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Antigen tests or polymerase chain reaction (PCR) amplification are currently COVID-19 diagnostic tools. However, developing complementary diagnosis tools is mandatory. Thus, we performed a plasma cytokine array in COVID-19 patients to identify novel diagnostic biomarkers. A discovery–validation study in two independent prospective cohorts was performed. The discovery cohort included 136 COVID-19 and non-COVID-19 patients recruited consecutively from 24 March to 11 April 2020. Forty-five cytokines’ quantification by the MAGPIX system (Luminex Corp., Austin, TX, USA) was performed in plasma samples. The validation cohort included 117 patients recruited consecutively from 15 to 25 April 2020 for validating results by ELISA. COVID-19 patients showed different levels of multiple cytokines compared to non-COVID-19 patients. A single chemokine, IP-10, accurately identified COVID-19 patients who required hospital admission (AUC: 0.962; 95%CI (0.933–0.992); p < 0.001)). The results were validated in an independent cohort by multivariable analysis (OR: 25.573; 95%CI (8.127–80.469); p < 0.001) and AUROC (AUC: 0.900; 95%CI (0.846–0.954); p < 0.001). Moreover, showing IP-10 plasma levels over 173.35 pg/mL identified COVID-19 with higher sensitivity (86.20%) than the first SARS-CoV-2 PCR. Our discover–validation study identified IP-10 as a robust biomarker in clinical practice for COVID-19 diagnosis at hospital. Therefore, IP-10 could be used as a complementary tool in clinical practice, especially in emergency departments.

Tras el surgimiento de nuevas demandas de formación y/o capacitación, nace la necesidad de evaluar el desempeño académico de los estudiantes de CEIPA, Business School, tras la incorporación de su propio modelo pedagógico centrado en el constructivismo con el propósito de brindarle las habilidades necesarias para razonar, hacer cálculos y resolver operaciones numéricas de manera rápida y sistemática dentro del competitivo y globalizado mercado laboral. En principio, se desarrolló un estudio comparativo sobre el desempeño académico en la competencia cuantitativa dentro del ámbito universitario y luego, se implementó una metodología cuantitativa de tipo exploratoria y explicativa, tomando como muestra 543 estudiantes. Para los resultados, se hicieron tablas elaboradas por el Software SPSS de acuerdo con cada tipo de evaluación: debates, exámenes y trabajos. Los resultados muestran que no existen diferencias estadísticamente significativas bajo los regímenes de estudio presencial y virtual, principalmente en la evaluación de los aprendizajes a partir de los exámenes y trabajos. Sin embargo, en los debates no existe la misma simetría, pues se muestra un mayor desempeño en la modalidad virtual., After the emergence of new training and / or training demands, the need arose to evaluate the academic performance of CEIPA, Business School students, after the incorporation of their own pedagogical model focused on constructivism; with the purpose of providing you with the necessary skills to reason, do calculations and solve numerical operations quickly and systematically within the competitive and globalized labor market. In principle, a comparative study is developed on academic performance in quantitative competence within the university environment and then, a quantitative methodology of an exploratory and explanatory type is followed, taking as a sample 543 students. For the results, tables prepared by the SPSS Software were made according to each type of evaluation: debates, exams and assignments. The results show that there are no statistically significant differences under the face-to-face and virtual study regimes, mainly in the evaluation of learning from exams and assignments. However, in the debates there is not the same symmetry, on the contrary, a higher performance is shown in the virtual mode.

The digital resources called Memoria Digital de Canarias (mdc) and Biblioteca Digital (bd), managed by the libraries of the University of Las Palmas de Gran Canaria and the University of La Laguna (Teneriffe) respectively are assessed. An intensive exploration of its interfaces is made and the determining data of its operation are detailed, from which a final assessment is presented in which the different conception of what a digital library is and the guidelines that distinguish both sources are taken into account., Se evalúan los recursos digitales denominados Memoria Digital de Canarias (mdc) y Biblioteca Digital (bd), gestionados por las bibliotecas de las universidades de Las Palmas de Gran Canaria y de La Laguna (Tenerife), respectivamente. Se hace una exploración intensiva de sus interfaces y se detallan los datos determinantes de su funcionamiento, a partir de los cuales se presenta una valoración final en la que se tiene en cuenta la concepción dispar de qué es una biblioteca digital y las líneas directrices que diferencian ambos recursos.