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En la actualidad, el uso de nuevas tecnologías ha revolucionado la manera en que se trabaja y se resuelven las tareas. Una de las aplicaciones interesantes de estos nuevos medios tecnológicos es la posibilidad de crear materiales didácticos personalizados e innovadores por parte de los docentes (hombres y mujeres) para las diferentes etapas educativas. La propuesta que se presenta utiliza las tecnologías de diseño y fabricación digital para crear tres materiales didácticos personalizados para el aprendizaje de la escritura de los glifos egipcios en educación infantil. Así, partiendo del temario específico que se estaba impartiendo en el centro educativo –la cultura egipcia–, se crearon unos sellos en goma EVA para escribir sobre papiro, unas plantillas de acetato para escribir sobre papel reciclado, con un plotter de corte, y unos sellos impresos en 3D para estampar en arcilla. Estos materiales didácticos se probaron en un aula de segundo curso del segundo ciclo de educación infantil con 20 alumnos (niños y niñas). A partir de la puesta en práctica de distintas actividades, se pudieron valorar dichos materiales, atendiendo a su adecuación a la etapa educativa de infantil, analizando su usabilidad y la calidad de los resultados. Finalmente, aunque los docentes y los futuros maestros desconocían las herramientas que se utilizaron para la elaboración del material, consideran que son muy funcionales y prácticas y que se podrían generar múltiples propuestas motivadoras y adecuadas para la edad de los estudiantes en función de los resultados obtenidos de la validación en el aula.

Recensión del libro: ALEJANDRO GONZÁLEZ-VARAS IBÁÑEZ, Ideologías y creencias en la formación del derecho en un contexto global, Ediciones Olejnik, Argentina, 2023, 145 pp., ISBN: 9789564073637.

Aim: To describe the latest scientific evidence regarding community-based interventions performed on patients in need of palliative care worldwide. Introduction and background: Given the rise of chronic diseases, their complexities and the fragility of patients, we are facing around 56.8 million people in need of palliative care. Community-based healthcare, particularly palliative care, can address social inequalities and improve the biopsychosocial health of disadvantaged populations. Therefore, primary care, as the main health referent in the community, has a central role in the care of these patients. Methods: This is an integrative review from January 2017 to June 2022 that follows the PRISMA statement and has been registered in PROSPERO. PubMed, Cuiden, the Web of Science (WoS), Cochrane and LILACS were the five databases searched. The scientific quality assessment of the articles was carried out following the CASPe methodology. Study selection was carried out by two researchers, A.V.L. and J.M.C.T., using the inclusion and exclusion criteria mentioned below. In cases of doubt or discrepancy, a third author (J.R.S.) was consulted. Results: The interventions mentioned in the 16 articles analysed were classified under the following categories: music therapy, laughter therapy, spiritual and cognitive interventions, aromatherapy, interdisciplinary and community-based teams, advance care planning and community, volunteering, telemedicine and care mapping. Example: Educating people to talk about different ethical issues could improve their quality of life and help develop more compassionate cities. Conclusions: We have identified interventions that are easily accessible (laughter therapy, telemedicine or music therapy), simple enough to be carried out at the community level and do not incur high costs. This is why they are recommended for people with palliative care needs in order to improve their quality of life.

(1) Background: To analyze the prevalence of physical activity (PA) according to the presence of overweight or obesity and other sociodemographic factors in the Spanish adult population. (2) Methods: Cross-sectional study using the European Health Interview Surveys for Spain from 2014 and 2020. (3) Results: In overweight and obese people, the percentage of those who reported not performing any type of PA remained constant between 2014 and 2020, while a statistically significant increase was observed in the percentage of people who walked for 10 min a day and exercised at least 2 days a week. The probability of being obese with respect to normal weight was higher in individuals who reported not engaging in PA during leisure time (OR 1.42; 95% CI 1.31–1.53), those who did not walk 10 min a day at least 2 days a week (OR 1.25; 95% CI 1.15–1.35), and those who did not exercise at least 2 days a week (OR 1.42; 95% CI 1.32–1.53). The probability of being overweight was higher in individuals who reported not performing PA during leisure time (OR 1.07; 95% CI 1.02–1.15) and in those who did not exercise at least 2 days per week (OR 1.15; 95% CI 1.09–1.22). (4) Conclusions: Small increases in PA have been observed in both overweight and obese individuals from 2014 to 2020.

In recent years, there has been a growing interest in developing portable and personal devices for measuring air quality and surrounding pollutants, partly due to the need for ventilation in the aftermath of COVID-19 situation. Moreover, the monitoring of hazardous chemical agents is a focus for ensuring compliance with safety standards and is an indispensable component in safeguarding human welfare. Air quality measurement is conducted by public institutions with high precision but costly equipment, which requires constant calibration and maintenance by highly qualified personnel for its proper operation. Such devices, used as reference stations, have a low spatial resolution since, due to their high cost, they are usually located in a few fixed places in the city or region to be studied. However, they also have a low temporal resolution, providing few samples per hour. To overcome these drawbacks and to provide people with personalized and up-to-date air quality information, a personal device (smartwatch) based on MEMS gas sensors has been developed. The methodology followed to validate the performance of the prototype was as follows: firstly, the detection capability was tested by measuring carbon dioxide and methane at different concentrations, resulting in low detection limits; secondly, several experiments were performed to test the discrimination capability against gases such as toluene, xylene, and ethylbenzene. principal component analysis of the data showed good separation and discrimination between the gases measured.

