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Günümüzde toplumsal, örgütsel, teknolojik ve politik alanda ortaya çıkan ve çalışma hayatını etkileyen değişiklikler, bazı açılardan çalışanları olumsuz etkileyebilmektedir. Bu olumsuzluklardan biri olan ve bu çalışmada üzerinde durulacak olan konu iş güvencesizliğidir. Bu kapsamda araştırmada iki soruya cevap aranmıştır. Bu sorulardan ilki, otel işletmeleri çalışanlarının iş güvencesizliği algısının hangi düzeyde olduğu ile ilgili iken; ikincisi sosyodemografik değişkenlerin iş güvencesizliği algısı üzerinde hangi yönde ve ne derece etkisi olduğu ile ilgilidir. Nicel araştırma yönteminin kullanıldığı araştırmada, Antalya ilinde bulunan otel işletmeleri çalışanları ile yüz yüze görüşülmüş ve anket tekniği ile veri toplanmıştır. İlk araştırma sorusunun cevabını verebilmek için ölçek ortalaması hesaplanmış; ikinci sorunun cevabı ise ikili lojistik regresyon analizi ile tespit edilmeye çalışılmıştır. Elde edilen sonuçlar otel işletmeleri çalışanlarının anket yapılan dönem itibariyle düşük seviyede iş güvencesizliği algısı taşıdıklarını göstermektedir. Ayrıca cinsiyet ve gelir düzeyinin iş güvencesizliği algısını etkilediği tespit edilmiştir. Buna göre erkek ve alt gelir grubunda yer alan çalışanların daha fazla iş güvencesizliği algısı taşıdıkları ifade edilebilir. Çalışmada, ulaşılan sonuçlara göre uygulayıcılara çeşitli öneriler sunulmuştur.

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The purpose of this study is to investigate the effects of anxiety sensitivity in adolescents on childhood depression and anxiety disorder. Mood disorders and anxiety disorders in children and adolescents can be given examples of important research topics in recent years. The participants of the study consist of 670 students in Erzurum city. The data were collected through anxiety sensitivity index and anxiety and depression index for children and adolescents. For data analysis, correlation analysis and structural equation model were used. The results revealed that anxiety sensitivity impacts anxiety disorder and childhood depression through direct and indirect effects in a positive way. The results are discussed in line with the relevant literature.

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Akademik başarının, bireylerin öğrencilik yaşamlarına başlamaları ile birlikte her aşamada elde edebilmek için çaba gösterdikleri en öncelikli hedeflerden biri olduğu söylenebilir. Akademik başarıyı olumlu ya da olumsuz birçok faktör etkilemektedir. Bu araştırmada kaygı düzeyi ve akademik özyeterlik inancının akademik başarı üzerindeki etkisi araştırılmıştır. Bu kapsamda lisans düzeyinde turizm eğitimi verilen bir yükseköğretim kurumunda yüz yüze görüşme yöntemine göre anket tekniği ile 256 öğrenciden veri toplanmıştır. Elde edilen verilere açıklayıcı faktör analizi uygulanmış ve doğrulayıcı faktör analizi ile de modelin uygunluğu test edilmiştir. Değişkenler arasındaki ilişkileri inceleyebilmek amacı ile korelasyon analizi ve aşamalı regresyon analizi yapılmıştır. Sonuçlara göre akademik başarının, akademik özyeterlik inancı ve kaygı düzeyinin alt boyutlarından olan başarısızlık hissi ile anlamlı ilişkisi vardır. Regresyon analizi sonuçları ise akademik başarı üzerinde, akademik özyeterlik inancının daha büyük yordama gücüne sahip olduğunu göstermektedir.

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The construct of fragility of happiness, which is not a theory-driven construct, refers to the idea that happiness is fleeting and can simply turn into unhappiness. This study investigated for the first time the psychometric properties of the Turkish version of the Fragility of Happiness Scale (FOHS) among university students, focusing on its internal consistency, factor structure, discriminant validity, convergent validity and predictive validity. Data were collected from two student samples (online sample, n = 228; paper-pencil sample, n = 200). Participants completed measures of fragility of happiness, fear of happiness, externality of happiness and life satisfaction either as online questionnaires or a paper-pencil version of the questionnaires. FOHS demonstrated good internal consistency. Results of exploratory and confirmatory yielded a one-factor model. The results also supported convergent, divergent and predictive validity. These results suggest that the FOHS is a reliable and valid instrument among Turkish university students. It can be used for research purposes and in clinical practices. WOS:000672999800001 2-s2.0-85110584597

Giriş: Serviks kanseri, kadınlarda gözlenen malign tümörler arasında en yaygın görülen ve kadınlarda kanser sonucu gözlenen ölümler arasında ikinci sırada bulunan önemli bir hastalıktır. Platin temelli bir bileşik olan sisplatin (CDDP) bu kanserin tedavisinde sıklıkla kullanılan kemoterapötik ajanlardan birisidir ve sarkomlar ile solid tümörlerin tedavisinde etkili bir şekilde kullanılmaktadır. CDDP DNA’ya çapraz bağlanıp replikasyonu engelleyerek hasar oluşumuna neden olur. Bunun sonucunda da apoptotik yolaklar aktive olur ve hücre ölümü gerçekleşir. Çalışmamızda CDDP’nin, mTOR, AKT, Siklin D1 (CCND1) ve STAT3 genlerinin mRNA ifadesindeki etkisini serviks kanseri hücre hattı HeLa üzerinde araştırmayı amaçladık. Yöntem: Bu çalışmada HeLa hücrelerine 24 ve 48 saat süre ile değişen konsantrasyonlarda sisplatin uygulandı. Hücre canlılığı XTT yöntemi ile belirlendi. Ayrıca, seçilen CDDP dozlarının uygulanmasından sonra, mTOR, AKT, CCND1 ve STAT-3 genlerinin mRNA ifadesi qPCR yöntemi ile araştırıldı. Bulgular: CDDP’nin IC50 değerinin 24 saat için yaklaşık 60 uM, 48 saat için ise yaklaşık 8 uM olduğunu belirledik. Ayrıca, analizi yapılan genlerin ifadelerinin sadece 24 saat uygulamadan sonra azaldığını bulduk. Diğer taraftan, 48 saat CDDP uygulamasının mRNA ifadesi açısından istatistiksel açıdan anlamlı bir farkılılığa neden olmadığını gösterdik. Sonuç: Sonuç olarak, CDDP uygulamasından sonra, uygulama süresi açısından değişen, farklı mRNA ifade örüntülerinin olduğunu bulduk. Konvensiyonel kemoterapötik olan CDDP’nin hücre sağkalım yolakları üzerindeki etkisinin ortaya çıkarılması açısından çalışmamız literatüre katkı sağlamaktadır. Objective: Cervical cancer is one of the most tumors seen in womans and second leading cause of cancer death in women. Cisplatin (CDDP), a platin based compound, is the most important chemotherapeutic agent and effectively used for the treatment of sarcomas and solid tumors. It binds to the DNA with crosslinks and leads inhibition of replication, causing DNA damage. As a result of this action, apoptotic pathways are induced and cell death occurs. In our study, we aimed to investigate the effect of CDDP on relative mRNA expression of mTOR, AKT, Cyclin D1 (CCND1) ve STAT3 on cervical cancer cell line. Method: In this study, HeLa cells were treated with different concentrations of CDDP at 24 and 48 hours. Cell viability was determined by XTT method. Moreover, after treatment with selected doses of cisplatin, quantitative mRNA expression of mTOR, AKT, CCND1 and STAT-3 genes was analyzed using Real-Time PCR. Results: IC50 concentration of CDDP was found to be about 60 µM for 24h and 8 µM for 48h treatment. Moreover, all analyzed genes’ expression was shown to diminish only after 24 h treatment. On the other hand, no statistically significant change was found after 48 h cisplatin exposure with respect to quantitative mRNA expression. Conclusion: In summary, different mRNA expression pattern was found after CDDP treatment regarding to exposure time. Our study has been contributed the literature in terms of detecting the effect of conventional chemotherapeutic CDDP on cell survival pathways.

