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Your search keyword '"(0000-0002-9347-922X) Obhodas, J."' showing total 6 results
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6 results on '"(0000-0002-9347-922X) Obhodas, J."'

1. A hybrid multi-particle approach to range assessment-based treatment verification in particle therapy

Author

(0000-0001-5659-3907) Meric, I., Alagoz, E., (0000-0002-7593-7549) Hysing, L., (0000-0002-9501-0898) Kögler, T., (0000-0003-3810-1926) Lathouwers, D., (0000-0003-0971-4678) Lionheart, W., (0000-0003-4561-6995) Mattingly, J., (0000-0002-9347-922X) Obhodas, J., (0000-0002-2336-0178) Pausch, G., (0000-0003-4879-771X) Pettersen, H., (0000-0003-3761-5415) Ratliff, H., Rovituso, M., (0000-0002-9742-8518) Schellhammer, S., (0000-0001-7765-7308) Setterdahl, L., (0000-0002-3164-3100) Skjerdal, K., (0000-0001-9764-546X) Sterpin, E., (0000-0002-2374-9319) Sudac, D., (0000-0002-1400-4120) Turko, J. A. B., (0000-0002-3597-1611) Ytre-Hauge, K., (0000-0001-5659-3907) Meric, I., Alagoz, E., (0000-0002-7593-7549) Hysing, L., (0000-0002-9501-0898) Kögler, T., (0000-0003-3810-1926) Lathouwers, D., (0000-0003-0971-4678) Lionheart, W., (0000-0003-4561-6995) Mattingly, J., (0000-0002-9347-922X) Obhodas, J., (0000-0002-2336-0178) Pausch, G., (0000-0003-4879-771X) Pettersen, H., (0000-0003-3761-5415) Ratliff, H., Rovituso, M., (0000-0002-9742-8518) Schellhammer, S., (0000-0001-7765-7308) Setterdahl, L., (0000-0002-3164-3100) Skjerdal, K., (0000-0001-9764-546X) Sterpin, E., (0000-0002-2374-9319) Sudac, D., (0000-0002-1400-4120) Turko, J. A. B., and (0000-0002-3597-1611) Ytre-Hauge, K.

Abstract

Particle therapy (PT) used for cancer treatment can spare healthy tissue and reduce treatment toxicity. However, full exploitation of the dosimetric advantages of PT is not yet possible due to range uncertainties, warranting development of range-monitoring techniques. This study proposes a novel range-monitoring technique introducing the yet unexplored concept of simultaneous detection and imaging of fast neutrons and prompt-gamma rays produced in beam-tissue interactions. A quasi-monolithic organic detector array is proposed, and its feasibility for detecting range shifts in the context of proton therapy is explored through Monte Carlo simulations of realistic patient models. The results indicate that range shifts of 1 mm can be detected at relatively low proton intensities (6 million/spot) when spatial information obtained through imaging of both particle species are used simultaneously. This study lays the foundation for multi-particle detection and imaging systems in the context range verification in PT.

Published
2023

2. A hybrid multi-particle approach to range assessment-based treatment verification in particle therapy

Author

(0000-0001-5659-3907) Meric, I., Alagoz, E., (0000-0002-7593-7549) Hysing, L., (0000-0002-9501-0898) Kögler, T., (0000-0003-3810-1926) Lathouwers, D., (0000-0003-0971-4678) Lionheart, W., (0000-0003-4561-6995) Mattingly, J., (0000-0002-9347-922X) Obhodas, J., (0000-0002-2336-0178) Pausch, G., (0000-0003-4879-771X) Pettersen, H., (0000-0003-3761-5415) Ratliff, H., Rovituso, M., (0000-0002-9742-8518) Schellhammer, S., (0000-0001-7765-7308) Setterdahl, L., (0000-0002-3164-3100) Skjerdal, K., (0000-0001-9764-546X) Sterpin, E., (0000-0002-2374-9319) Sudac, D., (0000-0002-1400-4120) Turko, J. A. B., (0000-0002-3597-1611) Ytre-Hauge, K., (0000-0001-5659-3907) Meric, I., Alagoz, E., (0000-0002-7593-7549) Hysing, L., (0000-0002-9501-0898) Kögler, T., (0000-0003-3810-1926) Lathouwers, D., (0000-0003-0971-4678) Lionheart, W., (0000-0003-4561-6995) Mattingly, J., (0000-0002-9347-922X) Obhodas, J., (0000-0002-2336-0178) Pausch, G., (0000-0003-4879-771X) Pettersen, H., (0000-0003-3761-5415) Ratliff, H., Rovituso, M., (0000-0002-9742-8518) Schellhammer, S., (0000-0001-7765-7308) Setterdahl, L., (0000-0002-3164-3100) Skjerdal, K., (0000-0001-9764-546X) Sterpin, E., (0000-0002-2374-9319) Sudac, D., (0000-0002-1400-4120) Turko, J. A. B., and (0000-0002-3597-1611) Ytre-Hauge, K.

