1. Anti-Inflammatory Action of Dietary Wild Olive (Acebuche) Oil in the Retina of Hypertensive Mice
- Author
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Santiago Milla-Navarro, Pedro de la Villa, Claudia Reyes-Goya, Helder André, Alfonso Mate, Carmen Vázquez, Álvaro Santana-Garrido, Agencia Estatal de Investigación (España), Ministerio de Ciencia e Innovación (España), Junta de Andalucía, Universidad de Sevilla, Ministerio de Ciencia, Innovación y Universidades (España), [Santana-Garrido,A, Reyes-Goya,C, Vázquez,CM, Mate,A] Departamento de Fisiología, Facultad de Farmacia, Universidad de Sevilla, Sevilla, Spain. [Santana-Garrido,A, Mate,A] Epidemiología Clínica y Riesgo Cardiovascular, Instituto de Biomedicina de Sevilla (IBIS), Hospital Universitario Virgen del Rocío/Consejo Superior de Investigaciones Científicas/ Universidad de Sevilla, Sevilla, Spain. [Milla-Navarro,S, de la Villa,P] Department of Systems Biology, University of Alcalá, Madrid, Spain. [de la Villa,P] Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain. [André,H] Department of Clinical Neuroscience, St. Erik Eye Hospital, Karolinska Institutet, Stockholm, Sweden., This research and the APC were funded by Agencia Estatal de Investigación, Ministerio de Ciencia e Innovación, Gobierno de España (PID2019-109002RB-I00/AEI/10.13039/501100011033), Consejería de Economía, Conocimiento, Empresas y Universidad, Junta de Andalucía (2020/275 and 2021/188, CTS-584), and VI PPIT Universidad de Sevilla (IV.7 Ayuda Suplementaria a Grupos de Investigación por captación de fondos en las convocatorias de proyectos de investigación del Plan Estatal, 2020/1163). AS is recipient of an FPU predoctoral fellowship from Ministerio de Universidades (FPU17/03465). CR-G was supported by Ministerio de Ciencia e Innovación, Ayudas para la Promoción de Empleo Joven e Implantación de la Garantía Juvenil en I + D+i 2017–2020 (PEJ2018-004474-A)., Universidad de Sevilla. Departamento de Fisiología, and Agencia Estatal de Investigación. España AEI/10.13039/501100011033
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retina ,Health (social science) ,Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Intercellular Signaling Peptides and Proteins::Cytokines::Interleukins::Interleukin-6 [Medical Subject Headings] ,Diseases::Eye Diseases [Medical Subject Headings] ,Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Amino Acids::Amino Acids, Basic::Arginine::Nitroarginine [Medical Subject Headings] ,Plant Science ,Pharmacology ,Health Professions (miscellaneous) ,acebuche ,Organisms::Eukaryota::Animals [Medical Subject Headings] ,medicine.diagnostic_test ,digestive, oral, and skin physiology ,Acebuche ,Dietary supplements ,olive oil ,Aceite de oliva ,Wild olive tree ,medicine.anatomical_structure ,Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Amino Acids::Amino Acids, Basic::Arginine::NG-Nitroarginine Methyl Ester [Medical Subject Headings] ,Suplementos dietéticos ,Technology and Food and Beverages::Food and Beverages::Food::Dietary Supplements [Medical Subject Headings] ,medicine.symptom ,Erg ,Diseases::Eye Diseases::Ocular Hypertension [Medical Subject Headings] ,Chemicals and Drugs::Biological Factors::Biological Markers::Biomarkers, Pharmacological [Medical Subject Headings] ,Arterial hypertension ,arterial hypertension ,medicine.drug_class ,Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::DNA-Binding Proteins::Receptors, Cytoplasmic and Nuclear::Peroxisome Proliferator-Activated Receptors [Medical Subject Headings] ,Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Intercellular Signaling Peptides and Proteins::Cytokines::Interleukins::Interleukin-1 [Medical Subject Headings] ,Inflammation ,TP1-1185 ,Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Inflammatory Agents [Medical Subject Headings] ,Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Diet [Medical Subject Headings] ,Microbiology ,Organisms::Eukaryota::Plants::Viridiplantae::Streptophyta::Embryophyta::Angiosperms::Oleaceae::Olea [Medical Subject Headings] ,Anti-inflammatory ,Retina ,Article ,Proinflammatory cytokine ,Coroides ,Downregulation and upregulation ,Olea ,Hipertensión ,medicine ,wild olive tree ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Techniques, Ophthalmological::Electroretinography [Medical Subject Headings] ,Anatomy::Sense Organs::Eye::Uvea::Choroid [Medical Subject Headings] ,Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Mice [Medical Subject Headings] ,Inflamación ,business.industry ,Choroid ,Chemical technology ,Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Multienzyme Complexes::Prostaglandin-Endoperoxide Synthases::Cyclooxygenase 2 [Medical Subject Headings] ,inflammation ,Anatomy::Sense Organs::Eye::Retina [Medical Subject Headings] ,Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Intercellular Signaling Peptides and Proteins::Cytokines::Interleukins::Interleukin-10 [Medical Subject Headings] ,business ,Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Inflammation [Medical Subject Headings] ,Olive oil ,Food Science ,Electroretinography - Abstract
This article belongs to the Special Issue Extraction, Characterization and Biological Activity of Food Bioactive Compounds., Inflammation plays a crucial role in the course of eye diseases, including many vascular retinopathies. Although olive oil is known to have beneficial effects against inflammatory processes, there is no information available on the anti-inflammatory potential of the wild olive tree (namely, acebuche (ACE) for the primitive Spanish lineages). Here we investigate the anti-inflammatory effects of ACE oil in the retina of a mouse model of arterial hypertension, which was experimentally induced by administration of L-NAME (NG-nitro-L-arginine-methyl-ester). The animals were fed supplements of ACE oil or extra virgin olive oil (EVOO, for comparative purposes). Retinal function was assessed by electroretinography (ERG), and different inflammation-related parameters were measured in the retina and choroid. Besides significant prevention of retinal dysfunction shown in ERG recordings, ACE oil-enriched diet upregulated the expression of the anti-inflammatory markers PPARγ, PPARα and IL-10, while reducing that of major proinflammatory biomarkers, IL-1β, IL-6, TNF-α and COX-2. This is the first report to highlight the anti-inflammatory properties of an ACE oil-enriched diet against hypertension-related retinal damage. Noteworthy, dietary supplementation with ACE oil yielded better results compared to a reference EVOO., This research and the APC were funded by Agencia Estatal de Investigación, Ministerio de Ciencia e Innovación, Gobierno de España (PID2019-109002RB-I00/AEI/10.13039/501100011033); Consejería de Economía, Conocimiento, Empresas y Universidad, Junta de Andalucía (2020/275 and 2021/188; CTS-584); and VI PPIT Universidad de Sevilla (IV.7 Ayuda Suplementaria a Grupos de Investigación por captación de fondos en las convocatorias de proyectos de investigación del Plan Estatal, 2020/1163). AS is recipient of an FPU predoctoral fellowship from Ministerio de Universidades (FPU17/03465). CR-G was supported by Ministerio de Ciencia e Innovación, Ayudas para la Promoción de Empleo Joven e Implantación de la Garantía Juvenil en I + D+i 2017–2020 (PEJ2018-004474-A).
- Published
- 2021