Background: Limited data on electronic cigarette prevalence, patterns, and settings of use are available from several European countries. Methods: Within the TackSHS project, a face-to-face survey was conducted in 2017–2018 in 12 European countries (Bulgaria, England, France, Germany, Greece, Ireland, Italy, Latvia, Poland, Portugal, Romania and Spain). Overall, 11,876 participants, representative of the population aged ≽15 years in each country, provided information on electronic cigarette. Results: 2.4% (95% confidence interval [CI], 2.2–2.7%) of the subjects (2.5% among men and 2.4% among women; 0.4% among never, 4.4% among current- and 6.5% among ex-smokers) reported current use of electronic cigarette, ranging from 0.6% in Spain to 7.2% in England. Of the 272 electronic cigarette users, 52.6% were dual users (ie, users of both electronic and conventional cigarettes) and 58.8% used liquids with nicotine. In all, 65.1% reported using electronic cigarette in at least one indoor setting where smoking is forbidden; in particular, at workplaces (34.9%) and bars and restaurants (41.5%). Multivariable logistic regression analysis showed that electronic cigarette use was lower among older individuals (P for trend

Fibroblast growth factor 23 (FGF23) levels are often elevated in chronic kidney disease (CKD). FGF23 and inflammation are common characteristics in CKD, and both are associated with worse disease progression and the occurrence of complications. The existence of an interaction between FGF23 and inflammation has been suggested, each of which influences the expression and activity of the other, leading to a vicious feedback loop with adverse outcomes, including cardiovascular disease and mortality. In this work, we determined circulating FGF23 levels in a group of patients with CKD stages 3 and 4 subjected to elective femoral endarterectomy due to established peripheral artery disease (PAD), a condition resulting from an athero-inflammatory process, and we studied its associations with different inflammatory markers and mediators. We evaluated its association with serum tumor necrosis factor (TNF)α, interleukin (IL) 6, and IL10, as well as with the gene expression levels of these parameters and A disintegrin and metalloproteinase domain-containing protein (ADAM) 17 in femoral vascular tissue and peripheral blood circulating cells (PBCCs). We also analyzed its association with serum concentrations of C-reactive protein (CRP), the systemic immune inflammation index (SII), and the neutrophil-to-lymphocyte ratio (NLR). Finally, we determined the vascular immunoreactivity of protein TNFα in a subgroup of patients. FGF23 concentrations were independently associated with circulating and PBCC mRNA levels of TNFα. Worst kidney function and diabetes were also found to be contributing to FGF23 levels. Patients with higher levels of FGF23 also had greater vascular immunoreactivity for TNFα.

Development of applications related to closed-loop control requires either testing on the field or on a realistic simulator, with the latter being more convenient. To ease that need, this work introduces MVSim, a simulator for multiple vehicles or robots capable of running in real time dozens of agents in simple scenarios, or a handful of them in complex scenarios. MVSim employs realistic physics-grounded friction models for tire–ground interaction, and aims at accurate and GPU-accelerated simulation of most common modern sensors employed in mobile robotics and autonomous vehicle research, such as depth and RGB cameras, or 2D and 3D LiDAR scanners. All depth-related sensors are able to accurately measure distances to 3D models provided by the user to define custom world elements. Efficient simulation is achieved by means of focusing on ground vehicles, which allows the use of a simplified 2D physics engine for body collisions while solving wheel–ground interaction forces separately. The core parts of the system are written in C++ for maximum efficiency, while Python, ROS 1, and ROS 2 wrappers are also offered. A custom publish/subscribe protocol based on ZeroMQ (ZMQ) is defined to allow for multiprocess applications to access or modify a running simulation. This simulator enables and makes easier to do research and development on vehicular dynamics, autonomous navigation algorithms, and simultaneous localization and mapping (SLAM) methods. An experimental performance benchmarking is provided against other state-of-the-art simulators showing significant less CPU usage. The project source code is freely available online under the BSD 3-clause license in https://github.com/MRPT/mvsim.

ABSTRACT Low temperature limits the growth and the distribution of the key oceanic primary producer Prochlorococcus, which does not proliferate above a latitude of ca. 40°. Yet, the molecular basis of thermal acclimation in this cyanobacterium remains unexplored. We analyzed the transcriptional response of the Prochlorococcus marinus strain MIT9301 in long-term acclimations and in natural Prochlorococcus populations along a temperature range enabling its growth (17 to 30°C). MIT9301 upregulated mechanisms of the global stress response at the temperature minimum (17°C) but maintained the expression levels of genes involved in essential metabolic pathways (e.g., ATP synthesis and carbon fixation) along the whole thermal niche. Notably, the declining growth of MIT9301 from the optimum to the minimum temperature was coincident with a transcriptional suppression of the photosynthetic apparatus and a dampening of its circadian expression patterns, indicating a loss in their regulatory capacity under cold conditions. Under warm conditions, the cellular transcript inventory of MIT9301 was strongly streamlined, which may also induce regulatory imbalances due to stochasticity in gene expression. The daytime transcriptional suppression of photosynthetic genes at low temperature was also observed in metatranscriptomic reads mapping to MIT9301 across the global ocean, implying that this molecular mechanism may be associated with the restricted distribution of Prochlorococcus to temperate zones. IMPORTANCE Prochlorococcus is a major marine primary producer with a global impact on atmospheric CO2 fixation. This cyanobacterium is widely distributed across the temperate ocean, but virtually absent at latitudes above 40° for yet unknown reasons. Temperature has been suggested as a major limiting factor, but the exact mechanisms behind Prochlorococcus thermal growth restriction remain unexplored. This study brings us closer to understanding how Prochlorococcus functions under challenging temperature conditions, by focusing on its transcriptional response after long-term acclimation from its optimum to its thermal thresholds. Our results show that the drop in Prochlorococcus growth rate under cold conditions was paralleled by a transcriptional suppression of the photosynthetic machinery during daytime and a loss in the organism’s regulatory capacity to maintain circadian expression patterns. Notably, warm temperature induced a marked shrinkage of the organism’s cellular transcript inventory, which may also induce regulatory imbalances in the future functioning of this cyanobacterium.