New polymeric microspheres containing azomethine (1a-1c and 2a-2c) were synthesized by condensation to compare the enzymatic properties of the enzyme glucose oxidase (GOx) and to investigate antimutagenic and antimicrobial activities. The polymeric microspheres were characterized by elemental analysis, infrared spectra (FT-IR), proton nuclear magnetic resonance spectra, thermal gravimetric analysis, and scanning electron microscopy analysis. The catalytic activity of the glucose oxidase enzyme follows Michaelis-Menten kinetics. Influence of temperature, reusability, and storage capacity of the free and immobilized glucose oxidase enzyme were investigated. It is determined that immobilized enzymes exhibit good storage stability and reusability. After immobilization of GOx in polymeric supports, the thermal stability of the enzyme increased and the maximum reaction rate (V-max) decreased. The activity of the immobilized enzymes was preserved even after 5 months. The antibacterial and antifungal activity of the polymeric microspheres were evaluated by well-diffusion method against some selected pathogenic microorganisms. The antimutagenic properties of all compounds were also examined against sodium azide in human lymphocyte cells by micronuclei and sister chromatid exchange tests. Novel polymeric microspheres including azomethine with Pt(IV) were synthesized by means of condensation method. Polymeric microspheres were characterized by means of spectral measurements. Glucose oxidase (GOx) enzyme was covalently immobilized on these polymeric microspheres and investigated the enzymatic properties of GOx. The catalytic activity of GOx enzyme followed Michaelis-Menten kinetics. The antibacterial and antifungal activities of all polymeric microspheres were investigated by the well-diffusion method as antimicrobial agents. The antimutagenic properties of these polymeric microspheres were evaluated against sodium azide (NaN3) in human lymphocyte cells by micronuclei (MN) and sister chromatid exchange (SCE) tests. WOS:000533970100011 2-s2.0-85076776596 PubMed: 31851403

The aim of this investigation is to introduce two new subclasses of the class sigma related with the generalized Salagean differential operator and find estimates on the coefficients vertical bar a(2)vertical bar and vertical bar a(3)vertical bar for functions in these new subclasses. Moreover, we give some interesting results by using the relationship between Salagean's differential operator and generalized Salagean differential operator.

Glutatyon redüktaz (Glutatyon: NADP+ oksidoredüktaz, EC 1.8.1.7; GR) düşük (GSH) veya yüksek molekül ağırlıklı (GSSG) disülfit substratları ile indirgenmiş piridin nükleotidleri (NADPH) arasında elekton transferini katalizler. GR inhibitörleri son zamanlarda anti-sıtma ve kansere karşı faaliyetlerinin keşfedilmesi nedeniyle oldukça popüler hale gelmiştir. Enzimatik aktivite ölçümü Beutler metodu ve spektrofotometre kullanılarak 25°C’de yapıldı. Ölçüm sistemi 100 mM Tris-HCl tamponunda (pH 8;0), 0,5 mM EDTA, 3,3 mM GSSG ve 0,1 mM NADPH içeriyordu. Nitrobenzen (1), 3,5-dinitrosalisilik asit (2), (2,4-dinitrofenil) ((4-(prop-1-en-2-yl) sikloheks-1- enil)-metil) sulfan (3), ((7,7-dimetilbisiklo [2.2.1] heptan-1-il)metil)-(2,4-dinitrofenil)sulfan (4) ve ((2- kloro-7,7-dimetilbisiklo [2.2.1] heptan-1-il)metil)- (2,4-dinitrofenil)sulfan (5) maddelerinin GR enzimi üzerindeki in vitro inhibisyon etkisi incelendi. İnhibisyon etkisi gösteren maddeler için % aktivite- [I] grafikleri çizilerek IC50 değerleri bulunmuştur. Bu maddelerin GR için IC50 değerlerinin mikromolar seviyesinde olduğu gözlemlendi. Glutathione reductase (Glutathione: NADP+ oxidoreductase, EC 1.8.1.7; GR) catalyzes electron transfer between reduced (GSH) or high molecular weight (GSSG) disulfide substrates and reduced pyridine nucleotides (NADPH). Discovery of glutathione reductase (GR) inhibitors has become very popular recently due to antimalarial and anticancer activities. Enzymatic activity was measured by Beutler’s method with a Spectrophotometer, at 25°C. The assay system contained 100 mM Tris-HCl buffer pH 8.0, including 0.5 mM EDTA, 3.3 mM GSSG and 0.1 mM NADPH. Inhibition effects of Nitrobenzene (1), 3,5- Dinitrosalicylic acid (2), (2,4-Dinitrophenyl)((4-(prop1-en-2-yl)cyclohex-1-enyl)-methyl)sulfane (3), ((7,7- dimethylbicyclo[2.2.1]heptan-1-yl)methyl)-(2,4- dinitrophenyl)sulfane (4), and ((2-Chloro-7,7- dimethylbicyclo[2.2.1]heptan-1-yl)methyl)-(2,4- dinitrophenyl)sulfane (5) compounds on GR have been investigated in vitro. IC50 values were determined by drawing % activity- [I] graphs for compounds showing inhibition effects. IC50 values of GR for these substances were observed to be at micromolar level.

