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Context and Objectives: Respiratory muscle training (RMT) is considered an effective tool to improve cardiorespiratory limitations in athletes. The goals of this systematic review were to explore the role of RMT and its implementation within sport rehabilitation programs in para-athletes. Evidence Acquisition: Several databases were searched until January 2024. Eligible studies were independently reviewed by 2 reviewers. Quality assessment was made using the PEDro scale and version 2 of the Cochrane Risk-of-Bias Tool for Randomized Trials. Eight studies (a total of 108 participants) were selected for the analysis. Evidence Synthesis: Five studies preferred using resistive loading, while 2 studies used normocapnic hyperpnea, and 1 study used threshold inspiratory muscle training. Respiratory functions (respiratory muscle strength and endurance, spirometry measures) and exercise performance were assessed as the main outcomes. Significant increases in respiratory muscle strength were reported in 5 studies. Two studies observed improvement in respiratory muscle endurance and 3 studies reported increased exercise capacity. Conclusions: This review suggests that although RMT can enhance respiratory muscle strength and endurance, it should not be considered the primary method for boosting the exercise performance of para-athletes. Additional research is necessary to explore the impact of various RMT techniques on different outcomes from the perspective of sport rehabilitation in para-athletes. [ABSTRACT FROM AUTHOR]

BACKGROUND: Adherence challenges with oral tenofovir-based pre-exposure prophylaxis (PrEP) are common. We developed a point-of-care assay to objectively assess tenofovir in urine and conducted a pilot trial examining the impact of counselling informed by use of this urine assay on long-term PrEP adherence. METHODS: This randomised trial enrolled women not in serodiscordant partnerships 3 months after PrEP initiation at the Kenya Medical Research Institute to compare standard-of-care adherence counselling versus counselling informed by the urine assay (urine-test counselling group) every 3 months for 12 months. In the standard of care group, urine samples were stored and tested at study end without participant feedback. Here we report the adherence primary outcome of hair concentrations of tenofovir at 12 months as a long-term metric (undetectable levels defined long-term non-adherence), as well as urine concentrations of tenofovir at each visit as a short-term adherence metric and acceptability of the assay assessed by quantitative surveys. Data were analysed by randomisation group. This completed trial was registered with ClinicalTrials.gov (NCT03935464). FINDINGS: From March 17, 2021 to Jan 18, 2022 we enrolled 49 women in the urine-test counselling group and 51 in the standard of care group; retention was 86 (86%) of 100. Nine (21%) of 42 in the urine-test counselling group had hair samples at 12 months with tenofovir concentrations below the limit of quantification compared with 15 (37%) of 41 in the standard of care group. The relative odds of long-term non-adherence in the standard of care group compared with urine-test counselling were 3·53 (95% CI 1·03-12·03; p=0·044). Pre-intervention, urine tenofovir was detectable in 65% in the urine-test counselling group and 71% in the standard of care group (p=0·68). At 12 months, 31 (72%) of 43 in the intervention group had detectable urine tenofovir compared with 19 (45%) of 42 in the standard of care group (p=0·0015). 40 (93%) of 43 participants liked the test very much and only one disliked the test. One participant in the standard of care group was withdrawn at the 6-month visit due to HIV seroconversion. INTERPRETATION: A low-cost urine tenofovir assay to inform PrEP counselling resulted in improvement in both short-term and long-term metrics of adherence. This urine tenofovir assay could help to improve long-term PrEP adherence. FUNDING: National Institute of Allergy and Infectious Diseases and National Institutes of Health.

Pain, detected by nociceptors, is an integral part of injury, yet whether and how it can impact tissue physiology and recovery remain understudied. Here, we applied chemogenetics in mice to locally activate dermal TRPV1 innervations in naive skin and found that it triggered new regenerative cycling by dormant hair follicles (HFs). This was preceded by rapid apoptosis of dermal macrophages, mediated by the neuropeptide calcitonin gene-related peptide (CGRP). TRPV1 activation also triggered a macrophage-dependent induction of osteopontin (Spp1)-expressing dermal fibroblasts. The neuropeptide CGRP and the extracellular matrix protein Spp1 were required for the nociceptor-triggered hair growth. Finally, we showed that epidermal abrasion injury induced Spp1-expressing dermal fibroblasts and hair growth via a TRPV1 neuron and CGRP-dependent mechanism. Collectively, these data demonstrated a role for TRPV1 nociceptors in orchestrating a macrophage and fibroblast-supported mechanism to promote hair growth and enabling the efficient restoration of this mechano- and thermo-protective barrier after wounding.

Tik Tok is an emerging social media platform that provides a novel opportunity for health practitioners such as dermatologists to disseminate accurate health information.

In the article there is an analysis of the difference of powers of the Board Chair, Chief Executive Officer and Company Secretary under the one-tier corporate governance structure in Ukraine, also the legal nature of the formalization of their duties. The article objective is to establish and articulate the differences of their powers, which is achieved through the study and analysis of legislative acts and relevant scientific researches. It has been determined that the election of the Board Chair and the Chief Executive Officer must take place at the first meeting of the newly elected Board of Directors, while the appointment of the Corporate Secretary occurs upon the appearance of this position. It has been established that the Board Chair and the Chief Executive Officer are elected by the Board of Directors, while the Corporate Secretary is appointed by the Board. The author examines the role of the Board Chair in corporate governance and concludes that the Chair convenes the Board, presides over its meetings, and signs the meeting minutes. It is also noted that, during such meetings, the Board Chair may have the right to a casting vote in the event of a tie among the Board members, as specified in the corporate charter document. The author examines the role of the Chief Executive Officer in corporate governance and concludes that the CEO represents the interests of the corporation, performs legally significant actions on its behalf without the need for a power of attorney, including transactions, and issues orders and directives that are mandatory for all employees of the corporation. It is also noted that the use of the term «ordinary daily activities of the corporation» in paragraph 3 of part two of Article 65 of Law № 2465-IX, the literal interpretation of which could unpredictably limit the powers of the Chief Executive Officer, does not meet the «quality of law» criterion. The article suggests to harmonize the terminology used in Laws № 2465-IX and № 2275-VIII. The author examines the role of the Corporate Secretary in corporate governance and concludes that the Corporate Secretary facilitates the coordination of the Board of Directors and its committees, and the exchange of information between the Board, shareholders, and other stakeholders of the corporation. It is also noted that the Corporate Secretary cannot be a member of the Board of Directors. The article specifies that the Board Chair, the Chief Executive Officer, and the Corporate Secretary are all officials. [ABSTRACT FROM AUTHOR]

Purpose: The COVID-19 pandemic has affected lives and dental treatment. Aerosols and droplets generated during dental treatment present a risk of infection for dental care workers. However, detailed elucidation of the conditions under which those are generated has yet to be presented, and no clear countermeasures for protection have been established. The present study aimed to clarify the process of generation of aerosol and droplets in dental treatment, as well as their dynamics for establishment of effective countermeasures and protection strategies. Methods: Images were obtained using a high-speed camera of aerosol and droplets generated during dental treatments performed on a mannequin. The effects of intraoral vacuum and extraoral vacuum to reduce those, as well as splash range with different body position were examined. Quantitative evaluations of aerosol and droplets were also performed using water-sensitive paper. Results: Aerosol and droplets quantities were significantly reduced by use of both intraoral and extraoral vacuums as compared to no vacuum in both image analysis and findings obtained with water-sensitive paper (p < 0.05). Additionally, the intensity of aerosol and droplets when using the intraoral and extraoral vacuum devices with a body position of 45 degrees was a significantly less as compared to the other settings (p < 0.001). Conclusions: The present study demonstrated the effectiveness of visualization of the aerosol and droplets generated by dental tools using a high-speed camera. Use of an extraoral vacuum resulted in a reduction of those generated during simulated dental treatment, and also contributed to diffusion prevention to protect the operator and assistant. Nevertheless, it is necessary to be careful because the use of extraoral vacuums may reverse the spread of aerosol and droplets depending on the position of patient. [ABSTRACT FROM AUTHOR]