IntroductionKlotho protein is predominantly expressed in the kidneys and has also been detected in vascular tissue and peripheral blood circulating cells to a lesser extent. Carotid artery intima-media thickness (CIMT) burden, a marker of subclinical atherosclerosis, has been associated with reductions in circulating Klotho levels in chronic kidney disease patients, who show reduced levels of this protein at all stages of the disease. However, the contribution of serum Klotho and its expression levels in peripheral blood circulating cells and in the carotid artery wall on the CIMT in the absence of kidney impairment has not yet been evaluated.MethodsWe conducted a single-center study in 35 atherosclerotic patients with preserved kidney function (eGFR≥60 mL/min/1.73m2) subjected to elective carotid surgery. Serum levels of Klotho and cytokines TNFa, IL6 and IL10 were determined by ELISA and transcripts encoding for Klotho (KL), TNF, IL6 and IL10 from vascular segments were measured by qRT-PCR. Klotho protein expression in the intima-media and adventitia areas was analyzed using immunohistochemistry.ResultsAPatients with higher values of CIMT showed reduced Klotho levels in serum (430.8 [357.7-592.9] vs. 667.8 [632.5-712.9] pg/mL; p

Staphylococcus aureus is one of the species with the greatest clinical importance and greatest impact on public health. In fact, methicillin-resistant S. aureus (MRSA) is considered a pandemic pathogen, being essential to develop effective medicines and combat its rapid spread. This study aimed to foster the translation of clinical research outcomes based on metallodrugs into clinical practice for the treatment of MRSA. Bearing in mind the promising anti-Gram-positive effect of the heteroscorpionate ligand 1,1’-(2-(4-isopropylphenyl)ethane-1,1-diyl)bis(3,5-dimethyl-1H-pyrazole) (2P), we propose the coordination of this compound to platinum as a clinical strategy with the ultimate aim of overcoming resistance in the treatment of MRSA. Therefore, the novel metallodrug 2P-Pt were synthetized, fully characterized and its antibacterial effect against the planktonic and biofilm state of S. aureus evaluated. In this sense, three different strains of S. aureus were studied, one collection strain of S. aureus sensitive to methicillin and two clinical MRSA strains. To appraise the antibacterial activity, minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), minimum biofilm inhibitory concentration (MBIC), and minimum biofilm eradication concentration (MBEC) were determined. Moreover, successful outcomes on the development of biofilm in a wound-like medium were obtained. The mechanism of action for 2P-Pt was proposed by measuring the MIC and MBC with EDTA (cation mediated mechanism) and DMSO (exogenous oxidative stress mechanism). Moreover, to shed light on the plausible antistaphylococcal mechanism of this novel platinum agent, additional experiments using transmission electron microscopy were carried out. 2P-Pt inhibited the growth and eradicated the three strains evaluated in the planktonic state. Another point worth stressing is the inhibition in the growth of MRSA biofilm even in a wounded medium. The results of this work support this novel agent as a promising therapeutic alternative for preventing infections caused by MRSA.

Abstract Cardiovascular disease is the leading cause of death worldwide. New therapeutic strategies are aimed to modulate the athero-inflammatory process that partially orchestrates underlying vascular damage. Peripheral blood circulating cells include different immune cells with a central role in the development of the atherogenic inflammatory response. The anti-aging protein α-Klotho has been related to protective effects against CVD. KL is expressed in monocytes, macrophages, and lymphocytes where it exerts anti-inflammatory effects. In this work, we analyse the relationships of the levels of inflammatory markers with the expression of the KL gene in PBCCs and with the serum levels of soluble KL in atherosclerotic vascular disease. For this, we conducted a cross-sectional single-center case–control study including a study group of 76 CVD patients and a control group of 16 cadaveric organ donors without medical antecedent or study indicating CVD. Vascular artery fragments and whole blood and serum samples were obtained during elective or organ retrieval surgery. Serum levels of sKL, TNFα and IL10, and gene expression levels of KL, TNF, IL10, NFKB1, DNMT1, and DNMT3A in PBCCs were measured. In these cells, we also determined KL promoter methylation percentage. Histological and immunohistochemical analyses were employed to visualize atherosclerotic lesions and to measure IL10 and TNFα levels in vascular fragments. Patients with CVD presented higher values of proinflammatory markers both at systemic and in the vasculature and in the PBCCs, compared to the control group. In PBCCs, CVD patients also presented lower gene expression levels of KL gene (56.4% difference, P < 0.001), higher gene expression levels of DNMT1 and DNMT3A (P < 0.0001, for both) and a higher methylation status of in the promoter region of KL (34.1 ± 4.1% vs. 14.6 ± 3.4%, P < 0.01). In PBCCs and vasculature, KL gene expression correlated inversely with pro-inflammatory markers and directly with anti-inflammatory markers. sKL serum levels presented similar associations with the expression levels of pro- and anti-inflammatory markers in PBCCs. The differences in KL expression levels in PBCCs and in serum sKL levels with respect to control group was even greater in those CVD patients with macroscopically observable atheromatous plaques. We conclude that promoter methylation-mediated downregulation of KL gene expression in PBCCs is associated with the pro-inflammatory status in atherosclerotic vascular disease.

The 21st century has witnessed a growing interest in the analysis of time series data. While most of the literature on the topic deals with real-valued time series, ordinal time series have typically received much less attention. However, the development of specific analytical tools for the latter objects has substantially increased in recent years. The R package otsfeatures attempts to provide a set of simple functions for analyzing ordinal time series. In particular, several commands allowing the extraction of well-known statistical features and the execution of inferential tasks are available for the user. The output of several functions can be employed to perform traditional machine learning tasks including clustering, classification, or outlier detection. otsfeatures also incorporates two datasets of financial time series which were used in the literature for clustering purposes, as well as three interesting synthetic databases. The main properties of the package are described and its use is illustrated through several examples. Researchers from a broad variety of disciplines could benefit from the powerful tools provided by otsfeatures.

