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3. Consensus statement on the use of alemtuzumab in daily clinical practice in Spain

Author

Meca-Lallana, J.E., Fernández-Prada, M., García Vázquez, E., Moreno Guillén, S., Otero Romero, S., Rus Hidalgo, M., Villar Guimerans, L.M., Eichau Madueño, S., Fernández Fernández, Ó., Izquierdo Ayuso, G., Álvarez Cermeño, J.C., Arnal García, C., Arroyo González, R., Brieva Ruiz, L., Calles Hernández, C., García Merino, A., González Plata, M., Hernández Pérez, M.Á., Moral Torres, E., Olascoaga Urtaza, J., Oliva-Nacarino, P., Oreja-Guevara, C., Ortiz Castillo, R., Oterino, A., Prieto González, J.M., Ramió-Torrentá, L., Rodríguez-Antigüedad, A., Saiz, A., Tintoré, M., and Montalbán Gairin, X.

Published
2022
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4. Consenso de expertos sobre el uso de alemtuzumab en la práctica clínica diaria en España

Author

Meca-Lallana, J.E., Fernández-Prada, M., García Vázquez, E., Moreno Guillén, S., Otero Romero, S., Rus Hidalgo, M., Villar Guimerans, L.M., Eichau Madueño, S., Fernández Fernández, Ó., Izquierdo Ayuso, G., Álvarez Cermeño, J.C., Arnal García, C., Arroyo González, R., Brieva Ruiz, L., Calles Hernández, C., García Merino, A., González Platas, M., Hernández Pérez, M.Á., Moral Torres, E., Olascoaga Urtaza, J., Oliva-Nacarino, P., Oreja-Guevara, C., Ortiz Castillo, R., Oterino, A., Prieto González, J.M., Ramió-Torrentá, L., Rodríguez-Antigüedad, A., Saiz, A., Tintoré, M., and Montalbán Gairin, X.

Published
2022
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10. Assessment of the reproducibility of oligoclonal IgM band detection for its application in daily clinical practice

Author

Espiño, M., Abraira, V., Arroyo, R., Bau, L., Cámara, C., Campos-Ruiz, L., Casanova, B., Espejo, C., Fernández, O., García-Merino, A., García-Sánchez, M.I., Gómez, M., Gosis, A., Izquierdo, G., Meca, J., Montalban, X., Morandeira, F., Olascoaga, J., Prada, A., Quintana, E., Ramió-Torrentà, Ll., Rodríguez-Antigüedad, A., Salgado, G., Santiago, J.L., Sarasola, E., Simó-Castelló, M., Alvarez-Cermeño, J.C., and Villar, L.M.

Published
2015
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20. Diagnostic Value of Cerebrospinal Fluid Neurofilament Light Protein in Neurology: A Systematic Review and Meta-analysis

