Search

Your search keyword '"Zhu, Xia"' showing total 2,536 results
Start Over Author "Zhu, Xia"
2,536 results on '"Zhu, Xia"'

401. Corrigendum to ‘Targeting mammalian serine/threonine-protein kinase 4 through yes-associated protein/TEA domain transcription factor-mediated epithelial-mesenchymal transition ameliorates diabetic nephropathy orchestrated renal fibrosis [Metabolism Clinical and Experimental 108 (2020) 154258]

Author

Yang, Tingting, Heng, Cai, Zhou, Yi, Hu, Yinlu, Chen, Shangxiu, Wang, Haiyan, Yang, Hao, Jiang, Zhenzhou, Qian, Sitong, Wang, Yinan, Wang, Jianyun, Zhu, Xia, Du, Lei, Yin, Xiaoxing, and Lu, Qian

Published
2022
Full Text
View/download PDF

407. Genomic architecture of fetal central nervous system anomalies using whole-genome sequencing

Author

Yang, Ying, primary, Zhao, Sheng, additional, Sun, Guoqiang, additional, Chen, Fang, additional, Zhang, Tongda, additional, Song, Jieping, additional, Yang, Wenzhong, additional, Wang, Lin, additional, Zhan, Nianji, additional, Yang, Xiaohong, additional, Zhu, Xia, additional, Rao, Bin, additional, Yin, Zhenzhen, additional, Zhou, Jing, additional, Yan, Haisheng, additional, Huang, Yushan, additional, Ye, Jingyu, additional, Huang, Hui, additional, Cheng, Chen, additional, Zhu, Shida, additional, Guo, Jian, additional, Xu, Xun, additional, and Chen, Xinlin, additional

Published
2022
Full Text
View/download PDF

411. YY1 inactivated transcription co-regulator PGC-1α to promote mitochondrial dysfunction of early diabetic nephropathy-associated tubulointerstitial fibrosis

Author

Yang, Tingting, primary, Hu, Yinlu, additional, Chen, Shangxiu, additional, Li, Lin, additional, Cao, Xinyun, additional, Yuan, Jiayu, additional, Shu, Fanglin, additional, Jiang, Zhenzhou, additional, Qian, Sitong, additional, Zhu, Xia, additional, Wei, Chujing, additional, Wei, Rui, additional, Yan, Meng, additional, Li, Chenglin, additional, Yin, Xiaoxing, additional, and Lu, Qian, additional

Published
2022
Full Text
View/download PDF

413. Distinct Brain Dynamic Functional Connectivity Patterns in Schizophrenia Patients With and Without Auditory Verbal Hallucinations

Author

Zhang, Yao, primary, Wang, Jia, additional, Lin, Xin, additional, Yang, Min, additional, Qi, Shun, additional, Wang, Yuhan, additional, Liang, Wei, additional, Lu, Huijie, additional, Zhang, Yan, additional, Zhai, Wensheng, additional, Hao, Wanting, additional, Cao, Yang, additional, Huang, Peng, additional, Guo, Jianying, additional, Hu, Xuehui, additional, and Zhu, Xia, additional

Published
2022
Full Text
View/download PDF

417. Paeoniflorin Inhibits ASK1-TF Axis by Up-Regulating SOCS3 to Alleviate Radiation Enteritis

Author

Sheng, Lei, primary, Hu, Fan, additional, Yu, Hanqing, additional, Tao, Xueyou, additional, Jia, Rumeng, additional, Gu, Yufeng, additional, Chen, Lu, additional, Kong, Hong, additional, Miao, Chen, additional, Fei, Wenjing, additional, Yang, Yang, additional, Jia, Jinhui, additional, Zhu, Xia, additional, He, Xueming, additional, Hu, Liang, additional, Ma, Jianxin, additional, Liu, Wen-Tao, additional, and Yang, Mi, additional

Published
2022
Full Text
View/download PDF

421. Microglia Loss and Astrocyte Activation Cause Dynamic Changes in Hippocampal [18F]DPA-714 Uptake in Mouse Models of Depression

Author

Jiamei Guo, Tian Qiu, Lixia Wang, Lei Shi, Ming Ai, Zhu Xia, Zhiping Peng, Anhai Zheng, Xiao Li, and Li Kuang