Objective: To evaluate the impact of assistive mobility carts on companion animals and caretakers' quality of life by investigating factors pertaining to caretaker satisfaction, the ability to perform daily tasks, and complication rates. Materials and methods: A 23-question survey was distributed to caretakers of animals using carts to evaluate the animal and caretakers' quality of life, acceptance, ability to complete functional tasks, and complications. Data from canine, feline, and rabbit responses were analyzed separately. Results: Dogs and cats had improved quality of life in 62 and 57% of responses and 61 and 60% for their caretakers, respectively. There was no improvement in the quality of life of rabbits or their caretakers. Regarding the complication rate, 64% were reported to have at least one complication associated with cart use, 53% of which were wounds. Across all species, there was a reported improvement in ability to perform daily tasks and activities. Conclusions and clinical relevance: Caretakers reported that assistive mobility carts improve both companion animals' and caretakers' quality of life, despite high prevalence of complications, including wounds. Future studies exploring specific disease conditions and long-term outcomes will be useful for guiding clinical recommendations. [ABSTRACT FROM AUTHOR]

Background: Pubic hair removal (PHR) is common among women in the United States, and understanding current practices is important for public health efforts. The most recent national study focusing on U.S. women's PHR habits and their correlates was conducted over a decade ago. Objectives: The current study aims to provide an updated understanding of PHR practices among U.S. women, examining prevalence, methods, frequency, and motivations. We also examine characteristics of women who choose to remove their pubic hair. Design: A cross-sectional, nationally representative survey administered in Spring 2023 via Ipsos KnowledgePanel. Methods: Women (N = 522, ages 18–85 years) responded to items inquiring about their demographic characteristics, sexual behaviors, and social media use, as well as methods, prevalence, and motivations associated with PHR. We examine various demographic and behavioral correlates of lifetime and recent PHR among women. Results: Findings reveal that the majority of U.S. women have removed their pubic hair at some point in their lifetime, and almost half have done so within the past month. Frequency and preferred styles of PHR varied among women, indicating a wide range of individual preferences. Among top motivating factors for PHR were perceived cleanliness, comfort, and wanting to look good in a bikini. Race, age, and history of sexual activity were all statistically significant predictors of lifetime and recent PHR. Conclusions: Findings from the current study may assist skincare professionals in better addressing patient/client PHR needs and concerns while promoting health. Studies should continue examining trends in PHR over time, its relation to societal perceptions of beauty, and its implications for health and well-being. Plain language summary: Pubic hair removal practices among U.S. women Pubic hair removal (PHR) is a common practice among women in the United States, and it's important for public health experts to understand current habits. Since the last national study on this topic was conducted a decade ago, the goal of this research was to update our knowledge of how and why U.S. women remove their pubic hair, along with examining which personal characteristics are related to a higher likelihood of women's PHR. We surveyed 522 women aged 18 to 85 across the U.S. in Spring 2023 using Ipsos KnowledgePanel. We asked about their backgrounds, sexual behaviors, social media use, and their methods, frequency, and reasons for PHR. Our findings show that a majority of U.S. women have removed their pubic hair at some point, and nearly half have done so within the past month. Frequency and preferred styles vary, reflecting individual preferences. Most common reasons for PHR included feeling cleaner, more comfortable, and wanting to look good in swimsuit. We found that race, age, and sexual history significantly influenced women's likelihood of PHR in their lifetime and in the past month. Understanding these practices can help skincare professionals better meet the needs of their patients and clients, promoting women's overall health. Moving forward, it is important for studies to continue monitoring PHR trends among women, exploring its connection to evolving societal beauty norms and examining its impacts on health and well-being. [ABSTRACT FROM AUTHOR]

Background: It has been suggested that a short nap in the afternoon may improve sleepiness, alertness, and task performance. The present study evaluated the effects of a 30-min rest with a new nap chair on task performance, sleepiness, and neurophysiological measures. Methods: A randomized controlled crossover trial with a 1-week interval was carried out at the BOOCS Clinic Fukuoka in Japan. The subjects were male workers aged 20 to 64 years with suspected brain fatigue, which was defined by the Profile of Mood Status 2. The intervention was a 30-min rest with an office chair or a nap chair. The primary outcome was the performance in the Uchida-Kraepelin test. The secondary outcomes included the Karolinska Sleepiness Scale and 15-min heart rate variability (HRV). The changes after the nap-chair rest and office-chair rest were compared. Repeated measures analysis of variance with nesting was used in the statistical analysis. Results: Twenty participants were eligible and entered the crossover trial. The overall 15-min score in the Uchida-Kraepelin test improved after the nap-chair rest and after the office-chair rest to almost the same extent (5.9 vs. 5.5 points, P = 0.68). The Karolinska Sleepiness score significantly decreased after the nap-chair rest, and the between-treatment difference in the decrease was highly significant (P = 0.0004). The average duration of sleep during rest was prominently longer in the nap-chair rest than in the office-chair rest (19.0 vs. 7.6 min, P = 0.002). No participants experienced REM sleep during the rest. LF and HF powers of the HRV were greater during the nap-chair rest than during the office-chair rest, the difference in the HF power being substantial. Conclusion: A 30-min rest with the nap chair did not appreciably improve the performance in the Uchida-Kraepelin test as compared with the office-chair rest. The nap-chair rest induced a substantially longer sleep accompanied with a parasympathetic activation, thereby resulting in a material improvement in sleepiness after the rest. [ABSTRACT FROM AUTHOR]

Discarded Human hairs are considered as waste material in most parts of the world and its accumulation causing several environmental problems. However as a potential material resource, human hair has the advantage that it is completely biodegradable, renewable and available in every locality. Thus reutilizing human hair cut discards with a target of extracting a particular major nutrient supply, namely nitrogen, carbon, sulfur and so forth, can create a positive impact on solving soil's infertility problems and less productivity issues of concerned agrarian communities. This study has tried to develop waste human hair based bio-fertilizer by primarily identify the better performing hydrolyzing mixture rang of formulation (H5), ratio of human hair waste mass to aqueous hydrolyzer mixture usages (1:5), favorable reacting time (90 min) and temperature (70 oC) values progressively. Then the physicochemical characteristics were analyzed to reveal the resulted final product's viscosity (~ 76.0 cp.), density (~ 1.17 gm/l), pH (~ pH 9), organic nutrients availability concerning primary Macronutrients (~ 18:0.03:1 N-P-K ratio), Secondary Macronutrients (~ 0.13:0:7 Ca-Mg-S ratio) and other trace micronutrient constituents; which are considered as requirements for the soil nutrient enrichments and plant growths. [ABSTRACT FROM AUTHOR]