Dogan, Aysegul/0000-0003-4160-2270; demirci, serpil/0000-0002-6579-4273 WOS: 000449688300026 Wound healing is a well-orchestrated and tightly controlled process in which several cell types, cytokines and growth factor take place in an orderly fashion. Any break in the process would cause delay in healing which would increase hospitalization time, cost, mortality and morbidity. Scientists and clinicians are trying to find effective, safe and cheap methods to treat and manage acute and non-healing chronic wounds. Medicinal plants, in this line, have been widely investigated, and gained remarkable attention in this field due to having vital therapeutic molecules. In the current study, methanol extract of Verbascum speciosum leaves, collected in 2014 from Trabzon, Turkey, was integrated into a vaseline-based cream and tested on full-thickness wounds in vivo. The results revealed that 5% (w/v) and 10% (w/v) extract containing cream treated rats displayed significantly higher wound contraction compared to non-treated and base cream applied animals as evident by macroscopical analysis. However, no difference were found in histological examinations among the groups in terms of inflammatory cell infiltration, fibroblast density, collagen deposition and angiogenesis. Further studies are highly warranted in order to arrange dose and formulation of the plant extract and to understand the molecular mechanism for potential wound healing promoting activity. (C) 2018 SAAB. Published by Elsevier B.V. All rights reserved.

In the present study, two mediational mechanisms, religious self-regulation and self-determination, were hypothesized to account for the relationship between self-resilience and conflict management strategies across a sample of Muslim international students in Pakistan. This correlational study collected data from a university-based sample of 330 young adults (Mage = 22.53, SD = 1.90) enrolled in different programs in Pakistani universities. The study findings suggested that self-resilience was related to religious self-regulation, self-determination, and conflict management strategies. The strength of the relationship ranged from moderate to strong (.25 to.57). Results revealed that religious self-regulation fully mediated the path between self-resilience and conflict management style (e.g., collaborating). Self-determination demonstrated a partially but significantly mediated effect on the conflict management style (i.e., compromising). The current study suggests that religious self-regulation may play an imperative role in learning and executing effective conflict management strategies in international students in Pakistan. Directions for future research and study implications and limitations are also discussed. © 2023 Taylor & Francis.

PurposeRibociclib is a CDK4/6 inhibitor approved for the treatment of breast cancer; it inhibits the activity of CDK4/6 by competitively binding to adenosine 5'-triphosphate (ATP) binding sites. Although generally well-tolerated, ribociclib has been connected to a number of serious dermatologic complications. This study explored the effects of ATP on ribociclib-induced skin damage.Materials and methodsUsing a rat model, ATP 25 mg/kg was injected intraperitoneally in the ATP + Ribociclib (ATR) group (n = 6). Distilled water as solvent was applied to the healthy control (HC) group (n = 6) and ribociclib (RCB) group (n = 6). One hour after ATP and solvent administration, ribociclib (200 mg/kg) suspension prepared in distilled water was administered to the stomach by gavage (ATR and RCB groups). This was repeated once a day for 15 d. After that period, biochemical markers were studied in the skin tissues and histopathological evaluations were conducted.ResultsIn the histopathological evaluation of the RCB group, dermal necrosis, degeneration in hair follicles, and pycnosis in keratinocytes were observed. Only mild degeneration was observed in the ATR group; the HC group had a normal histological appearance. The malondialdehyde (MDA) values were significantly higher and the superoxide dismutase (SOD), catalase (CAT), and total glutathione (tGSH) levels were significantly lower in the RCB group in comparison to the HC group (p < .001). ATP reduced the ribociclib-induced increases in the MDA values and decreased the SOD, CAT, and tGSH levels in the ATR group (p < .001).ConclusionATP may be useful in the treatment of ribociclib-induced skin damage.

Pure and nickel doped copper oxide thin films were successfully grown on a soda lime glass substrates including various amounts (1, 2, 4, and 8%) of nickel dopants via ultrasonic spray pyrolysis method. The effects of the different impurity doping concentrations on the structural, morphological, optical, and H2 gas sensing properties of the prepared samples were assessed by performing X-ray Diffraction, scanning electron microscopy, ultraviolet–visible spectroscopy, photoluminescence spectroscopy, gas sensing measurements, and X-ray photoelectron spectroscopy. The structural observations revealed that the grown films have polycrystalline nature with monoclinic cubic crystal structure of copper oxide with no secondary phases present, and grain sizes increased in general as the doping percentage increased except for the 4% nickel doped sample. The morphological analysis showed that the impurities clearly led to modifications in the shapes of the grown copper oxide nanocrystals. In the optical measurements, it was uncovered that the ideal impurity level can enhance the absorbance features of the copper oxide material, and a slight increase in bandgap occurred due to the first level of impurity doping, but then the bandgap decreased as the impurity contents increased. A gradual decrease in the intensity of luminescent emissions was observed in the photoluminescence spectra as the doping concentration increased, which may be associated with the defects caused by the added nickel ions into the copper oxide lattices. Gas sensor measurements disclosed that the produced films were responsive when exposed to H2 gas, and enhanced responsivity was realized by the nickel doping compared to that of pure copper oxide sample. X-ray photoelectron spectroscopy confirmed the presence of aimed chemical compositions in the prepared thin films. © 2022 Hydrogen Energy Publications LLC

Fifteen tests have reported the experimental behavior of steel beam-column connections using cold-formed steel (CFS) sections with gusset plates attached to self-drilling screws. Using screws instead of bolts can be economical in cold-formed steel structures due to the nonexisting failure of bolts in tests. The aim of the study was to understand how gusset plate thickness, beam thickness, and stiffener use could affect screwed beam-column connections using cold-formed steel section behavior; experimental research using cantilever testing was carried out with full-scale specimens of the connections. The results presented here show which stiffeners can prevent the beam from collapsing at the gusset plate's end-point, but they cannot affect the failure modes. However, the stiffening cannot modify the failure mode; it does not affect the behavior and characteristic values of the moment-rotation curve. Additionally, the moment resistance significantly decreased in the beam thicknesses without stiffeners to less than 1.5 mm. Furthermore, the ductility of the joint with the thicknesses of the gusset plate (P) is 1.5 mm, and the C/P ratio (C is beam thickness) is less than 1, which decreased with the used stiffener in the test specimens. Thus, the gusset plate, beam thickness, and C/P ratio are essential in determining the failure mode shape and the moment resistance value. Additionally, the results presented here are compared with the literature.