Subjects
Cellular and Molecular Neuroscience, nervous system, depression, astrocytes, microglia, chronic unpredictable stress, [18F]DPA-714 PET, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

Major depression is a serious and chronic mental illness. However, its etiology is poorly understood. Although glial cells have been increasingly implicated in the pathogenesis of depression, the specific role of microglia and astrocytes in stress-induced depression remains unclear. Translocator protein (TSPO) has long been considered a marker of neuroinflammation and microglial activation. However, this protein is also present on astrocytes. Thus, it is necessary to explore the relationships between TSPO, microglia, and astrocytes in the context of depression. In this study, C57BL/6J male mice were subjected to chronic unpredictable stress (CUS) for 5 weeks. Subsequently, sucrose preference and tail suspension tests (TSTs) were performed to assess anhedonia and despair in these mice. [18F]DPA-714 positron emission tomography (PET) was adopted to dynamically assess the changes in glial cells before and 2, 4, or 5 weeks after CUS exposure. The numbers of TSPO+ cells, ionized calcium-binding adaptor molecule (Iba)-1+ microglial cells, TSPO+/Iba-1+ cells, glial fibrillary acidic protein (GFAP)+ astrocytes, TSPO+/GFAP+ cells, and TUNEL-stained microglia were quantified using immunofluorescence staining. Real-time PCR was used to evaluate interleukin (IL)-1β, IL-4, and IL-18 expression in the hippocampus. We observed that hippocampal [18F]DPA-714 uptake significantly increased after 2 weeks of CUS. However, the signal significantly decreased after 5 weeks of CUS. CUS significantly reduced the number of Iba-1+, TSPO+, and TSPO+/Iba-1+ cells in the hippocampus, especially in the CA1 and dentate gyrus (DG) subregions. However, this intervention increased the number of GFAP+ astrocytes in the CA2/CA3 subregions of the hippocampus. In addition, microglial apoptosis in the early stage of CUS appeared to be involved in microglia loss. Further, the expression of pro-inflammatory cytokines (IL-1β and IL-18) was significantly decreased after CUS. In contrast, the expression of the anti-inflammatory cytokine IL-4 was significantly increased after 2 weeks of CUS. These results suggested that the CUS-induced dynamic changes in hippocampal [18F]DPA-714 uptake and several cytokines may be due to combined microglial and astrocyte action. These findings provide a theoretical reference for the future clinical applications of TSPO PET.

Published
2022
Full Text
View/download PDF

422. Transport Model Comparison Studies of Intermediate-Energy Heavy-Ion Collisions

Author

Hermann Wolter, Maria Colonna, Dan Cozma, Pawel Danielewicz, Che Ming Ko, Rohit Kumar, Akira Ono, ManYee Betty Tsang, Jun Xu, Ying-Xun Zhang, Elena Bratkovskaya, Zhao-Qing Feng, Theodoros Gaitanos, Arnaud Le Fèvre, Natsumi Ikeno, Youngman Kim, Swagata Mallik, Paolo Napolitani, Dmytro Oliinychenko, Tatsuhiko Ogawa, Massimo Papa, Jun Su, Rui Wang, Yong-Jia Wang, Janus Weil, Feng-Shou Zhang, Guo-Qiang Zhang, Zhen Zhang, Joerg Aichelin, Wolfgang Cassing, Lie-Wen Chen, Hui-Gan Cheng, Hannah Elfner, K. Gallmeister, Christoph Hartnack, Shintaro Hashimoto, Sangyong Jeon, Kyungil Kim, Myungkuk Kim, Bao-An Li, Chang-Hwan Lee, Qing-Feng Li, Zhu-Xia Li, Ulrich Mosel, Yasushi Nara, Koji Niita, Akira Ohnishi, Tatsuhiko Sato, Taesoo Song, Agnieszka Sorensen, Ning Wang, and Wen-Jie Xie

Subjects
Nuclear Theory (nucl-th), Nuclear and High Energy Physics, Nuclear Theory, FOS: Physical sciences, Nuclear Experiment (nucl-ex), Nuclear Experiment
Abstract