Numerous plants evolve ingeniously microcantilever‐based hairs to ultra‐sensitively detect out‐of‐plane quasi‐static tactile loads, providing a natural blueprint for upgrading the industrial static mode microcantilever sensors, but how do the biological sensory hairs work mechanically? Here, the action potential‐producing trigger hairs of carnivorous Venus flytraps (Dionaea muscipula) are investigated in detail from biomechanical perspective. Under tiny mechanical stimulation, the deformable trigger hair, composed of distal stiff lever and proximal flexible podium, will lead to rapid trap closure and prey capture. The multiple features determining the sensitivity such as conical morphology, multi‐scale functional structures, kidney‐shaped sensory cells, and combined deformation under tiny mechanical stimulation are comprehensively researched. Based on materials mechanics, finite element simulation, and bio‐inspired original artificial sensors, it is verified that the omnidirectional ultra‐sensitivity of trigger hair is attributed to the stiff‐flexible coupling of material, the double stress concentration, the circular distribution of sensory cells, and the positive local buckling. Also, the balance strategy of slender hair between sensitivity and structural stability (i.e., avoiding disastrous collapse) is detailed revealed. The unique basic biomechanical mechanism underlying trigger hairs is essential for significantly enhancing the performance of the traditional industrial static mode microcantilever sensors, and ensure the stability of arbitrary load perception. [ABSTRACT FROM AUTHOR]

Chlortalidone (CLT) is a thiazide‐type diuretic with high affinity for the erythrocyte carbonic anhydrase. Therapeutically, it is mostly used to treat edema and hypertension due to liver cirrhosis, heart insufficiency, or renal dysfunction. Although diuretics and masking agents are prohibited by the World Anti‐Doping Agency (WADA) at all times in sports, substances belonging to this category are constantly detected in athlete samples, according to WADA's annual testing figures. Within this group of structurally diverse compounds, a threshold of 20 ng/mL has been introduced for six substances solely due to their presence as contaminants in other permitted drugs because of pharmaceutical production processes. In a recent presumptive doping case with a low urinary CLT concentration, the question of unintentional doping, for example, by contaminated non‐steroidal anti‐inflammatory drug intake, arose. To examine this potential scenario, a co‐elimination of low‐dose CLT and hydrochlorothiazide (HCTA; 20 × 50 μg, 0.2 mg/day each) was conducted on five consecutive days in two volunteers. Urine samples were subjected to liquid chromatography‐tandem mass spectrometry (LC–MS/MS). Moreover, we examined the incorporation of CLT in scalp hair. HCTA is rapidly excreted renally in comparatively high concentrations. In contrast, the elimination of CLT is considerably slower (terminal elimination half‐life extended by a factor of 12) and, consequently, much less concentrated in corresponding urine samples (45 and 53 ng/mL, respectively). Conversely, a higher hair incorporation of chlorthalidone was observed with simultaneous dosing of both. The results suggest that an unintentional intake of sub‐therapeutic CLT doses due to contamination might result in an adverse analytical finding. [ABSTRACT FROM AUTHOR]

In this paper we move from considering the chair as an (inanimate) object, to exploring its vitality through a more vibrant and active reading of this inescapable everyday item. We are inspired by feminist new materialism and how affect shapes our understanding of matter. Reading matter in this way surfaces our orientations toward everyday items that show embodied practices of mattering. This, in turn, shines light on how we imbue objects with meaning, and how objects exceed these designations and categorisations to form new unbounded relations with the world. We focus on affective and symbolic meanings to consider different types of chairs, the spaces they occupy, and who comes to sit in them. For example, the empty chair expects an arrival; the occupied chair raises questions related to place and hospitality. Exploring whose bodies occupy an academic chair enables us to understand our embodied relationships with objects and work. We use personal experiences to engage in acts of experimental writing, reflecting on our lived experiences, and combining philosophical musings that bring the chair to life. By re-thinking our relationships to chairs, we invite the reader to resist the urge to dismiss them as mundane pieces of furniture worthy of only function or dismissal, and instead foster an openness that expands consideration of the material relations that travel across bodies and nonhuman kin. [ABSTRACT FROM AUTHOR]

Purpose: This study is a randomized controlled trial (RCT) that examines the feasibility, acceptability, and initial efficacy of a home-based, remotely supported and supervised exercise training program that was developed using a three-step community engaged research process for persons with multiple sclerosis (MS) who are wheelchair users. Materials and Methods: The study design is a parallel group RCT (NCT05888727). We aim to enroll 24 wheelchair users with MS who will be randomly assigned using REDCap randomization module into exercise training or attention/contact wellness control conditions. The conditions will be delivered remotely over 16 weeks and supported using online, one-onone behavioral coaching. The feasibility outcomes of interest include recruitment and retention rates, and safety outcomes collected throughout the study period. The acceptability outcomes include participant satisfaction and perceptions measured using formative surveys and interviews following the 16-week period. Efficacy outcomes include metabolic health, MS symptoms, and exercise behavior measured before and after the 16-week period. The data analysis will follow intent-to-treat principles using 2 group by 2 time mixed factor ANOVA with estimation of Cohen's d values as effect sizes. Conclusions: The results will guide future research targeting health outcomes using exercise training among wheelchair users with MS who have largely been absent from health promotion research. IMPLICATION FOR REHABILITATION: The current study aims to test the first home-based exercise training program for wheelchair users with multiple sclerosis Community-engaged research methods across this research agenda aim to build partnerships with the target population This research may yield a scalable approach for rehabilitation research and practice by providing a critically needed home-based exercise training program for wheelchair user with multiple sclerosis [ABSTRACT FROM AUTHOR]

The IndieTrainer system, consisting of a mobility device and video-based gamified training modules, was developed to assist children in attaining power wheelchair (PWC) skills. The purposes of this small-scale trial were to explore the use of the IndieTrainer system to provide PWC skills training and document parental satisfaction with the IndieTrainer system. We hypothesized that PWC skills training provided using the IndieTrainer system would result in improvements in both children's understanding of how to use a PWC and their PWC skill execution, and that parental satisfaction would be high. An open-label, single-arm trial was conduct as follows: (a) Baseline testing (T0); (b) A 3-week intervention consisting of two, 60-min-PWC skills training sessions per week; (c) Post-intervention testing (T1); and (d) A single session retention trial held 4 weeks after completion of the intervention (T2). Outcome measures included the Assessment of Learning Powered mobility use (ALP), Wheelchair Skills Checklist (WSC), Canadian Occupational Performance Measure (COPM), and Client Satisfaction Questionnaire-8 (CSQ-8). 25 child/parent dyads participated. Between T0 and T1, statistically significant differences (p-value <.0001) with large effect sizes in mean ALP and WSC scores (ALP: d = 3.14; WSC: d = 3.25) and COPM performance and satisfaction scores (Performance: d = 4.66; Satisfaction: d = 3.24) were achieved. Mean T1 total CSQ-8 score was 31.52/32. At T2, all children maintained or improved their T1 ALP and WSC scores. This study provides initial support for the usability and feasibility of the IndieTrainer system. Futhermore, larger scaled studies using more rigorous research designs are indicated. IMPLICATIONS FOR REHABILITATION: The IndieTrainer system allows clinicians to tailor power wheelchair skills (PWC) skills training based on an individual child's specific goals and level of understanding. Selectively combining the use of progressive video-based gamified modules and real-world power mobility experiences may support children who are learning PWC skills. When provided with progressive PWC skills training, children with severe disabilities may improve their understanding of how to use a PWC and their PWC skills. [ABSTRACT FROM AUTHOR]