WOS: 000422959000002 In order to evaluate the composition and seasonal variations of the epilithic diatoms in Yedikir Dam Lake were studied using samples collected from the stones in the barrier area between November 2004 and April 2006. The diatom communities were diverse; 88 taxa were found, belonging to the Bacillariophyta. Cymbella minuta, Cyclotella ocellata and Encyonema silesiacum have become the most abundant organisms in the epilithon. Environmental variables together with biological data obtained during the monthly routine biomonitoring of epilithic samples in the dam were analysed to understand variability of epilithic diatom communities and their relationships with environmental variables. Moreover, cluster analysis was applied to the epilithic algal communities and the seasonal variations of the samples were classified according to their similarity levels. Speciess richness and shannon diversity of the samples which were counted were measured in monthly periods. The results of the diversity analysis and the counting did not exactly match up with each other. Multivariate analyses indicated that both the regional distribution and seasonal variation of some epilithic diatoms (e.g. Cymbella spp., Nitzschia spp., Amphora delicatissima) are mainly driven by nutrient concentrations. Furthermore, epilithic diatoms are predominantly affected by geochemical characteristics including pH and total alkalinity (CaCO3) levels.

A modified maximum power point tracking control technic for an off-grid photovoltaic system which include the interleaved hybrid DC-to-DC boost converter was presented in this paper. The input voltage was predicted by measured one branch current of the proposed hybrid DC-to-DC boost converter. The proposed control technic consists of maximum power point tracking with the predicted input voltage and PI controller. Thanks to the proposed control technic, the photovoltaic panel was forced to operate at maximum power point and the output voltage of the proposed converter ensured the desired value despite the varying input power. In addition, the interleaved hybrid DC-to-DC boost converter was increased the low output DC voltage of photovoltaic panel to the desired high voltage value and the stresses on the circuit elements was decreased by reducing the input current ripples. As a conclusion, the total cost of the proposed system is reduced by eliminating the sensing of the input voltage and the service lifespan of the proposed system is extended by using the interleave hybrid DC-to-DC boost converter. The simulation and experimental results of the proposed system were obtained by using MATLAB/Simulink and 400 W DSP TMS320F28379D based porotype, respectively., Yalova University Research Fund (YU-BAP); [2021/AP/0008], AcknowledgmentThe authors would like to acknowledge the support of Yalova University Research Fund (YU-BAP) for the financial support of this work with project number of 2021/AP/0008.

Purpose: To evaluate changes in cone functions using light-adapted (LA) 30 Hz flicker and LA 3.0 electroretinography (ERG) in intravitreal ranibizumab (IVR)-treated naïve neovascular age-related macular degeneration (nAMD) patients. Materials and methods: This retrospective interventional study reviewed the medical records of 32 nAMD patients (32 eyes) who received monthly IVR between January 2019 and January 2021. A comprehensive ophthalmic examination, including best-corrected visual acuity (BCVA) testing and slit-lamp biomicroscopy, was performed as part of their clinical care, followed by LA 30 Hz flicker and LA 3.0 ERGs, optical coherence tomography, and fundus fluorescein angiography. All measurements were taken before IVR (baseline), as well as at months 6 and 12 later. Treatment was resumed for up to 12 months if recurrence occurred. Results: Compared to baseline, visual acuity improved significantly at months 6 and 12, respectively, coinciding with a significant decrease in central macular thickness (p < 0.05 for all). LA 30 Hz flicker ERG b-wave amplitude decreased significantly between baseline and months 6 and 12, respectively (p < 0.05 for both). There were no significant changes in LA 3.0 ERG a- and b-wave amplitudes between baseline and month 6 (p > 0.05 for both), but a significant decrease existed between baseline and month 12 (p < 0.05 for both). While LA 3.0 ERG a-wave implicit time increased significantly (p < 0.05 for both) between baseline and months 6 and 12, respectively, b-wave implicit time did not (p > 0.05 for both). Also, LA 30 Hz flicker ERG b-wave implicit times did not differ significantly between baseline and months 6 and 12, respectively (p > 0.05, for both). Conclusions: IVR was associated with long-term electrophysiological changes in cone functions, as measured by LA 30 Hz flicker and LA 3.0 ERGs. © 2022 Taylor & Francis Group, LLC.

İlkokul 4. sınıf öğrencilerinin yardımseverlik değerine yönelik algı ve tecrübelerinin incelenmesini amaçlayan bu çalışmada yardımseverlik değerine yüklenilen anlam, yardımsever öğrencilerin yetişmesi için kullanılan teknik ve etkinlikler incelenmiştir. Çalışmada nitel araştırma yöntemlerinden fenomenoloji (olgu bilim) deseni kullanılmıştır. Araştırmanın çalışma grubunu 2021-2022 yılında Ağrı ilinde bir ilköğretim okulunda öğrenim görmekte olan 15 ilkokul 4. sınıf öğrencisi ve Ağrı merkezde 4. sınıfların öğretmeni olarak görev yapan 9 sınıf öğretmeni oluşturmaktadır. Öğrenciler ve öğretmenlerden elde edilen verilerin analizinde tematik analiz kullanılmıştır. Veriler ayrı ayrı olacak şekilde analiz edilmiştir. Aştırmadan elde edilen sonuçlardan bazıları şöyledir: öğrencilerle yapılan görüşmeler sonrasında yardımseverliği yaşlılara, anne-babaya, hayvanlara yardım etme ve komşuya ikramda bulunma şeklinde açıkladıkları görülmüştür. Öğretmenlerle yapılan görüşmelerde ise öğrencilerin yardımseverlik değerini kavramaları için ebeveynlerinin ve kendilerinin öğrencilere model olması gerektiğini, sınıf ortamındaki ve toplumdaki deneyimlerinin yardımsever bireyler olmalarında etkili olduğunu ifade etmişlerdir. Araştırmaya katılan öğretmenler yardımsever bir öğrenci yetiştirmek için drama ve rol oynama tekniğini kullandıklarını, okulda değerler eğitimi panosu hazırladıklarını, masal ve videolarla derslerini desteklediklerini belirtmişlerdir.

