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Overexpression of P-glycoprotein (Pgp) increases multidrug resistance (MDR) in cancer, which greatly impedes satisfactory clinical treatment and outcomes of cancer patients. Due to unknown pharmacokinetics, the use of Pgp inhibitors to overcome MDR in the clinical setting remains elusive despite promising in vitro results. The purpose of our current preclinical study is to investigate the pharmacokinetics and tolerability of NSC23925b, a novel and potent P-glycoprotein inhibitor, in rodents. Plasma pharmacokinetic studies of single-dose NSC23925b alone or in combination with paclitaxel or doxorubicin were conducted in male BALB/c mice and Sprague-Dawley rats. Additionally, inhibition of human cytochrome P450 (CYP450) by NSC23925b was examined in vitro. Finally, the maximum tolerated dose (MTD) of NSC23925b was determined. NSC23925b displayed favorable pharmacokinetic profiles after intraperitoneal/intravenous (I.P./I.V.) injection alone or combined with chemotherapeutic drugs. The plasma pharmacokinetic characteristics of the chemotherapy drugs were not affected when co-administered with NSC23925b. All the animals tolerated the I.P./I.V. administration of NSC23925b. Moreover, the enzymatic activity of human CYP450 was not inhibited by NSC23925b. Our results demonstrated that Pgp inhibitor NSC23925b exhibits encouraging preclinical pharmacokinetic characteristics and limited toxicity in vivo. NSC23925b has the potential to treat cancer patients with MDR in the future.

This document discusses the advancements in wearable sensing devices and technology. It presents a collection of papers that address various aspects of wearable technology, including authentication and security, localization in wireless sensor networks, sign language recognition, healthcare systems, enhancing user experience, and positioning and movement analysis. The document also highlights future research directions in the field, such as interdisciplinary integration, scalability and miniaturization, enhanced security, personalized healthcare, and improving user experience. Overall, this comprehensive overview provides valuable insights into the current state of wearable sensing devices and technology and sets the stage for future innovations in the field. [Extracted from the article]

This document is an editorial for a special issue of the journal Micromachines on the topic of exploring IoT sensors and their applications in smart environments. The editor highlights the importance of IoT sensors in various fields and discusses the advancements and challenges in this area. The editorial introduces ten research contributions that cover a range of applications and technologies, including wearable health monitoring systems, gesture recognition devices, low-light pedestrian detection systems, and gas sensors. The editor emphasizes the need for interdisciplinary collaboration, scalability of sensors, and data security in future research. Overall, this special issue provides valuable insights into the current state of IoT sensors and sets the stage for future innovations in this field. [Extracted from the article]

Laboratory Diagnosis of Infectious Diseases and Hospital Infection Control by Common Pathogens, one of the curriculum of Laboratory Diagnostics is both a starting point for most medical students to understand clinical microbes, and is also a platform for them to learn relevant basic knowledge. In the past, the course was instilled by teachers through electronic courseware in the classroom.As a result, student's learning passion is hard to be stimulated whtn lacked practical and intuitive understanding. In order to give full play to students' subjective initiative and maximize their interest in learning, the teaching team havemade new attempts and explorations on the form of teaching. The new mode enhances the capacity of self-learning, teamwork, and presentation to communication by increasing group interactive discussions, and presents a new look of learning and immersive learning with physical teaching.

Background: To address the molecular mechanism of the anti-inflammation effects of schisandrin B (Sch B) in atherosclerosis, we examined injured HMEC-1, HBMEC, and HUVEC-12 cells induced by high glucose (HG). Methods: Western blot was performed to detect the levels of the proteins Hsp27, Noxa, TLR5, p-I[kappa]B[alpha], and p-p65 in HG-induced cells, while ELISA was used to analyze the inflammatory cytokines TNF-[alpha], IL-6, MCP-1, and IL-1[beta] in cells with Hsp27 or Noxa stable expression. Results: Overexpression of Hsp27 upregulated the inflammatory cytokines and the release of I[kappa]B[alpha], promoted transportation of p65 into the nucleus, and lastly, affected the inflammation process, while Sch B counteracted the upregulation. In addition, the effect of Noxa overexpression, which is different from Hsp27 overexpression, was consistent with that of Sch B treatment. Conclusions: Sch B may inhibit the inflammatory cascade and alleviate the injury to HMEC-1, HBMEC, and HUEVC-12 cells caused by HG by regulating the Noxa/Hsp27/NF-[kappa]B signaling pathway. Key words: atherosclerosis, high glucose, Hsp27, inflammation, NF-[kappa]B, Noxa, schisandrin B. Contexte : Afin de comprendre le mecanisme moleculaire des effets anti-inflammatoires de la Sch B dans l'atherosclerose, les auteurs ont examine les cellules HMEC-1, HBMEC et HUVEC-12 endommagees par une concentration elevee de glucose. Methodes : Le transfert Western a ete realise pour detecter les niveaux proteiques de Hsp27, Noxa, TLR5, p-I[kappa]B[alpha] et p-p65 chez les cellules placees en presence de concentrations elevees de glucose, alors que le dosage ELISA a ete utilise pour analyser la presence des cytokines inflammatoires TNF-[alpha], IL-6, MCP-1 et IL-1[beta] dans les cellules exprimant Hsp27 et Noxa de facon stable. Resultats: La surexpression de Hsp27 regulait a la hausse les cytokines inflammatoires et la liberation d'I[kappa]B[alpha], favorisait le transport de p65 dans le noyau et affectait finalement le processus inflammatoire, alors que la Sch B contrecarrait cette regulation a la hausse. De plus, la surexpression de Noxa dont l'effet est different de celui de la surexpression de Hsp27, correspondait a l'effet du traitement a la Sch B. Conclusions : La Sch B peut inhiber la cascade inflammatoire et attenuer le dommage provoque par une concentration elevee de glucose dans les cellules HMEC-1, HBMEC et HUVEC-12 en regulant la voie de signalisation Noxa/Hsp27/NF-[kappa]B. [Traduit par la Redaction] Mots-cles: atherosclerose, concentration elevee de glucose, Hsp27, inflammation, NF-[kappa]B, Noxa, schisandrine B., Introduction Atherosclerosis (AS) is a common disease that seriously harms human health and is the main pathological basis of ischemic cardiovascular and cerebrovascular diseases, such as coronary heart disease, cerebrovascular [...]