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207 results on '"Álvarez-Linera, Juan"'

1. Social dysfunction relates to shifts within socioaffective brain systems among Schizophrenia and Alzheimer's disease patients

Author

Braak, Simon, Penninx, Brenda WJH, Su, Tanja, Pijnenburg, Yolande, Nijland, Daphne, Campos, Alba Vieira, de la Torre-Luque, Alejandro, Saris, Ilja M.J., Reus, Lianne M., Beckenstrom, Amy Christine, Malik, Asad, Dawson, Gerard R., Marston, Hugh, Alvarez-Linera, Juan, Ayuso-Mateos, Jose-Luis L., Arango, Celso, van der Wee, Nic, Kas, Martien J., and Aghajani, Moji

Published
2024
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8. Reversed hierarchy in the brain for general and specific cognitive abilities: A morphometric analysis

Author

Román, Francisco J, Abad, Francisco J, Escorial, Sergio, Burgaleta, Miguel, Martínez, Kenia, Álvarez‐Linera, Juan, Quiroga, María Ángeles, Karama, Sherif, Haier, Richard J, and Colom, Roberto

Subjects
Neurosciences, Mind and Body, Clinical Research, Adolescent, Adult, Brain, Cognition, Factor Analysis, Statistical, Female, Gray Matter, Humans, Individuality, Intelligence, Intelligence Tests, Magnetic Resonance Imaging, Male, Models, Psychological, Neuropsychological Tests, Organ Size, Psychometrics, Signal Processing, Computer-Assisted, Young Adult, intelligence, Voxel-based Morphometry, surface-based morphometry, cortical surface area, cortical thickness, Cognitive Sciences, Experimental Psychology
Abstract

Intelligence is composed of a set of cognitive abilities hierarchically organized. General and specific abilities capture distinguishable, but related, facets of the intelligence construct. Here, we analyze gray matter with three morphometric indices (volume, cortical surface area, and cortical thickness) at three levels of the intelligence hierarchy (tests, first-order factors, and a higher-order general factor, g). A group of one hundred and four healthy young adults completed a cognitive battery and underwent high-resolution structural MRI. Latent scores were computed for the intelligence factors and tests were also analyzed. The key finding reveals substantial variability in gray matter correlates at the test level, which is substantially reduced for the first-order and the higher-order factors. This supports a reversed hierarchy in the brain with respect to cognitive abilities at different psychometric levels: the greater the generality, the smaller the number of relevant gray matter clusters accounting for individual differences in intelligent performance.

Published
2014

10. Role of cortical excitatory/inhibitory imbalance in autism spectrum disorders from a symptom severity trajectories framework: a study protocol

Author

Colomar, Laura, primary, Cáceres, Antonia San José, additional, Álvarez-Linera, Juan, additional, González-Peñas, Javier, additional, Patón, Abigail Huertas, additional, de Blas, Daniel Martín, additional, Arrondo, Ana Paloma Polo, additional, Solís, Andrea, additional, Jones, Emily, additional, and Parellada, Mara, additional

Published
2023
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12. Functional dissociations between prefrontal and parietal cortex during task switching: A combined fMRI and TMS study

Author

Periáñez, José A., primary, Viejo-Sobera, Raquel, additional, Lubrini, Genny, additional, Álvarez-Linera, Juan, additional, Rodríguez Toscano, Elisa, additional, Moreno, María Dolores, additional, Arango, Celso, additional, Redolar-Ripoll, Diego, additional, Muñoz Marrón, Elena, additional, and Ríos-Lago, Marcos, additional

Published
2022
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13. The Effect of the Normalization Strategy on Voxel-Based Analysis of DTI Images: A Pattern Recognition Based Assessment

Author

Díaz, Gloria, Pajares, Gonzalo, Romero, Eduardo, Alvarez-Linera, Juan, López, Eva, Hernández-Tamames, Juan Antonio, Malpica, Norberto, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Sudan, Madhu, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Vardi, Moshe Y., Series editor, Weikum, Gerhard, Series editor, Goebel, Randy, editor, Siekmann, Jörg, editor, Wahlster, Wolfgang, editor, Yao, Yiyu, editor, Sun, Ron, editor, Poggio, Tomaso, editor, Liu, Jiming, editor, Zhong, Ning, editor, and Huang, Jimmy, editor

Published
2010
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17. Glycemia in Acute Stroke II study: a call to improve post‐stroke hyperglycemia management in clinical practice