Quinoxalines are heterocyclic compounds that contain a benzene ring and a pyrazine ring. The oxidation of both nitrogen of the pyrazine ring results in quinoxaline derivatives (QdNO), which exhibit a variety of biological properties, including antiparasitic activity. However, its activity against Entamoeba histolytica, the protozoan that causes human amebiasis, is poorly understood. Recently, our group reported that various QdNOs produce morphological changes in E. histolytica trophozoites, increase reactive oxygen species, and inhibit thioredoxin reductase activity. Notably, T-001 and T-017 derivatives were among the QdNOs with the best activity. In order to contribute to the characterization of the antiamebic effect of QdNOs, in this work we analyzed the proteomic profile of E. histolytica trophozoites treated with the QdNOs T-001 and T-017, and the results were correlated with functional assays. A total number of 163 deregulated proteins were found in trophozoites treated with T-001, and 131 in those treated with T-017. A set of 21 overexpressed and 24 under-expressed proteins was identified, which were mainly related to cytoskeleton and intracellular traffic, nucleic acid transcription, translation and binding, and redox homeostasis. Furthermore, T-001 and T-017 modified the virulence of trophozoites, since they altered their erythrophagocytosis, migration, adhesion and cytolytic capacity. Our results show that in addition to alter reactive oxygen species, and thioredoxin reductase activity, T-001 and T-017 affect essential functions related to the actin cytoskeleton, which eventually affects E. histolytica virulence and survival.

Abstract Background The preferences of citizens are a basic element to incorporate into the decision-making process when planning health policies. Contingent valuation (CV) is a common method for calculating the value for citizens that new technologies, interventions, and the provision of services or policies have. However, choosing the correct CV tool may not be a neutral decision. This work aims to assess the substitution of a healthcare service by comparing valuation differences between the willingness to pay (WTP) for the maintenance of the service versus the willingness to accept compensation (WTA) for its substitution, both of which are related to subject characteristics, with a particular focus on trust in institutions and risk aversion. Methods A CV study was designed to study Dutch population preferences when physician assistants replace anaesthesiologists. Differences between the distributions of WTA and WTP were compared through full decomposition methods, and conditional quantile regression was performed. Results Nearly two-thirds of surveyed citizens expressed null values for WTA and WTP. The other third systematically reported a value of WTA higher than that of WTP, which increased further with lower income and the possible presence of a strategic bias. In contrast, being more than 65 years old, having trust in government, and preferring anaesthesiologists decreased the WTA-WTP difference. Risk aversion had no clear association with the WTA-WTP gap. Conclusions Known differences between the perceived value of health services from the perspective of gains and losses could be related to people’s characteristics. Trust in government but not aversion to risk was related to the WTA-WTP differences. Identifying a profile of citizens who are averse to losing health services should be considered when designing and implementing health services or interventions or making disinvestment decisions.

Resumen: Objetivo: Conocer el grado de burnout en residentes MIR/PIR de Oviedo y su relación con factores laborales y docentes. Diseño: Se realizó un estudio descriptivo transversal. Emplazamiento: Área Sanitaria IV de Asturias. Participantes: Residentes de medicina y psicología clínica en formación en 2016. Mediciones: Se les administró el Inventario de Burnout de Maslach (MBI) y un cuestionario elaborado ad hoc sobre cuestiones referidas a aspectos laborales y docentes como la responsabilidad, la supervisión, etc. Resultados: Respondieron 90 residentes (29,5%) y se obtuvo un alto nivel de burnout en el 50% (IC 95%: 39,3-60,7), encontrando diferencias según la especialidad, y su relación con algunos de los factores laborales estudiados como la supervisión, ajuste de responsabilidad y calidad de vida e impacto emocional. Conclusiones: Existe un nivel medio alto de burnout entre los residentes. Abstract: Objective: To determine the level of burnout in residents in clinic psychology and medicine (MIR/PIR) of Oviedo and its relationship with occupational and teaching factors. Design: A cross-sectional descriptive study was performed. Site: Health Area IV of Asturias, Spain. Participants: Residents of medicine and clinical psychology in training in 2016. Measurements: The subjects were administered the Maslach Burnout Inventory (MBI) and an ad hoc questionnaire prepared on issues related to occupational and teaching aspects, such as responsibility, supervision, etc. Results: A total of 90 (29.5%) residents responded, and a high level of burnout was obtained in 50% (95% CI: 39.3-60.7). Differences were found according to the speciality, and their relationship with some of the studied occupational factors studied, such as supervision, adjustment of responsibility, and quality of life and emotional impact. Conclusions: There is a medium-high level of burnout among residents.

Objective: The TackSHS project aims to comprehensively elucidate the impact that exposure to second-hand smoke (SHS) from cigarettes and second-hand aerosols (SHA) from electronic cigarettes have on the respiratory health of the European population according to socioeconomic characteristics and other determinants. Method: The TackSHS project involves a series of coordinated studies carried out by 11 academic and public health organisations from six European countries. The project will investigate: a) the determinants of SHS and SHA exposure assessed at the individual level (surveys on representative general population samples) and in common environments (environmental sampling in specific settings); b) the overall disease burden, mortality and morbidity attributable to such exposure; and c) its economic impact in terms of direct health care costs. The project will also examine specific acute respiratory health changes in healthy individuals and patients with respiratory diseases exposed to SHS and SHA. In addition, the project will examine the effectiveness of a novel intervention to reduce SHS exposure in households where smoking is permitted. All these studies are inter-related and involve collaborative coordination among the participant organisations. Conclusion: The comprehensive, integrated approach of the TackSHS project will enable a significant step forward from the current status quo in the understanding of the impact of SHS and SHA exposure on health and provide the basis for health policy recommendations to help European countries to further reduce the harm caused by SHS and SHA exposure. Resumen: Objetivo: El proyecto TackSHS pretende caracterizar el impacto global de la exposición al humo ambiental de tabaco (HAT) y al aerosol de los cigarrillos electrónicos (ACE) en la salud respiratoria de la población europea según variables socioeconómicas y otros determinantes. Método: El proyecto TackSHS consiste en una serie de estudios coordinados y gestionados por 11 organizaciones académicas y de salud pública de seis países europeos. El proyecto estudiará: a) los determinantes de la exposición al HAT y al ACE a nivel individual (encuestas en muestras representativas de la población general) y en espacios comunes (muestras ambientales en lugares específicos); b) su carga general de enfermedad y la morbimortalidad atribuible a tal exposición; y c) su impacto económico en términos de costes sanitarios directos e indirectos. Además, el proyecto investigará cambios específicos a corto plazo en la salud respiratoria en personas sanas y en pacientes con enfermedades respiratorias expuestos al HAT y al ACE. También examinará la efectividad de una intervención novedosa para reducir la exposición al HAT en hogares donde se permite fumar. Todos estos estudios están interrelacionados y conllevan una coordinación colaborativa entre las instituciones participantes. Conclusión: El enfoque integral del proyecto TackSHS permitirá un avance significativo en la evidencia sobre la comprensión del impacto de la exposición al HAT y al ACE en la salud, y proporcionará una base para desarrollar recomendaciones políticas sanitarias para ayudar a los países europeos a reducir los daños causados por la exposición al HAT y al ACE. Keywords: Second-hand smoke, Passive smoking, Electronic cigarette, Electronic nicotine delivery systems, Aerosols, Second-hand aerosols, Respiratory health, Burden of disease, Economic impact, Palabras clave: Humo ambiental del tabaco, Tabaquismo pasivo, Cigarrillos electrónicos, Sistemas electrónicos de administración de nicotina, Exposición al aerosol, Salud respiratoria, Carga de enfermedad, Impacto económico

Vocation is one of the determining factors taken into account by students when choosing their university studies. However, when the students start their studies, in their first year, they will find a series of basic subjects that barely motivate or stimulate them. In the specific case of mathematics, the problem is aggravated when many of the students already begin the first year showing rejection towards this subject. The lack of motivation for mathematics also affects the subject of physics because “the role of mathematics is to be the language of physics”. The EXPLORIA project proposed by the CEU Cardenal Herrera University is a potential solution to this problem. The objective of this project is the implementation of STEAM learning (Science Technology Engineering Art Mathematics) in the Degree in Fundamentals of Architecture at CEU Cardenal Herrera University through the EXPLORIA project. This article focuses on the activities carried out in the subject of physics in the Degree in Fundamentals of Architecture, corresponding to the part of mechanical engineering in order to show that through the realization of different challenges, we can develop creative products, new buildings with their logos and storytelling, as well as connect with the rest of subjects. For its development, students must use everyday objects within their reach, such as forks, spoons, knives, shoes, etc., to build an object or structure that must remain in a “creative balance” and this will serve as an inspiration for new buildings. These new creations are evaluated by an architecture team who fills in a rubric to evaluate the creativity and originality of the products. The number of students included in this project was 24 and the participants’ age ranged between 18 and 20 (similarly distributed). At the end of the work, an anonymous ad hoc questionnaire was carried out to show the students’ assessment of the new teaching methodology and the challenges developed in the subject of physics.

Excessive alcohol consumption is a major public health issue that can negatively affect behavior among university students. The objective of this study was to estimate the frequency of alcohol consumption in nursing students as well as to describe the pattern of alcohol consumption after COVID-19 lockdown. A descriptive, cross-sectional observational study was carried out, in which 1162 degree-level nursing students were evaluated. Sociodemographic characteristics, lifestyles and levels of physical activity were determined using the International Physical Activity Questionnaire: Short Form (IPAQ-SF), and alcohol consumption was determined using the ISCA (Systematized Alcohol Consumption Questionnaire) and AUDIT (Alcohol Use Disorders Inventory Test) questionnaires. According to the AUDIT questionnaire, 36.7% of the students met the criteria for excessive alcohol consumption (26.8% men vs. 39.9% women; p < 0.001). The prevalence of hazardous drinkers was found to be 10.2% (95% CI 5.6–11.7), with the difference between men and women being statistically significant. The IPAQ-SF questionnaire indicated that 26.1% of students were sedentary. No relationship was observed between alcohol consumption and the level of physical activity. The frequency of hazardous drinkers was significantly higher in women (OR: 2.2) and in smokers (OR: 4.2). In conclusion, approximately 10% of nursing students can be considered hazardous drinkers, with significant differences between the sexes. The percentage is higher in women and in smokers. Strategies should be created that encourage healthy lifestyles, emphasizing preventive activities against excessive alcohol consumption. Furthermore, given the differences in excessive alcohol consumption between men and women, it would be advisable to include the gender perspective in these activities.