Author

Bridel, C. (Claire), Van Wieringen, W.N. (Wessel N.), Zetterberg, H. (Henrik), Tijms, B.M. (Betty M.), Teunissen, C.E. (Charlotte), Álvarez-Cermeño, J.C. (José C), Andreasson, U. (Ulf), Axelsson, M. (Markus), Bäckström, D.C. (David C.), Bartos, A. (Ales), Bjerke, M. (Maria), Blennow, K. (Kaj), Boxer, A.L. (Adam), Brundin, L. (Lou), Burman, J. (Joachim), Christensen, T. (Tove), Fialová, L. (Lenká), Forsgren, L. (Lars), Frederiksen, H., Gisslén, M. (Magnus), Gray, E. (Elizabeth), Gunnarsson, M. (Martin), Hall, S. (Sara), Hansson, O. (Oskar), Herbert, M.K. (Megan K.), Jakobsson, J. (Joel), Jessen-Krut, J. (Jan), Janelidze, S. (Shorena), Johannsson, G., Jonsson, M. (Michael), Kappos, L. (Ludwig), Khademi, M. (Mohsen), Khalil, M. (Michael), Kuhle, J. (Jens), Landén, M. (Mikael), Leinonen, V. (Ville), Logroscino, G. (Giancarlo), Lu, C.-H. (Ching-Hua), Lycke, J. (Jan), Magdalinou, N. (Nadia), Malaspina, A. (Andrea), Mattsson, N. (Niklas), Meeter, L.H.H. (Lieke), Mehta, S.R. (Sanjay R.), Modvig, S. (Signe), Olsson, T., Paterson, R.W. (Ross W.), Pérez-Santiago, J. (Josué), Piehl, F. (Fredrik), Pijnenburg, Y.A.L. (Yolande), Pyykkö, O.T. (Okko T.), Ragnarsson, O. (Oskar), Rojas, J.C. (Julio C.), Romme Christensen, J. (Jeppe), Sandberg, L. (Linda), Scherling, C.S. (Carole S.), Schott, J.M. (Jonathan M.), Sellebjerg, F. (Finn), Simone, I.L. (Isabella L.), Skillbäck, T. (Tobias), Stilund, M. (Morten), Sundström, P. (Peter), Svenningsson, A. (Anders), Tortelli, R. (Rosanna), Tortorella, C. (Carla), Trentini, A. (Alessandro), Troiano, M. (Maria), Turner, M.R. (Martin R.), Swieten, J.C. (John) van, Vågberg, M. (Mattias), Verbeek, M.M. (Marcel), Villar, L.M. (Luisa María), Visser, P. (Pim), Wallin, A. (Anders), Weiss, A. (Andreas), Wikkelsø, C. (Carsten), Wild, E.J. (Edward J.), Bridel, C. (Claire), Van Wieringen, W.N. (Wessel N.), Zetterberg, H. (Henrik), Tijms, B.M. (Betty M.), Teunissen, C.E. (Charlotte), Álvarez-Cermeño, J.C. (José C), Andreasson, U. (Ulf), Axelsson, M. (Markus), Bäckström, D.C. (David C.), Bartos, A. (Ales), Bjerke, M. (Maria), Blennow, K. (Kaj), Boxer, A.L. (Adam), Brundin, L. (Lou), Burman, J. (Joachim), Christensen, T. (Tove), Fialová, L. (Lenká), Forsgren, L. (Lars), Frederiksen, H., Gisslén, M. (Magnus), Gray, E. (Elizabeth), Gunnarsson, M. (Martin), Hall, S. (Sara), Hansson, O. (Oskar), Herbert, M.K. (Megan K.), Jakobsson, J. (Joel), Jessen-Krut, J. (Jan), Janelidze, S. (Shorena), Johannsson, G., Jonsson, M. (Michael), Kappos, L. (Ludwig), Khademi, M. (Mohsen), Khalil, M. (Michael), Kuhle, J. (Jens), Landén, M. (Mikael), Leinonen, V. (Ville), Logroscino, G. (Giancarlo), Lu, C.-H. (Ching-Hua), Lycke, J. (Jan), Magdalinou, N. (Nadia), Malaspina, A. (Andrea), Mattsson, N. (Niklas), Meeter, L.H.H. (Lieke), Mehta, S.R. (Sanjay R.), Modvig, S. (Signe), Olsson, T., Paterson, R.W. (Ross W.), Pérez-Santiago, J. (Josué), Piehl, F. (Fredrik), Pijnenburg, Y.A.L. (Yolande), Pyykkö, O.T. (Okko T.), Ragnarsson, O. (Oskar), Rojas, J.C. (Julio C.), Romme Christensen, J. (Jeppe), Sandberg, L. (Linda), Scherling, C.S. (Carole S.), Schott, J.M. (Jonathan M.), Sellebjerg, F. (Finn), Simone, I.L. (Isabella L.), Skillbäck, T. (Tobias), Stilund, M. (Morten), Sundström, P. (Peter), Svenningsson, A. (Anders), Tortelli, R. (Rosanna), Tortorella, C. (Carla), Trentini, A. (Alessandro), Troiano, M. (Maria), Turner, M.R. (Martin R.), Swieten, J.C. (John) van, Vågberg, M. (Mattias), Verbeek, M.M. (Marcel), Villar, L.M. (Luisa María), Visser, P. (Pim), Wallin, A. (Anders), Weiss, A. (Andreas), Wikkelsø, C. (Carsten), and Wild, E.J. (Edward J.)

Abstract

Importance: Neurofilament light protein (NfL) is elevated in cerebrospinal fluid (CSF) of a number of neurological conditions compared with healthy controls (HC) and is a candidate biomarker for neuroaxonal damage. The influence of age and sex is largely unknown, and levels across neurological disorders have not been compared systematically to date. Objectives: To assess the associations of age, sex, and diagnosis with NfL in CSF (cNfL) and to evaluate its potential in discriminating clinically similar conditions. Data Sources: PubMed was searched for studies published between January 1, 2006, and January 1, 2016, reporting cNfL levels (using the search terms neurofilament light and cerebrospinal fluid) in neurological or psychiatric conditions and/or in HC. Study Selection: Studies reporting NfL levels measured in lumbar CSF using a commercially available immunoassay, as well as age and sex. Data Extraction and Synthesis: Individual-level data were requested from study authors. Generalized linear mixed-effects models were used to estimate the fixed effects of age, sex, and diagnosis on log-transformed NfL levels, with cohort of origin modeled as a random intercept. Main Outcome and Measure: The cNfL levels adjusted for age and sex across diagnoses. Results: Data were collected for 10059 individuals (mean [SD] age, 59.7 [18.8] years; 54.1% female). Thirty-five diagnoses were identified, including inflammatory diseases of the central nervous system (n = 2795), dementias and predementia stages (n = 4284), parkinsonian disorders (n = 984), and HC (n = 1332). The cNfL was elevated compared with HC in a majority of neurological conditions studied. Highest levels were observed in cognitively impaired HIV-positive individuals (iHIV), amyotrophic lateral sclerosis, frontotemporal dementia (FTD), and Huntington disease. In 33.3% of diagnoses, including HC, multiple sclerosis, Alzheimer disease (AD), and Parkinson disease (PD), cNfL was higher in men than women. The cNfL incr

