1. The Role of the Dorsal Nucleus of the Lateral Lemniscus in Shaping the Auditory Response Properties of the Central Nucleus of the Inferior Collicular Neurons in the Albino Mouse.
- Author
-
Wang, Huimei, Shen, Shuang, Zheng, Tihua, Bi, Liyan, Li, Bo, Wang, Xin, Yang, Ying, and Jen, Philip H.-S.
- Subjects
- *
LEMNISCUS (Anatomy) , *NEURONS , *LABORATORY rats , *INFERIOR colliculus , *AUDITORY cortex , *SIGNAL processing - Abstract
Highlights • Focal electrical stimulation of the DNLL (ES DNLL) produces variation in response parameters of modulated IC neurons. • Brief ES DNLL produces variation in the number of impulses, response latency and duration of modulated IC neurons. • 30-minute short-term ES DNLL also produces BF and MT shift. • Response variation after 30-minute ES DNLL recovers in different manner and time course among modulated IC neurons. Abstract In the ascending auditory pathway, the central nucleus of the inferior colliculus (IC) receives and integrates excitatory and inhibitory inputs from many bilateral lower auditory nuclei, intrinsic projections within the IC, contralateral IC through the commissure of the IC and from the auditory cortex. All these presynaptic excitatory and inhibitory inputs dynamically shape and modulate the auditory response properties of individual IC neurons. For this reason, acoustic response properties vary among individual IC neurons due to different activity pattern of presynaptic inputs. The present study examines modulation of auditory response properties of IC neurons by combining sound stimulation with focal electrical stimulation of the contralateral dorsal nucleus of the lateral lemniscus (referred to as ES DNLL) in the albino mouse. Brief ES DNLL produces variation (increase or decrease) in the number of impulses, response latency and discharge duration of modulated IC neurons. Additionally, 30-minute short-term ES DNLL alone produces variation in the best frequency (BF) and minimum threshold (MT) of modulated IC neurons. These varied response parameters recover in different manner and time course among individual modulated IC neurons. Possible pathways and neural mechanisms underlying these findings are discussed. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF