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1. Türkiye’de akciğer kanseri hastalarında uyku bozuklukları

Author

Yılmaz Bülbül, Sibel Özkurt, Hadice Selimoglu Sen, Serap Argun Baris, Hulya Gunbatar, Hidir Esme, Zehra Yasar, Mehmet Muharrem Erol, Selvi Asker, Ozlem Oruc, Makbule Ozlem Akbay, Serhat Erol, Serdar Berk, Ufuk Yilmaz, Perran Fulden Yumuk, Melike Ozcelik, Durdu Mehmet Yavsan, Gulfidan Cakmak, Ahmet Emin Erbaycu, Arife Ulas, Gamze Kirkil, Buğra Kerget, Neslihan Özçelik, Yurdanur Erdogan, Hüseyin Can, Talat Kilic, Tevfik Özlü, Mehmet Besiroglu, Ilknur Basyigit, Dursun Tatar, Berna Akıncı Özyürek, Fahrettin Talay, Leyla Saglam, Levent Cem Mutlu, Ümran Toru, Sibel Arinc, Aysegul Senturk, Yavuz Selim Intepe, Sibel Ayik, Ayse Dalli, Murat Acat, Ayse Bahadir, Turgut Teke, Turgut Teke: 0000-0001-5955-6255, Durdu Mehmet Yavşan: 0000-0002-3334-1026, Necmettin Erbakan Üniversitesi, Meram Tıp Fakültesi, Dahili Tıp Bilimleri, Göğüs Hastalıkları Anabilim Dalı, [Bulbul, Yilmaz -- Ozlu, Tevfik -- Ozcelik, Neslihan] Karadeniz Tech Univ, Farabi Hosp, Dept Chest Dis, Fac Med, Trabzon, Turkey -- [Arinc, Sibel -- Akbay, Makbule O. -- Oruc, Ozlem] Istanbul Sureyyapasa Chest Dis & Chest Surg Train, Clin Chest Dis, Istanbul, Turkey -- [Akinci Ozyurek, Berna -- Senturk, Aysegul -- Erdogan, Yurdanur] Ankara Ataturk Chest Dis & Chest Surg Training &, Clin Chest Dis, Ankara, Turkey -- [Gunbatar, Hulya -- Asker, Selvi] Yuzuncu Yil Univ, Fac Med, Dept Chest Dis, Van, Turkey -- [Bahadir, Ayse] Istanbul Yedikule Chest Dis & Chest Surg Training, Clin Chest Dis, Istanbul, Turkey -- [Ozcelik, Melike] Istanbul Lutfi Kirdar Kartal Training & Res Hosp, Div Med Oncol, Istanbul, Turkey -- [Yilmaz, Ufuk -- Alizoroglu, Dursun -- Erol, Serhat -- Erbay, Ahmet Emin] Izmir Dr Suat Seren Chest Dis & Chest Surg Traini, Clin Chest Dis, Izmir, Turkey -- [Saglam, Leyla -- Kerget, Bugra] Ataturk Univ, Fac Med, Dept Chest Dis, Erzurum, Turkey -- [Kilic, Talat] Inonu Univ, Turgut Ozal Med Ctr, Dept Chest Dis, Malatya, Turkey -- [Kirkil, Gamze] Firat Univ, Fac Med, Dept Chest Dis, Elazig, Turkey -- [Argun Baris, Serap] Kocaeli Univ, Fac Med, Dept Chest Dis, Kocaeli, Turkey -- [Yavsan, Durdu M. -- Teke, Turgut] Necmettin Erbakan Univ, Dept Chest Dis, Fac Med, Konya, Turkey -- [Sen, Hadice S.] Dicle Univ, Dept Chest Dis, Fac Med, Diyarbakir, Turkey -- [Berk, Serdar] Cumhuriyet Univ, Fac Med, Dept Chest Dis, Sivas, Turkey -- [Acat, Murat] Karabuk Univ, Dept Chest Dis, Fac Med, Karabuk, Turkey -- [Cakmak, Gulfidan] Istanbul Haseki Training & Res Hosp, Clin Chest Dis, Istanbul, Turkey -- [Yumuk, Perran F. -- BesIroglu, Mehmet] Marmara Univ, Div Med Oncol, Fac Med, Istanbul, Turkey -- [Intepe, Yavuz Selim] Bozok Univ, Fac Med, Dept Chest Dis, Yozgat, Turkey -- [Toru, Umran] Dumlupinar Univ, Dept Chest Dis, Fac Med, Kutahya, Turkey -- [Oktem Ayik, Sibel -- Dalli, Ayse] Izmir Katip Celebi Univ, Dept Chest Dis, Fac Med, Izmir, Turkey -- [Ozkurt, Sibel] Pamukkale Univ, Dept Chest Dis, Fac Med, Denizli, Turkey -- [Mutlu, Levent C.] Namik Kemal Univ, Dept Chest Dis, Fac Med, Tekirdag, Turkey -- [Yasar, Zehra -- Talay, Fahrettin] Abant Izzet Baysal Univ, Dept Chest Dis, Fac Med, Bolu, Turkey -- [Esme, Hidir] Meram Training & Res Hosp, Clin Thorac Surg, Konya, Turkey -- [Erol, Mehmet M.] Uludag Univ, Dept Thorac Surg, Fac Med, Bursa, Turkey -- [Ulas, Arife] Ataturk Educ & Res Hosp, Clin Med Oncol, Ankara, Turkey -- [Can, Huseyin] Izmir Katip Celebi Univ, Fac Med, Dept Family Med, Izmir, Turkey, intepe, yavuz selim -- 0000-0002-5697-5291, Acat, Murat -- 0000-0002-7163-4882, Yumuk, Perran Fulden -- 0000-0001-8650-299X, Bulbul, Yilmaz -- 0000-0002-8488-3650, BAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Talay, Fahrettin, and Yaşar, Zehra