In this single-blind randomized controlled trial, we tested the hypotheses that, in comparison with control participants receiving only self-study materials (SS group), caregivers of manual wheelchair users who additionally receive remote training (RT group) have greater total Wheelchair Skills Test Questionnaire (WST-Q) performance and confidence scores post-training and at follow-up; and that self-study and remote training each individually lead to such gains. We studied 23 dyads of wheelchair users and their caregivers. Caregivers in the SS group received a handbook and videorecording. Those in the RT group also received up to four real-time ("synchronous") sessions remotely. The WST-Q 5.1 was administered pre-training (T1), post-training (T2), and after a 3-month follow-up (T3). The mean total WST-Q scores of both groups rose slightly at each new assessment. For the T2-T1 and T3-T1 gains, there were no statistically significant differences between the groups for either WST-Q performance or WST-Q confidence. For performance, the T2-T1 gain was statistically significant for the RT group and the T3-T2 gain was statistically significant for the SS group. For both groups, the T3-T1 gains in performance were statistically significant with gains of 12.9% and 18.5% relative to baseline for the SS and RT groups. For confidence, only the T3-T1 gain for the SS group was statistically significant with a gain of 4.5% relative to baseline. Although less than the gains previously reported for in-person training, modest but important gains in total WST-Q performance scores can be achieved by self-study, with or without remote training. Registration Number: NCT03856749. IMPLICATIONS FOR REHABILITATION: Self-study can improve the manual wheelchair skills of caregivers. Remote training can improve the manual wheelchair skills of caregivers. Improvements are slightly less than those reported in the literature for in-person training. [ABSTRACT FROM AUTHOR]

Wheelchair provision training is essential to overcome barriers related to the lack of knowledge of health professionals on this topic. Appropriate knowledge of the service provision process may lead to higher quality service and products, and thus be more likely to help people with mobility impairments achieve the fundamental human right of personal mobility. This study aimed to describe a training intervention for two groups of future physiotherapists in Colombia, assess cohort differences in performance on a knowledge test, and explore their post-training perceptions. A quantitative retrospective study with a historical, descriptive-comparative design was conducted. 525 sixth-semester participants completed the International Society of Wheelchair Professionals Wheelchair Service Provision – Basic Test online in Spanish after curriculum modifications were implemented. The test assesses knowledge in seven domains: Assessment; Prescription; Products; Fitting; User training; Follow-up, maintenance, and repairs; and Process. The training intervention was successfully implemented with Physiotherapy students from two institutions, resulting in a 57% increase in test approval rates. Participants demonstrated increased knowledge, satisfaction with the course content, and application of learning to their current work. These results suggest implications for what pedagogical approach to employ, when curricular change may be warranted, and specific considerations for the Colombian context. Furthermore, identifying the minimal knowledge basis for undergraduate programs and facilitating its dissemination can support interprofessional education and enhance professionals' capacity to support wheelchair provision services. IMPLICATIONS FOR REHABILITATION: Developing pedagogical materials and resources should address academic needs while also being adaptable to the healthcare system and cultural and economic resources. Establishing minimal knowledge bases for physiotherapists and facilitating their dissemination to support interprofessional education are crucial steps. Sharing pedagogical experiences that improve health workforce training promotes the quality of wheelchair service provision, benefiting the functional independence and well-being of people with disabilities. The use of international resources such as the ISWP test in the training of the health workforce contributes to the standardization of the training process regardless of the context. [ABSTRACT FROM AUTHOR]

Using scanning electron microscopy (SEM), six Salsola species from Iran were examined for their epidermis, seed, and fruit micromorphology. Among them were S. brachiata from section Heterotricha, S dendroides, S. incanescens, and S. orientalis from section Caroxylon, S. kali from section Kali, and S. turcomanica from section Physurus. Epidermal cells are divided into three types. There were diamond, irregular, and polygonal cells, as well as straight and undulated walls. Studied species of Salsola have smooth or sculptured fruit surfaces, and there are three main types of fruit surface ornamentation. There is a significant difference between these species based on the type of hair and density of the fruit. Seed shape and color have little systematic significance. The seed epidermis is composed of polygonal, elongated polygonal, irregular, and diamond cells. Although polygonal and irregular testa cells are most common, their size and shape can provide additional information and useful diagnostic characteristics at both specific and infraspecific levels. For taxonomic separation, the current study provides novel insights at micromorphological levels. Research Highlights: This article reports halophyte are shown as models for adaptation to extreme habitats.These plants are placed among the ecological communities of xerophytes. Here, for the first time, the microstructural analysis of Salsola has been investigated.Additionally, it provides new insights into plant species' response to extreme conditions, as well as possible adaptation strategies at the micromorphological level. [ABSTRACT FROM AUTHOR]

The 4D-5D connection allows us to view the same near horizon geometry as part of a 4D black hole or a 5D black hole. A much studied example of this phenomenon is the BMPV black hole uplifted to 6D with flat base space versus Taub-NUT base space. These black holes have identical near horizon AdS3 × S3 geometry. In this paper, we study modes in AdS3 × S3 and identify those that correspond to supersymmetric hair modes in the full black hole spacetimes. We show that these modes satisfy non-normalisable boundary conditions in AdS3. The non-normalisable boundary conditions are different for different hair modes and for different asymptotic completion. We also discuss how the supersymmetric hair modes on BMPV black holes fit into the classification of supersymmetric solutions of 6D supergravity. [ABSTRACT FROM AUTHOR]

A wearable chair is designed to reduce musculoskeletal disorders in workers. Two-staged optimization process using The Bees Algorithm is conducted to determine the lowest operable height of the chair and minimize the maximum force among the three supports. Geometric, dimensional, and rotational angle constraints are defined accordingly. A CAD model of the chair is imported into ADAMS software for simulation. The simulation results identified the most stressed rod in the chair. A spring is selected and implemented in ADAMS to counteract the applied force on this rod. A comparison between the force on the most stressed support and the spring force through a defined motion revealed minimal differences, indicating that the spring effectively counteracted the applied force. The results demonstrated the successful application of The Bees Algorithm to wearable chairs and the successful implementation of a spring to counteract applied force, thereby achieving the objectives of this study. [ABSTRACT FROM AUTHOR]

Mercury is a pollutant that poses a considerable health risk. The concentration of mercury in scalp hair can be used to estimate past mercury exposure. Methods such as atomic absorption spectrophotometry and inductively coupled plasma‐based techniques have been used to determine the concentrations of trace elements in scalp hairs; however, these analytical methods have several limitations, including the need for expensive equipment, complex sample preparation, and large samples of more than 100 hairs. Therefore, simpler and more cost‐effective methods are required. X‐ray fluorescence (XRF) spectroscopy is a simple and fast analytical method. To improve the sensitivity, we applied a secondary target method to enhance the XRF excitation and reduce the background. In conventional secondary target methods, the primary x‐rays irradiate a secondary target of a pure substance, and the sample is then irradiated with the fluorescent x‐rays from the secondary target. We placed high‐purity Y₂O₃ powder, which served as the secondary target, behind the hair samples. The XRF intensities of trace elements such as mercury and zinc in the hair were enhanced by applying the secondary target behind the hair. [ABSTRACT FROM AUTHOR]

Background: Falls are prevalent among people living with Multiple Sclerosis (PwMS) and Spinal Cord Injury (PwSCI) who use wheelchairs or scooters (WC/S) full time, however, there is a scarcity of evidence-based fall prevention and management programs. Objective: To describe the systematic translation of an in-person fall prevention and management program (Individualized Reduction Of FaLLs - iROLL) for PwMS to an online platform, extending its scope to include PwSCI, and to evaluate the preliminary useability, usefulness, and safety of the intervention. Methods: iROLL was systematically translated to an online platform (iROLL-O). PwMS and PwSCI who use a WC/S full time, experienced at least one fall within the past 36 months, and could transfer independently or with minimal to moderate assistance, enrolled in iROLL-O. Usability, usefulness, and safety were evaluated through 1:1 semi-structured interviews, gathering feedback on: perceived impact of the intervention on falls and functional mobility, program experiences, adverse events, and recommendations for improvement. Results: Five participants successfully completed the iROLL-O program. No safety concerns were raised by participants. Themes emerging from the semistructured interviews included: (1) barriers and facilitators to program access, (2) motivation for participation, (3) program outcomes, and (4) program content and structure. Participants reported reduced concerns about falling, enhanced functional mobility skills, and highlighted the supportive nature of synchronous group meetings for learning. Conclusion: No adverse events occurred during the implementation of iROLL-O and participants found the program to be useable and useful. Further testing is needed to examine efficacy among a large and diverse population. [ABSTRACT FROM AUTHOR]

