson, Grigorios Theodosiou, Florence J Dalgard, Scott Montgomery, Laura von Kobyletzki, and Alexandra Metsini
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Adult ,Male ,medicine.medical_specialty ,Adolescent ,Social Determinants of Health ,Comorbidity ,Dermatology ,Anxiety ,Severity of Illness Index ,Dermatitis, Atopic ,educational status ,Young Adult ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Cost of Illness ,Risk Factors ,Internal medicine ,Epidemiology ,Prevalence ,medicine ,Humans ,030212 general & internal medicine ,Depression (differential diagnoses) ,Aged ,Asthma ,Sweden ,global burden of disease ,atopic dermatitis ,Depression ,business.industry ,General Medicine ,Atopic dermatitis ,Middle Aged ,medicine.disease ,Health Surveys ,Confidence interval ,Population based study ,Cross-Sectional Studies ,Mental Health ,Relative risk ,RL1-803 ,Income ,Female ,epidemiology ,medicine.symptom ,business - Abstract
The burden of atopic dermatitis (AD) was assessed. A population-based, cross-sectional questionnaire study was performed among 34,313 Swedish adults in 2017. The prevalence of AD was 14%. Adults with mild AD had an increased relative risk ratio (RRR) of severe depression (aRRR 1.78, 95% confidence interval (95% CI) 1.50-2.12) and anxiety (aRRR 1.97, 95% CI 1.69-2.30), which was higher for severe AD (aRRR 6.22 95% CI 4.60- 8.42, aRRR 5.62 95% CI 4.10-7.71, respectively). Persons with severe AD were less likely to have a university degree (aRRR 0.55, 95% CI 0.34-0.90) and more likely to have a lower annual income (238,000-324,000 SEK: aRRR 0.51, 95% CI 0.39-0.77; 325,000 SEK or more 0.36; 0.25-0.58) compared with individuals without AD. These results suggest that AD implies an increased prevalence of comorbid mental conditions and an adverse impact on academic achievement and work. These adverse associations increase substantially for patients with severe AD and comorbid asthma.
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- 2019
41. Quality of life measurement in hidradenitis suppurativa: position statement of the European Academy of Dermatology and Venereology task forces on Quality of Life and Patient-Oriented Outcomes and Acne, Rosacea and Hidradenitis Suppurativa
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Francesca Sampogna, Damiano Abeni, H.H. van der Zee, Thrasyvoulos Tzellos, Anthony Bewley, Andrew Yule Finlay, Dennis Linder, Åke Svensson, Lucia Tomas-Aragones, N. Pustišek, Christos C. Zouboulis, Servando E Marron, Jacek C Szepietowski, Saskia Spillekom-van Koulil, Pavel V Chernyshov, L. Manolache, Gregor Be Jemec, Matthias Augustin, and Dermatology
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medicine.medical_specialty ,Venereology ,Advisory Committees ,MEDLINE ,Dermatology ,Severity of Illness Index ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,All institutes and research themes of the Radboud University Medical Center ,Quality of life ,Severity of illness ,Acne Vulgaris ,Medicine ,Humans ,Hidradenitis suppurativa ,Patient Reported Outcome Measures ,business.industry ,Dermatology Life Quality Index ,medicine.disease ,humanities ,Hidradenitis Suppurativa ,Women's cancers Radboud Institute for Health Sciences [Radboudumc 17] ,Clinical trial ,Europe ,Infectious Diseases ,Rosacea ,030220 oncology & carcinogenesis ,Practice Guidelines as Topic ,Quality of Life ,business - Abstract
This paper is organized jointly by the European Academy of Dermatology and Venereology (EADV) Task Force (TF) on Quality of Life (QoL) and Patient-Oriented Outcomes and the EADV TF on acne, rosacea and hidradenitis suppurativa (ARHS). The purpose of this paper was to present current knowledge about QoL assessment in HS, including data on HS-specific health-related (HR) QoL instruments and HRQoL changes in clinical trials, and to make practical recommendations concerning the assessment of QoL in people with HS. HS results in significant quimp that is higher than in most other chronic skin diseases. HS impact in published studies was assessed predominantly (84% of studies) by the Dermatology Life Quality Index (DLQI). There is a lack of high-quality clinical trials in HS patients where HRQoL instruments have been used as outcome measures. One double-blind randomized placebo-controlled trial on infliximab with low number of participants reported significantly better HRQoL improvement in the treatment group than in the placebo group. Well-designed clinical studies in HS patients to compare different treatment methods, including surgical methods and assessing long-term effects, are needed. Because of lack of sufficient validation, the Task Forces are not at present able to recommend existing HS-specific HRQoL instruments for use in clinical studies. The EADV TFs recommend the dermatology-specific DLQI questionnaire for use in HS patients. The EADV TFs encourage the further development, validation and use of other HS-specific, dermatology-specific and generic instruments but such use should be based on the principles presented in the previous publications of the EADV TF on QoL and Patient-Oriented Outcomes.