Bu araştırma, bireylerin organik bitkisel ve hayvansal üretim, organik ürün tüketim alışkanlıkları ile bilgi kaynaklarını ortaya koymak amacıyla yapılmıştır. Çalışmada Ana Kitle Oranlarına Dayalı Basit Tesadüfi Olasılık Örneklemesi Yöntemi’ne göre belirlenen 399 kişiyle anket çalışması yapılmıştır. Araştırmada, katılımcıların %95.0’i organik tarım hakkında bilgi sahibiyken, %5.0’i herhangi bir bilgiye sahip olmadıklarını bildirmişlerdir. “Tüketilen gıdanın güvenilir olduğunu düşünüyor musunuz?” sorusuna en yüksek frekansla “bazen” cevabı (%33.8) verilmiştir, “hayır” şeklinde cevap verenlerin oranının da %15.3 olduğu görülmüştür. En önemli gıda riski olarak, çoğunlukla (%60.4) kimyasallar, genetiği değiştirilmiş organizma (GDO), deli dana hastalığı ve radyasyon uygulamaları; en az oranda da (%16.0) mikroorganizmaların olduğu belirtmiştir. Katılımcıların %55.1’i gıda üzerindeki etiketleri bazen okuduklarını; %4.5’i ise hiçbir zaman okumadıklarını ifade etmişlerdir. Organik gıdayı daha mı güvenilir buldukları sorusuna ise, %77.9’u evet cevabını vermiştir. Katılımcıların %80.2’sinin organik ürün tükettiği belirlenmiştir. Organik ürün tüketmeyen tüketicilere, organik ürün satın almama nedenleri sorulduğunda, %55.9 ile organik olduğuna güvenmeme, %12.8 ile ek bir fayda getireceğine inanmama, %9.8 ile de fiyatının yüksek olması olarak belirtilmiştir. Katılımcıların çoğu (%84.2) daha önce organik yem kavramını duyduklarını ayrıca barınak koşullarının hayvansal ürün kalitesine etkisinin (%97.5) olduğunu belirtmişlerdir. Katılımcıların organik, güvenilir ve sağlıklı ürünlere daha fazla fiyat ödemeye razı oldukları (%78.7) ve organik hayvansal ürün satın alırken ürünlerin tanınmış marka olmasına dikkat ettikleri (%82.0) görülmüştür., This research was organized in order to reveal people's organic plant and animal production, product, information, and consumption habits. In this study, a survey was applied to 399 people. In the study, while 95.0% of the participants knew about organic agriculture, 5.0% reported that they had no information. Do you think the food consumed is safe? The most frequently answered question was sometimes (33.8%), and the rate of those who answered no was 15.3%. They stated that the most important food risk was chemicals (60.4%), GMOs, mad cow disease, and radiation applications, and the least amount (16.0%) was microorganisms. Considering the rate of those who read the labels on the food, 55.1% answered sometimes; 4.5% stated that they have never read. When asked whether organic food is more reliable, 77.9% replied yes. It was determined that 80.2% of the participants consumed organic products. When consumers were asked what their reasons were for not buying organic products, 55.9% said they did not trust that it was organic, 12.8% did not believe that it would bring any additional benefit, and 9.8% said it had a high price. Participants stated that they had heard of the concept of organic feed (84.2%) before, and that the conditions of the shelter affected the quality of animal products (97.5%). It has been observed that the participants are willing to pay more for organic, reliable, and healthy products (78.7%), and they pay attention to being a well-known brand (82.0%) when buying organic animal products.

Bu araştırma Türkiye’de 2006-2022 yılları arasında yazılan etik liderlik ve etik kodlar konulu lisansüstü tezlerin genel bir örüntüsünü ortaya koymayı amaçlamaktadır. Türkiye Yükseköğretim Kurumu Ulusal Tez Merkezi’nde (YÖKTEZ) 1 Ocak 2022 – 15 Şubat 2022 tarihleri arasında etik liderlik ve etik kodlar anahtar kelimeleriyle yapılan arama sonucunda 151’i etik liderlik ve 11’i etik kodlar olmak üzere toplam 162 lisansüstü teze ulaşılmıştır. Araştırmanın evren ve örneklemini oluşturan 162 lisansüstü tez, tür ve sayıları, yayınladığı yıllar, hazırlandığı üniversiteler, alanları, yayın dilleri, danışman unvanları, amaç, kapsam ve yöntem parametreleri çerçevesinde sistematik derlemeye dayalı analiz edilmiştir. YÖK TEZ ’den elde edilen verilere betimsel analiz ve içerik analizi uygulanarak araştırma soruları kapsamında yorumlanmıştır. Araştırma sonucunda en fazla lisansüstü tezin 2019 yılında yazıldığı tespit edilmiştir. Lisansüstü tezlere en çok Dr. Öğr. Üyesi unvanlı akademisyenlerin danışmanlık yaptığı fark edilmiştir. Lisansüstü tezleri yayınlandığı dil bakımında ele alındığında en çok Türkçe olarak yayınlandığı anlaşılmıştır. Lisansüstü tezler amaç kapsam ve yöntem bakımından ele alındığında ağırlıklı olarak eğitim öğretim ve işletme alanında yer alan örgütsel davranış konuları ile ilişkilendirildikleri sonucuna ulaşılmıştır. Araştırma sistematik derleme ve değerlendirme üzerinden yapılması açısından önem arz etmenin yanı sıra ulusal literatüre katkı sunması açısından çalışmanın değerini artırmaktadır.