Nanotechnology is a developing field that has boomed in recent years due to the multiple qualities of nanoparticles (NPs), one of which is their antimicrobial capacity. We propose that NPs anchored with 2-(dimethylamino)ethyl methacrylate (DMAEMA) have antibacterial properties and could constitute an alternative tool in this field. To this end, the antimicrobial effects of three quaternised NPs anchored with DMAEMA were studied. These NPs were later copolymerized using different methylmethacrylate (MMA) concentrations to evaluate their role in the antibacterial activity shown by NPs. Clinical strains of Staphylococcus aureus, S. epidermidis, S. lugdunensis and Enterococcus faecalis were used to assess antibacterial activity. The minimal inhibitory concentration (MIC) was determined at the different concentrations of NPs to appraise antibacterial activity. The cytotoxic effects of the NPs anchored with DMAEMA were determined in NIH3T3 mouse fibroblast cultures by MTT assays. All the employed NPs were effective against the studied bacterial strains, although increasing concentrations of the MMA added during the synthesis process diminished these effects without altering toxicity in cell cultures. To conclude, more studies with other copolymers are necessary to improve the antibacterial effects of NPs anchored with DMAEMA.

With recent advances in Machine Learning techniques based on Deep Neural Networks (DNNs), automated plankton image classification is becoming increasingly popular within the marine ecological sciences. Yet, while the most advanced methods can achieve human-level performance on the classification of everyday images, plankton image data possess properties that frequently require a final manual validation step. On the one hand, this is due to morphological properties manifesting in high intra-class and low inter-class variability, and, on the other hand is due to spatial-temporal changes in the composition and structure of the plankton community. Composition changes enforce a frequent updating of the classifier model via training with new user-generated training datasets. Here, we present a Dynamic Optimization Cycle (DOC), a processing pipeline that systematizes and streamlines the model adaptation process via an automatic updating of the training dataset based on manual-validation results. We find that frequent adaptation using the DOC pipeline yields strong maintenance of performance with respect to precision, recall and prediction of community composition, compared to more limited adaptation schemes. The DOC is therefore particularly useful when analyzing plankton at novel locations or time periods, where community differences are likely to occur. In order to enable an easy implementation of the DOC pipeline, we provide an end-to-end application with graphical user interface, as well as an initial dataset of training images. The DOC pipeline thus allows for high-throughput plankton classification and quick and systematized model adaptation, thus providing the means for highly-accelerated plankton analysis.

Objetivo: determinar la relación entre cognición y capacidad funcional en el adulto mayor.Método: Investigación descriptiva transversal, correlacional, realizada en 2015-2016 en La Libertad (Perú) con 1110 adultos mayores de 60 años y más, ambos sexos, aptos o no física y mentalmente, quienes cumplieron los criterios de inclusión y aceptaron voluntariamente participar en el estudio. Se midieron las variables cognición con el Minimental State Examination (MMSE) de Folstein y cols, la capacidad funcional con el indice de Katz para actividades básicas de la vida diaria (ABVD) y la escala de Lawton y Brody para las actividades instrumentales de la vida diaria (AIVD). Recolectada la información, se hizo un análisis bivariado para determinar la relación entre las variables utilizando la prueba chi cuadrado.Resultados: El mayor porcentaje (22.7%) de los adultos fue 60-64 años, 58.8% mujeres, 47.4% con instrucción primaria, 93.6 % cognición normal, y 83,4 y 60 % fueron independientes en actividades básicas de la vida diaria y en actividades instrumentales de la vida diaria, respectivamente. Existe relación altamente significativa entre cognición y capacidad funcional de las actividades básicas de la vida diaria (x2=206.0 valor p= 0.000) y actividades instrumentales de la vida diaria (x2=289.0 valor p= 0.000).Conclusiones: Existe una íntima relación entre la cognición y la capacidad funcional a través de las actividades de la vida diaria determinantes importantes para el envejecimiento saludable y bienestar en la vejez, y para enfermería son desafíos promover y/o mantener estos determinantes al nivel más alto posible.

Available design codes provide formulations to evaluate the maximum spacing between the cracks, which then is used to calculate the crack width in concrete structures. This paper discusses the parameters controlling the crack spacing and develops an experimental test program on a set of industrial-scale reinforced concrete elements cast with self-healing concretes to be tested under flexural actions. This study provides a wide picture of the limits of maximum, minimum, and average spacing occurring in the beams. A comparison is highlighted between the calculated and experimentally evaluated measures. It was observed that the provisions given in Eurocode 2 and Model code 2010 present a good approach for the calculation, always with a small degree of overestimation for concrete without fibres. On the other hand, the values calculated using recommendations from NFP 18-710, the overestimation is higher. The influence of loading levels seems to not affect the number of cracks with an increase in concrete cover. The experimentally evaluated ranges to relate maximum and minimum spacing with the average value in a loaded region are given. No influence of using self-healing agents was detected.

Purpose. To evaluate the weight of intraocular lenses (IOLs) depending on their material, dioptric power, toricity, focality, and haptic design. Methods. Twenty-eight different IOL models from nine different medical companies (a total of 38 IOLs) and 1 capsular tension ring (CTR) were evaluated. IOLs were weighed using a precision scale, in hydrated conditions, as an approximation to their intraocular status. Results. Hydrophilic IOLs were heavier than hydrophobic lenses (p

We aimed to determine if an adolescent patient presenting with neurological impairment has xeroderma pigmentosum (XP). For this purpose, whole-exome sequencing was performed to assess mutations in XP genes. Dermal fibroblasts were established from a skin biopsy and XPA expression determined by immunoblotting. Nucleotide excision repair (NER) capacity was measured by detection of unscheduled DNA synthesis (UDS) in UVC-irradiated patient fibroblasts. Genetic analysis revealed two recessive mutations in XPA, one known c.682C>T, p.Arg228Ter, and the other c.553C>T, p.Gln185Ter, only two cases were reported. XPA protein was virtually undetectable in lysates from patient-derived fibroblast. The patient had significantly lower UV-induced UDS (3.03 ± 1.95%, p < 0.0001) compared with healthy controls (C5RO = 100 ± 12.2; C1UMN = 118 ± 5.87), indicating significant NER impairment. In conclusion, measurement of NER capacity is beneficial for the diagnosis of XP and in understanding the functional impact of novel mutations in XP genes. Our findings highlight the importance of neurologists considering XP in their differential diagnosis when evaluating patients with atypical neurodegeneration.