The epidermis of the skin and skin appendages, such as nails, hair and sebaceous glands, depend on a balance of cell proliferation and terminal differentiation in order to fulfill their functions at the interface of the body and the environment. The differentiation of epithelial cells of the skin, commonly referred to as keratinocytes, involves major remodeling processes that generate metabolically inactive cell remnants serving as building blocks of the epidermal stratum corneum, nail plates and hair shafts. Only sebaceous gland differentiation results in cell disintegration and holocrine secretion. A series of studies performed in the past decade have revealed that the lysosome-dependent intracellular degradation mechanism of autophagy is active during keratinocyte differentiation, and the blockade of autophagy significantly alters the properties of the differentiation products. Here, we present a model for the autophagy-mediated degradation of organelles and cytosolic proteins as an important contributor to cellular remodeling in keratinocyte differentiation. The roles of autophagy are discussed in comparison to alternative intracellular degradation mechanisms and in the context of programmed cell death as an integral end point of epithelial differentiation. [ABSTRACT FROM AUTHOR]

Construction is one of the primary drivers of development and economic activity in Pakistan. Many activities are performed at the construction site including cement mixing, carpentry, and painting. Workers working in these activities are exposed to toxic heavy metals. Due to exposure to these heavy metals, subjects are at high risk of developing diseases mainly respiratory diseases. Human hair and nail samples of construction workers in Rawalpindi, Pakistan were collected to assess the heavy metals. Heavy metals such as Al, As, Cd, Cr, Ni, K, Pb, and Zn were analyzed in the hair and fingernails of the construction workers. To determine the level of selected heavy metals, Inductively Coupled Plasma optical emission spectrometry was used. Results revealed that Al was the highest with a mean concentration of 7.54 μg/g in all three groups. Whereas Cd was below the detection limit. Heavy metal concentration was high in hair (1.77 μg/g) in two groups including cement mixing and carpentry. However, in the carpentry group heavy metal concentration was high in nails (1.19 μg/g). Additionally, the workers of the carpentry group have higher metal concentrations when compared to the other two groups and this group was at high risk of toxic metal exposure. After the correlation analysis, the results revealed that age was significantly correlated to body burden of metals (r = 0.496, p ≤ 0.05). Moreover, some of the heavy metals in hair and nails were significantly correlated with each other. Since all groups, especially carpenters, show high levels of heavy metals, there is a need for regular monitoring of heavy metals at construction sites. Most importantly, the implementation of training programs is needed to raise awareness among construction workers. [ABSTRACT FROM AUTHOR]

This study investigated arsenic (As) concentrations in diverse environmental components and their potential impact on the health risks faced by residents of the arsenic (As)-contaminated Nadia district in West Bengal, India. A random selection of 182 cattle and 255 goats from 40 livestock farmers in the district revealed that both animals and humans were naturally exposed to elevated arsenic levels through contaminated drinking water, foods, grasses, concentrate feeds, various fodder tree leaves, and other food/feed resources. The mean As concentration in roughages (483.18 µg/kg DM) was significantly higher (p < 0.001) than in tree leaves (391.53 µg/kg DM), and concentrate feed/ingredients (186.66 µg/kg DM). Pond water exhibited higher arsenic levels (106.11 µg/L) compared to shallow tube well water (47.96 µg/L) and deep tube well water/tap water (10.64 µg/L and 10.04 µg/L, respectively). The mean arsenic concentration in soils DM of fodder fields, crop fields, and grassland was 10.25, 10.58, and 10.20 mg/kg, respectively. It was observed that protein-rich feeds had lower levels of arsenic accumulation (p < 0.048), while fiber-rich feeds containing more cellulose, hemicellulose, and lignin had higher arsenic levels (p < 0.017). Goats consumed 73.46% more arsenic per kg body weight compared to dairy cows. Although chronic and sub-chronic arsenic exposure in the district did not typically manifest symptoms or visible signs in ruminant animals, concentrations in the hair and feces of both cattle and goats exceeded normal values. Cattle feces had significantly higher arsenic (410.43 µg/kg DM) levels (p < 0.001) than goat feces (227.00 µg/kg DM), and arsenic concentration in cattle hair (1917.74 µg/kg DM) was also significantly greater (p < 0.001) than goat hair (1435.74 µg/kg DM). Arsenic levels in milk samples from both species were below 10 µg/kg. Liver (356.02 µg/kg DM) and kidney (317.22 µg/kg DM) contained significantly higher (p < 0.001) levels of arsenic compared to muscle (204.23 µg/kg DM), and bone (161.98 µg/kg DM) in local meat-type adult male goats. The skin accumulated the highest amount of arsenic (576.24 µg/kg DM) among the non-edible parts of the goat carcass. The cumulative cancer risk value for adults was 4.96 × 10−3, exceeding the threshold value (1 × 10−6). This suggests a significant risk of cancer development for the population in arsenic-affected areas. Non-cancer risks (hazard indexes) were estimated at 11.01 for adults. Our observations revealed that the highest bioaccumulation of arsenic occurred in the hair of cows, and goats in the examined localities. The biotransformation factor (BTF) for hair was much higher compared to other excreted samples from both species. The calculated BTF followed the order: hair > feces > milk for cows and goats. Livestock farmers in Nadia district are advised to carefully select feed resources, prioritizing those high in crude protein and low in neutral detergent fiber, and they should provide drinking water from deep aquifers to ensure the safety of milk and meat for human consumption. [ABSTRACT FROM AUTHOR]

Background: Stress is today a common feature of patients seeking medical care and a growing public health issue in society. A method has been developed to measure biological chronic stress by Hair Cortisol Concentrations (HCC). This biomarker, for chronic stress, captures information about cumulative cortisol levels over the course of several months. Long-term stress might be one of the factors contributing to the onset of cardiovascular conditions and also affecting different risk factors. The aim of this study was to analyse the association between Hair Cortisol Concentrations and previous cardiovascular diseases and cardiovascular risk factors. Methods: The method of measuring chronic stress by Hair Cortisol Concentration was applied in a large Swedish national observational cross-sectional study. A population-based random sample of N = 4,821 Swedish middle-aged men and women was analysed for hair cortisol levels in relation to diagnosed previous cardiovascular diseases and biologically measured cardiovascular risk factors. Results: Long-term stress, measured by hair cortisol, was significantly associated with the classical cardiovascular risk factors hypertension and high cholesterol, but not smoking. Those with elevated HCC levels also had a significantly increased pre-history of myocardial infarction, type 2 diabetes, atrial fibrillation and by-pass surgery, but not regarding stroke, angina pectoris or sleep apnoea. Higher HCC was significantly associated (p < 0.001) with Body mass index and waist circumference, but only for females. HCC was also associated with the risk markers leukocytes, and high-sensitivity CRP, indicating a possible linkage between HCC and inflammation and hypothetically also the bodily immune defense. No association was found between perceived stress and HCC. Conclusions: An overall conclusion of our results is that health care should put more emphasis on patients reporting that they have been exposed to long term stress. Altogether, these analyses of Hair cortisol levels in a large middle-aged population show that chronically elevated cortisol levels represent a relevant and significant factor associated with cardiovascular diseases and classical cardiovascular risk factors. [ABSTRACT FROM AUTHOR]