Transport models are the main method to obtain physics information from low to relativistic-energy heavy-ion collisions. The Transport Model Evaluation Project (TMEP) has been pursued to test the robustness of transport model predictions in reaching consistent conclusions from the same type of physical model. Calculations under controlled conditions of physical input and set-up were performed with various participating codes. These included both calculations of nuclear matter in a box with periodic boundary conditions, and more realistic calculations of heavy-ion collisions. In this intermediate review, we summarize and discuss the present status of the project. We also provide condensed descriptions of the 26 participating codes, which contributed to some part of the project. These include the major codes in use today. We review the main results of the studies completed so far. They show, that in box calculations the differences between the codes can be well understood and a convergence of the results can be reached. These studies also highlight the systematic differences between the two families of transport codes, known as BUU and QMD type codes. However, when the codes were compared in full heavy-ion collisions using different physical models, as recently for pion production, they still yielded substantially different results. This calls for further comparisons of heavy-ion collisions with controlled models and of box comparisons of important ingredients, like momentum-dependent fields, which are currently underway. We often indicate improved strategies in performing transport simulations and thus provide guidance to code developers. Results of transport simulations of heavy-ion collisions from a given code will have more significance if the code can be validated against benchmark calculations such as the ones summarized in this review., 114 pages, 14 figures, 479 references, accepted for publication in Progress of Particle and Nuclear Phsics

Published
2022

426. Additional file 1 of Haploidentical CD7 CAR T-cells induced remission in a patient with TP53 mutated relapsed and refractory early T-cell precursor lymphoblastic leukemia/lymphoma

Author

Dai, Hai-ping, Cui, Wei, Cui, Qing-ya, Zhu, Wen-juan, Meng, Hui-min, Zhu, Min-qing, Zhu, Xia-ming, Yang, Lin, Wu, De-pei, and Tang, Xiao-wen

Abstract

Additional file 1 : Supplementary Figure 1. Flow cytometry analysis on the anti-CD7 CAR T-cells. Supplementary Figure 2. Cytotoxicity analysis of the anti-CD7 CAR T-cells. Supplementary Figure 3. Timeline of treatments and responses. Supplementary Figure 4. T-cell fractions in the PB post CAR T-cells infusion. Supplementary Table 1. Baseline clinical characteristics of the patient. Supplementary Table 2. A panel of 222 genes detected by next generation sequencing.

Published
2022
Full Text
View/download PDF

429. Mitoquinone alleviates bleomycin-induced acute lung injury via inhibiting mitochondrial ROS-dependent pulmonary epithelial ferroptosis

Author

Ping, Zhan, Xue, Lu, Zhao, Li, Wen-Jing, Wang, Kun, Peng, Nan-Nan, Liang, Yan, Wang, Jian, Li, Lin, Fu, Hui, Zhao, De-Xiang, Xu, and Zhu-Xia, Tan

Subjects
Male, Pharmacology, Acute Lung Injury, Immunology, Mitochondria, Mice, Inbred C57BL, Mice, Bleomycin, Humans, Animals, Ferroptosis, Immunology and Allergy, Reactive Oxygen Species, Lung
Abstract

Numerous studies demonstrated that bleomycin (BLM) caused acute lung injury (ALI). This study explored the role of mitochondrial reactive oxygen species (ROS) on BLM-induced ALI and pulmonary epithelial ferroptosis. Male C57BL/6J mice were intratracheally injected with BLM (3.0 mg/kg). BEAS-2B cells, human bronchial epithelial cells, were cultured with BLM (10 μg/ml). Pulmonary MDA and 4-HNE, two markers of lipid peroxidation, were elevated in BLM-exposed mice. Oxidized lipids were upregulated in BLM-exposed BEAS-2B cells. Ferroptosis-characteristic ultrastructure, mainly disappearance of mitochondrial bilayer membrane structure and cristae, was observed in BLM-exposed pulmonary epithelium. Ferrostatin-1, a specific inhibitor of ferroptosis, attenuated BLM-evoked pulmonary lipid peroxidation, ferroptosis-characteristic mitochondrial ultrastructure and pulmonary epithelial death. The in vitro experiments showed that mitochondrial membrane potentials (MMPs) were decreased and mitochondrial ROS were increased in BLM-exposed BEAS-2B cells. Mitoquinone (MitoQ), a mitochondria-targeted antioxidant, prevented BLM-induced MMP reduction and mitochondrial ROS elevation in BEAS-2B cells. The in vivo experiment found that MitoQ attenuated BLM-evoked GSH depletion and lipid peroxidation in mouse lungs. Moreover, MitoQ prevented BLM-induced ferroptosis-characteristic mitochondrial changes, pulmonary epithelial death and ALI. In conclusion, mitochondrial ROS are an initiator of BLM-induced pulmonary epithelial ferroptosis. Mitochondria-targeted antioxidants may be used as potential therapeutic agents for BLM-induced ALI.