Abstract

Particle therapy (PT) used for cancer treatment can spare healthy tissue and reduce treatment toxicity. However, full exploitation of the dosimetric advantages of PT is not yet possible due to range uncertainties, warranting development of range-monitoring techniques. This study proposes a novel range-monitoring technique introducing the yet unexplored concept of simultaneous detection and imaging of fast neutrons and prompt-gamma rays produced in beam-tissue interactions. A quasi-monolithic organic detector array is proposed, and its feasibility for detecting range shifts in the context of proton therapy is explored through Monte Carlo simulations of realistic patient models. The results indicate that range shifts of 1 mm can be detected at relatively low proton intensities (6 million/spot) when spatial information obtained through imaging of both particle species are used simultaneously. This study lays the foundation for multi-particle detection and imaging systems in the context range verification in PT.

Published
2022

3. NOVO - Neutron and Prompt Gamma-Ray Range Verification in Particle Therapy

Author

(0000-0002-9501-0898) Kögler, T., Alagoz, E., (0000-0002-3597-1611) Ytre-Hauge, K. S., (0000-0002-7593-7549) Hysing, L. B., (0000-0003-3810-1926) Lathouwers, D., (0000-0003-0971-4678) Lionheart, W., (0000-0002-9347-922X) Obhodas, J., (0000-0002-2336-0178) Pausch, G., (0000-0003-4879-771X) Pettersen, H. E. S., (0000-0003-3761-5415) Ratliff, H. N., Rovituso, M., (0000-0002-9742-8518) Schellhammer, S., (0000-0001-7765-7308) Setterdahl, L. M., (0000-0002-3164-3100) Skjerdal, K., (0000-0002-2374-9319) Sudac, D., (0000-0002-1400-4120) Turko, J. A. B., (0000-0001-5659-3907) Meric, I., (0000-0002-9501-0898) Kögler, T., Alagoz, E., (0000-0002-3597-1611) Ytre-Hauge, K. S., (0000-0002-7593-7549) Hysing, L. B., (0000-0003-3810-1926) Lathouwers, D., (0000-0003-0971-4678) Lionheart, W., (0000-0002-9347-922X) Obhodas, J., (0000-0002-2336-0178) Pausch, G., (0000-0003-4879-771X) Pettersen, H. E. S., (0000-0003-3761-5415) Ratliff, H. N., Rovituso, M., (0000-0002-9742-8518) Schellhammer, S., (0000-0001-7765-7308) Setterdahl, L. M., (0000-0002-3164-3100) Skjerdal, K., (0000-0002-2374-9319) Sudac, D., (0000-0002-1400-4120) Turko, J. A. B., and (0000-0001-5659-3907) Meric, I.

Abstract

Due to its high sensitivity to anatomical changes, particle therapy will only unfold its full potential together with a functioning online range verification. We present a detector concept making use of a large fraction of the secondary particles available by hybrid prompt gamma-ray and fast neutron imaging. The system is expected to exhibit a high detection sensitivity to these particles, a high time, energy and position resolution, excellent pulse shape discrimination, and a small footprint. It comprises a quasi-monolithic organic detector array consisting of novel organic scintillators with dual-ended silicon photomultiplier light read-out and fast digitizers. The reconstruction of the proton range from the events registered by the detector is based on gamma/neutron scatter kinematics, cone back-projection and maximum likelihood expectation maximization. Multiple studies are currently ongoing investigating the feasibility of this concept on an experimental and simulation level. A first Monte Carlo simulation study involving realistic patient data and an idealized detector has revealed that a range-shift sensitivity of 1 mm per spot is attainable for clinical spot weights. These results demonstrate the potential of particle treatment verification by fast neutrons and prompt gamma-rays and strengthen the potential of this hybrid system for clinical application.