Subjects
Male, cancer pain, Lung Neoplasms, Palliative care, Turkey, insomnia, Female, Humans, Lung Neoplasms/*complications/therapy, Middle Aged, Palliative Care, Prevalence, Prospective Studies, Sleep Wake Disorders/*epidemiology/etiology, Turkey/epidemiology, Critical Care and Intensive Care Medicine, Edmonton Symptom Assessment System, lung tumor, 0302 clinical medicine, İnsomni, middle aged, Insomnia, Medicine, Uyku bozukluğu, Prospective cohort study, sleep disorder, Sleep disorder, adult, Kulak, daytime somnolence, clinical trial, sleep quality, anxiety, nausea, Sleep in non-human animals, aged, comorbidity, Semptom, female, risk factor, 030220 oncology & carcinogenesis, Anesthesia, depression, Lung cancer, medicine.symptom, nocturia, prospective study, Sleep Wake Disorders, Pulmonary and Respiratory Medicine, medicine.medical_specialty, palliative therapy, Symptom, Burun, Sleep disturbance, Pain, complication, İnsomnia, Article, 03 medical and health sciences, Solunum Sistemi, turkey (bird), Internal medicine, sleep disturbance, symptom, pain, dyspnea, Akciğer kanseri, cross-sectional study, Kulak, Burun, Boğaz, Symptom control, In patient, human, Dispne, coughing, non small cell lung cancer, Sleep quality, Boğaz, business.industry, cancer staging, questionnaire, Advanced stage, interview, Cancer, medicine.disease, major clinical study, body weight loss, multicenter study, Dyspnea, quality of life, Multicenter study, Ağrı, fatigue, Surgery, small cell lung cancer, business, 030217 neurology & neurosurgery
Abstract