Published
2022

430. Juvenile arsenic exposure aggravates goblet cell hyperplasia and airway mucus secretion in ovalbumin-sensitized mice

Author

Xue Lu, Zhu-Xia Tan, Wen-Jing Wang, Ping Zhan, Yan Wang, Lin Fu, Lan Gao, Hui Zhao, Hua Wang, and De-Xiang Xu

Subjects
Mice, Inbred BALB C, Hyperplasia, Ovalbumin, Drinking Water, Health, Toxicology and Mutagenesis, General Medicine, Toxicology, Pollution, Asthma, Arsenic, Mice, Disease Models, Animal, Mucus, Pregnancy, Animals, Cytokines, Female, Goblet Cells, Lung, Bronchoalveolar Lavage Fluid
Abstract

Gestational arsenic (As) exposure has been associated with adverse developmental outcomes. The purpose of this study was to explore the impacts of As exposure in different periods on susceptibility to allergic asthma. In model 1, dams were administered with NaAsO

Published
2022

437. BrainIAK: The Brain Imaging Analysis Kit

Author

Kumar, Manoj, primary, Anderson, Michael J., additional, Antony, James W., additional, Baldassano, Christopher, additional, Brooks, Paula P., additional, Cai, Ming Bo, additional, Chen, Po-Hsuan Cameron, additional, Ellis, Cameron T., additional, Henselman-Petrusek, Gregory, additional, Huberdeau, David, additional, Hutchinson, J. Benjamin, additional, Li, Y. Peeta, additional, Lu, Qihong, additional, Manning, Jeremy R., additional, Mennen, Anne C., additional, Nastase, Samuel A., additional, Richard, Hugo, additional, Schapiro, Anna C., additional, Schuck, Nicolas W., additional, Shvartsman, Michael, additional, Sundaram, Narayanan, additional, Suo, Daniel, additional, Turek, Javier S., additional, Turner, David, additional, Vo, Vy A., additional, Wallace, Grant, additional, Wang, Yida, additional, Williams, Jamal A., additional, Zhang, Hejia, additional, Zhu, Xia, additional, Capota˘, Mihai, additional, Cohen, Jonathan D., additional, Hasson, Uri, additional, Li, Kai, additional, Ramadge, Peter J., additional, Turk-Browne, Nicholas B., additional, Willke, Theodore L., additional, and Norman, Kenneth A., additional

Published
2022
Full Text
View/download PDF

439. Systematic review with meta‐analysis: loss of response and requirement of ustekinumab dose escalation in inflammatory bowel diseases

Author

Yang, Hongsheng, primary, Li, Bingyang, additional, Guo, Qin, additional, Tang, Jian, additional, Peng, Bo, additional, Ding, Ni, additional, Li, Miao, additional, Yang, Qingfang, additional, Huang, Zicheng, additional, Diao, Na, additional, Zhu, Xia, additional, Deng, Jun, additional, Guo, Huili, additional, Hu, Pinjin, additional, Chao, Kang, additional, and Gao, Xiang, additional

Published
2022
Full Text
View/download PDF

445. Sodium butyrate ameliorated diabetic nephropathy-associated tubulointerstitial inflammation by modulating tight junction of renal tubular epithelial cells

Author

Yang, Tingting, primary, Li, Lin, additional, Heng, Cai, additional, Sha, pian, additional, Wang, yi ying, additional, Shen, jia ming, additional, Jiang, Zhen-zhou, additional, Qian, Sitong, additional, Wei, Chujing, additional, Yang, Hao, additional, Zhu, Xia, additional, Wang, Tao, additional, Wu, Mengying, additional, Wang, Jianyun, additional, Lu, Qian, additional, and Yin, Xiaoxing, additional

Published
2022
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results