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- 2019
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42. Dermatology textbooks in Scandinavia should prepare medical students for ethnic diversity
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Åke Svensson, A. Elyas, and Florence J Dalgard
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Medical education ,Students, Medical ,Infectious Diseases ,business.industry ,Cultural diversity ,Ethnicity ,Humans ,Medicine ,Cultural Diversity ,Dermatology ,Scandinavian and Nordic Countries ,business - Published
- 2021
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43. Skin exposure to scented products used in daily life and fragrance contact allergy in the European general population - The EDEN Fragrance Study
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Cynthia C. A. van Amerongen, Luigi Naldi, Magnus Bruze, Robert Ofenloch, Margarida Gonçalo, Åke Svensson, Marie L A Schuttelaar, Peter Elsner, Simone Cazzaniga, and Public Health Research (PHR)
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Male ,household products ,Skin Cream ,contact dermatitis ,rinse‐ ,030207 dermatology & venereal diseases ,0302 clinical medicine ,leave‐ ,Prevalence ,Immunology and Allergy ,Medicine ,030212 general & internal medicine ,610 Medicine & health ,education.field_of_study ,Skin sensitization ,Skin exposure ,Female sex ,Hygiene ,Middle Aged ,Perfume ,Europe ,Fragrance allergy ,fragrances ,on products ,scented products ,Dermatitis, Allergic Contact ,Female ,Original Article ,epidemiology ,Adult ,Adolescent ,Population ,Dermatology ,off products ,Sensitive skin ,03 medical and health sciences ,Young Adult ,Environmental health ,Humans ,education ,Aged ,business.industry ,Original Articles ,medicine.disease ,leave‐on products ,Cross-Sectional Studies ,Contact allergy ,exposure ,Odorants ,contact allergy ,rinse‐off products ,business ,Contact dermatitis - Abstract
BACKGROUND Fragrances are widely used in scented products used in daily life with the potential to induce skin sensitization. OBJECTIVE To evaluate exposure to scented products and to explore associations between exposure and fragrance contact allergy. METHODS A cross-sectional study on individuals from 18 to 74���years of age, who were randomly selected from the general population in five European countries. A random sample (N = 3119) was patch tested and interviewed on exposure to scented products. RESULTS Female participants were strongly associated with exposure to scented products relative to male participants. Participants age 40���years and older showed an inverse association with exposure to scented products. Compared to Sweden, The Netherlands followed by Germany showed the highest overall exposure to scented products. Sensitive skin was associated with exposure to scented products and with fragrance allergy. In univariable regression analysis, exposure to leave-on products and to specific scented product subgroups was significantly associated with fragrance allergy. CONCLUSION Exposure to scented products depends primarily on sex and age. Female sex and sensitive skin are relevant indicators for developing fragrance allergy. Because aggregate exposure, especially to scented leave-on products, may enhance the prevalence of contact allergy to fragrances, further investigations into exposure amounts and frequencies is warranted.