WOS:000455820300004, PubMed ID: 30683024, Introduction: Sleep quality is known to be associated with the distressing symptoms of cancer. The purpose of this study was toanalyze the impact of cancer symptoms on insomnia and the prevalence of sleep-related problems reported by the patients with lung cancer in Turkey. Materials and Methods: Assesment of Palliative Care in Lung Cancer in Turkey (ASPECT) study, a prospective multicenter study conducted in Turkey with the participation of 26 centers and included all patients with lung cancer, was re-evaluated in terms of sleep problems, insomnia and possible association with the cancer symptoms. Demographic characteristics of patients and information about disease were recorded for each patient by physicians via face-to-face interviews, and using hospital records. Patients who have difficulty initiating or maintaining sleep (DIMS) is associated with daytime sleepiness/fatigue were diagnosed as having insomnia. Daytime sleepiness, fatigue and lung cancer symptoms were recorded and graded using the Edmonton Symptom Assessment Scale. Results: Among 1245 cases, 48.4% reported DIMS, 60.8% reported daytime sleepiness and 82.1% reported fatigue. The prevalence of insomnia was 44.7%. Female gender, patients with stage 3-4 disease, patients with metastases, with comorbidities, and with weight loss 5 kg had higher rates of insomnia. Also, patients with insomnia had significantly higher rates of pain, nausea, dyspnea, and anxiety. Multivariate logistic regression analysis showed that patients with moderate to severe pain and dyspnea and severe anxiety had 2-3 times higher rates of insomnia. Conclusion: In conclusion, our results showed a clear association between sleep disturbances and cancer symptoms. Because of that, adequate symptom control is essential to maintain sleep quality in patients with lung cancer., Giriş: Uyku kalitesinin, kanser semptomlarının şiddetiyle ilişkili olduğu bilinmektedir. Bu çalışmada, Türkiye’de akciğer kanseri hastalarında uyku ile ilişkili sorunların prevalansı ve kanser semptomlarının insomnia üzerine etkisinin araştırılması amaçlandı. Materyal ve Metod: Türkiye’de 26 merkezin katılımıyla gerçekleştirilen, akciğer kanserli olguların dahil edildiği çok merkezli bir çalışma olan ASPECT çalışması verileri, bu hastalarda görülen uyku sorunları, insomni ve bunların kanser semptomları ile ilişkisi yönüyle yeniden değerlendirildi. Hastaların demografik özellikleri ve hastalıkları hakkında bilgi, hasta ile yüz yüze görüşülerek ve hastane kayıtları aracılığıyla derlendi. Uykuyu başlatma ve sürdürme zorluğu (DIMS) ile gündüz artmış uyku hali veya yorgunluk tanımlayan olgular insomni olarak değerlendirildi. Gündüz uyku hali, yorgunluk ve akciğer kanseri semptomları Edmonton Semptom Değerlendirme Skalası kullanılarak kaydedildi. Bulgular: Katılan 1245 olgunun, %48.4’ünde DIMS, %60.8’inde gündüz uyku hali ve %82.1’inde yorgunluk mevcuttu. Insomni prevalansı %44.7 olarak bulundu. Kadın cinsiyet, evre 3-4 hastalık, metastatik hastalık, komorbid hastalıklar ve kilo kaybı 5 kg olan olgularda insomnia oranı anlamlı olarak daha yüksekti. Diğer yandan insomnisi olan hastalarda ağrı, bulantı, dispne ve anksiyete semptomları anlamlı düzeyde yüksek bulundu. Multivariate lojistik regresyon analizi, orta ileri şiddetli ağrısı ve dispnesi olan, ayrıca ciddi anksiyetesi olan hastalarda insomni sıklığının 2-3 kat fazla olduğunu ortaya koydu. Sonuç: Çalışmamız, kanser semptomları ile uyku kalitesi arasında yakın bir ilişki olduğunu ortaya koymuştur. Bu nedenle, akciğer kanserli hastalarda kaliteli bir uyku için, kanser semptomların yeterince kontrol edilmesi gereklidir.