Walnuts are widely used, although they come in a variety of types and qualities. It is essential to choose the correct walnut variety with the necessary ecological characteristics to continue the production of walnut fruit, which has positive benefits on human health. Because planting a walnut garden is expensive and the harvesting process takes a while. However, since the colour and feel of walnut leaves are so similar, it can be challenging to tell them apart. Experts must devote a significant amount of time to differentiating walnut kinds, and morphological tests should be conducted. There are different studies in the literature for walnut variety differentiation. Nevertheless, those are studies conducted with the classification of a small number of walnut varieties or laboratory experiments. With the advancement of technology, deep learning techniques based on computers are now routinely utilized for leaf recognition. These technologies enable significant reductions in error rates, time saves, and cost. With a total of 1751 leaf pictures collected from 18 species of walnuts, a special walnut dataset was constructed for this study in order to identify walnut types from walnut leaves. To automatically classify the provided dataset, images are trained with residual block-based convolutional neural network architectures. Following the discovery of each image's deep features, the Atom Search Optimization algorithm was used to choose the most distinctive characteristics. Support vector machines (SVM) were used to classify walnut species with the new feature set created. The experimental studies of the proposed model based on Residual block and Atom Search optimization successfully categorised the walnut dataset with an accuracy rating of 87.42%.

The COVID-19 pandemic has affected the well-being and mental health of populations worldwide. This study sought to examine whether religious coping mediated the relationship between COVID-19-related fear and death distress. We administered an online survey to 390 adult participants (66.15% females; Mage = 30.85 ± 10.19 years) across Turkey. Participants completed a series of questionnaires measuring the fear they had experienced during the COVID-19 pandemic, their levels of religious coping and their levels of death anxiety and depression. Our findings revealed that (a) fear of COVID-19 was associated with positive religious coping, negative religious coping, death anxiety and death distress; (b) negative religious coping was associated with death anxiety and depression and (c) negative religious coping mediated the relationship between fear of COVID-19 and death anxiety and depression. These results highlight the detrimental effect of negative religious coping in increasing the adverse effect of the COVID-19 fear on death depression.

Ectoine and hydroxyectoine are compatible solutes with enormous potential for use in the medical and cosmetic industries. Considering the excellent osmoprotective properties of these compatible solutes, we investigate the presence of four compatible solutes (ectoine, hydroxyectoine, proline, and glutamic acid) quantitatively by liquid chromatography-tandem mass spectrometry (LC-MS/MS) in forty-five halophilic/halotolerant bacterial isolates. We determined ectoine production by Marinibacillus sp., Nesterenkonia xinjiangensis, Halobacillus sp., Bacillus patagoniensis, Virgibacillus picturae, Halomonas neptunia, Bacillus patagoniensis, Gracilibacillus sp., Thalassobacillus devorans, Microbacterium sp., Nesterenkonia sp., and Bacillus agaradhaerens, and this production was NaCl dependent. Additionally, the production of hydroxyectoine was observed in six bacterial isolates (Nesterenkonia xinjiangensis, Halobacillus sp., Halomonas neptunia, Thalassobacillus devorans, Nesterenkonia sp., and Bacillus agaradhaerens) which was NaCl and temperature dependent. The study identified new bacterial isolates producing ectoine or hydroxyectoine. While the ectoine production in many different Bacillus members and a few Nesterenkonia have been documented before, ectoine production by Bacillus patagoniensis and Nesterenkonia xinjiangensis has not been shown so far. Further, ectoine production by a member of the genus Thalassobacillus (Thalassobacillus devorans) was demonstrated experimentally for the first time. The findings reported in the study may serve as a basis for the large-scale production of ectoine and hydroxyectoine in the future.

The purpose of this study was twofold. First, to explore middle and high school students’ intuitively-based (mis)conceptions in probability, particularly availability and representativeness heuristics. Second, to investigate teachers’ awareness of these intuitively-based (mis)conceptions and the effectiveness of their instructional practices to support students’ understanding of probability beyond heuristics. The participants were two middle school mathematics teachers, three high school mathematics teachers and their students. Data were collected through a diagnostic test administered to students as a pretest and posttest, interviews with the teachers and two students from each class and classroom observations. The findings indicated the existence of intuitively-based (mis)conceptions regarding availability and representativeness heuristics among middle and high school students. In general, the teachers did not consider the students’ intuitions and difficulties in probability in their instructions. Not only did they rarely guide students to analyze and solve the tasks coherently and deliberately, but they also did not discuss students’ intuitively-based (mis)conceptions. The results highlighted that if teachers do not attend to student thinking and change their instructional practices accordingly, their knowledge about students’ difficulties will not necessarily help students overcome their intuitions and attain a probabilistic way of thinking.

In this study, theoretical investigation derived from experimental correlations and the artificial bee colony optimization method are used to determine the optimum geometrical parameters which maximize the termohydraulic efficiency of some artificially roughened solar air heaters. Nine different roughness types are considered, i.e., transverse wedge-shaped rib roughness, protrusion roughness, multiple v-ribs roughness, rib-grooved roughness, metal grit ribs roughness, compound turbulators roughness, v-shaped rib roughness, arc-shaped wire roughness, and discrete v-down ribs roughness. The effects of the artificial roughness element parameters on the best thermal performance and the thermohydraulic performance are compared. Optimum results are obtained with multiple v-ribs roughness for the low mass flow rate (MFR = 0.1 kg/s) and with protrusion roughness for the high mass flow rate (MFR = 0.5 kg/s). Optimum roughness parameters and corresponding thermal and thermohydraulic efficiencies are tabulated for each solar collector type. As expected, increased roughness geometry leads to higher pressure loss and reduces thermohydraulic efficiency.

In this article, inequalities of reverse Minkowski type involving weighted fractional operators are investigated. In addition, new fractional integral inequalities related to Minkowski type are also established.

Aim The objective of this study was to examine the effect of delayed umbilical cord clamping on the newborn's oxygen saturation and sucking success in primiparas. Methods The study was conducted based on the experimental model with a control group, between March 15-November 10, 2020. The sample of the study consisted of 101 primiparous pregnant (48 primiparous with delayed cord clamping within 1-3 min and 53 primiparous with early cord clamping within 1 min) (having no high-risk pregnancy, 38-42 weeks, vaginal birth) in Turkey. The data were collected using a personal information form, the LATCH breastfeeding tool and the pulse oximetry. Statistical analyses were conducted using percentage distribution, arithmetic means, chi-square testing, and independent samples t-testing. Results Oxygen saturation values of newborns with delayed umbilical cord clamping were higher than those of newborns with early cord clamping. The saturation was first minute 66.43 versus 74.37, fifth minute 81.90 versus 88.60, tenth minute 91.77 versus 94.50 (p < 0.05). When compared to the group with early cord clamping, oxygen saturation is higher in the first by 11.95%, in the fifth by 8.18%, and in the tenth minute by 2.97% in the group with delayed cord clamping. The LATCH breastfeeding scores were found to be higher in the group with delayed cord clamping compared to the group with early cord clamping. Conclusion It was determined that delayed cord clamping positively affected oxygen saturation values and sucking success in neonatal babies. Delayed umbilical cord clamping is an important issue that needs to be addressed in its different dimensions.