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- 2021
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44. Risk of severe allergic reactions to COVID-19 vaccines among patients with allergic skin diseases - practical recommendations. A position statement of ETFAD with external experts
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Mette Deleuran, Dagmar Simon, Michael J. Cork, Ph.I. Spuls, R. Fölster-Holst, Ulf Darsow, J. Ring, Stéphanie Christen-Zaech, Carle Paul, U. Gieler, Jacob P. Thyssen, Carsten Flohr, DirkJan Hijnen, Thilo Jakob, B. Kunz, M. Worm, J. Gutermuth, Magdalena Trzeciak, Sébastien Barbarot, A. Wollenberg, Christine Bangert, L. De Raeve, T. Bieber, Z. Szalai, Annice Heratizadeh, J. F. Stalder, Åke Svensson, Thomas Werfel, L Klimek, Pavel V Chernyshov, Julien Seneschal, S. Weidinger, L.B. von Kobyletzki, Christian Vestergaard, M S de Bruin-Weller, Antonio Torrelo, Alain Taieb, Carlo Gelmetti, Dermatology, AII - Inflammatory diseases, APH - Methodology, APH - Quality of Care, Physiopathologie des Adaptations Nutritionnelles (PhAN), Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Artificial Intelligence supported Modelling in clinical Sciences, Gerontology, Skin function and permeability, and Surgical clinical sciences
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Position statement ,medicine.medical_specialty ,Allergy ,2019-20 coronavirus outbreak ,COVID-19 Vaccines ,Coronavirus disease 2019 (COVID-19) ,[SDV]Life Sciences [q-bio] ,Covid‐19 Special Forum ,macromolecular substances ,Dermatology ,Dermatitis, Atopic ,03 medical and health sciences ,0302 clinical medicine ,SDG 3 - Good Health and Well-being ,Dermatitis, Atopic/prevention & control ,medicine ,Humans ,Anaphylaxis ,COVID-19 ,SARS-CoV-2 ,Vaccines ,030212 general & internal medicine ,Letter to the Editor ,ComputingMilieux_MISCELLANEOUS ,business.industry ,Anaphylactic reactions ,Atopic dermatitis ,medicine.disease ,3. Good health ,Vaccination ,Infectious Diseases ,030228 respiratory system ,business - Abstract
Since the introduction of active vaccination against SARS-CoV-2 infection, there has been a debate about the risk of developing severe allergic or anaphylactic reactions among individuals with a history of allergy. Indeed, rare cases of severe allergic reactions have been reported in the United Kingdom and North America. By february 2021 a rate of 4,5 severe allergic reactions occurred among 1 million patients vaccinated with the mRNA-based COVID-19 vaccines, which is higher than the generally expected rate of severe allergic reactions to vaccinations of around 1 in 1 million.
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- 2021
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45. Methods to improve quality of life, beyond medicines. position statement of the European Academy of Dermatology and Venereology task force on quality of life and patient oriented outcomes
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Françoise Poot, Anthony Bewley, Pavel V Chernyshov, L. Manolache, Alina Suru, Åke Svensson, Mir-saeed Salek, Andrew Yule Finlay, Francesca Sampogna, Servando E Marron, and L. Tomas Aragones
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Balneotherapy ,medicine.medical_specialty ,Hypnosis ,Venereology ,business.industry ,medicine.medical_treatment ,Advisory Committees ,Psychological intervention ,MEDLINE ,Dermatology ,Disease ,Skin Diseases ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Infectious Diseases ,Quality of life ,Quality of Life ,medicine ,Cognitive therapy ,Humans ,030212 general & internal medicine ,business - Abstract
The pharmaceutical approach to skin disease has been hugely successful, but despite effective drugs being available and used, there are still vast numbers of people who continue to have some level of persisting skin disease and continue to experience quality of life (QoL) impairment. So the question that needs to be answered, while we await further advances in our drug-based armamentarium, is how can we improve patients' QoL, beyond drugs? A working group was formed from members of the EADV Task Force on QoL and Patient Oriented Outcomes. Participants were asked to suggest all the ways in which they considered patients' QoL may be improved beyond medicines. Four groups of management approaches that may improve QoL in dermatology were identified: interventions within the dermatology service (hospitalization, multidisciplinary teams, patch testing and establishing relevant allergens and education), external services (corrective make-up, climatotherapy and balneotherapy), psychological (psychological intervention, cognitive therapy, hypnosis), lifestyle (lifestyle behavioural changes, religion and spirituality and music). The ultimate aim of therapy is to eradicate a disease in an individual and return the person's life to normal. But until the day comes when this has been achieved for every skin disease and for every patient there will be a need to support and assist many patients in additional non-pharmaceutical ways. These 'adjuvant' approaches receive too little attention while dermatologists and researchers strive for better pharmacological therapy. The different ways in which patients may benefit have been reviewed in our paper, but the reality is that most have a very poor evidence base. The research challenges that we have to meet are to identify those approaches that might be of value and to provide evidence for their optimal use. In the meantime, clinicians should consider the use of these approaches where QoL remains impaired despite optimal use of standard therapy.