Published
2018

2. Prognostic importance of central thrombus in hemodynamically stable patients with pulmonary embolism

Author

Sevinc Sarinc Ulasli, Servet Kayhan, Serap Duru, Ebru Çakır, Aygül Güzel, Aysegul Senturk, Ezgi Demirdogen, Fatih Yakar, Serdar Berk, Savas Ozsu, RTEÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kayhan, Servet, Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Hastalıkları Anabilim Dalı., Demirdöǧen, Ezgi, AAH-9812-2021, OMÜ, and [Senturk, Aysegul] Ankara Ataturk Training & Res Hosp, Dept Pulm Med, TR-06800 Ankara, Turkey -- [Ozsu, Savas] Karadeniz Tech Univ, Sch Med, Dept Pulm Med, Trabzon, Turkey -- [Duru, Serap] Ankara Diskapi Training & Res Hosp, Dept Pulm Med, Ankara, Turkey -- [Cakir, Ebru] Trakya Univ, Sch Med, Dept Pulm Med, Edirne, Turkey -- [Ulasli, Sevinc Sarinc] Afyon Kocatepe Univ, Sch Med, Dept Pulm Med, Afyon, Turkey -- [Demirdogen, Ezgi] Uludag Univ, Sch Med, Dept Pulm Med, Bursa, Turkey -- [Kayhan, Servet] Recep Tayyip Erdogan Univ, Sch Med, Dept Pulm Med, Rize, Turkey -- [Guzel, Aygul] 19 Mayis Univ, Sch Med, Dept Pulm Med, Samsun, Turkey -- [Yakar, Fatih] Bezmi Alem Univ, Sch Med, Dept Pulm Med, Istanbul, Turkey -- [Berk, Serdar] Cumhuriyet Univ, Sch Med, Dept Pulm Med, Sivas, Turkey

Subjects
Male, Hemoptysis, Chi square distribution, Turkey, Epidemiology, Peripheral occlusive artery disease, Procedures, Time factor, 0302 clinical medicine, Observational study, Medicine, Treatment outcome, Aged, 80 and over, General Medicine, Central thrombus, Multicenter study, Clinical trial, cardiovascular system, Diagnostic imaging, Lung embolism, Cardiology and Cardiovascular Medicine, Combİnatİon, Anticoagulant agent, Human, medicine.medical_specialty, Metaanalysİs, Burden, Major clinical study, Article, Fibrinolytic therapy, Multidetector computed tomography, 03 medical and health sciences, Thrombolysİs, medicine.artery, Faintness, Humans, Aged, Time factors, Computed tomographic angiography, Pulmonary embolism, Very elderly, Follow up, medicine.disease, Pulmonary artery, Thrombolytic therapy, Dyspnea, 030228 respiratory system, Risk factors, Bİomarkers, Computed tomography angiography, Comparative study, Risk factor, Cardiac & cardiovascular systems, 030204 cardiovascular system & hematology, Lung Embolism, Embolectomy, Blood Clot Lysis, Hemodynamically stable, Fibrinolytic agents, Heparin, low-molecular-weight, Middle aged, Thorax pain, Low molecular weight heparin, Mortality rate, Multidetector ct, Heparin, Odds ratio, Cardiology, Female, Radiology, Thrombus, medicine.drug, Adult, Proportional hazards models, medicine.drug_class, Fibrinolytic agent, Proportional hazards model, Pathophysiology, Anticoagulation, Internal medicine, Computer assisted tomography, cardiovascular diseases, Prospective study, Mortality, Emergency-department, Risk stratİfİcatİon, business.industry, Hemodynamics, Anticoagulants, Thrombosis, Arterial occlusive diseases, Chi-square distribution, Cardiovascular system & cardiology, Young adult, Multivariate analysis, Therapy, business, Heparİn, Controlled study
Abstract

WOS: 000414152700007, PubMed ID: 28248408, Background: The association between mortality and localization of central thrombus in hemodynamically stable patients with pulmonary embolism (PE) is unclear. Sufficient data are not available to help clinicians to select between low molecular weight heparin (LMWH), unfractionated heparin (UFH) and thrombolytics for the management of central thrombus. The present study aims to investigate whether central thrombus in the pulmonary artery affects 30-day mortality rate, and to compare the outcomes of different treatment approaches in patients with central thrombus. Methods: This multi-central, prospective, observational study included 874 hemodynamically stable patients with PE confirmed by multidetector computed tomography scan. The localization of the emboli was evaluated and categorized as central (saddle or at least one main pulmonary artery), lobar or distal. The primary study outcome was 30-day all-cause mortality. Results: Localization of the emboli was central in 319 (36.5%) patients, lobar in 264 (30.2%) and distal in 291 (33.2%) patients. Seventy-four (8.5%) patients died during the 30-day follow-up period. All-cause mortality rate was 11.9%, 6.8% and 6.2% in patients with central, lobar, and distal emboli, respectively (p < 0.001). Multivariate analysis did not show that hemodynamically stable central thrombus was an independent predictor of mortality. Additionally, mortality rate was not significantly different between UFH, LMWH and thrombolytic therapy groups. Conclusions: The present study showed that central thrombus was not an independent predictor of mortality in hemodynamically stable PE patients. LMWH and UFH were similarly effective in the treatment of this patient group.