Background: Spinal cord injury (SCI) is one of the most catastrophic injuries that might lead to permanent use of a wheelchair and severely affects the quality of life, hence SCI patients report lower satisfaction with life (SWL) than the general population. Therefore, it is important to identify factors that determine SWL among wheelchair users with SCI. Our study aimed to assess the prevalence of low SWL and to identify its determinants among wheelchair users with SCI in Egypt. Methods: A cross-sectional study included 105 wheelchair users with SCI from the Al Hassan Foundation for wheelchair users in Egypt. The main outcome measure was low SWL, while the independent variables included sociodemographic characteristics, injury-related characteristics, anxiety, depression, neuropathic pain, functional independence, and environmental barriers. Results: The prevalence of low SWL among study participants was 57.1%. We found significant associations between SWL and age, area of living, and age at injury. Additionally, SWL correlated negatively with anxiety, depression, neuropathic pain, and environmental barriers, and positively with functional independence. Finally, the binary multiple logistic regression revealed that living in Upper Egypt (p = 0.017, OR = 13.7), depression (p = 0.034, OR = 6.08), older age (p = 0.002, OR = 1.21), and work and school environmental barriers (p = 0.022, OR = 0.46) were the predictors of low SWL. Conclusion: To improve the SWL for wheelchair users with SCI we need to effectively manage neuropathic pain, depression, and anxiety, and promote functional independence. There is an urgent need to reinforce legislation to improve the living conditions for wheelchair users with SCI in Egypt, especially in Upper Egypt. [ABSTRACT FROM AUTHOR]

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The Israel–Carter theorem (also known as the "no-hair theorem") puts a restriction on the existence of parameters other than mass, electric charge, and angular momentum of a black hole. In this context, Bekenstein proposed no-hair theorems in various black hole models with neutral and electrically charged scalar fields. In this paper, we take the Einstein–Maxwell-charged scalar model with an electrically charged scalar field gauge-coupled to the Maxwell field surrounding a charged black hole with a static spherically symmetric metric. In particular, we consider a quadratic scalar potential without any higher order terms and we do not impose any restriction on the magnitude of the scalar charge with respect to the black hole charge. With this setting, we ascertain the validity of all energy conditions coupled with the causality condition, suggesting the possibility of existence of charged hairy solutions. Consequently, we obtain, by exact numerical integration, detailed solutions of the field equations that incorporate backreaction on the spacetime due to the presence of the charged scalar field. The solutions exhibit damped oscillatory behaviours for the charged scalar hair. We also find that the electric potential is a monotonic function of the radial coordinate, as required by electrodynamics. In order to ascertain the existence of our charged hairy solutions, we carry out dynamic stability analyses against time-dependant perturbations about the static solutions. For a definite conclusion, we employ two different methodologies. The first methodology involves a Sturm–Liouville equation, whereas the second methodology employs a Schrödinger-like equation, for the dynamic perturbations. We find that our solutions are stable against time-dependant perturbations by both methodologies, confirming the existence of the charged hairy solutions. [ABSTRACT FROM AUTHOR]

This autobiographical narrative reflects challenges I have faced, throughlines I have identified, and insights I have drawn and can share from my experience as the first Black male chair of the social work department in a predominantly White postsecondary context. This reflection offers a historical profile of my lived experiences with occurrences and patterns of interpersonal racism that have shaped and intersected with my goals, duties, and responsibilities as an administrative leader and department chair. I share and unpack these details here to provide context and support to scholars and academic leaders of color still to come. [ABSTRACT FROM AUTHOR]

Epilepsy remains a disease that affects many people around the world. With the development of new drugs to treat this condition, the importance of therapeutic drug monitoring continues to rise and remains a challenge for the medical community. This review article explores recent advances in the detection of antiepileptic drugs across various sample types commonly used for drug monitoring, with a focus on their applications and impact. Some of these new methods have proven to be simpler, greener, and faster, making them easier to apply in the context of therapeutic drug monitoring. Additionally, besides the classic use of blood and its derivatives, there has been significant research into the application of alternative matrices due to their ease of sample collection and capacity to reflect drug behavior in blood. These advances have contributed to increasing the efficacy of therapeutic drug monitoring while enhancing its accessibility to the population. [ABSTRACT FROM AUTHOR]

Protonitazene is a synthetic benzimidazole opioid of the nitazenes class, developed in the 1950s as an effective analgesic, but never released on the market due to severe side effects and possible dependence. Despite its increasing use as a new psychoactive substance starting in 2019, its detection in human hair of intoxicated and deceased consumers has never been reported. We present the development and validation of a specific procedure to identify protonitazene in hair by liquid chromatography with tandem mass spectrometry. Drugs were incubated overnight at 40°C in 1 mL borate buffer, pH 9.5 with 20 mg pulverized hair and 1 ng/mg fentanyl-d5 used as internal standard. Drugs were then extracted with a mixture of organic solvents. The chromatographic separation was performed using an HSS C18 column with a 15-min gradient elution. Linearity was verified from 1 to 100 pg/mg. The limit of detection was estimated at 0.1 pg/mg. No interference was noted from a large panel of natural and synthetic opioids, fentanyl derivatives, or other new synthetic opioids. Protonitazene was identified at 70 and >7600 pg/mg in the whole head hair specimens of two male subjects deceased from an acute drug overdose in jail. Protonitazene was also identified at 14 and 54 pg/mg in two living co-prisoners. As nitazenes represent a growing threat to public health in various parts of the world, this method was developed in response to the challenges posed by the identification of this class of substances. [ABSTRACT FROM AUTHOR]

The hair follicle can cycle throughout a lifetime, undergoing periods of growth (anagen), regression (catagen) and relative quiescence (telogen). The time that a hair follicle spends in each of these stages is crucial to determine the length of hair fibre that it produces. Perturbations in this regard can manifest in various hair diseases such as anagen effluvium, or acute and chronic telogen effluvium. The established 'dogma' when considering how many hair follicles there are in each stage has long been that the majority are in anagen (85%–90%), followed by telogen (10%–15%) and catagen (1%–2%). These values are based on various studies using different methodologies such as hair plucking, phototrichograms and histology. However, these methods have flaws when it comes to differentiating between catagen and telogen follicles. We sought to determine the catagen: telogen ratio through the ex vivo stereomicroscopic examination of hundreds of hair follicles removed from the occipital scalp of 14 Caucasian males during routine hair transplantation procedures. Using this methodology, and in agreement with a similar observation by another research group, we found that the percentage of catagen hair follicles was higher (7.5%) than telogen (3.5%) in all patients assessed. Consequently, we believe that the percentage of catagen follicles is clearly underestimated and therefore challenge the current established dogma. [ABSTRACT FROM AUTHOR]

Satisfaction of 81 patients was evaluated before and after receiving occupational therapy services. There was a statistically significant difference between patients' scores before and after receiving occupational therapy services (p <.05). Over 85% indicated a high satisfaction in relation to quality and health outcomes attributed to occupational therapy services, 44% reported barriers related to limited availability, accessibility, and knowledge of occupational therapy services, and 35% made suggestions for improvements. Patient-therapist communication and easy access to occupational therapy services can enhance occupational therapy knowledge, lead to positive patient experience and quality health outcomes, and higher patient satisfaction. [ABSTRACT FROM AUTHOR]