Author

Fuentes, B., Sanz‐Cuesta, B. E., Gutiérrez‐Fernández, M., Martínez‐Sánchez, P., Lisbona, A., Madero‐Jarabo, R., Delgado‐Mederos, R., Gállego‐Cullere, J., Rodríguez‐Yáñez, M., Martínez‐Zabaleta, M., Freijo, M., Alonso de Leciñana, M., Portilla, J. C., Gil‐Núñez, A., Díez‐Tejedor, E., Ruiz‐Ares, Gerardo, Rodríguez‐Frutos, Berta, Ramos‐Cejudo, Jaime, Otero‐Ortega, Laura, Prefasi, Daniel, Mangas‐Guijarro, María Ángeles, Pallardo, Luis Felipe, Frutos, Remedios, Fernández‐Prieto, Andres, Madero, Rosario, Almirón, Mariana Díaz, García‐Sánchez, Juan Manuel, Gállego, Jaime, Aymerich, Nuria, Blanco, Miguel, Díez‐González, Noemí, de Arce, Ana, González, Félix, Martí‐Fábregas, Joan, Fernández‐Fournier, Mireya, Díaz‐Otero, Fernando, and Álvarez‐Linera, Juan

Published
2017
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23. Epilepsy surgery in children with developmental tumours

Author

García-Fernández, Marta, Fournier-Del Castillo, Concepción, Ugalde-Canitrot, Arturo, Pérez-Jiménez, Ángeles, Álvarez-Linera, Juan, De Prada-Vicente, Inmaculada, Suárez-Rodríguez, Jesús, Bernabeu-Verdú, Jordi, and Villarejo-Ortega, Francisco

Published
2011
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24. In vivo neurometabolic profiling in orthostatic tremor

Author

Benito-León, Julián, Louis, Elan D., Mato-Abad, Virginia, Dydak, Ulrike, Álvarez-Linera, Juan, Hernández-Tamames, Juan Antonio, Molina-Arjona, José Antonio, Malpica, Norberto, Matarazzo, Michele, Romero, Juan Pablo, and Sánchez-Ferro, Álvaro

Published
2016
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27. Neocortical Age and Fluid Ability: Greater Accelerated Brain Aging for Thickness, but Smaller for Surface Area, in High Cognitive Ability Individuals

Author

Santonja, Javier, primary, Román, Francisco J., additional, Martínez, Kenia, additional, Escorial, Sergio, additional, Álvarez-Linera, Juan, additional, Privado, Jesús, additional, Quiroga, Mª Ángeles, additional, Santarnecchi, Emiliano, additional, Iturria-Medina, Yasser, additional, and Colom, Roberto, additional

Published
2021
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34. Predicting conversion to multiple sclerosis by assessing cognitive impairment in radiologically isolated syndrome

Author

Domingo-Santos, Ángela, primary, Labiano-Fontcuberta, Andrés, additional, Aladro-Benito, Yolanda, additional, Martínez-Ginés, M Luisa, additional, Ayuso-Peralta, Lucía, additional, Puertas-Martín, Verónica, additional, Cerezo-García, Marta, additional, Higueras-Hernández, Yolanda, additional, Mato-Abad, Virginia, additional, Álvarez-Linera, Juan, additional, Hernández-Tamames, Juan Antonio, additional, and Benito-León, Julián, additional

Published
2021
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38. Epilepsy Associated with Temporal Pole Encephaloceles

Author

Martinez-Poles, Javier, primary, Toledano, Rafael, additional, Jiménez-Huete, Adolfo, additional, García-Morales, Irene, additional, Aledo-Serrano, Ángel, additional, Anciones, Carla, additional, Campo, Pablo, additional, Álvarez-Linera, Juan, additional, and Gil-Nagel, Antonio, additional

