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The [3+2] annulation of trifluoromethylated ketimines with acrylates has been enabled by rhenium-catalyzed C-H activation, delivering a variety of β-CF 3 β-amino esters. The reaction has exhibited broad substrate generality regarding aromatic CF 3 -ketimines and acrylates, the ability for gram scale synthesis, and facile derivation of the annulation products. The transformation is one of the few examples in which challenging sp 2 C-H bonds of CF 3 -ketimines have been functionalized. The rapid assembly of biologically important fluorinated β-amino esters by this strategy will benefit the related studies and inspire a new approach for fluorinated motif synthesis.

Transition metal catalyzed [3 + 2] annulation of imines with double bonds via directed C-H activation offers a direct access to amino cyclic motifs. However, owing to weak coordination and steric hindrance, trifluoromethylated ketimines have been an unaddressed challenge for TM-catalyzed annulations. Here, a rhenium-catalyzed [3 + 2] annulation of trifluoromethylated ketimines with isocyanates via C(sp 2 )-H activation has been disclosed. This approach provides an efficient platform for rapid access to a privileged library of CF 3 -containing iminoisoindolinones and polyamides by utilizing challenging CF 3 -ketimines as the annulation component. The capability of gram scale synthesis, the post-functionalization of the cyclization adduct, the derivation of complex natural molecules and the facile synthesis of polyamides highlight a diversity of synthetic potential of the current methodology., Competing Interests: The authors declare no competing financial interests., (© 2020 The Author(s).)

A transition metal-free approach was developed for the direct difunctionalization of disubstituted alkynes and terminal alkenes with concomitant formation of C-SCF2PO(OEt)2 and C-Cl bonds. The BiCl3-mediated reaction offered access to high value-added functionalized scaffolds in a single operation under mild conditions. Extension to SCF2PO(OEt)2-containing alkynes was also studied.

RNA editing results in post-transcriptional modification and could potentially contribute to carcinogenesis. However, RNA editing in advanced lung adenocarcinomas has not yet been studied. Based on whole genome and transcriptome sequencing data, we identified 1,071,296 RNA editing events from matched normal, primary and metastatic samples contributed by 24 lung adenocarcinoma patients, with 91.3% A-to-G editing on average, and found significantly more RNA editing sites in tumors than in normal samples. To investigate cancer relevant editing events, we detected 67,851 hyper-editing sites in primary and 50,480 hyper-editing sites in metastatic samples. 46 genes with hyper-editing in coding regions were found to result in amino acid alterations, while hundreds of hyper-editing events in non-coding regions could modulate splicing or gene expression, including genes related to tumor stage or clinic prognosis. Comparing RNA editome of primary and metastatic samples, we also discovered hyper-edited genes that may promote metastasis development. These findings showed a landscape of RNA editing in matched normal, primary and metastatic tissues of lung adenocarcinomas for the first time and provided new insights to understand the molecular characterization of this disease.

In recent years, much interest has been paid to difluoromethylthiolated molecules as the "SCF 2 " moiety is a key motif in drug and agrochemical research. Consequently, the development of versatile strategies for the selective synthesis of SCF 2 H- and SCF 2 FG-containing molecules (FG=functional group) has attracted a lot of attention and inspired the scientific community to design new tools. This Minireview highlights the major progress made in this field. Particularly, methodologies developed for the difluoromethylation of sulfur-containing molecules and the direct construction of C-SCF 2 bonds in various classes of compounds are showcased and discussed., (© 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.)

An unprecedented electrophilic difluoromethylthiolating reagent (MesNHSCF 2 PO(OEt) 2 ) was designed. Under mild and metal-free conditions, this new reagent reacted with various nucleophiles, thus offering an efficient and operationally simple tool for the construction of C-SCF 2 PO(OR) 2 , N-SCF 2 PO(OR) 2 , and S-SCF 2 PO(OR) 2 bonds. Finally, thanks to this new methodology, the synthesis of the non-stereoidal anti-inflammatory diflumidone was achieved., (© 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.)

A facile one-pot sequential conjugate addition/dearomative fluorination transformation of isoxazol-5(4H)-ones with nitroolefins and N-fluorobenzenesulfonimide (NFSI) has been developed. By using a bifunctional chiral tertiary amino-thiourea catalyst, a series of chiral fluorinated isoxazol-5(4H)-ones containing one fluorine-substituted quarternary stereocenter were obtained in high yields with high enantio- and diastereoselectivities. Further transformation of adducts could afford isoxazolidin-5-one derivatives with three contiguous stereocenters.

In this paper, the non-Markovian dynamics of a microcavity coupled to a waveguide in photonic crystals is studied based on a semi-finite tight binding model. Using the exact master equation, we solve analytically and numerically the general and exact solution of the non-Markovain dynamics for the cavity coupled to the waveguide in different coupling regime. A critical transition is revealed when the coupling increases between the cavity and the waveguide. In particular, the cavity field becomes dissipationless when the coupling strength goes beyond a critical value, as a manifestation of strong non-Markovian memory effect. The result also indicates that the cavity can maintain in a coherent state with arbitrary small number of photons when it strongly couples to the waveguide at very low temperature. These properties can be measured experimentally through the photon current flowing over the waveguide in photonic crystals.