Published
2022

4. A hybrid multi-particle approach to range assessment-based treatment verification in particle therapy

Author

(0000-0001-5659-3907) Meric, I., Alagoz, E., (0000-0002-7593-7549) Hysing, L., (0000-0002-9501-0898) Kögler, T., (0000-0003-3810-1926) Lathouwers, D., (0000-0003-0971-4678) Lionheart, W., (0000-0003-4561-6995) Mattingly, J., (0000-0002-9347-922X) Obhodas, J., (0000-0002-2336-0178) Pausch, G., (0000-0003-4879-771X) Pettersen, H., (0000-0003-3761-5415) Ratliff, H., Rovituso, M., (0000-0002-9742-8518) Schellhammer, S., (0000-0001-7765-7308) Setterdahl, L., (0000-0002-3164-3100) Skjerdal, K., (0000-0001-9764-546X) Sterpin, E., (0000-0002-2374-9319) Sudac, D., (0000-0002-1400-4120) Turko, J. A. B., (0000-0002-3597-1611) Ytre-Hauge, K., (0000-0001-5659-3907) Meric, I., Alagoz, E., (0000-0002-7593-7549) Hysing, L., (0000-0002-9501-0898) Kögler, T., (0000-0003-3810-1926) Lathouwers, D., (0000-0003-0971-4678) Lionheart, W., (0000-0003-4561-6995) Mattingly, J., (0000-0002-9347-922X) Obhodas, J., (0000-0002-2336-0178) Pausch, G., (0000-0003-4879-771X) Pettersen, H., (0000-0003-3761-5415) Ratliff, H., Rovituso, M., (0000-0002-9742-8518) Schellhammer, S., (0000-0001-7765-7308) Setterdahl, L., (0000-0002-3164-3100) Skjerdal, K., (0000-0001-9764-546X) Sterpin, E., (0000-0002-2374-9319) Sudac, D., (0000-0002-1400-4120) Turko, J. A. B., and (0000-0002-3597-1611) Ytre-Hauge, K.

Abstract

Particle therapy (PT) used for cancer treatment can spare healthy tissue and reduce treatment toxicity. However, full exploitation of the dosimetric advantages of PT is not yet possible due to range uncertainties, warranting development of range-monitoring techniques. This study proposes a novel range-monitoring technique introducing the yet unexplored concept of simultaneous detection and imaging of fast neutrons and prompt-gamma rays produced in beam-tissue interactions. A quasi-monolithic organic detector array is proposed, and its feasibility for detecting range shifts in the context of proton therapy is explored through Monte Carlo simulations of realistic patient models. The results indicate that range shifts of 1 mm can be detected at relatively low proton intensities (6 million/spot) when spatial information obtained through imaging of both particle species are used simultaneously. This study lays the foundation for multi-particle detection and imaging systems in the context range verification in PT.

Published
2022

5. NOVO - Neutron and Prompt Gamma-Ray Range Verification in Particle Therapy

Author

(0000-0002-9501-0898) Kögler, T., Alagoz, E., (0000-0002-3597-1611) Ytre-Hauge, K. S., (0000-0002-7593-7549) Hysing, L. B., (0000-0003-3810-1926) Lathouwers, D., (0000-0003-0971-4678) Lionheart, W., (0000-0002-9347-922X) Obhodas, J., (0000-0002-2336-0178) Pausch, G., (0000-0003-4879-771X) Pettersen, H. E. S., (0000-0003-3761-5415) Ratliff, H. N., Rovituso, M., (0000-0002-9742-8518) Schellhammer, S., (0000-0001-7765-7308) Setterdahl, L. M., (0000-0002-3164-3100) Skjerdal, K., (0000-0002-2374-9319) Sudac, D., (0000-0002-1400-4120) Turko, J. A. B., (0000-0001-5659-3907) Meric, I., (0000-0002-9501-0898) Kögler, T., Alagoz, E., (0000-0002-3597-1611) Ytre-Hauge, K. S., (0000-0002-7593-7549) Hysing, L. B., (0000-0003-3810-1926) Lathouwers, D., (0000-0003-0971-4678) Lionheart, W., (0000-0002-9347-922X) Obhodas, J., (0000-0002-2336-0178) Pausch, G., (0000-0003-4879-771X) Pettersen, H. E. S., (0000-0003-3761-5415) Ratliff, H. N., Rovituso, M., (0000-0002-9742-8518) Schellhammer, S., (0000-0001-7765-7308) Setterdahl, L. M., (0000-0002-3164-3100) Skjerdal, K., (0000-0002-2374-9319) Sudac, D., (0000-0002-1400-4120) Turko, J. A. B., and (0000-0001-5659-3907) Meric, I.