Giant aortic aneurysms are rare entities with a high mortality, and only a few cases have been described. Spinal cord ischemia secondary to an aortic aneurysm occurs even more rarely. We present the case of a giant aneurysm of the infrarenal abdominal aorta that was initially manifested through bilateral lower limb weakness.

Purpose – This study aims to propose a theoretical framework and provide empirical evidence on the most successful marketing strategies for obtaining behavioural loyalty in small and medium enterprises (SMEs). Design/methodology/approach – The data are based on 475 telephone surveys conducted among Spanish hairdressers. The authors have used ordinary least squares to estimate the empirical model. Findings – Pricing, services and communication (Web page and in-store communication) are the main drivers of customer loyalty. SMEs have to be cautious with the use of social networks to avoid damaging loyalty. In addition, those positioned at high-price segments should pay more attention to communication on the Web, and all companies should find a balance between in-store communication and the sale of products for use at home. Research limitations/implications – Further research should try to replicate the findings with data from consumers and firms. Practical implications – Service managers need to understand the optimal strategy to succeed in the market. The key insights of this study could also apply to other sectors, such as health, personal care and wellness services. Originality/value – Previous research focussed mainly on large companies, while the role of loyalty in the success of SMEs has been poorly studied, with focus only on the antecedents and the measurement of loyalty. This study contributes to the previous research by analysing the effect of the strategy (price, range of services, communication, size and location) in the achievement of loyalty in SMEs.

Interactions between autotrophic and heterotrophic bacteria are fundamental for marine biogeochemical cycling. How global warming will affect the dynamics of these essential microbial players is not fully understood. The aims of this study were to identify the major groups of heterotrophic bacteria present in a Synechococcus culture originally isolated from the Red Sea and assess their joint responses to experimental warming within the metabolic ecology framework. A co-culture of Synechococcus sp. RS9907 and their associated heterotrophic bacteria, after determining their taxonomic affiliation by 16S rRNA gene sequencing, was acclimated and maintained in the lab at different temperatures (24–34°C). The abundance and cellular properties of Synechococcus and the three dominant heterotrophic bacterial groups (pertaining to the genera Paracoccus, Marinobacter, and Muricauda) were monitored by flow cytometry. The activation energy of Synechococcus, which grew at 0.94–1.38 d–1, was very similar (0.34 ± 0.02 eV) to the value hypothesized by the metabolic theory of ecology (MTE) for autotrophs (0.32 eV), while the values of the three heterotrophic bacteria ranged from 0.16 to 1.15 eV and were negatively correlated with their corresponding specific growth rates (2.38–24.4 d–1). The corresponding carrying capacities did not always follow the inverse relationship with temperature predicted by MTE, nor did we observe a consistent response of bacterial cell size and temperature. Our results show that the responses to future ocean warming of autotrophic and heterotrophic bacteria in microbial consortia might not be well described by theoretical universal rules.

In the past twelve years, digital image colorimetry (DIC) on smartphones has acquired great importance as an alternative to the most common analytical techniques. This analysis method is based on fast, low-cost, and easily-accessible technology, which can provide quantitative information about an analyte through the color changes of a digital image. Despite the fact that DIC is very widespread, it is not exempt from a series of problems that are not fully resolved yet, such as variability of the measurements between smartphones, image format in which color information is stored, power distribution of the illuminant used for the measurements, among others. This article proposes a methodology for the standardization and correction of these problems using self-developed software, together with the use of a 3D printed light box. This methodology is applied to three different colorimetric analyses using different types and brands of smartphones, proving that comparable measurements between devices can be achieved. As color can be related to many target analytes, establishing this measurement methodology can lead to new control analysis applicable to diverse sectors such as alimentary, industrial, agrarian, or sanitary.

The temperature-size Rule (TSR) states that there is a negative relationship between ambient temperature and body size. This rule has been independently evaluated for different phases of the life cycle in multicellular eukaryotes, but mostly for the average population in unicellular organisms. We acclimated two model marine cyanobacterial strains (Prochlorococcus marinus MIT9301 and Synechococcus sp. RS9907) to a gradient of temperatures and measured the changes in population age-structure and cell size along their division cycle. Both strains displayed temperature-dependent diel changes in cell size, and as a result, the relationship between temperature and average cell size varied along the day. We computed the mean cell size of new-born cells in order to test the prediction of the TSR on a single-growth stage. Our work reconciles previous inconsistent results when testing the TSR on unicellular organisms, and shows that when a single-growth stage is considered the predicted negative response to temperature is revealed.

LA OBRA DE ANTONIO AGUSTÍN, VISTA POR GREGORIO MAYANS Y SISCAR

We propose Fast Forest of Flexible Features (F4), a novel approach for classifying multivariate time series, which is aimed to discriminate between underlying generating processes. This goal has barely been addressed in the literature. F4 consists of two steps. First, a set of features based on the quantile cross-spectral density and the maximum overlap discrete wavelet transform are extracted from each series. Second, a random forest is fed with the extracted features. An extensive simulation study shows that F4 outperforms some powerful classifiers in a wide variety of situations, including stationary and nonstationary series. The proposed method is also capable of successfully discriminating between electrocardiogram (ECG) signals of healthy subjects and those with myocardial infarction condition. Additionally, despite lacking shape-based information, F4 attains state-of-the-art results in some datasets of the University of East Anglia (UEA) multivariate time series classification archive.