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- 2021
46. Quality of life measurement in alopecia areata. Position statement of the European Academy of Dermatology and Venereology Task Force on Quality of Life and Patient Oriented Outcomes
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Matthias Augustin, Anthony Bewley, Francesca Sampogna, Åke Svensson, Alina Suru, Dennis Linder, L. Manolache, Andrew Yule Finlay, Andrea W M Evers, Jacek C Szepietowski, Sam Salek, Christine Blome, Carmen Salavastru, Damiano Abeni, Servando E Marron, Gregor B.E. Jemec, Lucia Tomas-Aragones, N. Pustišek, Saskia Spillekom-van Koulil, Pavel V Chernyshov, and Françoise Poot
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Position statement ,medicine.medical_specialty ,Venereology ,Alopecia Areata ,MEDLINE ,Dermatology ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Quality of life ,Patient oriented ,medicine ,Humans ,030212 general & internal medicine ,skin and connective tissue diseases ,integumentary system ,Task force ,business.industry ,Dermatology Life Quality Index ,Alopecia areata ,medicine.disease ,Women's cancers Radboud Institute for Health Sciences [Radboudumc 17] ,Infectious Diseases ,Quality of Life ,business ,Hair - Abstract
New treatment options may lead to an increased interest in using reliable and sensitive instruments to assess health-related quality of life in people with alopecia areata (AA). The purpose of this paper is to present current knowledge about quality of life assessment in AA. The dermatology-specific Dermatology Life Quality Index (DLQI) was the most widely reported health-related quality of life instrument used in AA. Three AA-specific (Alopecia Areata Symptom Impact Scale, Alopecia Areata Quality of Life Index and Alopecia Areata Patients'' Quality of Life) and three hair disease-specific instruments (Hairdex, Scalpdex and ‘hair-specific Skindex-29’) were identified with a range of content and validation characteristics: there is little evidence yet of the actual use of these measures in AA. Scalpdex is the best-validated hair disease-specific instrument. Further extensive validation is needed for all of the AA-specific instruments. The European Academy of Dermatology and Venereology Task Force on Quality of Life and Patient Oriented Outcomes recommends the use of the dermatology-specific DLQI questionnaire, hair disease-specific Scalpdex and the alopecia areata-specific instruments the Alopecia Areata Symptom Impact Scale or Alopecia Areata Quality of Life Index, despite the limited experience of their use. We hope that new treatment methods will be able to improve both clinical signs and health-related quality of life in patients with AA. In order to assess the outcomes of trials on these new treatment methods, it would be helpful when further development and validation of AA-specific instruments is being encouraged and also conducted. © 2021 European Academy of Dermatology and Venereology.
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- 2021
47. Selection process of measures for core outcome set should utilize the highest methodology level and should be maximally free of bias. Comment on ‘IDQoL, CDLQI and the 45‐item CADIS received a sufficient content validity rating during the HOME VII meeting in Japan: a group discussion study’
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Åke Svensson, M. J. Boffa, Françoise Poot, Anthony Bewley, N. Pustišek, J. S. Szepietowski, Pavel V Chernyshov, Carmen Salavastru, Damiano Abeni, Vincenzo Bettoli, Servando E Marron, Francesca Sampogna, Andrea W M Evers, and L. Tomas Aragones
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business.industry ,Dermatology ,Outcome (probability) ,Dermatitis, Atopic ,Core (game theory) ,Infectious Diseases ,Group discussion ,Japan ,Surveys and Questionnaires ,Outcome Assessment, Health Care ,Statistics ,Quality of Life ,Content validity ,Humans ,Medicine ,business ,Set (psychology) ,Selection (genetic algorithm) - Published
- 2020
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48. European Task Force on Atopic Dermatitis (ETFAD): treatment targets and treatable traits in atopic dermatitis
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Carsten Flohr, S. Cristen-Zaech, Carle Paul, Magdalena Trzeciak, Thomas Bieber, Ulf Darsow, Åke Svensson, Stephan Weidinger, A. Wollenberg, L.B. von Kobyletzki, J. Ring, Sébastien Barbarot, Alain Taieb, Thomas Werfel, M. Deleuran, Michael J. Cork, Julien Seneschal, Antonio Torrelo, R. Fölster-Holst, Carlo Gelmetti, J. F. Stalder, Jacob P. Thyssen, Annice Heratizadeh, DirkJan Hijnen, Dagmar Simon, Christian Vestergaard, Pavel V Chernyshov, Z. Szalai, L. De Raeve, de Bruin-Weller, Uwe Gieler, Surgical clinical sciences, Dermatology, Skin function and permeability, Herlev and Gentofte Hospital, Copenhagen Research Group for Inflammatory Skin (CORGIS), Aarhus University Hospital, Univ Med Ctr Utrecht, Dept Pediat Gastroenterol, Wilhelmina Childrens Hosp, University Hospital Bonn, Université de Bordeaux (UB), University of Sheffield [Sheffield], Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées, King‘s College London, Schleswig-Holstein University Hospitals, Hannover Medical School [Hannover] (MHH), Physiopathologie des Adaptations Nutritionnelles (PhAN), Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Technische Universität Munchen - Université Technique de Munich [Munich, Allemagne] (TUM), Bern University Hospital [Berne] (Inselspital), Hospital Infantil Universitario Niño Jesús [Madrid, Spain] (HIUNJ), National Medical University, Centre hospitalier universitaire de Nantes (CHU Nantes), Università degli Studi di Milano [Milano] (UNIMI), Heim Pál Children's Hospital, Skane University Hospital [Malmo], Lund University [Lund], University Clinic Schleswig–Holstein, Centre Hospitalier Universitaire Vaudois [Lausanne] (CHUV), Centre médical Érasme, Justus-Liebig-Universität Gießen (JLU), Ludwig-Maximilians-Universität München (LMU), Klinikum der Universität [München], and Technical University of Munich (TUM)