Undoped and cobalt (Co) doped tin oxide (SnO2) films were prepared onto glass slides via the successive ionic layer adsorption and reaction (SILAR). Variable characterization methods were applied to examine the effects of cobalt impurities on physical properties of SnO2 films. The performed characterization measurements were X-ray diffraction, Ultraviolet-visible spectrometer, Photoluminescence, and Raman. No peak ascribed to Co, SnO, or Sn was found in the XRD spectrum which may indicate the integration of cobalt in SnO2 crystal lattices. And the obtained XRD peaks may be related to the tetragonal rutile phase of pure SnO2. SEM images exposed that the Co dopant atoms affectedthe sample morphologies. The optical analyses showed that the transmittance and reflectance percentages dropped by the introduction of impurities to the SnO2 system as the absorbance values of doped SnO2 samples increased. Thus,a red shift (2.6-1.8 eV) occurred in the bandgapsas Co concentration changed in the films. The Raman spectra of pure SnO2 and Co:SnO2 samples exhibited major peaksaround 481 cm-1, 571 cm-1 and 602 cm-1. In photoluminescence spectrum, it was noted that the emission intensity can both increase or decrease due to the different cobalt doping ratios in the SnO2 nanostructures. Resistance measurements displayed that the resistivity increased with the increment of doping concentration. However, it was shown that the electrical conductivities could be increased after the heat treatment of glass substrates up to 500 oC, a common behavior of semiconductor materials., Agri Ibrahim Cecen University; [MYO-20-003], The authors thank Agri Ibrahim Cecen University for financial support of the study (Project no: MYO-20-003) .

Bu çalışma, Türkiye için 2000Q1 ve 2009Q4 döneminde finansal risk endeksi ve finansal stres endeksi ilişkisinin incelenmesi amacı ile yapılmıştır. Bu kapsamda finansal risk ve finansal stres endeksine ilişkin çeyrek dönemlik veriler kullanılmıştır. Araştırma verileri Granger nedensellik testi ile analiz edilmiştir. Yapılan analiz sonucunda Türkiye için 2000Q1 ve 2009Q4 döneminde finansal risk endeksinden finansal stres endeksine doğru tek yönlü nedensellik tespit edilmiştir, This study is conducted in order to analyze the relationship between financial risk and financial stress index for Turkey in 2000Q1-2009Q4 period. Within this scope, quarter period data related to financial stress index and financial risk were used. Research data were analyzed with Granger causality analysis. As a result of the analysis, for Turkey in 2000Q1 and 2009Q4 period, uniletaral causality from financial risk to financial stress index was determined

Objective: The purpose of the study is to determine work-related tension, using the methods of overcoming the stress and the affecting factors in emergency staff Material and Methods: The universe of the study in descriptive type is consisted of health team members in institutions rendering emergency health service belong to public sector in Turkey. Turkey was divided into 4 clusters (east, west, south and north) by taking the geographical settlement areas into consideration and a province was selected from each cluster in random. The number of people within the scope of the research is 769 and 560 people was reached (response rate is 72.82%). Approval of ethical committee and written permissions were acquired from the related institutions before the research. There are questions including the demographic characteristics of the participants and their opinions on the job in first section of the form in which data were gathered, and “Work-Related Tension Scale-WRTS” in the second section, and “Overcoming the Stress Scale-OSS” in the third section. The data were recorded in statistical program. The averages were given with standard deviations and p

The purpose of this prospective longitudinal study was to determine the prevalence of sexual dysfunction (SD) in women in the third trimester of pregnancy and at 8 week and 6 months in the postpartum period, as well as to identify the factors affecting sexual function in the postpartum period. 110 pregnant women were included in the study. The results showed significant differences in the scores between pregnancy and 6 months after delivery and between 8 weeks and 6 months after delivery. The scores in desire, sexual arousal, lubrication, orgasm, and satisfaction subdimensions were significantly higher and the score in pain subdimension was significantly lower at 6 months than during pregnancy and at eight weeks after delivery. Sexual dysfunction is a common problem in women in the last trimester of pregnancy and at eight weeks after delivery. However, this problem substantially resolves at postpartum 6 months.IMPACT STATEMENT What is already known on this subject? Physiological, psychological, and hormonal changes, especially during pregnancy and postpartum period, have a considerable impact on sexual function. Therefore, identifying various aspects of sexual problems during pregnancy and postpartum period and improving the body of knowledge about sexual function would contribute to the health of women and couples. What the results of this study add? Sexual dysfunction is a common problem in women in the last trimester of pregnancy and at 8 weeks after delivery. However, this problem substantially resolves at postpartum 6 months. What the implications are of these findings for clinical practice and/or further research? A striking finding in the study is the increase of SD risk in the sixth month of postpartum with women's starting to work. This problem, which has been addressed sparsely in the current literature, can be considered a condition requiring an in-depth research., Eskisehir Osmangazi University; Eskisehir Osmangazi University, Commission of Scientific Research Projects [2018-1961], The authors wish to thank Eskisehir Osmangazi University for financial support. The authors are grateful to Eskisehir Osmangazi University, Commission of Scientific Research Projects for financial support to Project 2018-1961.

This study aimed to determine the correlation between stress coping styles and self-efficacy with regard to the spiritual and religious coping of mothers with disabled children. The descriptive and relational screening model was used in this study. The research was completed with 227 mothers in a private rehabilitation center at Turkey. The data were collected using Maternal Spiritual Coping, Religious Coping Styles, Stress Coping Styles Scales (SCSS), and General Self-Efficacy Scales. As a result of the study, there was a statistically advanced degree of significant correlation in a positive direction between effective coping with stress and spiritual coping (p < 0.001), and a negative significant correlation between ineffective coping with stress and general self-efficacy (p < 0.05). Additionally, there was a negative significant correlation between the SCSS-effective coping dimension with the SCSS-ineffective coping points (p < 0.05). The high level of spiritual coping of mothers and its effect on coping with stress is an important result. For the participation of children with disabilities and their parents in society, it is essential to identify components such as mental health and spiritual coping that will improve mothers' mental health so that mothers can effectively cope with the difficulties they experience.