Published
2020
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41. Autores

Author

Álvarez-Linera, Juan, Astillero-López, Verónica, Báez, Sandra, Bajo, Miriam, Beato-Fernández, Luis, Bernabeu, Purificación, Blanco, Amalio, Blanco, Rubén, Botella, Cristina, Bretón-López, Juani, Briñol, Pablo, Colom, Roberto, Couto, Blas, Díaz, Darío, Fernández-Abascal, Enrique, Fernández-Berrocal, Pablo, Flores-Cuadrado, Alicia, Gandarillas, Beatriz, Castillo, José Antonio García del, Gascó, Margarita, Ibáñez, Agustín, de la Rosa-Prieto, Carlos, Latorre-Postigo, José Miguel, Lázaro, Miguel, Leal, César, Martínez-Marcos, Alino, Mayordomo, Teresa, Meléndez, Juan Carlos, Miret, Marta, Moreno, Lorena, Navarro-Bravo, Beatriz, Neipp, M.ª Carmen, Nieto, Marta, Valenzuela, M.ª Pilar Pamplona, Peñacoba, Cecilia, Pellicer, Olga, Pons, Nieves, Quero, Soledad, Ramos-Fuentes, María Isabel, Requero, Blanca, Ricarte-Trives, Jorge Javier, Rodríguez-Cano, Teresa, Rodríguez-Marín, Jesús, Rodríguez-Santos, Laura, Ros, Laura, Saiz-Sánchez, Daniel, Sales, Alicia, Sancho-Bielsa, Francisco, Santos, David, Satorres, Encarnación, Serrano, Juan Pedro, Simón, Teresa, Sitges, Esther, Stavraki, María, Tirado, Sonia, Úbeda-Bañón, Isabel, Hofstadt, Carlos J. van-der, and Vaz-Leal, Francisco J.

Published
2021
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45. Resting state functional MRI reveals abnormal network connectivity in orthostatic tremor

Author

Benito Léon, Julián, Louis, Elan D., Manzanedo, Eva, Hernández-Tamames, Juan Antonio, Álvarez-Linera, Juan, Molina-Arjona, José Antonio, Matarazzo, Michele, Romero Muñoz, Juan Pablo, Domínguez-González, Cristina, Domingo-Santos, Ángela, and Sánchez-Ferro, Álvaro

Subjects
Functional connectivity, Magnetic resonance imaging, Case–control study, Orthostatic tremor
Abstract

Very little is known about the pathogenesis of orthostatic tremor (OT). We have observed that OT patientsmight have deficits in specific aspects of neuropsychological function, particularly those thought to rely on the integrity of the prefrontal cortex, which suggests a possible involvement of frontocerebellar circuits. We examined whether resting-state functional magnetic resonance imaging (fMRI) might provide further insights into the pathogenesis on OT. Resting-state fMRI data in 13 OT patients (11 women and 2 men) and 13 matched healthy controls were analyzed using independent component analysis, in combination with a “dual-regression” technique, to identify group differences in several resting-state networks (RSNs). All participants also underwent neuropsychological testing during the same session. Relative to healthy controls, OT patients showed increased connectivity in RSNs involved in cognitive processes (default mode network [DMN] and frontoparietal networks), and decreased connectivity in the cerebellumand sensorimotor networks.Changes in network integrity were associated not onlywith duration (DMN and medial visual network), but also with cognitive function. Moreover, in at least 2 networks (DMN and medial visual network), increased connectivity was associated with worse performance on different cognitive domains (attention, executive function, visuospatial ability, visual memory, and language). In this exploratory study, we observed selective impairments ofRSNs inOT patients. This and other future resting-state fMRI studiesmight provide a novelmethod to understand the pathophysiological mechanisms of motor and nonmotor features of OT. post-print 619 KB

Published
2016

46. In vivo neurometabolic profiling in orthostatic tremor

Author

Benito-León, J., Elan D., Louis, Mato-Abad, Virginia, Dydak, Ulrike, Álvarez-Linera, Juan, Hernández-Tamames, Juan Antonio, Molina-Arjona, José Antonio, Malpica, Norberto, Matarazzo, Michele, Romero Muñoz, Juan Pablo, and Sánchez-Ferro, Álvaro

Subjects
Magnetic resonance imaging, Proton magnetic, nervous system, Case–control study, Cerebellum, Orthostatic tremor, Resonance spectroscopy, Pathophysiology
Abstract

