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4 results on '"[11C]FECIT PET"'

1. A voxel-based PET study of dopamine transporters in Parkinson's disease: Relevance of age at onset

Author

Andrea Panzacchi, Rosa Maria Moresco, Valentina Garibotto, Angelo Antonini, Clara Gobbo, Ioannis U. Isaias, Stefano Goldwurm, Lorena Bonaldi, Assunta Carpinelli, Gianni Pezzoli, Ferruccio Fazio, and Daniela Perani

Subjects
Dopamine transporter, [11C]FECIT PET, Parkinson's disease, Age at onset, Genetics, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

We used positron emission tomography (PET) and the dopamine transporter (DAT) ligand [11C]FECIT to measure loss of nigrostriatal dopaminergic neurons in early phase of early onset (EOPD) and late onset Parkinson's disease (LOPD). The analysis was carried out with both regions of interest and voxelwise method (SPM2), at group and single subject levels. Genetic analysis tested for the mutations occurring most frequently in Caucasian population.A significant, bilateral, asymmetric DAT reduction was observed in both EOPD and LOPD. Noteworthy, the side and severity of DAT binding reduction significantly correlated with the severity and asymmetry of motor clinical scores. The two EOPD patients carrying mutations in the PARK2 and PARK6 genes, respectively, displayed the lowest values, bilaterally.This work demonstrates that severity of nigrostriatal damage in early disease phase of sporadic PD is not dependent on age at onset. Genetically determined PD is associated with more severe and widespread dopaminergic impairment.

Published
2008
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2. A voxel-based PET study of dopamine transporters in Parkinson's disease: Relevance of age at onset

Author

Panzacchi, Andrea, Moresco, Rosa Maria, Garibotto, Valentina, Antonini, Angelo, Gobbo, Clara, Isaias, Ioannis U., Goldwurm, Stefano, Bonaldi, Lorena, Carpinelli, Assunta, Pezzoli, Gianni, Fazio, Ferruccio, and Perani, Daniela

Subjects
*POSITRON emission tomography, *PARKINSON'S disease, *DOPAMINERGIC mechanisms, *GENETIC mutation
Abstract

Abstract: We used positron emission tomography (PET) and the dopamine transporter (DAT) ligand [11C]FECIT to measure loss of nigrostriatal dopaminergic neurons in early phase of early onset (EOPD) and late onset Parkinson''s disease (LOPD). The analysis was carried out with both regions of interest and voxelwise method (SPM2), at group and single subject levels. Genetic analysis tested for the mutations occurring most frequently in Caucasian population. A significant, bilateral, asymmetric DAT reduction was observed in both EOPD and LOPD. Noteworthy, the side and severity of DAT binding reduction significantly correlated with the severity and asymmetry of motor clinical scores. The two EOPD patients carrying mutations in the PARK2 and PARK6 genes, respectively, displayed the lowest values, bilaterally. This work demonstrates that severity of nigrostriatal damage in early disease phase of sporadic PD is not dependent on age at onset. Genetically determined PD is associated with more severe and widespread dopaminergic impairment. [Copyright &y& Elsevier]

Published
2008
Full Text
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3. A voxel-based PET study of dopamine transporters in Parkinson's disease: relevance of age at onset

Author

Panzacchi A. 1, Moresco R.M. 2, 3, Garibotto V. 3, 4, Antonini A. 5, Gobbo C. 1, Isaias I.U. 5, Goldwurm S. 5, Bonaldi L. 2, Carpinelli A. 2, Pezzoli G. 5, Fazio F. 1, 2, and Perani D. 1

Subjects
[11C]FECIT PET, nervous system, Parkinson's disease, Dopamine transporter, Genetics, Age at onset
Abstract

We used positron emission tomography (PET) and the dopamine transporter (DAT) ligand [(11)C]FECIT to measure loss of nigrostriatal dopaminergic neurons in early phase of early onset (EOPD) and late onset Parkinson's disease (LOPD). The analysis was carried out with both regions of interest and voxelwise method (SPM2), at group and single subject levels. Genetic analysis tested for the mutations occurring most frequently in Caucasian population. A significant, bilateral, asymmetric DAT reduction was observed in both EOPD and LOPD. Noteworthy, the side and severity of DAT binding reduction significantly correlated with the severity and asymmetry of motor clinical scores. The two EOPD patients carrying mutations in the PARK2 and PARK6 genes, respectively, displayed the lowest values, bilaterally. This work demonstrates that severity of nigrostriatal damage in early disease phase of sporadic PD is not dependent on age at onset. Genetically determined PD is associated with more severe and widespread dopaminergic impairment.

Published
2008

4. A voxel-based PET study of dopamine transporters in Parkinson's disease: relevance of age at onset

Author

Rosa Maria Moresco, Andrea Panzacchi, Angelo Antonini, Lorena Bonaldi, Valentina Garibotto, Ferruccio Fazio, C. Gobbo, Ioannis U. Isaias, Stefano Goldwurm, Daniela Perani, A. Carpinelli, Gianni Pezzoli, Panzacchi, Andrea, Moresco Rosa, Maria, Garibotto, Valentina, Antonini, Angelo, Gobbo, Clara, Nullu, nullIsaias Ioanni, Goldwurm, Stefano, Bonaldi, Lorena, Carpinelli, Assunta, Pezzoli, Gianni, Fazio, Ferruccio, Perani, DANIELA FELICITA L., Panzacchi, A, Moresco, R, Antonini, A, Gobbo, C, Isaias, U, Goldwurm, S, Bonaldi, L, Carpinelli, A, Pezzoli, G, Fazio, F, and Perani, D

Subjects
Adult, Male, medicine.medical_specialty, Pathology, Parkinson's disease, Dopamine Transporters, Parkinson's Disease, PET, early onset, Late onset, medicine.disease_cause, lcsh:RC321-571, [11C]FECIT PET, Dopamine, Internal medicine, medicine, Genetics, Image Processing, Computer-Assisted, Humans, Carbon Radioisotopes, Age of Onset, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, Dopamine transporter, Neurons, Mutation, Dopamine Plasma Membrane Transport Proteins, medicine.diagnostic_test, biology, Dopaminergic, Age at onset, Brain, Parkinson Disease, Middle Aged, medicine.disease, Endocrinology, Neurology, nervous system, Positron emission tomography, Positron-Emission Tomography, Nerve Degeneration, biology.protein, Female, Age of onset, Radiopharmaceuticals, Psychology, medicine.drug
Abstract

We used positron emission tomography (PET) and the dopamine transporter (DAT) ligand [(11)C]FECIT to measure loss of nigrostriatal dopaminergic neurons in early phase of early onset (EOPD) and late onset Parkinson's disease (LOPD). The analysis was carried out with both regions of interest and voxelwise method (SPM2), at group and single subject levels. Genetic analysis tested for the mutations occurring most frequently in Caucasian population. A significant, bilateral, asymmetric DAT reduction was observed in both EOPD and LOPD. Noteworthy, the side and severity of DAT binding reduction significantly correlated with the severity and asymmetry of motor clinical scores. The two EOPD patients carrying mutations in the PARK2 and PARK6 genes, respectively, displayed the lowest values, bilaterally. This work demonstrates that severity of nigrostriatal damage in early disease phase of sporadic PD is not dependent on age at onset. Genetically determined PD is associated with more severe and widespread dopaminergic impairment.

Published
2007

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