Background: Female pattern hair loss (FPHL) is women's most common form of alopecia. The study aimed to evaluate the efficacy of extracorporeal shock waves for hair growth and regeneration in women with FPHL. Methods: A prospective single‐center noncontrolled study was conducted in patients with FPHL who underwent eight treatment sessions with C‐Actor, a shock wave applicator. Outcome measures included total hair count, number of follicular units (FUs)—single FUs, double FUs, triple and bigger FUs—the average thickness, cumulative hair thickness, and changes in the Derived Sinclair scale, assessed with Tricholab (Fotofinder System). Patients completed a survey to assess their subjective perceptions of hair improvement regarding softness, hair loss, quality, and volume. Results: Twenty women were included with a mean age of 43 (SD = 5.65). The mean increase in total hair count was 8.9% (p < 0.00001), in number of FUs 4.6% (p = 0.00031), in number of triple and bigger FUs 18.4% (p = 0.0004), in cumulative hair thickness 8.0% (p < 0.00001), with a decrease of 5.7% in mean Derived Sinclair scale value by 2.2–2.1 (p < 0.0001). After 3 months, 85% of patients perceived improvement in hair volume. Conclusion: Extracorporeal shock waves for hair growth and capillary regeneration in women with FPHL showed statistically significant outcomes, and all patients reported an improvement in hair characteristics. [ABSTRACT FROM AUTHOR]

To improve the use experience of airport chairs, this study adopted morphological analysis to conduct systematic deconstruction, analysis, and statistics on the modeling features of existing airport chairs. The KJ method was used to determine the design requirements of airport chairs. The study combined the Kano model to classify the functional attributes and prioritize the requirements, and it merged the module and demand analysis to build a Function-Behavior-Structure mapping model. In this way, passengers' demand for airport chairs can be clearly defined, and airport chair configuration planning can be carried out according to the difference in preferences. Further, different module combination schemes can be formed to improve the functional allocation efficiency of airport chairs, optimize the overall service quality of airports, and provide some basis and reference for the future design of airport chairs. [ABSTRACT FROM AUTHOR]

Human hair cortisol concentration (HCC) has previously been found to be highly stable for a 1‐year interval (r = 0.73) in terms of a product–moment correlation. The present study aimed to replicate this finding and compare HCC stability regarding 1‐year and 2‐year test–retest intervals. Female university students (N = 39) provided hair strands twice (t1 and t2) at intervals of 1 (n = 21) or 2 years (n = 18). Multiple regression analysis predicting HCC at t2 revealed a significant interaction term (HCC at t1 × time interval condition). It was determined that HCCs were substantially related for the 1‐year interval but unrelated for the 2‐year interval. The findings were not attributable to potential influences, such as hair treatment. The product–moment correlation showed nearly identical consistency with previous research regarding the 1‐year test–retest interval. There was no significant product–moment correlation for the 2‐year interval. Overall, these findings indicate that within a temporal framework of 1 year, HCCs may be stable predictors in correlational studies where the focus is on the rank orders of measured values. [ABSTRACT FROM AUTHOR]

Manual wheelchair propulsion represents a repetitive and constraining task, which leads mainly to the development of joint injury in spinal cord-injured people. One of the main reasons is the load sustained by the shoulder joint during the propulsion cycle. Moreover, the load at the shoulder joint is highly correlated with the force and moment acting at the handrim level. The main objective of this study is related to the estimation of handrim reactions forces and moments during wheelchair propulsion using only a single inertial measurement unit per hand. Two approaches are proposed here: Firstly, a method of identification of a non-linear transfer function based on the Hammerstein–Wiener (HW) modeling approach was used. The latter represents a typical multi-input single output in a system engineering modeling approach. Secondly, a specific variant of recurrent neural network called BiLSTM is proposed to predict the time-series data of force and moments at the handrim level. Eleven subjects participated in this study in a linear propulsion protocol, while the forces and moments were measured by a dynamic platform. The two input signals were the linear acceleration as well the angular velocity of the wrist joint. The horizontal, vertical and sagittal moments were estimated by the two approaches. The mean average error (MAE) shows a value of 6.10 N and 4.30 N for the horizontal force for BiLSTM and HW, respectively. The results for the vertical direction show a MAE of 5.91 N and 7.59 N for BiLSTM and HW, respectively. Finally, the MAE for the sagittal moment varies from 0.96 Nm (BiLSTM) to 1.09 Nm for the HW model. The approaches seem similar with respect to the MAE and can be considered accurate knowing that the order of magnitude of the uncertainties of the dynamic platform was reported to be 2.2 N for the horizontal and vertical forces and 2.24 Nm for the sagittal moments. However, it should be noted that HW necessitates the knowledge of the average force and patterns of each subject, whereas the BiLSTM method do not involve the average patterns, which shows its superiority for time-series data prediction. The results provided in this study show the possibility of measuring dynamic forces acting at the handrim level during wheelchair manual propulsion in ecological environments. [ABSTRACT FROM AUTHOR]

An evaluation of forensic hair analysisbetween experts, novices and the recently developed machine learning platform, HairNet, was conducted to assess accuracy and reliability. Our hypothesis stated experts and the machine learning platform will outperform novices in classifications of hair as human or non-human and suitability for nDNA analysis based on specialist knowledge and from training of the model. Statistically significant differences between novices and experts were found and attributed to training and experience for more complex classifications. For more simplistic classifications, no statistically significant difference between the novice and the experts was found. HairNet proved responses similar to expert responses in all classifications. Encouraging feedback was received regarding the use of technology and machine learning. The utilization of technology undoubtedly holds great promise to become part of the forensic tool kit for improving the efficiency and reliability of forensic hair analysis and in research, education and competency testing. [ABSTRACT FROM AUTHOR]

The increasing demand for effective hair care products has highlighted the necessity for rigorous claims substantiation methods, particularly for products that target specific hair types. This is essential because the effectiveness of a product can vary significantly based on the hair's condition and characteristics. A well-defined bleaching protocol is crucial for creating a standardized method to assess product efficacy, especially for products designed to repair damaged hair. The objective of this study was to create a practical bleaching protocol that mimics real-world consumer experiences, ensuring that hair samples exhibit sufficient damage for testing. This approach allows for a reliable assessment of how well various products can repair hair. The protocol serves as a framework for evaluating hair properties and the specific effects of each product on hair structure. Color, brightness, lightness, morphology, and topography were primarily used to understand the big differences in the hair fiber when treated with two repair benchmark products, K18® and Olaplex®, in relation to the Bleached hair. The devised bleaching protocol proved to be a fitting framework for assessing the properties of hair and the unique characteristics of each tested product within the hair fiber. This protocol offers valuable insights and tools for substantiating consumer claims, with morphological and mechanical methods serving as indispensable tools for recognizing and validating claims related to hair. The addition of K18® and Olaplex® demonstrated an increase in hair brightness (Y) and lightness (L* and a*) in relation to the Bleached samples, which were considered relevant characteristics for consumers. Olaplex®'s water-based nature creates a visible inner sheet, effectively filling empty spaces and improving the disulfide linkage network. This enhancement was corroborated by the increased number of disulfide bonds and evident changes in the FTIR profile. In contrast, K18®, owing to the lipophilic nature of its constituents, resulted in the formation of an external layer above the fiber. The composition of each of the products had a discrete impact on the fiber distribution, which was an outcome relevant to the determination of spreadability by consumers. [ABSTRACT FROM AUTHOR]