Published
2019
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23. A guide to treating gait impairment with prolonged-release fampridine (Fampyra ® ) in patients with multiple sclerosis

Author

Ramió-Torrentà, L., primary, Álvarez-Cermeño, J.C., additional, Arroyo, R., additional, Casanova-Estruch, B., additional, Fernández, O., additional, García-Merino, J.A., additional, Hernández, M.A., additional, Izquierdo, G., additional, Martínez-Yélamos, S., additional, Meca, J., additional, Moral, E., additional, Olascoaga, J., additional, Prieto, J.M., additional, and Saiz, A., additional

Published
2018
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24. Guía de tratamiento del deterioro de la marcha con fampridina de liberación prolongada (Fampyra ® ) en pacientes con esclerosis múltiple

Author

Ramió-Torrentà, L., primary, Álvarez-Cermeño, J.C., additional, Arroyo, R., additional, Casanova-Estruch, B., additional, Fernández, O., additional, García-Merino, J.A., additional, Hernández, M.A., additional, Izquierdo, G., additional, Martínez-Yélamos, S., additional, Meca, J., additional, Moral, E., additional, Olascoaga, J., additional, Prieto, J.M., additional, and Saiz, A., additional

Published
2018
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25. Guía de tratamiento del deterioro de la marcha con fampridina de liberación prolongada (Fampyra®) en pacientes con esclerosis múltiple

Author

Ramió-Torrentà, L., Álvarez-Cermeño, J.C., Arroyo, R., Casanova-Estruch, B., Fernández, O., García-Merino, J.A., Hernández, M.A., Izquierdo, G., Martínez-Yélamos, S., Meca, J., Moral, E., Olascoaga, J., Prieto, J.M., and Saiz, A.

Abstract

La alteración de la marcha es frecuente en la esclerosis múltiple (EM) y tiene un gran impacto negativo en los pacientes pues conlleva a la pérdida progresiva de autonomía personal y social, y de productividad laboral. Esta guía pretende establecer recomendaciones para la evaluación del deterioro de la marcha y el uso de fampridina de liberación prolongada (fampridina-LP) como tratamiento de pacientes con EM y deterioro de la marcha en España.

Published
2024
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26. Utility of oligoclonal IgG band detection for MS diagnosis in daily clinical practice

Author

Abraira, V., Alvarez-Cermeño, J.C., Arroyo, R., Cámara, C., Casanova, B., Cubillo, S., de Andrés, C., Espejo, C., Fernández, O., Ferrer, J., Figueredo, M.A., García-Merino, A., García-Sánchez, M.I., García-Trujillo, J.A., Gómez, M., González-Oria, C., Gosis, A., Izquierdo, G., Jímenez, J., López-Trascasa, M., Montalbán, X., Moreno, M.J., Muñoz, D., Nuñez, V., Muriel, A., Navarro, J., Olascoaga, J., Oreja-Guevara, C., Prada, A., Ramil, E., Ramo-Tello, C., Rodríguez, C., Rodríguez, E., Rodríguez-Frías, F., Rodríguez-Antigüedad, A., Rodríguez-Molina, J.J., Ruiz, E., Saiz, A., Sarasola, E., Simó, M., Yagüe, J., and Villar, L.M.

Published
2011
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30. The expression of integrins on activated T-cells in multiple sclerosis. Effect of intravenous methylprednisolone treatment.

Author

Luján, S., Masjuan, J., Roldán, E., Villar, L.M., González-Porqué, P., and Álvarez-Cermeño, J.C.

Subjects
DRUGS, LYMPHOCYTES, MULTIPLE sclerosis, CELL adhesion molecules, INTEGRINS
Abstract

We studied the effect of intravenous methylprednisolone (MP) on the expression of the integrins, LFA-1 and VLA-4, on activated blood T-lymphocytes in 17 patients with relapses of clinically definite relapsing-remitting MS. MP treatment did not induce changes in the expression of CD3, CD4, DR, LFA-1 or VLA-4 markers when measured in the total population of lymphocytes in MS patients in relation to treatment. Treatment influenced neither the LFA-1 nor VLA-4 positive cells within the CD3+ population. MP treatment clearly decreased the DR+ CD3+ cells (P<0.01) and the percentage of DR+ CD3+ lymphocytes bearing VLA-4 (P<0.01). However, this was not the case when we studied the percentage of lymphocytes which expressed LFA-1. Glucocorticoids did not influence the mean intensity of the expression of the two integrins quantified in either total or DR+ CD3+ lymphocytes. Although, further research seems warranted to investigate a possible effect of MP on lymphocyte integrin function, this work corroborates the idea that MP treatment may interfere with the mechanisms of T-cell migration into CNS, thus modulating the activity of multiple sclerosis. [ABSTRACT FROM AUTHOR]

Published
1998

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