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The article discusses the modernization of the National Spatial Reference System (NSRS) by the National Geodetic Survey (NGS) in the United States. The modernization involves updating reference frames and vertical datums, impacting the geospatial industry. The benefits of the Modernized NSRS include improved accuracies and enhanced interoperability. The article provides recommendations for industry professionals to prepare for the upcoming changes and emphasizes proactive measures for a smooth transition to the new reference frames and vertical datum. [Extracted from the article]

Background and Objective: Tacrolimus is an immunosuppressant commonly administered after solid organ transplantation. It is characterized by a narrow therapeutic window and high variability in exposure, demanding personalized dosing. In recent years, population pharmacokinetic models have been suggested to guide model-informed precision dosing of tacrolimus. We aimed to provide a comprehensive overview of population pharmacokinetic models and model-informed precision dosing software modules of tacrolimus in all solid organ transplant settings, including a simulation-based investigation of the impact of covariates on exposure and target attainment. Methods: We performed a systematic literature search to identify population pharmacokinetic models of tacrolimus in solid organ transplant recipients. We integrated selected population pharmacokinetic models into an interactive software tool that allows dosing simulations, Bayesian forecasting, and investigation of the impact of covariates on exposure and target attainment. We conducted a web survey amongst model-informed precision dosing software tool providers and benchmarked publicly available tools in terms of models, target populations, and clinical integration. Results: We identified 80 population pharmacokinetic models, including 44 one-compartment and 36 two-compartment models. The most frequently retained covariates on clearance and distribution parameters were cytochrome P450 3A5 polymorphisms and body weight, respectively. Our simulation tool, hosted at https://lpmx.shinyapps.io/tacrolimus/, allows thorough investigation of the impact of covariates on exposure and target attainment. We identified 15 model-informed precision dosing software tool providers, of which ten offer a tacrolimus solution and nine completed the survey. Conclusions: Our work provides a comprehensive overview of the landscape of available tacrolimus population pharmacokinetic models and model-informed precision dosing software modules. Our simulation tool allows an interactive thorough exploration of covariates on exposure and target attainment. [ABSTRACT FROM AUTHOR]

This study examines how the product evokes agency in discursive strategizing. Rather than solely being outcomes of strategizing, products also play a role in the initial formation of strategy, which eventually may both hinder and promote strategic renewal. Theoretically, we draw from ideas of posthumanist performativity, which considers discourse and materiality as inseparable and allows us to elucidate the ways in which materiality evokes agency in managers' discursive strategizing. Empirically, we conducted a longitudinal real-time study by participating in a software company's strategizing meetings for 2 years. Our findings reveal two forms of material agency evoked by the company product during discursive strategizing: indwelling and outdwelling agency. Indwelling agency manifests when the product's logic starts to frame the scope of strategy discourse. Outdwelling agency manifests when the product attracts unexpected customers, which later alters managers' strategic scope. These findings enrich the understanding of the contribution of materiality to strategic outcomes. [ABSTRACT FROM AUTHOR]

Maintaining software quality is a significant challenge as the complexity of software is increasing with the rise of the software industry. Software defects are a primary concern in complex modules, and predicting them in the early stages of the software development life cycle (SDLC) is difficult. Previous techniques to address this issue have not been very promising. We have proposed “A hybrid ensemble model for software defect prediction using AI‐based techniques with feature preservation” to overcome this problem. We have used the National Aeronautics and Space Administration (NASA) dataset from the PROMISE repository for testing and validation. By applying exploratory data analysis (EDA), feature engineering, scaling, and standardization, we found that the dataset is imbalanced, which can negatively affect the model's performance. To address this, we have used the Synthetic Minority Oversampling (SMOTE) technique and the edited nearest neighbor (ENN) (SMOTE‐ENN). We have also used recursive feature elimination cross‐validation (RFE‐CV) with a pipeline to prevent data leaking in CV and kernel‐based principal component analysis (K‐PCA) to minimize dimensionality and selectively relevant features. The reduced dimensional data is then given to the eXtreme Gradient Boosting (XGBoost) for classification, resulting in the hybrid‐ensemble (SMERKP‐XGB) model. The proposed SMERKP‐XGB model is better than previously developed models in terms of accuracy (CM1: 97.53%, PC1: 92.05%, and PC2: 97.45%, KC1:95.65%), and area under the receiver operating characteristic curve values (CM1:96.30%, PC1:98.30%, and PC2:99.30%: KC1: 93.54) and other evaluation criteria mentioned in the literature. [ABSTRACT FROM AUTHOR]