The pathogenesis of orthostatic tremor (OT) remains unclear, although some evidence points to dysfunction in the brainstem or cerebellum. We used single voxel proton magnetic resonance spectroscopy (1H-MRS) (3 T) to investigate whether neurochemical changes underlie abnormal cerebellar or cortical function in OT. Fourteen OT patients and 14 healthy controls underwent 1H-MRS studies with voxels placed in midparietal gray matter and cerebellum (vermis and central white matter). Spectral analysis was analyzed using the software package LCModel (version 6.3). The absolute metabolite concentrations and ratios of total N-acetylaspartate+N-acetylaspartyl glutamate (NAA), choline-containing compounds, myoinositol, and glutamate+glutamine to creatine were calculated. In midparietal gray matter spectra, we found a significant decrease in the absolute concentration of NAA in OT patients versus healthy controls (7.76±0.25 vs 8.11±0.45, P=0.017). A similar decrease in NAA was seen in the cerebellar vermis (7.33±0.61 vs 8.55±1.54, P=0.014) and cerebellar white matter (8.54±0.79 vs 9.95±1.57, P=0.010). No differences in the other metabolites or their ratios were observed. Reductions in both cerebral cortical and cerebellar NAA suggest that there is neuronal damage or loss in OT, raising the intriguing question as to whether OT is a neurodegenerative disease. Along with clinical history and electrophysio0logical examination, 1H-MRS could serve as a useful diagnostic aid for OT. post-print 338 KB

Published
2016

47. Altered Functional Connectivity in Essential Tremor

Author

Benito León, Julián, Louis, Elan D., Romero Muñoz, Juan Pablo, Hernández Tamames, J.A., Manzanedo Sáenz, Eva, Álvarez Linera, Juan, Bermejo Pareja, Félix, Posada Rodríguez, Ignacio Javier, and Rocón de Lima, Eduardo

Subjects
Informática, Male, Medicina, Essential Tremor, Robótica e Informática Industrial, Observational Study, Brain, Middle Aged, Neuropsychological Tests, Magnetic Resonance Imaging, Case-Control Studies, Humans, Female, Nerve Net, Research Article
Abstract

Essential tremor (ET) has been associated with a spectrum of clinical features, with both motor and nonmotor elements, including cognitive deficits. We employed resting-state functional magnetic resonance imaging (fMRI) to assess whether brain networks that might be involved in the pathogenesis of nonmotor manifestations associated with ET are altered, and the relationship between abnormal connectivity and ET severity and neuropsychological function. Resting-state fMRI data in 23 ET patients (12 women and 11 men) and 22 healthy controls (HC) (12 women and 10 men) were analyzed using independent component analysis, in combination with a “dual-regression” technique, to identify the group differences of resting-state networks (RSNs) (default mode network [DMN] and executive, frontoparietal, sensorimotor, cerebellar, auditory/language, and visual networks). All participants underwent a neuropsychological and neuroimaging session, where resting-state data were collected. Relative to HC, ET patients showed increased connectivity in RSNs involved in cognitive processes (DMN and frontoparietal networks) and decreased connectivity in the cerebellum and visual networks. Changes in network integrity were associated not only with ET severity (DMN) and ET duration (DMN and left frontoparietal network), but also with cognitive ability. Moreover, in at least 3 networks (DMN and frontoparietal networks), increased connectivity was associated with worse performance on different cognitive domains (attention, executive function, visuospatial ability, verbal memory, visual memory, and language) and depressive symptoms. Further, in the visual network, decreased connectivity was associated with worse performance on visuospatial ability. ET was associated with abnormal brain connectivity in major RSNs that might be involved in both motor and nonmotor symptoms. Our findings underscore the importance of examining RSNs in this population as a biomarker of disease.

Published
2015

49. Effect of water T2 shortening in the quantification of in-vitro proton MR spectroscopy

Author

Hernández-Tamames, Juan Antonio, Mato-Abad, Virginia, García-Álvarez, Roberto, González-Zabaleta, Javier, Pereira-Loureiro, Javier, and Álvarez-Linera, Juan

Subjects
Iron, Metabolite quantification, Magnetic resonance spectroscopy, Water T2 relaxation time
Abstract

Short communication [Abstract] PURPOSE. This work studies the relationship between in-vitro Proton Magnetic Resonance Spectroscopy metabolite quantification and water T2 decay. MATERIALS AND METHODS. An in-vitro correspondence is established between the iron accumulation and the shortening of water T2 relaxation times using seven spherical phantoms, 6 of them were doped with an increasing concentration of iron metal nanoparticles solution. This is later proposed as a source of error during the LCModel metabolite quantification of either absolute concentrations or ratios. RESULTS. The Pearson's correlation coefficient between water T2 values against absolute metabolite concentrations was on average [r] = 0.97 and on average [r] = 0.85 for metabolite ratios. CONCLUSION. These results suggest that the shortening of T2 values should be taken into account when performing metabolite quantification. Also, the need of demonstrated similar results in in-vivo studies, since the presence of iron deposits or other factors affecting the water T2 decay measurements could explain part of the inter-subject variability in the metabolite concentration and ratio quantification.

Published
2015

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