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medicine.medical_specialty ,[SDV]Life Sciences [q-bio] ,Advisory Committees ,Eczema ,MEDLINE ,Dermatology ,Dermatitis, Atopic ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Treatment targets ,TARGETS ,EFTAD ,medicine ,Humans ,atopic dermatitis ,Task force ,business.industry ,Atopic dermatitis ,Patch Tests ,medicine.disease ,3. Good health ,Infectious Diseases ,030228 respiratory system ,business - Abstract
International audience; Background: Surgery is a radical treatment for hidradenitis suppurativa (HS) and may be considered as the only one potentially curative. Objectives: To characterize HS recurrence in patients after surgery and assess the risk factors of recurrence. Methods: We conducted a monocentric retrospective cohort study. All consecutive patients who had surgery (January 1, 2012 to March 31, 2017) were included. We estimated the rate of recurrence of HS lesions after surgery (
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- 2020
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49. ETFAD/EADV Eczema task force 2020 position paper on diagnosis and treatment of atopic dermatitis in adults and children
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Michael J. Cork, Mette Deleuran, Jean-François Stalder, Stephan Weidinger, Magdalena Trzeciak, Ulf Darsow, Z. Szalai, Annice Heratizadeh, L.B. von Kobyletzki, Johannes Ring, Jacob P. Thyssen, DirkJan Hijnen, Dagmar Simon, Thomas Werfel, Julien Seneschal, Sébastien Barbarot, R. Fölster-Holst, Christian Vestergaard, Åke Svensson, M S de Bruin-Weller, Andreas Wollenberg, S. Christen-Zäch, Alain Taieb, U. Gieler, B. Kunz, L. De Raeve, Carle Paul, Ludwig-Maximilians-Universität München (LMU), Physiopathologie des Adaptations Nutritionnelles (PhAN), Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Internal Medicine, and Dermatology
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Adult ,medicine.medical_specialty ,[SDV]Life Sciences [q-bio] ,Provocation test ,Calcineurin Inhibitors ,Anti-Inflammatory Agents ,Eczema ,Dermatology ,Tacrolimus ,Dermatitis, Atopic ,030207 dermatology & venereal diseases ,03 medical and health sciences ,Pimecrolimus ,0302 clinical medicine ,Food allergy ,medicine ,Adjuvant therapy ,Humans ,030212 general & internal medicine ,SCORAD ,Child ,medicine.diagnostic_test ,business.industry ,Pruritus ,Atopic dermatitis ,medicine.disease ,Dupilumab ,3. Good health ,Infectious Diseases ,business ,medicine.drug - Abstract
International audience; Atopic dermatitis (AD) is a highly pruritic, chronic inflammatory skin disease. The diagnosis is made using evaluated clinical criteria. Disease activity and burden are best measured with a composite score, assessing both objective and subjective symptoms, such as SCORing Atopic Dermatitis (SCORAD). AD management must take into account clinical and pathogenic variabilities, the patient's age and also target flare prevention. Basic therapy includes hydrating and barrier-stabilizing topical treatment universally applied, as well as avoiding specific and unspecific provocation factors. Visible skin lesions are treated with anti-inflammatory topical agents such as corticosteroids and calcineurin inhibitors (tacrolimus and pimecrolimus), which are preferred in sensitive locations. Topical tacrolimus and some mid-potency corticosteroids are proven agents for proactive therapy, which is defined as the long-term intermittent anti-inflammatory therapy of frequently relapsing skin areas. Systemic anti-inflammatory or immunosuppressive treatment is a rapidly changing field requiring monitoring. Oral corticosteroids have a largely unfavourable benefit-risk ratio. The IL-4R-blocker dupilu-mab is a safe, effective and licensed, but expensive, treatment option with potential ocular side-effects. Other biologicals targeting key pathways in the atopic immune response, as well as different Janus kinase inhibitors, are among emerging treatment options. Dysbalanced microbial colonization and infection may induce disease exacerbation and can justify additional antimicrobial treatment. Systemic antihistamines (H1R-blockers) only have limited effects on AD-related itch and eczema lesions. Adjuvant therapy includes UV irradiation, preferably narrowband UVB or UVA1. Coal tar may be useful for atopic hand and foot eczema. Dietary recommendations should be patient-specific, and elimination diets should only be advised in case of proven food allergy. Allergen-specific immunotherapy to aeroallergens may be useful in selected cases. Psychosomatic counselling is recommended to address stress-induced exacerbations. Efficacy-proven 'Eczema school' educational programmes and therapeutic patient education are recommended for both children and adults.