Risk management (RM) plays a role in project management in the software development field. As information technology (IT) systems become more essential across industries and IT projects continue to face failure rates effective project management becomes crucial. However, the utilization of methodologies in risk management is not widely considered, specifically in Malaysia. This study aims to investigate how software practitioners in Malaysia have implemented risk management and discover strategies that can enhance risk management for agile contexts. The main focus of this study is the limited integration of methodologies into risk management practices, which has created a gap within the software risk domain. Successful risk management is essential for the achievement of software projects, and the findings from this study can offer insights for software development organizations to make informed decisions and improve project outcomes. By utilizing a quantitative approach and adapted questionnaires, this comprehensive study collected data from 60 practitioners and conducted descriptive analysis to identify key risk elements that have significant potential to affect project performance. The findings highlight these risk elements that can significantly impact project success. Agile methodologies, with their emphasis on collaboration, communication within teams, and engagement with stakeholders, including top management, are instrumental in aligning project objectives, identifying potential risks, and resolving issues promptly. This study provides empirical insights into the risk management practices of agile practitioners in Malaysia, which can equip software development organizations with valuable knowledge for informed decision‐making. By enhancing project outcomes and guiding future strategic actions, the findings of this study can contribute to the improvement of agile risk management in the software development industry, particularly in the Malaysian context. [ABSTRACT FROM AUTHOR]

The Exascale Computing Project (ECP) Software Technology and Co-Design teams addressed the growing complexities in high-performance computing (HPC) by developing scalable software libraries and tools that leverage exascale system capabilities. As we enter the exascale era, the need for reusable, optimized software solutions that can handle the unique challenges posed by these systems becomes increasingly important. The primary challenges the ECP teams faced were to create software libraries and tools that are performant on exascale architectures and portable and usable across diverse hardware platforms. Efforts addressed issues related to concurrent execution, memory management, and the integration of heterogeneous computing resources, such as GPUs from multiple vendors. The ECP's strategy involved a structured development process encompassing the creation, optimization, and deployment of software in collaboration with industry, academia, and national laboratories. The project was organized into several technical areas: co-design of domain-specific suites with target applications, programming models and runtimes, development tools, mathematical libraries, data and visualization tools, and software ecosystem and delivery mechanisms. ECP has successfully developed a large portfolio of software libraries and tools that demonstrate significant improvements in performance and scalability on exascale systems. These products have been integrated into the Department of Energy's computing facilities, supporting various scientific applications and ensuring robust performance across different hardware setups. ECP advancements in software development for exascale computing highlight the importance of a collaborative and adaptive approach to handling next-generation HPC systems complexities. The lessons learned emphasize the need for continuous engagement with end-users and vendors, and the importance of maintaining a balance between innovation and practical implementation. Future efforts will focus on ensuring scalability, keeping pace with rapid hardware advancements, and further enhancing the interoperability and usability of the software ecosystem. Subsequent articles in this special issue provide in-depth discussions and case studies into specific library and tool efforts. [ABSTRACT FROM AUTHOR]