Molting is an evolutionarily ancient trait in which the outermost layer of an organism is replenished, usually according to a regular circannual rhythm. It is a metabolically costly process and, in vertebrates, is generally timed around other energetically demanding events such as reproduction and migration. In mammals, molting involves replacement of the fur coat—one of the most distinct innovations of the mammalian lineage. Despite the obvious importance of hair to mammalian fitness, our knowledge of hair growth cycles, circannual molting patterns, and hair structure remains largely restricted to marine and domesticated mammals, and our ability to identify explicit adaptive advantages of molting strategies in any mammal is therefore limited. In this review, we summarize what is known of these topics in wild, terrestrial mammals with a particular emphasis on marmots (Marmota spp.). Marmots are the largest extant ground squirrels and are well adapted to seasonally cold environments. Molting may be particularly relevant to fitness in marmots given the presumed importance of a healthy, insulative coat for metabolic efficiency in cold environments. Moreover, marmots hibernate for 7 to 8 months each year, meaning the annual molt and all other energetically demanding life-history events (such as parturition, lactation, fat accumulation, and dispersal) are constrained to an active period of only 4 to 5 months. Because the energetics of hibernation, fat accumulation, reproduction, and social behavior are already well studied, examining how molt is timed with respect to other important events and how it is influenced by local conditions may inform how molting is prioritized and how molting strategies evolve under specific selective pressures. [ABSTRACT FROM AUTHOR]

Methandienone is an anabolic‐androgenic steroid that is prohibited in equine sports due to its potential performance enhancing properties. Metabolism and detection of methandienone in equine urine have been investigated comprehensively in literature; however, there is a limited knowledge about its metabolites in equine plasma and no information about its detection in equine hair. Following a multi‐dose oral administration of methandienone to two Thoroughbred horses, 17‐epimethandienone, methyltestosterone, two mono‐hydroxylated, two di‐hydroxylated and three 17α‐methylandrostanetriol metabolites were detected in plasma. The majority of these were present as free analytes, whilst the mono‐hydroxylated metabolites and one isomer of 17α‐methylandrostanetriol were partially conjugated. Estimated peak concentrations of methandienone were 6,000 and 11,100 pg/ml; meanwhile, they were 25.4 and 40.5 pg/ml for methyltestosterone. The most abundant analyte in the post‐administration plasma samples of both horses was the mono‐hydroxylated metabolite; however, the parent compound provided the longest detection (up to 96 h). Screening analysis of hair enabled the detection of methandienone in mane hair samples only, for up to 3 months. Its mono‐ and di‐hydroxylated metabolites were detected with greater peak responses for up to 6 months post‐administration in both mane and tail samples, showing that these metabolites could be better analytical targets for hair analysis when administered orally. A follow‐up methodology with an extensive wash procedure confirmed the presence of methandienone and its metabolites in a number of post‐administration hair samples. Final wash samples were also analysed to assess the degree of internal incorporation (via bloodstream) against possible external deposition (via sweat/sebum). [ABSTRACT FROM AUTHOR]

Context: Airborne pathogens, defined as microscopic organisms, pose significant health risks and can potentially cause a variety of diseases. Given their ability to spread through diverse transmission routes from infected hosts, there is a critical need for accurate monitoring of these pathogens. This study aims to develop a sensor by investigating the vibrational responses of cantilever and bridged boundary-conditioned single-layer graphene (SLG) sheets with microorganisms, specifically SARS-CoV-2, attached at various positions on the sheet. The dynamic analysis of SLG with different boundary conditions and lengths was conducted using the atomistic finite element method (AFEM). Simulations were performed to evaluate SLG's performance as a sensor for biological entities. Altering the sheet's length and the mass of the attached biological object revealed observable frequency differences. This sensor design shows promise for enhancing the detection capabilities of graphene-based technologies for viruses. Methods: Finite element method (FEM) analysis is employed to model the sensor's performance and optimize its design parameters. The simulation results highlight the sensor's potential for achieving high sensitivity and rapid detection of SARS-CoV-2. Bridged and cantilever boundary conditions are applied at the ends of the SLG structure by using ANSYS software. Simulations have been conducted to observe how SLG behaves when used as sensors. In armchair graphene, under both boundary conditions, an SLG (5, 5) structure with a length of 50 nm displayed the highest frequency when a SARS-CoV-2 molecule with a mass of 2.6594 × 10−18 g was attached. Conversely, the chiral SLG (17, 1) structure exhibited its lowest frequency at a length of 10 nm. This insight is crucial for grasping detection limits and how factors such as size and boundary conditions influence sensor efficacy. These biosensors hold immense promise in biological sciences and medical applications, revolutionizing patient care by enabling early detection and accurate pathogen identification in clinical settings. [ABSTRACT FROM AUTHOR]

Purpose: The manual, user-operated Arise Standing Wheelchair (SWC) is the end result of multiple design iterations based on findings and feedback from user trials. The Arise SWC provides standing functionality, outdoor mobility, affordability, and customisability. This paper describes a long-term community integration study of the Arise SWC. Methods: All participants (N = 8; 7 Male, 1 Female) were persons with spinal cord injuries. During the study period (six months), the participants integrated the Arise SWC into their daily routines. To assess the impact of the Arise SWC on various outcome measures, participants' responses were captured using a Likert-scale questionnaire at the beginning of the study, after 30 days, and after 180 days of Arise SWC usage. Results: The long-term usage of the Arise SWC positively impacted the users' standing performance (ability to stand regularly, stand at different locations, and stand in community settings), productive ability (accessibility to environmental controls and ability to perform overhead reaches), and pathophysiology (spasticity and ability to get proper sleep). Furthermore, all the users were able to independently move using the Arise SWC over even and uneven terrain (some needed minimal assistance over uneven terrain). Conclusions: Overall, we believe that Arise SWC will benefit eligible users and improve their ability and performance in daily activities. IMPLICATIONS FOR REHABILITATION: Arise Standing Wheelchair (SWC) positively impacted users' standing performance, mobility over uneven terrain, ability to transfer between surfaces, and overhead reaches. Arise SWC positively impacted users' overall physical well-being. The study shows that Arise SWC improved the users' overall daily living activities. Arise SWC, an affordable solution, is anticipated to have a global impact, especially on low-income nations. [ABSTRACT FROM AUTHOR]

Purpose: Activity-based locomotor training improves intrinsic trunk control in children with spinal cord injury (SCI). To reinforce these improvements, there is a need to develop community integration activities to allow a patient to apply the retrained nervous system at home. One activity that has been explored is rocking in a rocking chair. This paper describes the design, fabrication, and evaluation of a rocking chair for children with SCI. Materials and Methods: The Quality Function Deployment (QFD) design process was used. Fundamental needs and features for the rocking chair were defined in a focus group with experienced therapists, and needs were then rated for importance. A House of Quality (HOQ) matrix was developed to correlate needs with design features, and a prototype design was generated. Virtual motion studies and finite element analysis (FEA) were utilized to assess the design. The chair was fabricated and physical testing was performed, including tipping and static and dynamic load assessments. Results and Conclusions: The needs identified through the QFD process were categorized into (1) safety, (2) therapeutic, (3) practical and aesthetic, and (4) data to track chair use. Features selected to meet these needs include safety stops, padding, straps, a stable base, armrests, adjustable footrest, and sensors to capture rocking data. FEA showed a factor of safety (FOS) > 5. Physical testing confirmed physical integrity, load-bearing capacity, and stability of the prototype glider rocking chair. The prototype provides a safe tool for further investigation of rocking for promotion of trunk muscle activation in children with SCI. IMPLICATIONS FOR REHABILITATION: Rocking in a rocking chair promotes carryover of gained trunk control capacity, from clinic to home in a population that is non-ambulatory. Rocking provides opportunity for self-practice in population with severely compromised capacity. Rocking is a movement that may be performed when other types of movement cannot be readily performed, e.g., resistance exercise, movement against gravity. Rocking creates opportunity for repetitive, voluntary, self-directed movement that is inherently pleasurable and reinforcing. [ABSTRACT FROM AUTHOR]