Purpose Five different types of synthesized azadispiro derivatives have been analyzed for radiation absorption capacity and determined their potential to be exploited as substances for a drug to be developed against radiation has been investigated. Material and methods Fast neutron attenuation parameters like the effective mean free path, half-value layer (HVL), removal cross-sections, and neutron transmission number were found with the Monte Carlo simulation Geometry And Tracking (GEANT4) code. Gamma radiation absorption parameters, such as effective atom number (Z(eff)), mean free path (MFP), mass attenuation coefficient (MAC), and half-value layer (HVL) were theoretically determined with WinXCom software. Besides, the exposure build-up factor (EBF) was calculated by using GP fitting parameters. Neutron absorption dose rate was experimentally calculated with Am-241-Be fast neutron source which has 4.5 MeV of energy, 74 GBq activity, and portative BF3 neutron detector. Ames/Salmonella test systems were used for the genotoxic potentials of the azadispiro derivatives Results and conclusions Experimental and theoretical results were checked with paraffin and High-Density Polyethylene. The results showed that Azadispiro derivatives have neutron radiation absorption capability close to paraffin and High-Density Polyethylene. The gamma radiation absorption properties for azadispiro derivatives have been investigated, and it has been observed that these materials can absorb gamma radiation. Ames/Salmonella assay was used to examine whether the derivatives had a genotoxic effect probability or not. The results showed that these derivatives were genotoxic and safe at test doses (up to 5 mM). Consequently, it has been understood that these azadispiro derivatives can be used as active and genotoxic safety ingredients in the production of a protective drug against both neutrons and gamma rays.

A dominating set of a graph $G$ which intersects every independent set of a maximum cardinality in $G$ is called an independent transversal dominating set. The minimum cardinality of an independent transversal dominating set is called the independent transversal domination number of $G$ and is denoted by $\gamma_{it}(G)$. In this paper we investigate the independent transversal domination number for the transformation graph of the path graph $P_{n}^{+-+}$, the cycle graph $C_{n}^{+-+}$, the star graph $S_{1,n}^{+-+}$, the wheel graph $W_{1,n}^{+-+}$ and the complete graph $K_{n}^{+-+}$.

Nowadays, direct current (DC) voltage is required for the operation of the machines used in many industrial applications. DC voltage generating photovoltaic (PV) panels or other DC voltage generators need to be converted from the voltage level produced by the DC voltage levels required for the operation of the machines. The conversion of a DC voltage to a different DC voltage is performed by DC-DC converters. The most commonly used DC-DC converters in the literature are buck, boost, buck-boost, CUK and SEPIC converter. In this study, different control methods are used in order to reach the desired voltage level of the output voltage of the equivalent series resistance and ideal SEPIC converter in continuous current mode. Conventional Proportional-Integral (PI) and Sliding Mode Control (SMC) methods are used to ensure that the converter reaches the desired voltage level. PI controller parameter values are calculated according to trial and error method. In order to compare the performances of the controller used in the case ideal and equivalent series resistance cases, the controller parameters are taken the same. SMC is shown to perform better in ideal and equivalent series resistance SEPIC converter compared to the traditional PI controller from simulation results. Besides, modeling and controller applications of SEPIC converter are realized by using MATLAB / SIMULINK program.

Görme yetersizliği olan öğrenciler, temel eğitime erişim noktasında pek çok sorunlar yaşamaktadır. Fen kavramlarının öğretiminde yaşanan sıkıntılar göz önünde bulundurulduğunda görme yetersizliği olan öğrencilerin fen kavramlarını daha iyi öğrenebilmeleri için uygun materyal ve etkinliğin geliştirilmesi bu etkinliklerin uygulanması ve değerlendirilmesi bu çalışmanın amacını oluşturmaktadır. Biri total kör beşi ise az gören olan toplam altı öğrenci bu çalışmanın örneklemini oluşturmaktadır. Nitel araştırma yaklaşımlarından durum çalışması kullanılarak yapılan çalışmada Fen Etkinlik Gözlem Formu (FEGF) veri toplama aracı olarak kullanılmıştır. Buna göre görme yetersizliği olan öğrencilere “Kinetik Enerji ve Sıcaklık” kavramının öğretimine yönelik geliştirilen fen etkinliğinin öğretim, öğrenme, işlevsellik ve kullanışlılık boyutlarında belirlenen gereksinimlerin çoğunu karşıladığı tespit edilmiştir.

This study aims to determine the effects of kangaroo care at birth on exclusively breastfeeding, infant growth and development according to attachment theory. The study is a randomized controlled trial. The sample of the study consisted of 132 pregnant women between 36 and 38 gestational weeks. Kangaroo care group received 'kangaroo care and breastfeeding training' and practiced kangaroo care at birth. The control group received routine care. Mothers' attachment levels, exclusively breastfeeding duration for six months, growth and development parameters were evaluated for nine months. A statistically significant difference was found between the groups in exclusive breastfeeding duration (KCG: 5.22 mo +/- 1.18 mo; CG: 3.47 mo +/- 1.51 mo), growth parameters of infants and mothers' attachment scale mean scores for nine months (p < 0.05). There was no significant difference between development parameters of the infants (p > 0.05). It was found that kangaroo care had a positive effect on exclusively breastfeeding and baby's growth.

In the process of measuring and assessing high-level cognitive skills, interference of rater errors in measurements brings about a constant concern and low objectivity. The main purpose of this study was to investigate the impact of rater training on rater errors in the process of assessing individual performance. The study was conducted with a pretest-posttest control group quasi-experimental design. In this research, 45 raters were employed, 23 from the control group and 22 from the experimental group. As data collection tools, a writing task that was developed by IELTS and an analytical rubric that was developed to assess academic writing skills were used. As part of the experimental procedure, rater training was provided and this training was implemented by combining rater error training and frame of reference training. When the findings of the study were examined, it was found that the control and experimental groups were similar to each other before the experiment, however, after the experimental process, the study group made more valid and reliable measurements. As a result, it was investigated that the rater training given had an impact on rater errors such as rater severity, rater leniency, central tendency, and Halo effect. Based on the obtained findings, some suggestions were offered for researchers and future studies.