Objective: The aim of the project was to reduce the risk of patients using the estrogen only part of their hormone replacement therapy (HRT) inadvertently in Banstead PCN. Although understanding about the risk of unopposed estrogen is well understood by prescribers, there are numerous flash points where this exposure can occur which was highlighted by several cases encountered during a study period of 3 months. Study design: Cases encountered revealed numerous reasons for this exposure which were split into three areas: Prescribing factors, dispensing checks and patient understanding. Main outcome measures: Quality improvement suggestions were tailored to the factors involved. IT system changes to EMIS, our main computer software provider, were proposed to enable safer prescribing. Following discussion with key stakeholders, increased education for pharmacists was proposed alongside an alert sticker system at the dispensing end point. Patient understanding and education for all parties was delivered through various routes. Results: The IT system alterations required are complex and still awaited. Funding was obtained and stickers distributed. The results from a re-audit from this intervention are awaited. Interim education measures at an individual level were meantime explored and the impact of them assessed. Patient education and the role of social media were explored. I produced a short video which was circulated to doctors with the plan to distribute via other clinician social media accounts. Conclusions: A key discovery through this study is that many of the flash points identified can be difficult to detect and many are not measurable. The increasing number of HRT prescriptions, time pressures in primary care and the known risk from using unopposed estrogen of endometrial cancer means these changes are of potential great value. [ABSTRACT FROM AUTHOR]

Design/methodology/approach: Converting data into information and its diffusion along all organization units has become a vital survival skill. At this point, an ERP system provides an invisible network among a company's internal and external stakeholders and plays a strategic role. Moreover, ERP systems offer some advantages. For example, integrating financial, customer, and order information, speeding up production processes, and reducing stock level and order lead time. Therefore, we propose an integrated spherical fuzzy-analytical hierarchy process (SF-AHP) and spherical fuzzy-combinative distance-based assessment (SF-CODAS) framework to prioritize the best ERP software provider for the defense industry. Purpose: Despite having the advantages mentioned above, some crucial aspects must be considered while selecting an ERP package. Factors such as high cost, difficulty in installation, and security threats can be very challenging. The latter issue needs special care in the defense industry. This study aims to design an evaluation framework for the ERP selection problem in the sector. Findings: One of the pivoting defense companies in Turkey is chosen as a case study. Seven ERP systems are evaluated with the proposed model. The results show that the proposed model can be successfully implemented in a defense company context. Furthermore, a sensitivity analysis proves the robustness of the approach to varying threshold parameters in CODAS and different fuzzy weighting approaches. Originality/value: The defense professionals prioritize a different set of selection criteria than conventional manufacturing firms. The study provides a rare holistic framework for the defense industry using a hybridized SF-AHP-CODAS technique. Thus, the study may serve as reference work for the researchers and decision-makers during the digitalization journey of defense firms. [ABSTRACT FROM AUTHOR]

The expanding software industry has increased the demand for proficient programming professionals. However, more than technical expertise is needed for successful software development; code quality assurance and effective teamwork are also indispensable. Unfortunately, recent graduates often exhibit deficiencies in programming, code quality assurance, and teamwork skills, highlighting the need for improvements in these areas. In response to these challenges, this study presents ProgEdu4Web, an innovative Automated Programming Assessment System designed to evaluate code quality and teamwork proficiency in web programming. The system integrates automatic source code evaluation tools for static code analysis, ensuring timely feedback on coding quality issues. To assess the effectiveness of ProgEdu4Web, a questionnaire and hypothesis model was employed, surveying a cohort of 111 students enrolled in web programming classes. The study's findings demonstrate that the system significantly alleviated instructor workload while motivating students to enhance their web programming with good code quality and teamwork abilities. [ABSTRACT FROM AUTHOR]

Despite growing efforts and encouraging successes in recent decades, fully formally verified projects are still rare in the industrial landscape. The industry often lacks the tools and methodologies to efficiently scale the proof development process. In this work, we give a comprehensible overview of the proof development process for proof developers and project managers. The goal is to support proof developers by rationalizing the proof development process, which currently relies heavily on their intuition and expertise, and by facilitating communication with the management line. To this end, we concentrate on the aspect of proof manufacturing and highlight the most significant sources of proof effort. We propose means to mitigate the latter through proof practices (proof structuring, proof strategies, and proof planning), proof metrics, and tools. Our approach is project-agnostic, independent of specific proof expertise, and computed estimations do not assume prior similar developments. We evaluate our guidelines using a separation kernel undergoing formal verification, driving the proof process in an optimised way. Feedback from a project manager unfamiliar with proof development confirms the benefits of detailed planning of the proof development steps, clear progress communication to the hierarchy line, and alignment with established practices in the software industry. [ABSTRACT FROM AUTHOR]