1. Tumor irradiation in mice with a laser-accelerated proton beam
- Author
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(0000-0002-0275-9892) Kroll, F., (0000-0002-9859-2408) Brack, F.-E., (0000-0003-1739-0159) Bernert, C., (0000-0002-1919-8585) Bock, S., Bodenstein, E., Brüchner, K., (0000-0002-5845-000X) Cowan, T., (0000-0002-6914-4083) Gaus, L., Gebhardt, R., Helbig, U., Karsch, L., (0000-0003-4861-5584) Kluge, T., (0000-0002-0638-6990) Kraft, S., (0000-0003-1776-9556) Krause, M., Leßmann, E., (0000-0002-5248-0910) Masood, U., Meister, S., (0000-0002-9556-0662) Metzkes-Ng, J., Nossula, A., (0000-0003-4128-5498) Pawelke, J., (0000-0002-1610-1493) Pietzsch, J., (0000-0002-4738-6436) Püschel, T., (0000-0003-4962-2153) Reimold, M., (0000-0001-6200-6406) Rehwald, M., (0000-0003-4261-4214) Richter, C., (0000-0003-4400-1315) Schlenvoigt, H.-P., (0000-0003-0390-7671) Schramm, U., (0000-0001-7332-7395) Umlandt, M. E. P., (0000-0002-3727-7017) Ziegler, T., (0000-0003-3926-409X) Zeil, K., (0000-0002-0582-1444) Beyreuther, E., (0000-0002-0275-9892) Kroll, F., (0000-0002-9859-2408) Brack, F.-E., (0000-0003-1739-0159) Bernert, C., (0000-0002-1919-8585) Bock, S., Bodenstein, E., Brüchner, K., (0000-0002-5845-000X) Cowan, T., (0000-0002-6914-4083) Gaus, L., Gebhardt, R., Helbig, U., Karsch, L., (0000-0003-4861-5584) Kluge, T., (0000-0002-0638-6990) Kraft, S., (0000-0003-1776-9556) Krause, M., Leßmann, E., (0000-0002-5248-0910) Masood, U., Meister, S., (0000-0002-9556-0662) Metzkes-Ng, J., Nossula, A., (0000-0003-4128-5498) Pawelke, J., (0000-0002-1610-1493) Pietzsch, J., (0000-0002-4738-6436) Püschel, T., (0000-0003-4962-2153) Reimold, M., (0000-0001-6200-6406) Rehwald, M., (0000-0003-4261-4214) Richter, C., (0000-0003-4400-1315) Schlenvoigt, H.-P., (0000-0003-0390-7671) Schramm, U., (0000-0001-7332-7395) Umlandt, M. E. P., (0000-0002-3727-7017) Ziegler, T., (0000-0003-3926-409X) Zeil, K., and (0000-0002-0582-1444) Beyreuther, E.
- Abstract
Recent oncological studies identified beneficial properties of radiation applied at ultra-high dose rates several orders of magnitude higher than the clinical standard of the order of Gy/min. Sources capable of providing these ultra-high dose rates are under investigation. Here, we show that a stable, compact laser-driven proton source with energies greater than 60 MeV enables radiobiological in vivo studies. We performed a pilot irradiation study on human tumors in a mouse model, showing the concerted preparation of mice and laser accelerator, the dose-controlled, tumor-conform irradiation using a laser-driven as well as a clinical reference proton source, and the radiobiological evaluation of irradiated and unirradiated mice for radiation-induced tumor growth delay. The prescribed homogeneous dose of 4 Gy was precisely delivered at the laser-driven source. The results demonstrate a complete laser-driven proton research platform for diverse user-specific small animal models, able to deliver tunable single-shot doses up to around 20 Gy to millimeter-scale volumes on nanosecond time scales, equivalent to around 1E9 Gy/s, spatially homogenized and tailored to the sample. The platform provides a unique infrastructure for translational research with protons at ultra-high dose rate.
- Published
- 2022