An essential operation in the mineral processing of copper ores into concentrates is blending, as it guarantees a constant feed for the flotation cells, increases metal recovery rate and reduces tailings. In this study, copper ores from Huelva province (Spain) were investigated by quantitative XRD (X-ray diffraction) methods to optimize blending and detect penalty minerals, which can affect flotation and concentrate quality. The Rietveld method in combination with cluster analysis, PLSR and more traditional chemical analysis provide a more complete and in-depth characterization of the ore and the whole process. The mineralogical monitoring can be fully automated to enable real-time decision making.

A cross-sectional study was conducted to evaluate 199 health sciences students in the city of Iquitos. Their socio-demographic characteristics, lifestyle, level of physical activity, type of food, substance abuse, and prevalence of overweight and obesity were ascertained using purpose-validated questionnaires, i.e., the Systematic Alcohol Consumption Interview (Interrogatorio Sistematizado de Consumos Alcohólicos/ISCA), a questionnaire on the frequency of dietary intake (CFCA), the International Physical Activity Questionnaire (IPAQ), and anthropometric measurements. The prevalence of overweight (body mass index (BMI) of 25.0–29.9 kg/m2) was 26.5% (95% CI = 19.9–33.0%) and that of obesity (BMI ≥ 30.0 kg/m2) was 7.9% (95% CI = 3.8–12.1%). A total of 34.4% of students (95% CI = 27.4–41.4%) presented with a BMI > 25 kg/m2. The frequency of overweight was significantly higher in persons aged over 20 years (OR = 2.5) and smokers (OR = 3.2), and the frequency of obesity was significantly higher in older students (OR = 4.1) and males (OR = 5.5). In conclusion, a considerable proportion of health sciences students in the Amazonia region presented with a high BMI. The proportion of students with overweight was higher among students aged over 20 years and smokers, while that of obesity was also higher among males. In the university setting, the development of more overweight- and obesity-preventive activities and educational interventions would therefore be desirable.

Introducción: El Proyecto Europeo EQUIPT pretende adaptar una herramienta de retorno de la inversión en tabaco para varios países, con el fin de proporcionar información sobre el retorno de invertir en estrategias y justificar la toma de decisiones. El objetivo de este estudio es identificar las necesidades de los usuarios en España para documentar la transferibilidad de la herramienta. Métodos: Entrevistas telefónicas con actores relevantes sobre la implementación de la Herramienta EQUIPT, intención de uso y estrategias de control del tabaco. Resultados: La herramienta puede añadir valor a la información utilizada al tomar decisiones y abogar por políticas coste-efectivas. Como inconvenientes, conocer cómo funcionará la herramienta, así como la formación y el tiempo que requerirá la consistencia y los cálculos internos. Conclusión: Se recogen conocimientos e ideas de los potenciales usuarios para ayudar a adaptar la Herramienta EQUIPT, de modo que proporcione ayuda en la toma de decisiones eficientes.

This paper is part of a wider study focused on divisibility. Participants were prospective elementary teachers. One of the aims of the research is to characterize the meanings of multiple shown by prospective teachers. In this paper, we present the results concerning this aim. We analyse the productions of 37 prospective elementary teachers collected in a practice session, designed and developed in the context of a teaching experiment. We characterize the meanings through the following elements of the didactic analysis: conceptual structure, representation systems and phenomenology. Prospective teachers showed mostly three meanings of multiple: product, relationship and dividend in an exact division.

Abstract: The autor proposes a new method for studying the Catalan vocalic system, which takes into account all the dialects and explais the neutral «e» as an internal necessity of the system.

Este escrito recoge una aproximación al estudio del modelo –como representación- de un profesor sobre fotosíntesis, que hace referencia a la interpretación de la representación gráfica y la explicación oral que construye un maestro que enseña ciencias naturales, en el grado quinto de educación básica primaria, acerca del concepto en mención. La fotosíntesis es considerada un concepto difícil de enseñar y aprender por lo abstracto y extenso (Macías, 2013), estableciéndose en el currículo entre los conceptos esenciales, según las disposiciones del Ministerio de Educación Nacional en Colombia (2006). Desde una metodología cualitativa, se busca explorar el modelo, aplicando técnicas e instrumentos para dar cuenta de: ¿Cuál es el modelo que está presente en el profesor de Ciencias Naturales, sobre el concepto fotosíntesis?. A manera de ejercicio ilustrativo, se muestra el modelo de un profesor, caracterizando dos aspectos: el constituyente ontológico y el epistemológico de su representación, mediante la aplicación del modelo ONEPSI (Gutiérrez 2001; López A., Arcuri G., 2014). Por último, se hace un análisis de las aproximaciones del modelo del profesor, con el modelo científico construido a partir de la revisión teórica, buscando identificar fortalezas y debilidades en la construcción del concepto y sus posibles implicaciones en los procesos de enseñanza y aprendizaje.

Electrohysterography (EHG) has been shown to provide relevant information on uterine activity and could be used for predicting preterm labor and identifying other maternal fetal risks. The extraction of high-quality robust features is a key factor in achieving satisfactory prediction systems from EHG. Temporal, spectral, and non-linear EHG parameters have been computed to characterize EHG signals, sometimes obtaining controversial results, especially for non-linear parameters. The goal of this work was to assess the performance of EHG parameters in identifying those robust enough for uterine electrophysiological characterization. EHG signals were picked up in different obstetric scenarios: antepartum, including women who delivered on term, labor, and post-partum. The results revealed that the 10th and 90th percentiles, for parameters with falling and rising trends as labor approaches, respectively, differentiate between these obstetric scenarios better than median analysis window values. Root-mean-square amplitude, spectral decile 3, and spectral moment ratio showed consistent tendencies for the different obstetric scenarios as well as non-linear parameters: Lempel–Ziv, sample entropy, spectral entropy, and SD1/SD2 when computed in the fast wave high bandwidth. These findings would make it possible to extract high quality and robust EHG features to improve computer-aided assessment tools for pregnancy, labor, and postpartum progress and identify maternal fetal risks.