1. Biomaterial design for regenerating aged bone: materiobiological advances and paradigmatic shifts.
- Author
-
(戴凯), Kai Dai, (耿振), Zhen Geng, (张文超), Wenchao Zhang, (魏雪), Xue Wei, (王靖), Jing Wang, (聂广军), Guangjun Nie, and (刘昌胜), Changsheng Liu
- Subjects
BIOMATERIALS ,BONE regeneration ,REGENERATION (Biology) ,BONE diseases ,POPULATION aging ,BLOOD vessels ,QUALITY of life - Abstract
China's aging demographic poses a challenge for treating prevalent bone diseases impacting life quality. As bone regeneration capacity diminishes with age due to cellular dysfunction and inflammation, advanced biomaterials-based approaches offer hope for aged bone regeneration. This review synthesizes materiobiology principles, focusing on biomaterials that target specific biological functions to restore tissue integrity. It covers strategies for stem cell manipulation, regulation of the inflammatory microenvironment, blood vessel regeneration, intervention in bone anabolism and catabolism, and nerve regulation. The review also explores molecular and cellular mechanisms underlying aged bone regeneration and proposes a database-driven design process for future biomaterial development. These insights may also guide therapies for other age-related conditions, contributing to the pursuit of 'healthy aging'. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF