Search

Your search keyword '"Álvarez-Doforno, Rita"' showing total 8 results
Start Over Author "Álvarez-Doforno, Rita"
8 results on '"Álvarez-Doforno, Rita"'

2. Actin polymerisation after FCγR stimulation of human fibroblasts is BCL10 independent

Author

Garcia-Gomez, Sonia, Alvarez Doforno, Rita, Martinez-Barricarte, Rubén, Torres, Juan Manuel, Ferreira Cerdan, Antonio, Davila, Marian, Hernández-Jiménez, Enrique, Toledano, Victor, Cubillos-Zapata, Carolina, Vallejo-Cremades, María Teresa, López-Collazo, Eduardo, Fernández Arquero, Miguel, Sánchez-Ramón, Silvia, Casanova, Jean-Laurent, and Pérez de Diego, Rebeca

Published
2016
Full Text
View/download PDF

4. Case report: lupus nephritis with autoantibodies to complement alternative pathway proteins and C3 gene mutation

Author

Ministerio de Economía y Competitividad (España), Comunidad de Madrid, Nozal, Pilar, Garrido, Sofía, Martínez-Ara, Jorge, Picazo, María Luz, Yébenes, Laura, Álvarez-Doforno, Rita, Pinto, Sheila, Rodríguez de Córdoba, Santiago, López Trascasa, Margarita, Ministerio de Economía y Competitividad (España), Comunidad de Madrid, Nozal, Pilar, Garrido, Sofía, Martínez-Ara, Jorge, Picazo, María Luz, Yébenes, Laura, Álvarez-Doforno, Rita, Pinto, Sheila, Rodríguez de Córdoba, Santiago, and López Trascasa, Margarita

Abstract

[Background] Glomerulonephritis is one of the most severe complications of lupus, a systemic disease with multi-organ involvement, with tissue damage produced mainly by complement activation. As a result of this activation, patients with active lupus present hypocomplementemia during disease flares, but C3 and C4 levels are recovered between episodes., [Case presentation] We present a patient who suffered two lupus nephritis episodes in 5 years, achieving complete remission with treatment after both of them, but with C3 levels persistently below normal range. Genetic study revealed that the patient carried a mutation in heterozygosis in the C3 gene. Serial sera samples were analyzed, and autoantibodies to complement alternative pathway proteins (Factor I, Factor B, C3 and Properdin) were found. Functional assays showed that these autoantibodies cause alternative pathway activation., [Conclusion] This case is the first reported of a heterozygous C3 mutation associated with lupus nephritis and autoantibodies against complement alternative pathway proteins (Factor I, Factor B, C3 and Properdin).These autoantibodies cause activation of this pathway and this fact could explain that the tissue damage is restricted to the kidney.

Published
2015

7. Taller de Autoinmunidad 2013 de la Sociedad Española de Inmunología. Anticuerpos anticitoplasma de neutrófilo (ANCA)

Author

Julià Benique, M. Rosa, primary, Martínez García, Pedro, additional, Villegas Martín, Eduardo, additional, Carrasco Sayalero, Ángela, additional, Sánchez Ibarrola, Alfonso, additional, Ocaña Pérez, Esther, additional, Marcaida Benito, Goitzane, additional, Rodríguez Delgado, Juana, additional, Martínez Becerra, María José, additional, Laporta Martín, Paz, additional, Fernández Pereira, Luis, additional, Pacho de Lucas, María Aránzazu, additional, Jiménez Garófano, Carmen, additional, Vinyas Gomis, Odette, additional, Garcia, Mila, additional, Dieli Crimi, Romina, additional, Eiras Martínez, Pablo, additional, Bas, Jordi, additional, Muñoz Calleja, Cecilia, additional, García Marcos, Margarita, additional, Calleja Antolín, Sara, additional, López Hoyos, Marcos, additional, Espárrago Rodilla, Manuel, additional, Gelpí Sabater, Carmen, additional, Prada Iñurrategui, Álvaro, additional, Sáez, Raquel, additional, Ontañón Rodríguez, Jesús, additional, Alcalá Peña, M. Inmaculada, additional, Vargas Pérez, M. Luisa, additional, Jurado Roger, Aurora, additional, Vlagea, Alexandru, additional, Pastor Barellas, Rosa María, additional, Roy Ariño, Garbiñe, additional, Jiménez Jiménez, Juana, additional, Muñoz Vico, Francisco Javier, additional, Martínez Cáceres, Eva M., additional, Pascual-Salcedo Pascual, Dora, additional, Álvarez Doforno, Rita, additional, Serrano, Antonio, additional, Paz Artal, Estela, additional, Torio Gómez, Silvina, additional, Cid Fernández, José Javier, additional, Mozo Avellaned, Lourdes, additional, Barrios del Pino, Yvelise, additional, Alarcón Torres, Inmaculada, additional, Rodríguez Mahou, Margarita, additional, Montes Ares, Olga, additional, Torio Ruiz, Alberto, additional, Almeida González, Delia, additional, Plaza López, Aresio, additional, Rodríguez Hernández, Carmen, additional, Aparicio Hernández, María Belén, additional, Marín Sánchez, Ana, additional, García Pacheco, José Marcos, additional, Montes Cano, Marco Antonio, additional, González Rodríguez, Concepción, additional, Jaimez Gámiz, Laura, additional, Rodríguez Gutiérrez, Juan Francisco, additional, Alsina Donadeu, Montserrat, additional, Pujalte Mora, Francisco, additional, and Amengual Guedan, María José, additional

Published
2013
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results