Abstract

Due to its high sensitivity to anatomical changes, particle therapy will only unfold its full potential together with a functioning online range verification. We present a detector concept making use of a large fraction of the secondary particles available by hybrid prompt gamma-ray and fast neutron imaging. The system is expected to exhibit a high detection sensitivity to these particles, a high time, energy and position resolution, excellent pulse shape discrimination, and a small footprint. It comprises a quasi-monolithic organic detector array consisting of novel organic scintillators with dual-ended silicon photomultiplier light read-out and fast digitizers. The reconstruction of the proton range from the events registered by the detector is based on gamma/neutron scatter kinematics, cone back-projection and maximum likelihood expectation maximization. Multiple studies are currently ongoing investigating the feasibility of this concept on an experimental and simulation level. A first Monte Carlo simulation study involving realistic patient data and an idealized detector has revealed that a range-shift sensitivity of 1 mm per spot is attainable for clinical spot weights. These results demonstrate the potential of particle treatment verification by fast neutrons and prompt gamma-rays and strengthen the potential of this hybrid system for clinical application.

Published
2022

6. A hybrid multi-particle approach to range assessment-based treatment verification in particle therapy

Author

(0000-0001-5659-3907) Meric, I., Alagoz, E., (0000-0002-7593-7549) Hysing, L., (0000-0002-9501-0898) Kögler, T., (0000-0003-3810-1926) Lathouwers, D., (0000-0003-0971-4678) Lionheart, W., (0000-0003-4561-6995) Mattingly, J., (0000-0002-9347-922X) Obhodas, J., (0000-0002-2336-0178) Pausch, G., (0000-0003-4879-771X) Pettersen, H., (0000-0003-3761-5415) Ratliff, H., Rovituso, M., (0000-0002-9742-8518) Schellhammer, S., (0000-0001-7765-7308) Setterdahl, L., (0000-0002-3164-3100) Skjerdal, K., (0000-0001-9764-546X) Sterpin, E., (0000-0002-2374-9319) Sudac, D., (0000-0002-1400-4120) Turko, J. A. B., (0000-0002-3597-1611) Ytre-Hauge, K., (0000-0001-5659-3907) Meric, I., Alagoz, E., (0000-0002-7593-7549) Hysing, L., (0000-0002-9501-0898) Kögler, T., (0000-0003-3810-1926) Lathouwers, D., (0000-0003-0971-4678) Lionheart, W., (0000-0003-4561-6995) Mattingly, J., (0000-0002-9347-922X) Obhodas, J., (0000-0002-2336-0178) Pausch, G., (0000-0003-4879-771X) Pettersen, H., (0000-0003-3761-5415) Ratliff, H., Rovituso, M., (0000-0002-9742-8518) Schellhammer, S., (0000-0001-7765-7308) Setterdahl, L., (0000-0002-3164-3100) Skjerdal, K., (0000-0001-9764-546X) Sterpin, E., (0000-0002-2374-9319) Sudac, D., (0000-0002-1400-4120) Turko, J. A. B., and (0000-0002-3597-1611) Ytre-Hauge, K.

Abstract

Particle therapy (PT) used for cancer treatment can spare healthy tissue and reduce treatment toxicity. However, full exploitation of the dosimetric advantages of PT is not yet possible due to range uncertainties, warranting development of range-monitoring techniques. This study proposes a novel range-monitoring technique introducing the yet unexplored concept of simultaneous detection and imaging of fast neutrons and prompt-gamma rays produced in beam-tissue interactions. A quasi-monolithic organic detector array is proposed, and its feasibility for detecting range shifts in the context of proton therapy is explored through Monte Carlo simulations of realistic patient models. The results indicate that range shifts of 1 mm can be detected at relatively low proton intensities (6 million/spot) when spatial information obtained through imaging of both particle species are used simultaneously. This study lays the foundation for multi-particle detection and imaging systems in the context range verification in PT.

Published
2022

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