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- 2020
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50. Associations of self-reported atopic dermatitis with comorbid conditions in adults: a population-based cross-sectional study
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Åke Svensson, Laura B von Kobyletzki, Scott Montgomery, Jevgenija Smirnova, and Magnus Lindberg
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0301 basic medicine ,Adult ,Male ,medicine.medical_specialty ,obesity ,hypertension ,Adolescent ,Cross-sectional study ,Dermatology ,Comorbidity ,Risk Assessment ,Severity of Illness Index ,Dermatitis, Atopic ,030207 dermatology & venereal diseases ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Risk Factors ,Internal medicine ,Epidemiology ,lcsh:Dermatology ,Odds Ratio ,Prevalence ,Medicine ,Humans ,Depression (differential diagnoses) ,Asthma ,Aged ,Atopic dermatitis ,Sweden ,business.industry ,Odds ratio ,lcsh:RL1-803 ,Middle Aged ,medicine.disease ,030104 developmental biology ,Cross-Sectional Studies ,Relative risk ,Chronic Disease ,diabetes mellitus ,Population study ,oral health ,Female ,epidemiology ,Self Report ,business ,Research Article - Abstract
Background The objective of this study was to investigate the relationships between atopic dermatitis (AD) and other common chronic health conditions in adults. Methods A cross-sectional survey was sent to a randomly selected population sample of 78,004 adults in Sweden. The questionnaires included measures of self-reported physical and mental health. Binary and multinomial logistic regression were used to examine the associations of AD with common chronic health conditions and psychological wellbeing. Results AD was self-reported by 4,175 respondents, representing almost 14% of the study population of 34,313 adults. Our results showed positive associations between AD and chronic health disorders, including conditions of the oral cavity: chronic obstructive pulmonary disease (adjusted odds ratio [aOR] = 1.58, 95% confidence interval [CI]: 1.30 to 1.92), asthma (aOR = 2.13, 95% CI: 1.91 to 2.38), mild recurrent gastrointestinal symptoms (adjusted relative risk ratio [aRRR] = 1.78, 95% CI: 1.64 to 1.92), high blood pressure (aOR = 1.16, 95% CI: 1.06 to 1.26), obesity (aOR = 1.34, 95% CI: 1.23 to 1.47), mild joint pain (aRRR = 1.47, 95% CI: 1.35 to 1.61), mild headache or migraine (aRRR = 1.50, 95% CI: 1.38 to 1.64), caries (aOR = 1.25, 95% CI: 1.04 to 1.49), bleeding gums (aOR = 1.69, 95% CI: 1.38 to 2.08), periodontitis (aOR = 1.42, 95% CI: 1.13 to 1.77), sensitive teeth (aOR = 1.57, 95% CI: 1.35 to 1.82), and dry mouth (aOR = 1.52, 95% CI: 1.33 to 1.74). Adjustment for asthma and depression attenuated the magnitude of the associations between AD and the study outcomes. AD was also associated with poorer general psychological wellbeing. Conclusions Adults reporting AD may be at increased risk of chronic disorders and decreased psychological wellbeing. Physicians should recognize that individuals with severe AD and those with comorbid asthma or depression may be especially vulnerable.
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- 2020
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