Published
2017

3. Should Low-Molecular-Weight Heparin be Preferred over Unfractionated Heparin after Thrombolysis for Severity Pulmonary Embolism?

Author

Aysegul Senturk, Bulent Altinsoy, Tevfik Özlü, Hadice Selimoglu Sen, Esra Ekbic Kadioglu, Gul Dabak, Savas Ozsu, Serdar Berk, Elif Yilmazel Ucar, Ebru Çakır, Zonguldak Bülent Ecevit Üniversitesi, [Ozlu, T. -- Ozsu, S.] Karadeniz Tech Univ, Sch Med, Trabzon, Turkey -- [Senturk, A.] Ankara Ataturk Training & Res Hosp, Ankara, Turkey -- [Ucar, E. Y.] Ataturk Univ, Sch Med, Erzurum, Turkey -- [Berk, S.] Cumhuriyet Univ, Sch Med, Sivas, Turkey -- [Altinsoy, B.] Bulent Ecevit Univ, Sch Med, Zonguldak, Turkey -- [Dabak, G.] Istanbul Kartal Kosuyolu Yuksek Ihtisas Training, Istanbul, Turkey -- [Cakir, E.] Trakya Univ, Sch Med, Edirne, Turkey -- [Kadioglu, E. E.] Erzurum Reg Training & Res Hosp, Erzurum, Turkey -- [Sen, H. S.] Dicle Univ, Sch Med, Diyarbakir, Turkey, Altinsoy, Bulent -- 0000-0002-2481-0978, and [Senturk, Aysegul] Ankara Ataturk Training & Res Hosp, Dept Pulm Med, Ankara, Turkey -- [Ucar, Elif Yilmazel] Ataturk Univ, Sch Med, Dept Pulm Med, Erzurum, Turkey -- [Berk, Serdar] Cumhuriyet Univ, Sch Med, Dept Pulm Med, Sivas, Turkey -- [Ozlu, Tevfik -- Ozsu, Savas] Karadeniz Tech Univ, Sch Med, Dept Pulm Med, Trabzon, Turkey -- [Altinsoy, Bulent] Bulent Ecevit Univ, Sch Med, Dept Pulm Med, Zonguldak, Turkey -- [Dabak, Gul] Istanbul Kartal Kosuyolu Yuksek Ihtisas Training, Dept Pulm Med, Istanbul, Turkey -- [Cakir, Ebru] Trakya Univ, Sch Med, Dept Pulm Med, Edirne, Turkey -- [Kadioglu, Esra Ekbic] Erzurum Reg Training & Res Hosp, Dept Pulm Med, Erzurum, Turkey -- [Sen, Hadice Selimoglu] Dicle Univ, Sch Med, Dept Pulm Med, Diyarbakir, Turkey

Subjects
medicine.medical_specialty, medicine.drug_class, medicine.medical_treatment, Low molecular weight heparin, 030204 cardiovascular system & hematology, Severity of Illness Index, 03 medical and health sciences, 0302 clinical medicine, Humans, Medicine, Thrombolytic Therapy, pulmonary thromboembolism, 030212 general & internal medicine, Intensive care medicine, low-molecular-weight heparin, Aged, business.industry, Hematology, General Medicine, Thrombolysis, Heparin, Heparin, Low-Molecular-Weight, Middle Aged, medicine.disease, unfractionated heparin, Pulmonary embolism, Anesthesia, Acute Disease, Pulmonary Embolism, business, medicine.drug
Abstract

International Conference of the American-Thoracic-Society (ATS) -- MAY 15-20, 2015 -- Denver, CO, WOS: 000377582806299, …, Amer Thorac Soc

Published
2014

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